The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Updating Fearful Memories with Extinction Training during Reconsolidation: A Human Study Using Auditory Aversive Stimuli
Open accessAbstract
Learning to fear danger in the environment is essential to survival, but dysregulation of the fear system is at the core of many anxiety disorders. As a consequence, a great interest has emerged in developing strategies for suppressing fear memories in maladaptive cases. Recent research has focused in the process of reconsolidation where memories become labile after being retrieved. In a behavioral manipulation, Schiller et al., (2010) reported that extinction training, administrated during memory reconsolidation, could erase fear responses. The implications of this study are crucial for the possible treatment of anxiety disorders without the administration of drugs. However, attempts to replicate this effect by other groups have been so far unsuccessful. We sought out to reproduce Schiller et al., (2010) findings in a different fear conditioning paradigm based on auditory aversive stimuli instead of electric shock. Following a within-subject design, participants were conditioned to two different sounds and skin conductance response (SCR) was recorded as a measure of fear. Our results demonstrated that only the conditioned stimulus that was reminded 10 minutes before extinction training did not reinstate a fear response after a reminder trial consisting of the presentation of the unconditioned stimuli. For the first time, we replicated Schiller et al., (2010) behavioral manipulation and extended it to an auditory fear conditioning paradigm.
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“These conditions include, but are not limited to, the type of psychophysiological measure employed, the schedule of reinforcement used during acquisition, the fear-relevancy of the conditioned stimuli presented, the strength of the fear memory following acquisition, and the presence or absence of on-line measures of expectancy or fear ratings [see Ref. (37, 91–93)].”
From Conditioned fear associated phenotypes as robust, translational indices of trauma-, stressor-, and anxiety-related behaviors (2014) · cites this paper as [92]
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Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior
Phelps, E. A., & LeDoux, J. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.025 · Cited by 3,203 · cited 2×
“Learning to fear is critical for human survival because it impels us to quickly recognize and avoid stimuli that could represent a threat to our lives [1].”
Fears, phobias, and preparedness: toward an evolved module of fear and fear learning
Öhman, A., & Mineka, S. (2001) · Psychological Review · doi:10.1037/0033-295x.108.3.483 · Cited by 3,147 · cited 1×
“These fearrelevant stimuli, although successfully extinguished on day 2, generated a stronger conditioning [39] making this fear association more resistant to undergo reconsolidation [40].”
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706
Context, ambiguity, and unlearning: sources of relapse after behavioral extinction
Bouton, M. E. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01546-9 · Cited by 1,662
Neural Mechanisms of Extinction Learning and Retrieval
Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645
Neurobiology of Pavlovian fear conditioning
Maren, S. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.897 · Cited by 1,543
Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress
Milad, M. R., & Quirk, G. J. (2012) · Annual Review of Psychology · doi:10.1146/annurev.psych.121208.131631 · Cited by 1,466
Bechara, A., Tranel, D., Damasio, H., Adolphs, R., Rockland, C., & Damasio, A. R. (1995) · Science · doi:10.1126/science.7652558 · Cited by 1,400
Rauch, S. L., Shin, L. M., & Phelps, E. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.004 · Cited by 1,397
Myers, K. M., & Davis, M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001939 · Cited by 1,277
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Temporal Dynamic and Biological Mechanism of Memory Reconsolidation
Zeng, X., Juan, D. U., Kaixin, W. A. N. G., & Zheng, X. (2015) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2015.00582 · Cited by 1
Zuccolo, P. F., & Hunziker, M. H. L. (2021) · Psychophysiology · doi:10.1111/psyp.13971 · Cited by 1
Caoyang, J., Li, J., Wei, C. H. E. N., Yang, Y., Hu, Y., & Zheng, X. (2019) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2019.00268 · Cited by 1
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Sánchez, A. T. (2022) · UMA Editorial eBooks · doi:10.24310/mumaedmumaed.5320 · Cited by 1
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Morales, S. V. (2022) · UMA Editorial eBooks · doi:10.24310/mumaedmumaed.5314 · Cited by 1
Kitamura, H. (2021) · Queensland University of Technology · doi:10.5204/thesis.eprints.207826 · Cited by 1
Neural mechanisms of memory reconsolidation
Exton-McGuinness, M. T. J. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham) · Cited by 1
Zuccolo, P. F. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.47.2014.tde-03122014-110949
Ecker, B. (2013)
Updating of Fear Memories by Behavioral Interventions during Memory Reconsolidation
Nitta, Y., Takahashi, T., & Kumano, H. (2016) · Anxiety Disorder Research · doi:10.14389/jsad.8.1_58
Extinction, erasure, and the recovery of fear memories
Golkar, A. (2013)
Cortisol and stress modulation of fear memory reconsolidation
Drexler, S. M. (2016)
Zuccolo, P. F. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.47.2019.tde-01022019-103752
Liu, P., & Shen, H. (2019) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2019.01417
Ganho-Ávila, A., Guiomar, R. N. R. M., Valério, D., Gonçalves, Ó. F., & Almeida, J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2019.12.18.880658
Huijser, D. (2019) · Utrecht University Repository (Utrecht University)
Komalasari, R. (2023) · Advances in psychology, mental health, and behavioral studies (APMHBS) book series · doi:10.4018/978-1-6684-5049-9.ch007
V Jornadas de investigación. Facultad de Psicología y Logopedia
Rey-Peña, L. (2022) · UMA Editorial eBooks · doi:10.24310/mumaedmumaed.53
Using Prediction Error and Memory Strength to Initiate Memory ReconsolidationPreprint
Paul, T., & Asthana, M. K. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5128555
Mitra, S., & Asthana, M. K. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5163907
Picco, S., Cavallino, L., Hoijer, P., Berón, J. C., Fernández, R. S., & Pedreira, M. E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.23.661086
Paul, T., & Asthana, M. K. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.07.014
Neural evidence for the effects of behavioral memory updating following fear conditioning
Timmers, I., Biggs, E. E., Heathcote, L. C., Fredrikson, M., Pine, D. S., Vlaeyen, J. W. S., Borsook, D., & Simons, L. E. (2025) · Communications Psychology · doi:10.1038/s44271-025-00328-0
Reconsolidação da memória e dependência de estado : mecanismos de atualização
Ordoñez, S., & Alejandro, R. (2012) · Americanae (AECID Library)
Metadata
- Authors
- Oyarzún, J. P., Lopez-Barroso, D., Fuentemilla, L., Cucurell, D., Pedraza, C., Rodriguez-Fornells, A., & de Diego-Balaguer, R.
- Affiliations
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Universidad de Málaga (ES)
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-06-29
- Volume
- 7
- Issue
- 6
- Pages
- e38849
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3387215
- OpenAlex
- W2091957319
- Cited by
- 125
- References
- 64
- Citations by year
- 2025: 6 · 2024: 3 · 2023: 4 · 2022: 11 · 2021: 7 · 2020: 6 · 2019: 11 · 2018: 14 · 2017: 14 · 2016: 11 · 2015: 11 · 2014: 17 · 2013: 8 · 2012: 2
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (publishedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion, cc-by)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Generalitat de Catalunya (2009 SGR 93)
- Ministerio de Ciencia e Innovación
- Universitat de Barcelona
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- fear memory reconsolidation, extinction training, fear extinction, auditory fear conditioning, anxiety disorders, skin conductance response, fear reinstatement, replication, aversive sounds
- MeSH terms
- Acoustic Stimulation, Extinction, Psychological, Fear, Female, Galvanic Skin Response, Humans, Male, Memory, Photic Stimulation, Young Adult
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