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Cited by 178Cardiovascular and exercise physiologySports Performance and TrainingMuscle metabolism and nutrition

Energy Metabolism during Repeated Sets of Leg Press Exercise Leading to Failure or Not

Open access
Gorostiaga, Esteban M., Navarro-Amézqueta, Ion, Calbet, José A. L., Hellsten, Ylva, Cusso, Roser, Guerrero, Mario, Granados, Cristina, González-Izal, Miriam +2 more·2012·PLoS ONE
DOI 10.1371/journal.pone.0040621PMC PMC3396634
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Abstract

This investigation examined the influence of the number of repetitions per set on power output and muscle metabolism during leg press exercise. Six trained men (age 34 ± 6 yr) randomly performed either 5 sets of 10 repetitions (10REP), or 10 sets of 5 repetitions (5REP) of bilateral leg press exercise, with the same initial load and rest intervals between sets. Muscle biopsies (vastus lateralis) were taken before the first set, and after the first and the final sets. Compared with 5REP, 10REP resulted in a markedly greater decrease (P<0.05) of the power output, muscle PCr and ATP content, and markedly higher (P<0.05) levels of muscle lactate and IMP. Significant correlations (P<0.01) were observed between changes in muscle PCr and muscle lactate (R(2) = 0.46), between changes in muscle PCr and IMP (R(2) = 0.44) as well as between changes in power output and changes in muscle ATP (R(2) = 0.59) and lactate (R(2) = 0.64) levels. Reducing the number of repetitions per set by 50% causes a lower disruption to the energy balance in the muscle. The correlations suggest that the changes in PCr and muscle lactate mainly occur simultaneously during exercise, whereas IMP only accumulates when PCr levels are low. The decrease in ATP stores may contribute to fatigue.

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  • When the last repetitions of a set are performed in the MaxV condition, only moderate levels of velocity loss and metabolic stress occur.

    “This implies that when the last repetitions of a set are being performed in the MaxV condition, only moderate levels of velocity loss and metabolic stress occur [ 12 , 32 ] .”

    From Effect of Movement Velocity during Resistance Training on Neuromuscular Performance (2014) · cites this paper as [12]

    The Results (Power and Force Production; page unavailable) report a 7–20% decline in peak power within five-repetition sets, and the Discussion (Muscle Metabolism; page unavailable) reports only modest lactate increases and maintained energy balance. The paper does not study a condition called MaxV or directly report velocity loss in that condition, so the claim’s specific application to MaxV is not established by this source. (LLM, conf=0.83)

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  • Intra-set VL is correlated with mechanical and metabolic fatigue markers, in addition to proximity to muscular failure.

    “Intra‐set VL is correlated with mechanical and metabolic fatigue markers, in addition to proximity to muscular failure (Gorostiaga et al., 2012).”

    From Acute systemic and energy metabolism responses to velocity-based resistance training following an oral glucose load in individuals with excess body weight (2026) · cites this paper as Gorostiaga et al., 2012

    The Results sections on power and force production and on muscle metabolites report larger within-set declines in peak power in sets leading to failure, and correlations between power changes and ATP and lactate levels. The paper reports power output, not an explicit correlation of intra-set velocity loss (VL) with those markers or with proximity to failure; its failure comparison is between exercise conditions. (LLM, conf=0.86)

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  • The metabolic stress and degree of fatigue induced by the RT protocols used in this investigation are far from those typically associated with exhaustive resistance training.

    “The metabolic stress and degree of fatigue induced by the RT protocols used in this investigation are far from those typically associated with exhaustive resistance training [ 12 , 32 ] .”

    From Effect of Movement Velocity during Resistance Training on Neuromuscular Performance (2014) · cites this paper as [12]

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Research works printed but not linked: 1

  1. [15]Storer TW Davis JA Caiozzo VJ 1990 Accurate prediction of VO2max in cycle ergometry. Med Sci Sports Exerc 22 704 712 2233211

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Authors
Gorostiaga, E. M., Navarro-Amézqueta, I., Calbet, J. A. L., Hellsten, Y., Cusso, R., Guerrero, M., Granados, C., González-Izal, M., Ibañez, J., & Izquierdo, M.
Affiliations
  • Gobierno de Navarra (ES)
  • Universidad de Las Palmas de Gran Canaria (ES)
  • University of Copenhagen (DK)
  • Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
Corresponding author
Gorostiaga, Esteban M.
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2012-07-13
Volume
7
Issue
7
Pages
e40621
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0040621
PMC
PMC3396634
OpenAlex
W2022174440
Cited by
178
References
45
Citations by year
2026: 12 · 2025: 13 · 2024: 16 · 2023: 14 · 2022: 18 · 2021: 18 · 2020: 27 · 2019: 15 · 2018: 14 · 2017: 10 · 2016: 4 · 2015: 10 · 2014: 6 · 2013: 1
FWCI
13.25
Type
journal article
Language
en
Update notices
correction (2013-01-17)
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by)
  • Academica-e (Universidad Pública de Navarra) (acceptedVersion, cc-by)
  • Acceda (Universidad de Las Palmas de Gran Canaria) (submittedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
leg press, muscle energy metabolism, muscle fatigue, phosphocreatine, ATP, muscle lactate, inosine monophosphate, output power, vastus lateralis
MeSH terms
Adult, Biomechanical Phenomena, Energy Metabolism, Humans, Leg, Male, Nucleotides, Phosphocreatine, Uric Acid, Exercise, Muscle, Skeletal, Lactic Acid, Metabolome

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