Regional Homogeneity within the Default Mode Network in Bipolar Depression: A Resting-State Functional Magnetic Resonance Imaging Study
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AIM: We sought to use a regional homogeneity (ReHo) approach as an index in resting-state functional magnetic resonance imaging (fMRI) to investigate the features of spontaneous brain activity within the default mode network (DMN) in patients suffering from bipolar depression (BD). METHODS: Twenty-six patients with BD and 26 gender-, age-, and education-matched healthy subjects participated in the resting-state fMRI scans. We compared the differences in ReHo between the two groups within the DMN and investigated the relationships between sex, age, years of education, disease duration, the Hamilton Rating Scale for Depression (HAMD) total score, and ReHo in regions with significant group differences. RESULTS: Our results revealed that bipolar depressed patients had increased ReHo in the left medial frontal gyrus and left inferior parietal lobe compared to healthy controls. No correlations were found between regional ReHo values and sex, age, and clinical features within the BD group. CONCLUSIONS: Our findings indicate that abnormal brain activity is mainly distributed within prefrontal-limbic circuits, which are believed to be involved in the pathophysiological mechanisms underlying bipolar depression.
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For MPFC, both increases and decreases in ReHo have been reported in patient populations; decreases in MPFC and ACC in depression, social anxiety, and Alzheimer disease, and a recent study in bipolar depression indicated an increase in MPFC ReHo.
“While decreases have been for MPFC and ACC in depression [74], but also social anxiety [75] or Alzheimer disease [76], a recent study in bipolar depression rather indicated an increase in MPFC ReHo [74].”
From State and training effects of mindfulness meditation on brain networks reflect neuronal mechanisms of its antidepressant effect (2016) · cites this paper as [75]
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“While decreases have been for MPFC and ACC in depression [74], but also social anxiety [75] or Alzheimer disease [76], a recent study in bipolar depression rather indicated an increase inMPFCReHo [74].”
BackgroundLiang, M.-J., Zhou, Q., Yang, K.-R., Yang, X.-L., Fang, J., Chen, W.-L., & Huang, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079999 · Cited by 135 · see citing works
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- Authors
- Liu, C.-H., Ma, X., Li, F., Wang, Y.-J., Tie, C.-L., Li, S.-F., Chen, T.-L., Fan, T.-T., Zhang, Y., Dong, J., Yao, L., Wu, X., & Wang, C.-Y.
- Affiliations
- Capital Medical University (CN)
- Beijing Normal University (CN)
- Corresponding author
- Wu, Xia
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-11-02
- Volume
- 7
- Issue
- 11
- Pages
- e48181
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3487908
- OpenAlex
- W2004696161
- Cited by
- 105
- References
- 66
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 3 · 2021: 10 · 2020: 12 · 2019: 8 · 2018: 7 · 2017: 1 · 2016: 11 · 2015: 9 · 2014: 18 · 2013: 9
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (61222113)
- Beijing Normal University
- Capital Medical University
- National Key Research and Development Program of China (2007CB512300, 61222113)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- bipolar depression, default mode network, regional homogeneity, resting-state brain activity, medial frontal gyrus, inferior parietal lobule, depression pathophysiology
- MeSH terms
- Adult, Algorithms, Bipolar Disorder, Brain, Brain Mapping, Depression, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Parietal Lobe, Regression Analysis, Models, Statistical, Case-Control Studies
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