Dynamic functional connectivity in bipolar disorder is associated with executive function and processing speed: A preliminary study
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OBJECTIVE: Disturbances in functional connectivity have been suggested to contribute to cognitive and emotion processing deficits observed in bipolar disorder (BD). Functional connectivity between medial prefrontal cortex (mPFC) and other brain regions may be particularly abnormal. The goal of the present study was to characterize the temporal dynamics of the default mode network (DMN) connectivity in BD and examine its association with cognition. METHOD: In a preliminary study, euthymic BD (n = 15) and healthy comparison (HC, n = 19) participants underwent resting-state functional MRI, using high-resolution sequences adapted from the Human Connectome Project, and completed neuropsychological measures of processing speed and executive function. A seed-based approach was used to measure DMN correlations in each participant, with regions of interest in the mPFC, posterior cingulate cortex (PCC), and lateral parietal cortex. Subsequently, to characterize temporal dynamics, correlational analyses between the mPFC and other DMN nodes were repeated using a sliding-window correlational analysis with subsets of the time series. RESULTS: When averaged across the entire scan, there were no group differences in overall connectivity strength between the mPFC and other regions of the DMN. However, dynamic connectivity between the mPFC and PCC was altered in BD, such that connectivity was less variable (i.e., more rigid) over time. Decreased connectivity variability was associated with slower processing speed and reduced cognitive set-shifting in BD patients. CONCLUSIONS: Variability in resting-state functional connectivity may be an index of internetwork flexibility that is reduced in BD and a correlate of ongoing cognitive impairment during periods of euthymia. (PsycINFO Database Record
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In depression, the precision might crash for positive priors, leading to hypo-learning and negativity.
“In depression (the other pole), the precision might crash for positive priors, leading to the state described earlier of hypo-learning and negativity (68, 69).”
From Predictive coding and neurocomputational psychiatry: a mechanistic framework for understanding mental disorders (2026) · cites this paper as [68]
The Methods (Participants; page not provided) study euthymic bipolar I participants, and the Discussion (page not provided) addresses attention and connectivity dynamics. Neither those passages nor searches for positive-prior precision, hypo-learning, and depression-related learning address the proposed mechanism. (LLM, conf=0.76)
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Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378 · see citing works
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630 · see citing works
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190 · see citing works
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913 · see citing works
(1998) · PubMed · Cited by 10,216 · see citing works
<i>The Brain's Default Network</i>: <i>Anatomy, Function, and Relevance to Disease</i>
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761 · see citing works
The organization of the human cerebral cortex estimated by intrinsic functional connectivity
Thomas Yeo, B. T., Krienen, F. M., Sepulcre, J., Sabuncu, M. R., Lashkari, D., Hollinshead, M., Roffman, J. L., Smoller, J. W., Zöllei, L., Polimeni, J. R., et al. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00338.2011 · Cited by 9,182 · see citing works
A Rating Scale for Mania: Reliability, Validity and Sensitivity
Young, R. C., Biggs, J. T., Ziegler, V. E., & Meyer, D. A. (1978) · British Journal of Psychiatry · doi:10.1192/bjp.133.5.429 · Cited by 8,744 · see citing works
The organization of the human cerebellum estimated by intrinsic functional connectivity
Buckner, R. L., Krienen, F. M., Castellanos, A., Diaz, J. C., & Yeo, B. T. T. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00339.2011 · Cited by 7,304 · see citing works
Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358 · see citing works
Andersson, J. L. R., Skare, S., & Ashburner, J. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00336-7 · Cited by 3,469 · see citing works
Exploring the brain network: A review on resting-state fMRI functional connectivity
van den Heuvel, M. P., & Hulshoff Pol, H. E. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.03.008 · Cited by 3,326 · see citing works
Structured clinical interview for DSM-IV axis I disorders : SCID-I : clinical version : scoresheet
First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1997) · American Psychiatric Press eBooks · Cited by 3,101 · see citing works
Gusnard, D. A., Akbudak, E., Shulman, G. L., & Raichle, M. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071043098 · Cited by 2,997 · see citing works
Tracking whole-brain connectivity dynamics in the resting state
Allen, E. A., Damaraju, E., Plis, S. M., Erhardt, E. B., Eichele, T., & Calhoun, V. D. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhs352 · Cited by 2,992 · see citing works
Dynamic functional connectivity: Promise, issues, and interpretations
Hutchison, R. M., Womelsdorf, T., Allen, E. A., Bandettini, P. A., Calhoun, V. D., Corbetta, M., Della Penna, S., Duyn, J. H., Glover, G. H., Gonzalez-Castillo, J., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.079 · Cited by 2,962 · see citing works
Thayer, J. F., Yamamoto, S. S., & Brosschot, J. F. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.09.543 · Cited by 2,276 · see citing works
The role of the posterior cingulate cortex in cognition and disease
Leech, R., & Sharp, D. J. (2014) · Brain · doi:10.1093/brain/awt162 · Cited by 2,247 · see citing works
Spreng, R. N., Mar, R. A., & Kim, A. S. N. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.21029 · Cited by 2,143 · see citing works
Andrews‐Hanna, J. R., Smallwood, J., & Spreng, R. N. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12360 · Cited by 2,102 · see citing works
Time–frequency dynamics of resting-state brain connectivity measured with fMRI
Chang, C., & Glover, G. H. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.011 · Cited by 1,808 · see citing works
Disruption of Large-Scale Brain Systems in Advanced Aging
Andrews-Hanna, J. R., Snyder, A. Z., Vincent, J. L., Lustig, C., Head, D., Raichle, M. E., & Buckner, R. L. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.038 · Cited by 1,592 · see citing works
Moeller, S., Yacoub, E., Olman, C. A., Auerbach, E., Strupp, J., Harel, N., & Uğurbil, K. (2010) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22361 · Cited by 1,586 · see citing works
Reduced resting-state brain activity in the “default network” in normal aging
Damoiseaux, J. S., Beckmann, C. F., Arigita, E. J. S., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., & Rombouts, S. A. R. B. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm207 · Cited by 1,187 · see citing works
Resting-state functional connectivity in neuropsychiatric disorders
Greicius, M. (2008) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328306f2c5 · Cited by 1,180 · see citing works
The brain's default network and its adaptive role in internal mentation
Andrews-Hanna, J. R. (2012) · The Neuroscientist · doi:10.1177/1073858411403316 · Cited by 1,114 · see citing works
Damaraju, E., Allen, E. A., Belger, A., Ford, J. M., McEwen, S. C., Mathalon, D. H., Mueller, B. A., Pearlson, G. D., Potkin, S. G., Preda, A., et al. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.07.003 · Cited by 1,066 · see citing works
Functional system and areal organization of a highly sampled individual human brain
Laumann, T. O., Gordon, E. M., Adeyemo, B., Snyder, A. Z., Joo, S. J., Chen, M.-Y., Gilmore, A. W., McDermott, K. B., Nelson, S. M., Dosenbach, N. U. F., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.037 · Cited by 911 · see citing works
Mazoyer, B., Zago, L., Mellet, E., Bricogne, S., Etard, O., Houdé, O., Crivello, F., Joliot, M., Petit, L., & Tzourio-Mazoyer, N. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00437-8 · Cited by 906 · see citing works
The effect of scan length on the reliability of resting-state fMRI connectivity estimates
Birn, R. M., Molloy, E. K., Patriat, R., Parker, T., Meier, T. B., Kirk, G. R., Nair, V. A., Meyerand, M. E., & Prabhakaran, V. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.099 · Cited by 875 · see citing works
Brain connectivity related to working memory performance
Hampson, M., Driesen, N. R., Skudlarski, P., Gore, J. C., & Constable, R. T. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3408-06.2006 · Cited by 853 · see citing works
Denny, B. T., Kober, H., Wager, T. D., & Ochsner, K. N. (2012) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00233 · Cited by 830 · see citing works
The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings
Strakowski, S. M., DelBello, M. P., & Adler, C. M. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001585 · Cited by 818 · see citing works
Leech, R., Kamourieh, S., Beckmann, C. F., & Sharp, D. J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5626-10.2011 · Cited by 759 · see citing works
Hutchison, R. M., Womelsdorf, T., Gati, J. S., Everling, S., & Menon, R. S. (2012) · Human Brain Mapping · doi:10.1002/hbm.22058 · Cited by 715 · see citing works
Functional Specialization within Rostral Prefrontal Cortex (Area 10): A Meta-analysis
Gilbert, S. J., Spengler, S., Simons, J. S., Steele, J. D., Lawrie, S. M., Frith, C., & Burgess, P. W. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2006.18.6.932 · Cited by 681 · see citing works
Wise, R. G., Ide, K., Poulin, M. J., & Tracey, I. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.025 · Cited by 664 · see citing works
Sakoğlu, Ü., Pearlson, G. D., Kiehl, K. A., Wang, Y. M., Michael, A. M., & Calhoun, V. D. (2010) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-010-0197-8 · Cited by 620 · see citing works
Schilbach, L., Eickhoff, S. B., Rotarska-Jagiela, A., Fink, G. R., & Vogeley, K. (2008) · Consciousness and Cognition · doi:10.1016/j.concog.2008.03.013 · Cited by 615 · see citing works
Shmueli, K., van Gelderen, P., de Zwart, J. A., Horovitz, S. G., Fukunaga, M., Jansma, J. M., & Duyn, J. H. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.037 · Cited by 542 · see citing works
Disruption of cortical association networks in schizophrenia and psychotic bipolar disorder
Baker, J. T., Holmes, A. J., Masters, G. A., Yeo, B. T. T., Krienen, F., Buckner, R. L., & Öngür, D. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.3469 · Cited by 435 · see citing works
Kurtz, M. M., & Gerraty, R. T. (2009) · Neuropsychology · doi:10.1037/a0016277 · Cited by 433 · see citing works
Non-Stationarity in the “Resting Brain’s” Modular Architecture
Jones, D. T., Vemuri, P., Murphy, M. C., Gunter, J. L., Senjem, M. L., Machulda, M. M., Przybelski, S. A., Gregg, B. E., Kantarci, K., Knopman, D. S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039731 · Cited by 427 · see citing works
Default mode network abnormalities in bipolar disorder and schizophrenia
Öngür, D., Lundy, M. Y., Greenhouse, I., Shinn, A. K., Menon, V., Cohen, B. M., & Renshaw, P. F. (2010) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.04.008 · Cited by 408 · see citing works
Rashid, B., Damaraju, E., Pearlson, G. D., & Calhoun, V. D. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00897 · Cited by 399 · see citing works
Calhoun, V. D., Maciejewski, P. K., Pearlson, G. D., & Kiehl, K. A. (2007) · Human Brain Mapping · doi:10.1002/hbm.20463 · Cited by 344 · see citing works
Medication Effects in Neuroimaging Studies of Bipolar Disorder
Phillips, M. L., Travis, M. J., Fagiolini, A. M., & Kupfer, D. J. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07071066 · Cited by 343 · see citing works
Abnormal Medial Prefrontal Cortex Resting-State Connectivity in Bipolar Disorder and Schizophrenia
Chai, X. J., Whitfield, S., Shinn, A. K., Gabrieli, J. D. E., Nieto-Castañón, A., McCarthy, J. M., Cohen, B. M., & Öngür, D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.88 · Cited by 322 · see citing works
Yan, C., Liu, D., Yong He, A., Zou, Q., Zhu, C., Zuo, X., Long, X., & Zang, Y. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005743 · Cited by 304 · see citing works
Relationship between respiration, end-tidal CO2, and BOLD signals in resting-state fMRI
Chang, C. E., & Glover, G. H. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.04.048 · Cited by 292 · see citing works
Hassel, S., Almeida, J. R., Kerr, N., Nau, S., Ladouceur, C. D., Fissell, K., Kupfer, D. J., & Phillips, M. L. (2008) · Bipolar Disorders · doi:10.1111/j.1399-5618.2008.00641.x · Cited by 277 · see citing works
On the Role of the Ventromedial Prefrontal Cortex in Self-Processing: The Valuation Hypothesis
D’Argembeau, A. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00372 · Cited by 270 · see citing works
A systematic literature review of resting state network—functional MRI in bipolar disorder
Vargas, C., López‐Jaramillo, C., & Vieta, E. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.05.083 · Cited by 268 · see citing works
What about the “Self” is Processed in the Posterior Cingulate Cortex?
Brewer, J. A., Garrison, K. A., & Whitfield-Gabrieli, S. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00647 · Cited by 263 · see citing works
Global Prefrontal and Fronto-Amygdala Dysconnectivity in Bipolar I Disorder with Psychosis History
Anticevic, A., Brumbaugh, M. S., Winkler, A. M., Lombardo, L. E., Barrett, J., Corlett, P. R., Kober, H., Gruber, J., Repovs, G., Cole, M. W., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.031 · Cited by 263 · see citing works
The cognitive and neurophysiological basis of emotion dysregulation in bipolar disorder.
Green, M., Cahill, C., & Malhi, G. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.01.024 · Cited by 247 · see citing works
Reproducibility of Single-Subject Functional Connectivity Measurements
Anderson, J. S., Ferguson, M. A., Lopez-Larson, M. P., & Yurgelun-Todd, D. A. (2011) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2330 · Cited by 195 · see citing works
Rizzo, L. B., Costa, L. G., Mansur, R. B., Swardfager, W., Belangero, S. I., Grassi-Oliveira, R., McIntyre, R. S., Bauer, M. E., & Brietzke, E. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.004 · Cited by 183 · see citing works
Neuroprogression and Cognitive Functioning in Bipolar Disorder: A Systematic Review
Cardoso, T., Bauer, I. E., Meyer, T. D., Kapczinski, F. P., & Soares, J. C. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0605-x · Cited by 156 · see citing works
Cardiorespiratory effects on default‐mode network activity as measured with fMRI
van Buuren, M., Gladwin, T. E., Zandbelt, B. B., van den Heuvel, M. P., Ramsey, N. F., Kahn, R. S., & Vink, M. (2009) · Human Brain Mapping · doi:10.1002/hbm.20729 · Cited by 119 · see citing works
P4‐158: Nonstationarity in the ‘resting brain's’ modular architecture
Jones, D. T., Vemuri, P., Murphy, M. C., Gunter, J. L., Senjem, M. L., Machulda, M. M., Przybelski, S. A., Gregg, B. E., Kantarci, K., Knopman, D. S., et al. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.05.1862 · Cited by 116 · see citing works
Liu, C.-H., Ma, X., Li, F., Wang, Y.-J., Tie, C.-L., Li, S.-F., Chen, T.-L., Fan, T.-T., Zhang, Y., Dong, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048181 · Cited by 105 · see citing works
fMRI evidence for abnormal resting-state functional connectivity in euthymic bipolar patients
Favre, P., Baciu, M. V., Pichat, C., Bougerol, T., & Polosan, M. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.04.054 · Cited by 94 · see citing works
Neurocognitive and Neuroimaging Predictors of Clinical Outcome in Bipolar Disorder
Bearden, C. E., Woogen, M., & Glahn, D. C. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0151-5 · Cited by 46 · see citing works
Glover (2000) · doi:10.1002/1522-2594(200007)44:1
Flagged first, then by citations
Cited by
Sorted by citations
Liu, J., Liao, X., Xia, M., & Yong He, A. (2017) · Human Brain Mapping · doi:10.1002/hbm.23890 · Cited by 205 · see citing works
Wang, J., Wang, Y., Huang, H., Jia, Y., Zheng, S., Zhong, S., Chen, G., Huang, L., & Huang, R. (2019) · Psychological Medicine · doi:10.1017/s003329171900028x · Cited by 138 · see citing works
Long, Y., Cao, H., Yan, C., Chen, X., Li, L., Castellanos, F. X., Bai, T., Bo, Q., Chen, G., Chen, N., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102163 · Cited by 131 · see citing works
Cottam, W. J., Iwabuchi, S. J., Drabek, M. M., Reckziegel, D., & Auer, D. P. (2018) · Pain · doi:10.1097/j.pain.0000000000001209 · Cited by 110 · see citing works
Pang, Y., Chen, H., Wang, Y., Long, Z., He, Z., Zhang, H., Liao, W., Cui, Q., & Chen, H. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.03.020 · Cited by 110 · see citing works
Li, Y., Zhu, Y., Nguchu, B. A., Wang, Y., Wang, H., Qiu, B., & Wang, X. (2020) · Autism Research · doi:10.1002/aur.2212 · Cited by 95 · see citing works
Default mode network activity in bipolar disorder
Zovetti, N., Rossetti, M. G., Perlini, C., Maggioni, E., Bontempi, P., Bellani, M., & Brambilla, P. (2020) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796020000803 · Cited by 82 · see citing works
Vellante, F., Ferri, F., Baroni, G., Croce, P., Migliorati, D., Pettorruso, M., Berardis, D. D., Martinotti, G., Zappasodi, F., & Giannantonio, M. D. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.03.175 · Cited by 70 · see citing works
Cotrena, C., Branco, L. D., Ponsoni, A., Samamé, C., Shansis, F., & Fonseca, R. P. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13121 · Cited by 62 · see citing works
Pang, Y., Zhang, H., Cui, Q., Yang, Q., Lu, F., Chen, H., He, Z., Wang, Y., Wang, J., & Chen, H. (2020) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867420924089 · Cited by 53 · see citing works
Nyatega, C. O., Li, Q., Adamu, M. J., Younis, A., & Kawuwa, H. B. (2021) · Applied Sciences · doi:10.3390/app112311392 · Cited by 53 · see citing works
Luo, Z., Chen, G., Jia, Y., Zhong, S., Gong, J., Chen, F., Wang, J., Qi, Z., Liu, X., Huang, L., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.11.012 · Cited by 52 · see citing works
Bora, E. (2017) · European Psychiatry · doi:10.1016/j.eurpsy.2017.06.003 · Cited by 48 · see citing works
Little, B., Anwyll, M., Norsworthy, L., Corbett, L., Schultz‐Froggatt, M., & Gallagher, P. (2023) · Bipolar Disorders · doi:10.1111/bdi.13396 · Cited by 43 · see citing works
Cortico-limbic connectivity as a possible biomarker for bipolar disorder: where are we now?
Vai, B., Bertocchi, C., & Benedetti, F. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1562338 · Cited by 41 · see citing works
Transition and Dynamic Reconfiguration of Whole-Brain Network in Major Depressive Disorder
Wang, S., Wen, H., Hu, X., Xie, P., Qiu, S., Qian, Y., Qiu, J., & He, H. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01995-2 · Cited by 44 · see citing works
Cattarinussi, G., Giorgio, A. D., Moretti, F., Bondi, E., & Sambataro, F. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110827 · Cited by 46 · see citing works
Resting state networks activity in euthymic bipolar disorder
Bellani, M., Bontempi, P., Zovetti, N., Rossetti, M. G., Perlini, C., Dusi, N., Squarcina, L., Marinelli, V., Zoccatelli, G., Alessandrini, F., et al. (2020) · Bipolar Disorders · doi:10.1111/bdi.12900 · Cited by 40 · see citing works
van Geest, Q., Hulst, H. E., Meijer, K. A., Hoyng, L., Geurts, J. J. G., & Douw, L. (2018) · Brain and Behavior · doi:10.1002/brb3.954 · Cited by 38 · see citing works
Lu, F., Chen, Y., Cui, Q., Guo, Y., Pang, Y., Luo, W., Yu, Y., Chen, J., Gao, J., Sheng, W., et al. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhac534 · Cited by 36 · see citing works
Long, Y., Liu, X., & Liu, Z. (2023) · Brain Sciences · doi:10.3390/brainsci13030429 · Cited by 36 · see citing works
Shunkai, L., Su, T., Zhong, S., Chen, G., Zhang, Y., Zhao, H., Chen, P., Tang, G., Qi, Z., He, J., et al. (2021) · Psychological Medicine · doi:10.1017/s0033291721004906 · Cited by 35 · see citing works
Electroencephalographic Microstates in Schizophrenia and Bipolar Disorder
Wang, F., Hujjaree, K., & Wang, X. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.638722 · Cited by 34 · see citing works
Neural correlates of childhood trauma with executive function in young healthy adults
Lu, S., Pan, F., Gao, W., Wei, Z., Wang, D., Hu, S., Huang, M., Xu, Y., & Li, L. (2017) · Oncotarget · doi:10.18632/oncotarget.20051 · Cited by 33 · see citing works
Common and distinct functional stability abnormalities across three major psychiatric disorders
Zhu, J., Zhang, S., Cai, H., Wang, C., & Yu, Y. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102352 · Cited by 33 · see citing works
Long, Y., Ouyang, X., Yan, C., Wu, Z., Huang, X., Pu, W., Cao, H., Liu, Z., & Palaniyappan, L. K. (2023) · Human Brain Mapping · doi:10.1002/hbm.26202 · Cited by 32 · see citing works
Du, M., Zhang, L., Li, L., Ji, E., Han, X., Huang, G., Liang, Z., Shi, L., Yang, H., & Zhang, Z. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.04.005 · Cited by 31 · see citing works
Yue, J.-L., Li, P., Shi, L., Lin, X., Sun, H., & Lü, L. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.02.025 · Cited by 31 · see citing works
Massalha, Y., Maggioni, E., Callari, A., Brambilla, P., & Delvecchio, G. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.03.084 · Cited by 30 · see citing works
Disrupted default mode network connectivity in bipolar disorder: a resting-state fMRI study
Zhao, L., Bo, Q., Zhang, Z., Feng, L., Zhou, Y., & Wang, C. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05869-y · Cited by 31 · see citing works
Fateh, A. A., Cui, Q., Duan, X., Yang, Y., Chen, Y., Li, D., He, Z., & Chen, H. (2020) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2020.111149 · Cited by 28 · see citing works
Nyatega, C. O., Li, Q., Adamu, M. J., & Kawuwa, H. B. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1054380 · Cited by 27 · see citing works
Gong, J., Chen, G., Zhou, M., Jia, Y., Zhong, S., Chen, F., Lai, S., Luo, Z., Wang, J., Xu, H., et al. (2020) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867420948960 · Cited by 25 · see citing works
Abnormal intrinsic brain functional network dynamics in unmedicated depressed bipolar II disorder
Wang, J., Wang, Y., Huang, H., Jia, Y., Zheng, S., Zhong, S., Huang, L., & Huang, R. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.04.103 · Cited by 24 · see citing works
Rashid, B., Dev, S., Esterman, M., Schwarz, N., Ferland, T., Fortenbaugh, F. C., Milberg, W., McGlinchey, R., Salat, D., & Leritz, E. (2019) · Brain and Behavior · doi:10.1002/brb3.1333 · Cited by 23 · see citing works
Guo, Z., Xiao, S., Chen, G., Zhong, S., Zhong, H., Sun, S., Chen, P., Tang, X., Yang, H., Jia, Y., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03207-0 · Cited by 24 · see citing works
McPhilemy, G., Nabulsi, L., Kilmartin, L., Whittaker, J. R., Martyn, F. M., Hallahan, B. P., McDonald, C., Murphy, K., & Cannon, D. M. (2020) · Brain Connectivity · doi:10.1089/brain.2019.0709 · Cited by 22 · see citing works
Advances in the fMRI analysis of the default mode network: a review
Sanz‐Morales, E., & Melero, H. (2024) · Brain Structure and Function · doi:10.1007/s00429-024-02888-z · Cited by 23 · see citing works
Zhang, H., Palaniyappan, L. K., Wu, Y., Cong, E., Wu, C., Ding, L., Jin, F., Qiu, M., Huang, Y., Wu, Y., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.05.148 · Cited by 20 · see citing works
Ye, J., Sun, H., Gao, S., Dadashkarimi, J., Rosenblatt, M., Rodriguez, R. X., Mehta, S., Jiang, R., Noble, S., Westwater, M. L., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.03.024 · Cited by 20 · see citing works
Cui, G., Wang, Y., Wang, X., Zheng, L., Li, L., Li, P., Zhang, L., Guo, Y. Q., Chen, Y., Sun, Z., et al. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112335 · Cited by 19 · see citing works
Tassi, E., Boscutti, A., Mandolini, G. M., Moltrasio, C., Delvecchio, G., & Brambilla, P. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.11.019 · Cited by 18 · see citing works
Chen, P., Chen, G., Zhong, S., Chen, F., Ye, T., Gong, J., Tang, G., Pan, Y., Luo, Z., Qi, Z., et al. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.03.023 · Cited by 18 · see citing works
Wu, Y., Su, Y., Zhu, L.-L., Li, J., Li, Q., Dai, Y., Lin, J., Li, K., & Si, T. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-05083-2 · Cited by 18 · see citing works
Luperdi, S. C., Correa‐Ghisays, P., Vila‐Francés, J., Selva‐Vera, G., Salazar-Fraile, J., Cardoner, N., Ruíz-Veguilla, M., Livianos, L., Tabarés‐Seisdedos, R., & Balanzá‐Martínez, V. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.07.008 · Cited by 18 · see citing works
Zhong, S., Chen, P., Lai, S., Chen, G., Zhang, Y., Lv, S., He, J., Tang, G., Pan, Y., Wang, Y., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.09.050 · Cited by 16 · see citing works
Liang, Y., Jiang, X., Zhu, W., Shen, Y., Xue, F., Li, Y., & Chen, Z. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.537981 · Cited by 15 · see citing works
Wang, H., Zhu, R., Tian, S., Zhang, S., Dai, Z., Shao, J., Li, X., Yao, Z., & Lü, Q. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.03.010 · Cited by 15 · see citing works
Biomarker identification in bipolar disorder
Martella, F., Caporali, A., Macellaro, M., Cafaro, R., de Pasquale, F., Dell’Osso, B. M., & D’Addario, C. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108823 · Cited by 13 · see citing works
Xu, Y., Shang, H., Lu, H., Zhang, J., Yao, L., & Long, Z. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.758137 · Cited by 13 · see citing works
Balsa, L. B., Abu-Akel, A. M., & Mevorach, C. (2024) · Autism Research · doi:10.1002/aur.3117 · Cited by 12 · see citing works
Sastry, N. C., & Banerjee, A. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02929-5 · Cited by 10 · see citing works
Sun, H., Yan, R., Hua, L., Xia, Y. X., Chen, Z., Huang, Y., Wang, X., Xia, Q., Yao, Z., & Lü, Q. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.01.028 · Cited by 10 · see citing works
Shaw, A. D., Sumner, R. L., & Berndt, L. C. S. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1713833 · Cited by 9 · see citing works
State and Trait Anxiety Share Common Network Topological Mechanisms of Human Brain
Li, Y., & Jiang, L. (2022) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2022.859309 · Cited by 9 · see citing works
Cai, L., Shi, J., Dong, Q., Wei, J., & Chen, H. (2022) · Brain Imaging and Behavior · doi:10.1007/s11682-022-00696-9 · Cited by 9 · see citing works
Zhuo, C., Ji, F., Lin, X., Tian, H., Wang, L., Xu, Y. J., Wang, W., & Jiang, D. (2020) · Brain and Behavior · doi:10.1002/brb3.1637 · Cited by 7 · see citing works
Qiu, L., Ye, J., Ji, F., Li, G., Li, G., Ma, X., Li, R., Tian, H., Wang, L., Chen, G., et al. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00222-4 · Cited by 6 · see citing works
Time varying dynamics of hallucinations in clinical and non-clinical voice-hearers
Marschall, T. M., Koops, S., Brederoo, S., Cabral, J., Ćurĉić‐Blake, B., & Sommer, I. E. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103351 · Cited by 5 · see citing works
An Overview of Machine Learning Applications in Mood Disorders
Topolski, N., Jeong, S. H., & Mwangi, B. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.017 · Cited by 4 · see citing works
Rich club characteristics of dynamic brain functional networks in resting state
Jiao, Z., Wang, H., Cai, M., Cao, Y., Zou, L., & Wang, S. (2018) · Multimedia Tools and Applications · doi:10.1007/s11042-018-6424-4 · Cited by 4 · see citing works
Hanna, S., Ho, V. M., Lucas, M., Vadera, S., Qing, K. Y., Deng, D., King‐Stephens, D., Sazgar, M., Mnatsakanyan, L., Lin, J., et al. (2026) · Journal of Neural Engineering · doi:10.1088/1741-2552/ae60d0 · Cited by 3 · see citing works
Zhang, C., Liang, J., Yan, H., Yu, Y. H., Li, X., Huang, W., Li, X., Tang, C., Xu, J., Ou, Y., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119572 · Cited by 3 · see citing works
Yoon, H., Dev, S. I., Sutherland, A. N., & Eyler, L. T. (2018) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2018.03.005 · Cited by 3 · see citing works
Dissociation Pattern in Default-Mode Network Homogeneity in Drug-Naive Bipolar Disorder
Li, S., Teng, Z., Qiu, Y., Pan, P., Wu, C., Jin, K., Wang, L., Chen, J., Tang, H., Xiang, H., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.699292 · Cited by 3 · see citing works
(2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018 · Cited by 3 · see citing works
Chen, Y., Fang, C., Xie, J., Zheng, J., He, Y., Liu, X., Roberts, N., Shen, Y. M., Bai, Y., Wei, W., et al. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111612 · Cited by 2 · see citing works
Neuroimaging Studies of Effects of Psychotherapy in Depression
Bauer, I. E., & Meyer, T. D. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.021 · Cited by 2 · see citing works
Zhang, X., Cheng, X., Chen, J., Sun, J., Yang, X., Li, W., Chen, L., Mao, Y., Liu, Y., Zeng, X., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.04.063 · Cited by 2 · see citing works
Electrophysiological Biomarkers for Mood Disorders
Ramakrishnan, N., Murphy, N., Selvaraj, S., & Cho, R. Y. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.015 · Cited by 2 · see citing works
Zhao, L., Bo, Q., Zhang, Z., Li, F., Zhou, Y., & Wang, C. (2021) · Research Square · doi:10.21203/rs.3.rs-194210/v1 · Cited by 2 · see citing works
Ye, J., Mehta, S., Peterson, H., Ibrahim, A., Saeed, G., Linsky, S., Kreinin, I., Tsang, S. W., Nwanaji-Enwerem, U., Raso, A., et al. (2024) · medRxiv · doi:10.1101/2024.02.25.24303340 · Cited by 2 · see citing works
Na, W.-Q., Su, W., Sun, J., Chen, H.-Z., Wu, L.-N., Li, J., & Mei, L.-F. (2020) · Iranian Red Crescent Medical Journal · doi:10.32592/ircmj.2020.22.12.65 · Cited by 1 · see citing works
Fateh, A. A., Smahi, A., Hassan, M. H. U. H., Cañete‐Massé, C., Mohammed, A. A. Q., Yue, F., Hu, Z., & Zeng, H. (2025) · Epilepsy Research · doi:10.1016/j.eplepsyres.2025.107665 · Cited by 1 · see citing works
Soleimani, N., Wiafe, S.-L., Iraji, A., Pearlson, G. D., & Calhoun, V. D. (2025) · Network Neuroscience · doi:10.1162/netn.a.505 · Cited by 1 · see citing works
Olivo, D., Miola, A., Comini, F. F., Trevisan, N., Librizzi, G., Toffanin, T., Manara, R., & Sambataro, F. (2025) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2025.11.015 · Cited by 1 · see citing works
The impact of functional architecture dynamics in bipolar disorder staging
Caporali, A., Martella, F., Saluzzi, S., Girone, N., Feliciani, B., Cavallotto, C., Pettorruso, M., Gerevini, S., Bondi, E., Perrotta, C., et al. (2026) · NeuroImage Clinical · doi:10.1016/j.nicl.2026.104045 · Cited by 1 · see citing works
Wu, Y.-K., Zhu, L.-L., Li, J., Li, Q., Dai, Y.-R., Li, K., Mitchell, P. B., Si, T., & Su, Y. (2024) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2024.04.014 · Cited by 1 · see citing works
Mechanisms underpinning neurocognitive dysfunction in bipolar disorder
Bora, E. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819182-8.00007-7 · Cited by 1 · see citing works
Brain Imaging and the Mechanisms of Antidepressant Action
Godlewska, B. R., Selvaraj, S., & Cowen, P. J. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.020 · Cited by 1 · see citing works
Effects of Lithium on Brain Structure in Bipolar Disorder
Kaur, J., Kafantaris, V., & Szeszko, P. R. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.018 · Cited by 1 · see citing works
Functional Connectome in Bipolar Disorder
Cha, J., & Anand, A. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.008 · Cited by 1 · see citing works
Imaging Genetic and Epigenetic Markers in Mood Disorders
Poletti, S., Mazza, E. A., Vai, B., & Benedetti, F. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.012
Brain Imaging of Reward Dysfunction in Unipolar and Bipolar Disorders
Kumar, P., Jiang, Y., & Whitton, A. E. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.006
Resting-State Functional Connectivity in Unipolar Depression
Chen, Z., & Gong, Q. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.007
Brain Imaging Methods in Mood Disorders
Selvaraj, S., Brambilla, P., & Soares, J. C. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.002
Kious, B. M., & Renshaw, P. F. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.009
Neuroimaging Brain Inflammation in Mood Disorders
Meyer, J. H. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.011
Functional Near-Infrared Spectroscopy Studies in Mood Disorders
Matsuo, K., & Matsubara, T. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.014
Neuroanatomical Findings in Unipolar Depression and the Role of the Hippocampus
Arnone, D. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.003
Neuroimaging Biomarkers in Pediatric Mood Disorders
West, M. P., Tang, W. J., & Singh, M. K. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.005
fMRI Neurofeedback as Treatment for Depression
Skottnik, L., & Linden, D. E. J. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.013
Neuroanatomical Findings in Bipolar Disorder
Tronchin, G., & McDonald, C. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.004
Imaging Glutamatergic and GABAergic Abnormalities in Mood Disorders
Scotti-Muzzi, E., Otaduy, M. C. G., Soeiro‐de‐Souza, M. G., & Machado‐Vieira, R. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.010
Molecular Imaging of Dopamine and Antipsychotics in Bipolar Disorder
Jauhar, S. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.019
Magnetoencephalography Studies in Mood Disorders
Nugent, A. C. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.016
Executive Function Deficits in Bipolar Disorder
Jiang, W., Xu, Z., & Zhao, J. (2021) · Advances in Social Science, Education and Humanities Research/Advances in social science, education and humanities research · doi:10.2991/assehr.k.210806.095
Selvaraj, S., Brambilla, P., & Soares, J. C. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.022
Selvaraj, S., Brambilla, P., & Soares, J. C. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.001
Ye, J., Sun, H., Gao, S., Dadashkarimi, J., Rosenblatt, M., Rodriguez, R. X., Mehta, S., Jiang, R., Noble, S., Westwater, M. L., et al. (2022) · medRxiv · doi:10.1101/2022.10.07.22280835
- Authors
- Nguyen, T. T., Kovacevic, S., Dev, S. I., Lu, K., Liu, T. T., & Eyler, L. T.
- Affiliations
- VA San Diego Healthcare System (US)
- San Diego State University (US)
- University of California San Diego (US)
- Venue
- Neuropsychology
- Published
- 2017-01
- Volume
- 31
- Issue
- 1
- Pages
- 73-83
- ISSN
- 0894-4105 (ISSN-L)
- 1931-1559
- PMC
- PMC5471616
- OpenAlex
- W2538606748
- Cited by
- 109
- References
- 67
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 11 · 2023: 11 · 2022: 7 · 2021: 33 · 2020: 17 · 2019: 7 · 2018: 6 · 2017: 3
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropsychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (5r01mh083968-05)
- National Institute of Mental Health (R01-MH083968, T32MH019934)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- bipolar disorder, dynamic functional connectivity, default mode network, medial prefrontal cortex, posterior cingulate cortex, processing speed, executive function, set-shifting, cognitive flexibility, euthymia, cognitive impairment
- MeSH terms
- Adult, Bipolar Disorder, Brain, Brain Mapping, Cognition, Cognition Disorders, Emotions, Female, Gyrus Cinguli, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Neuropsychological Tests, Parietal Lobe, Psychometrics, Reaction Time, Reference Values, Prefrontal Cortex, Executive Function
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