Effect of Fruit Juice on Cholesterol and Blood Pressure in Adults: A Meta-Analysis of 19 Randomized Controlled Trials
Open accessAbstract
BACKGROUND: The effect of fruit juice on serum cholesterol and blood pressure in humans has generated inconsistent results. We aimed to quantitatively evaluate the effect of fruit juice on serum cholesterol and blood pressure in adults. METHODS: We performed a strategic literature search of PubMed, EMBASE, and the Cochrane Library (updated to October, 2012) for randomized controlled trials that evaluated the effects of fruit juice on serum cholesterol and blood pressure. Study quality was assessed by using the Jadad scale. Weighted mean differences were calculated for net changes in cholesterol and blood pressure by using fixed-effects model. Prespecified subgroup and sensitivity analyses were conducted to explore the potential heterogeneity. RESULTS: Nineteen trials comprising a total of 618 subjects were included in this meta-analysis. Fruit juice consumption borderlinely reduced the diastolic blood pressure (DBP) by 2.07 mm Hg (95% CI: -3.75, -0.39 mm Hg; p = 0.02), but did not show significant effects on total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C) concentrations or systolic blood pressure (SBP) values. A significant reduction of TC concentration was observed in low-median intake of total polyphenols group. Subgroup analyses for HDL-C and LDL-C concentrations did not show statistically significant results. No significant heterogeneity was detected for all the measures. CONCLUSION: This meta-analysis suggested that fruit juice had a borderline significant effect on reducing DBP, but had no effect on TC, HDL-C, LDL-C concentrations or SBP.
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In short-term trials, fruit juice has no appreciable effects on blood pressure, cholesterol levels, or glucose-insulin homeostasis.
“In short-term trials, fruit juice has no appreciable effects on blood pressure, cholesterol levels, or glucose-insulin homeostasis.267, 268”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [267]
In short-term trials, fruit juice has no appreciable effects on blood pressure, cholesterol levels, or glucose-insulin homeostasis.
“In short-term trials, fruit juice has no appreciable effects on blood pressure, cholesterol levels, or glucose-insulin homeostasis.267, 268”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [268]
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Cites
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139 · see citing works
Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333 · see citing works
Moher, D., Pham, B., Jones, A., Cook, D. J., Jadad, A. R., Moher, M., Tugwell, P., & Klassen, T. P. (1998) · The Lancet · doi:10.1016/s0140-6736(98)01085-x · Cited by 3,560 · see citing works
Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study
Castelli, W. P. (1986) · JAMA · doi:10.1001/jama.256.20.2835 · Cited by 2,305 · see citing works
Dawber, T. R. (1980) · Harvard University Press eBooks · doi:10.4159/harvard.9780674492097 · Cited by 1,962 · see citing works
Cholesterol-lowering effects of dietary fiber: a meta-analysis
Brown, L., Rosner, B., Willett, W. W., & Sacks, F. M. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.1.30 · Cited by 1,857 · see citing works
Incidence of Coronary Heart Disease and Lipoprotein Cholesterol Levels
Castelli, W. P. (1986) · JAMA · doi:10.1001/jama.1986.03380200073024 · Cited by 1,620 · see citing works
Prevalence, Awareness, Treatment, and Control of Hypertension Among United States Adults 1999–2004
Ong, K. L., Cheung, B. M. Y., Man, Y. B., Lau, C. P., & Lam, K. S. L. (2007) · Hypertension · doi:10.1161/01.hyp.0000252676.46043.18 · Cited by 1,395 · cited 1× · see citing works
“In addition, accumulating evidence suggests that hypertension is a major risk factor for CVD, such as heart failure, stroke, and myocardial infarction [4].”
BackgroundVariance imputation for overviews of clinical trials with continuous response
Follmann, D. A., Elliott, P., Suh, I., & Cutler, J. A. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90054-q · Cited by 1,391 · see citing works
Dauchet, L., Amouyel, P., Hercberg, S., & Dallongeville, J. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.10.2588 · Cited by 1,204 · see citing works
Implications of Small Reductions in Diastolic Blood Pressure for Primary Prevention
Cook, N. R. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.1995.00430070053006 · Cited by 828 · see citing works
Blueberries Decrease Cardiovascular Risk Factors in Obese Men and Women with Metabolic Syndrome
Basu, A., Du, M., Leyva, M. J., Sanchez, K., Betts, N. M., Wu, M., Aston, C. E., & Lyons, T. J. (2010) · Journal of Nutrition · doi:10.3945/jn.110.124701 · Cited by 507 · see citing works
Kannel, W. B., Neaton, J. D., Wentworth, D. N., Thomas, H. E., Stamler, J., Hulley, S. B., & Kjelsberg, M. O. (1986) · American Heart Journal · doi:10.1016/0002-8703(86)90481-3 · Cited by 502 · see citing works
Dietary intake of fruits and vegetables and risk of cardiovascular disease
Bazzano, L. A., Serdula, M. K., & Liu, S. (2003) · Current Atherosclerosis Reports · doi:10.1007/s11883-003-0040-z · Cited by 472 · see citing works
Morand, C., Dubray, C., Milenkovic, D., Lioger, D., Martin, J. F., Scalbert, A., & Mazur, A. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.004945 · Cited by 439 · see citing works
Clark, C. E., Taylor, R. S., Shore, A. C., Ukoumunne, O. C., & Campbell, J. L. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61710-8 · Cited by 421 · see citing works
Castilla, P., Echarri, R., Dávalos, A., Cerrato, F., Ortega, H., Teruel, J. L., Lucas, M. F., Gómez‐Coronado, D., Ortuño, J. Á., & Lasunción, M. A. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.252 · Cited by 368 · see citing works
Fruit and vegetable consumption and risk of stroke: A meta-analysis of cohort studies
Dauchet, L., Amouyel, P., & Dallongeville, J. (2005) · Neurology · doi:10.1212/01.wnl.0000180600.09719.53 · Cited by 339 · see citing works
Duthie, S. J., Jenkinson, A. M., Crozier, A., Mullen, W., Pirie, L. P., Kyle, J., Yap, L. S., Christen, P., & Duthie, G. G. (2005) · European Journal of Nutrition · doi:10.1007/s00394-005-0572-9 · Cited by 306 · see citing works
Sumner, M. D., Elliott‐Eller, M., Weidner, G., Daubenmier, J. J., Chew, M. H., Marlin, R. O., Raisin, C. J., & Ornish, D. M. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.05.026 · Cited by 306 · see citing works
Effects of cranberry juice consumption on vascular function in patients with coronary artery disease
Dohadwala, M. M., HOLBROOK, M. M., Hamburg, N. M., Shenouda, S. M., Chung, W. B., Titas, M., Kluge, M. A., Wang, N., Palmisano, J. N., Milbury, P. E., et al. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.004242 · Cited by 274 · see citing works
Karlsen, A., Paur, I., Bøhn, S. K., Sakhi, A. K., Borge, G. I., Serafini, M., Erlund, I., Laake, P., Tonstad, S., & Blomhoff, R. (2010) · European Journal of Nutrition · doi:10.1007/s00394-010-0092-0 · Cited by 216 · see citing works
Basu, A., Betts, N. M., Ortiz, J., Simmons, B. N., Wu, M., & Lyons, T. J. (2011) · Nutrition Research · doi:10.1016/j.nutres.2011.02.003 · Cited by 207 · see citing works
Multiple Risk Factor Intervention Trial
Eberly, L. E., Stamler, J., Kuller, L. H., & Neaton, J. D. (2014) · doi:10.1002/9781118596005.ch47 · Cited by 206 · see citing works
Castilla, P., Dávalos, A., Teruel, J. L., Cerrato, F., Fernández‐Lucas, M., Merino, J. L., Sánchez-Martín, C. C., Ortuño, J. Á., & Lasunción, M. A. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.1053 · Cited by 194 · see citing works
Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome
Basu, A., Fu, D. X., Wilkinson, M., Simmons, B. N., Wu, M., Betts, N. M., Du, M., & Lyons, T. J. (2010) · Nutrition Research · doi:10.1016/j.nutres.2010.06.016 · Cited by 184 · see citing works
Antioxidant properties of commercial alcoholic and nonalcoholic beverages
Lugasi, A., & Hóvári, J. (2003) · Food / Nahrung · doi:10.1002/food.200390031 · Cited by 141 · see citing works
Cerdá, B., Soto, C., Albaladejo, M. D., Martínez, P., Sánchez-Gascón, F., Tomás-Barberán, F. A., & Espı́n, J. C. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602309 · Cited by 130 · see citing works
Antihypertensive Effect of Sweetie Fruit in Patients With Stage I Hypertension
Reshef, N., Hayari, Y., Goren, C., Boaz, M., Madar, Z., & Knobler, H. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.05.021 · Cited by 120 · see citing works
Hollis, J., Houchins, J. A., Blumberg, J. B., & Mattes, R. D. (2009) · Journal of the American College of Nutrition · doi:10.1080/07315724.2009.10719789 · Cited by 112 · see citing works
Banini, A. E., Boyd, L. C., Allen, J. C., Allen, H. G., & Sauls, D. L. (2006) · Nutrition · doi:10.1016/j.nut.2006.08.012 · Cited by 100 · see citing works
Dohadwala, M. M., Hamburg, N. M., HOLBROOK, M. M., et al. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29905 · Cited by 86 · see citing works
Effect of Pomegranate Juice on Insulin Secretion and Sensitivity in Patients with Obesity
González-Ortı́z, M., Martínez‐Abundis, E., Espinel‐Bermúdez, M. C., et al. (2011) · Annals of Nutrition and Metabolism · doi:10.1159/000330116 · Cited by 71 · see citing works
Park, Y. K., Lee, S. H., Park, E., et al. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04907.x · Cited by 71 · see citing works
Murkovic, M., Abuja, P. M., Bergmann, A., et al. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601773 · Cited by 64 · see citing works
Aptekmann, N. P., & Cesar, T. B. (2010) · Maturitas · doi:10.1016/j.maturitas.2010.07.009 · Cited by 61 · see citing works
Yang, B., Chen, Y., Xu, T., Yu, Y., Huang, T., Hu, X., & Li, D. (2011) · PubMed · Cited by 54 · see citing works
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Mozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216 · see citing works
“In short-term trials, fruit juice has no appreciable effects on blood pressure, cholesterol levels, or glucose-insulin homeostasis.(267,268) In sum, moderate intake of 100% juice (eg, up to one serving/d) appears reasonable, especially given the low intakes of whole fruit in most populations; higher intake of 100% jui…”
Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
Wang, B., Liu, K., Mi, M., & Wang, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095323 · Cited by 53 · see citing works
Self-citationPeluso, I., Romanelli, L., & Palmery, M. (2014) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2014.880670 · Cited by 48 · see citing works
Wang, D., Chen, C., Wang, Y., Liu, J., & Lin, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107711 · Cited by 35 · see citing works
- Authors
- Liu, K., Xing, A., Chen, K., Wang, B., Zhou, R., Chen, S., Xu, H., & Mi, M.
- Affiliations
- Army Medical University (CN)
- Shenyang Center for Disease Control and Prevention (CN)
- Corresponding author
- Chen, Ka
- Mi, Mantian
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-04-24
- Volume
- 8
- Issue
- 4
- Pages
- e61420
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3634794
- OpenAlex
- W2000516107
- Cited by
- 43
- References
- 37
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 8 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 7
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Chongqing Science and Technology Commission (CSTC, 2011AB5040, 2011AB5040)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- fruit juice, serum cholesterol, blood pressure, diastolic blood pressure, total cholesterol, HDL cholesterol, LDL cholesterol, polyphenols, dietary intervention, cardiovascular risk factors
- MeSH terms
- Beverages, Blood Pressure, Cholesterol, Fruit, Humans, Cholesterol, HDL, Cholesterol, LDL, Randomized Controlled Trials as Topic, Publication Bias
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