Interactions between prebiotics, probiotics, polyunsaturated fatty acids and polyphenols: diet or supplementation for metabolic syndrome prevention?
Abstract
The metabolic syndrome can be prevented by the Mediterranean diet, characterized by fiber, omega-3 polyunsaturated fatty acids and polyphenols. However, the composition of the Mediterranean diet, which can be viewed as a natural multiple supplement, is poorly controlled, and its beneficial effects poorly predictable. The metabolic syndrome is associated with intestinal dysbiosis and the gut microbioma seems to be the main target and player in the interactions occurring between probiotics, prebiotics, omega 3 polyunsaturated fatty acids, and polyphenols. From the reviewed evidence, it is reasonable to manage growth and metabolism of gut microflora with specific prebiotics and polyphenols. Even though the healthy properties of functional foods and nutraceuticals still need to be fully elucidated, available data suggest that well-designed supplements, containing the better ratio of omega-3 polyunsaturated fatty acids and antioxidants, specific probiotic strains, and selected polyphenols and prebiotics, could be useful in metabolic syndrome prevention and treatment.
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Ageing and obesity are both associated with chronic low grade inflammation, immune impairment, and intestinal dysbiosis.
“ageing and obesity are both associated with chronic low grade inflammation, immune impairment, and intestinal dysbiosis.”
From Antioxidant, Immunomodulating, and Microbial‐Modulating Activities of the Sustainable and Ecofriendly <i>Spirulina</i> (2017) · cites this paper as [18]
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- Authors
- Peluso, I., Romanelli, L., & Palmery, M.
- Affiliations
- Sapienza University of Rome (IT)
- Corresponding author
- Palmery, Maura
- Venue
- International Journal of Food Sciences and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2014-01-28
- Volume
- 65
- Issue
- 3
- Pages
- 259-267
- ISSN
- 0963-7486 (ISSN-L)
- 1465-3478
- OpenAlex
- W2019340711
- Cited by
- 48
- References
- 136
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 8 · 2016: 2 · 2015: 6 · 2013: 1
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Food Sciences and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- metabolic syndrome, prebiotics, probiotics, omega-3 polyunsaturated fatty acids, polyphenols, Mediterranean diet, gut microbiota, gut dysbiosis, nutraceuticals, functional foods, dietary supplementation, antioxidants
- MeSH terms
- Diet, Humans, Intestines, Fatty Acids, Omega-3, Dietary Supplements, Probiotics, Metabolic Syndrome, Prebiotics, Polyphenols, Microbiota, Dysbiosis
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