The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Low- and High-Volume of Intensive Endurance Training Significantly Improves Maximal Oxygen Uptake after 10-Weeks of Training in Healthy Men
Open accessAbstract
UNLABELLED: Regular exercise training improves maximal oxygen uptake (VO2max), but the optimal intensity and volume necessary to obtain maximal benefit remains to be defined. A growing body of evidence suggests that exercise training with low-volume but high-intensity may be a time-efficient means to achieve health benefits. In the present study, we measured changes in VO2max and traditional cardiovascular risk factors after a 10 wk. training protocol that involved three weekly high-intensity interval sessions. One group followed a protocol which consisted of 4×4 min at 90% of maximal heart rate (HRmax) interspersed with 3 min active recovery at 70% HRmax (4-AIT), the other group performed a single bout protocol that consisted of 1×4 min at 90% HRmax (1-AIT). Twenty-six inactive but otherwise healthy overweight men (BMI: 25-30, age: 35-45 y) were randomized to either 1-AIT (n = 11) or 4-AIT (n = 13). After training, VO2max increased by 10% (∼5.0 mL⋅kg(-1)⋅min(-1)) and 13% (∼6.5 mL⋅kg(-1)⋅min(-1)) after 1-AIT and 4-AIT, respectively (group difference, p = 0.08). Oxygen cost during running at a sub-maximal workload was reduced by 14% and 13% after 1-AIT and 4-AIT, respectively. Systolic blood pressure decreased by 7.1 and 2.6 mmHg after 1-AIT and 4-AIT respectively, while diastolic pressure decreased by 7.7 and 6.1 mmHg (group difference, p = 0.84). Both groups had a similar ∼5% decrease in fasting glucose. Body fat, total cholesterol, LDL-cholesterol, and ox-LDL cholesterol only were significantly reduced after 4-AIT. Our data suggest that a single bout of AIT performed three times per week may be a time-efficient strategy to improve VO2max and reduce blood pressure and fasting glucose in previously inactive but otherwise healthy middle-aged individuals. The 1-AIT type of exercise training may be readily implemented as part of activities of daily living and could easily be translated into programs designed to improve public health. TRIAL REGISTRATION: ClinicalTrials.govNCT00839579.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The present work, and recent studies by others [10]–[12], [27], confirm that very brief bouts of all-out exercise, performed a few times per week, is a very time efficient strategy to improve VO2 peak”
From Three minutes of all-out intermittent exercise per week increases skeletal muscle oxidative capacity and improves cardiometabolic health (2014) · cites this paper as [27]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc11-s062 · Cited by 14,094
(2014) · Medical Entomology and Zoology · Cited by 9,400
Corretti, M. C., Anderson, T. J., Benjamin, E. J., Celermajer, D. S., Charbonneau, F., Creager, M. A., Deanfield, J. E., Drexler, H., Gerhard‐Herman, M. D., Herrington, D. M., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01746-6 · Cited by 4,606
Exercise capacity and mortality among men referred for exercise testing
Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S., & Atwood, J. E. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011858 · Cited by 4,114
Correlates of adults??? participation in physical activity: review and update
TROST, S. G., OWEN, N., BAUMAN, A. E., SALLIS, J. F., & BROWN, W. (2002) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200212000-00020 · Cited by 3,040
Endothelial Function and Dysfunction: Testing and Clinical Relevance
Deanfield, J. E., Halcox, J. P., & Rabelink, T. J. (2007) · Circulation · doi:10.1161/circulationaha.106.652859 · Cited by 2,710
Wisløff, U., Støylen, A., Loennechen, J. P., Bruvold, M., Rognmo, Ø., Haram, P. M., Tjønna, A. E., Helgerud, J., Slørdahl, S. A., Lee, S. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.675041 · Cited by 1,996
Self-citationFletcher, G. F., Balady, G. J., Amsterdam, E. A., Chaitman, B., Eckel, R., Fleg, J., Froelicher, V. F., Leon, A. S., Piña, I. L., Rodney, R., et al. (2001) · Circulation · doi:10.1161/hc3901.095960 · Cited by 1,923
Wen, C. P., Wai, J. P. M., Tsai, M. K., Yang, Y. C., Cheng, T. Y. D., Lee, M.-C., Chan, H. T., Tsao, C. K., Tsai, S. P., & Wu, X. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60749-6 · Cited by 1,908
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–165 of 165
Molinari, T., Molinari, T., Rabello, R., & Rodrigues, R. (2022) · Sport Sciences for Health · doi:10.1007/s11332-021-00872-2 · Cited by 12
MacInnis, M. J., Skelly, L. E., Godkin, F. E., Martin, B. J., Tripp, T. R., Tarnopolsky, M. A., & Gibala, M. J. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2019-0403 · Cited by 7
Javad, M. (2021) · Physical Education of Students · doi:10.15561/20755279.2021.0305 · Cited by 9
Influence of endurance training and marathon running on red cell deformability in HIV patients
Ahmad, B., Glufke, K., Grau, M., Sandig, D., Rockstroh, J. K., Vogel, M., Wasmuth, J., Bloch, W., & Brixius, K. (2014) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-131767 · Cited by 7
Gajanand, T., Cox, E. R., Keating, S. E., Brown, W. J., Hordern, M., Burton, N. W., Chachay, V., Gomersall, S. R., Fassett, R. G., & Coombes, J. S. (2024) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2024-002046 · Cited by 6
Adel, B., Beboucha, W., Benhammou, S., Moussa, M., Bouzoualegh, M., & Dairi, A. (2024) · Scientific Journal of Sport and Performance · doi:10.55860/jixw8099 · Cited by 6
Endurance Capacity Is Not Correlated with Endothelial Function in Male University Students
Wang, Y., Xian-bo, Z., Yao, F., Wu, F., Su, C., Fan, Z., Zhu, Z., Tao, J., & Huang, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103814 · Cited by 6
Cycle ergometer training and resistance training similarly increase muscle strength in trained men
Silva, M. H., de Lira, C. A. B., Steele, J., Fisher, J. P., Mota, J. F., Gomes, A. C., & Gentil, P. (2021) · Journal of Sports Sciences · doi:10.1080/02640414.2021.2005282 · Cited by 6
Baker, C. J., HOCKING, S. L., Wang, X., Gerofi, J. A., Colagiuri, S., Sabag, A., Molyneaux, L. M., Xu, Y., Li, M., Bi, Y., et al. (2024) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2023-001878 · Cited by 6
Chen, Z., Jia, J., Gui, D., Liu, F., Li, J., & Tu, J. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1029738 · Cited by 5
Maillard, F., Pereira, B., & Boisseau, N. (2018) · Sports Medicine · doi:10.1007/s40279-018-0903-7 · Cited by 5
Effects of an eight-week exercise program on parameters of the lipid profile of female students
Juhas, I., Škof, B., Popović, D., Matić, M., & Janković, N. (2019) · Journal of Medical Biochemistry · doi:10.2478/jomb-2019-0006 · Cited by 5
Zhang, J., Zhang, F., Tao, J., Yu, M. T. X., & Wen, F. (2025) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-025-01314-z · Cited by 5
Huang, G., Chen, Y., Lee, B.-C., Qiu, Y., Mao, A., Liang, M., & Liu, M. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1555019 · Cited by 7
Clemente‐Suárez, V. J. (2015) · RICYDE Revista Internacional de Ciencias del Deporte · doi:10.5232/ricyde2015.041ed · Cited by 4
Rich, T., & Patterson‐Kane, J. C. (2014) · Equine Veterinary Journal · doi:10.1111/evj.12269 · Cited by 4
Ariningsih, D. M. W. (2021) · Sport and Fitness Journal · doi:10.24843/spj.2021.v09.i02.p01 · Cited by 3
Roshan, V. D., Noorbakhsh, S., Ahmadi, S. F. Z., & Nikseresht, M. (2024) · Advances in Public Health · doi:10.1155/2024/5243088 · Cited by 3
Central hemodynamic response to interval aerobic jogging in healthy male students
Javad, M. (2017) · Pedagogics psychology medical-biological problems of physical training and sports · doi:10.15561/18189172.2017.0404 · Cited by 3
Less than recommended training of aerobic fitness and muscle strength: What to expect?
Benestad, H. B., Sand, K. L., & Bruusgaard, J. C. (2018) · Acta Physiologica · doi:10.1111/apha.13104 · Cited by 3
Ajeganova, S., Wörnert, M., & Hafström, I. (2021) · The Journal of Rheumatology · doi:10.3899/jrheum.201301 · Cited by 2
Loe, H., Mosti, M. P., Wisløff, U., Haberstroh, C., & Flemmen, G. (2022) · BMJ Open · doi:10.1136/bmjopen-2022-061014 · Cited by 2
Zhu, X., Jiao, J., Liang, W., Wang, X., & Zhang, H. (2023) · Research Square · doi:10.21203/rs.3.rs-3302158/v1 · Cited by 1
Zhu, X., Jiao, J., Liang, W., Wang, X., & Zhang, H. (2025) · Journal of Sports Sciences · doi:10.1080/02640414.2025.2559518 · Cited by 2
Multitissue responses to exercise: a MoTrPAC feasibility study
Chambers, T. L., Stroh, A. M., Chavez, C., Brandt, A. R., Claiborne, A., Fountain, W. A., Gries, K. J., JONES, A. M., Kuszmaul, D. J., Lee, G. A., et al. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00210.2023 · Cited by 1
RetractedXiao, Z., Huang, G., Li, G., Wang, H. H., Zheng, X., Li, Y., Gong, F., Lv, Y., & Li, J. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1344764 · Cited by 1
Treinamento Intervalado de Alta Intensidade: quebrando paradigmas na reabilitação cardiovascular
Dalpiaz, M., Dorneles, G. P., Pinkoski Souza, M., Peres, A., Monteiro, M. B., & Padilha Souza, M. (2016) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 1
김경진, Lee, M.-G., & Kim, Y. Y. (2016) · Korean Journal of Sport Science · doi:10.24985/kjss.2016.27.1.37 · Cited by 1
Xian, X., Tsow, F., Rai, S., Anderson, T., Prabhakar, A., Terrera, M., Ainsworth, B. E., Jackemeyer, D., Quach, A. E., Tao, N. J., et al. (2020) · Gazzetta Medica Italiana Archivio per le Scienze Mediche · doi:10.23736/s0393-3660.18.03945-1 · Cited by 1
Efeitos do HIIT no perfil metabólico de idosos com Diabetes Mellitus tipo 2
dos Santos, E. C. L., & Ribeiro, D. S. S. (2021) · Research Society and Development · doi:10.33448/rsd-v10i2.12656 · Cited by 1
Nongspung, K., Narang, K., & Thakur, J. S. (2021) · International Journal of Community Medicine and Public Health · doi:10.18203/2394-6040.ijcmph20211986 · Cited by 1
Metcalfe, R. S. (2015) · The University of Bath Online Publications Store (The University of Bath) · doi:10.13140/rg.2.1.4944.0088
Bonsu, B. (2013) · SUNScholar (Stellenbosch University)
Ndlovu, P. B. M. (2013) · SUNScholar (Stellenbosch University)
Guiraud, T., Labrunée, M., Pathak, A., Pillard, F., Stapley, P. J., & Grémeaux, V. (2015) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2015.05.002
Tangen, D. S. (2015) · NORA - Norwegian Open Research Archives
INFLUENCE OF ARCH SUPPORT INSOLE ON PEOPLE WITH FLATFOOT DURING UPHILL AND DOWNHILL WALKING
Huang, Y.-P., Kim, K., Song, C., Chen, Y.-H., & Peng, H. (2016) · ISBS - Conference Proceedings Archive
Investigating the Effects of High-Intensity Interval Training on Baroreflex Sensitivity
Cameron, A. J. (2016) · Brock University Digital Repository (Brock University)
Scribbans, T. D. (2016) · QSpace (Queen's University Library)
Chen, S.-W., Liaw, J., & Chang, B. (2017) · Computing in cardiology · doi:10.22489/cinc.2017.147-470
Blasio, A. D., Tranquilli, A., Santo, S. D., Marchetti, G., Bergamin, M., Bullo, V., Cugusi, L., Tavoletta, S., Gallazzi, A., Bucci, I., et al. (2018) · Sport Sciences for Health · doi:10.1007/s11332-018-0465-y
Ferrari, G. D. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2016.tde-29082016-105109
Tyre-pulling as concurrent training
Mamen, A., & Fredriksen, P. M. (2018) · Sport Sciences for Health · doi:10.1007/s11332-018-0476-8
Giudice, A. S. D., Sene, I. G. G., de Moraes, J. G. R., Martelli, A., & Delbim, L. R. (2018) · Ensaios e Ciência C Biológicas Agrárias e da Saúde · doi:10.17921/1415-6938.2018v22n1p53-57
Rodrigues, J. A. L. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.83.2018.tde-06122018-135815
Noori, J. A. (2016) · Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)
Physical Activity and Endurance Training Modalities: Evidences and Perspectives
Malatesta, D., Fanari, P., Salvadori, A., & Lanzi, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-32274-8_1
Na+, K+-ATPase in single skeletal muscle fibres and the effects of ageing, training and inactivity
Wyckelsma, V. L. (2014) · Victoria University Research Repository (Victoria University)
Sex Differences in Blood Pressure and Body Composition in Hypertensive Adults with Central Obesity
Adriyani, R., Iskandar, D., & Dana, A. H. (2021) · JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA · doi:10.17509/jpjo.v6i1.29937
SELECTED PHYSIOLOGICAL RESPONSES TO INTERVAL TRAINING IN THE ENHANCEMENT OF PHYSICAL FITNESS
Ojo, O. R. (2020) · SAPIENTIA FOUNDATION JOURNAL OF EDUCATION, SCIENCES AND GENDER STUDIES
Novel aspects of exercise training to promote human metabolic health
Mancilla, R. (2022) · Research Publications (Maastricht University) · doi:10.26481/dis.20220210rm
Kösemen, D. S., Kayabey, Ö., Babaoglu, A., Tuğral, O., & Demirci, D. (2022) · Spor ve Performans Araştırmaları Dergisi · doi:10.17155/omuspd.1176378
Khoshbin, M., Naghibi, S., ShariatzadehJoneydi, M., Vatandoost, M., & Banaadkouki, A. Z. (2022) · مجله علمی پزشکی جندی شاپور · doi:10.32598/jsmj.21.2.2552
Efficacy and Practical Application of High-Intensity Interval Training in Cardiac Rehabilitation
Choi, H. E. (2023) · Annals of CardioPulmonary Rehabilitation · doi:10.53476/acpr.2023.3.1.19
Impact of Linear vs. Change-of-Direction HIIT on Aerobic Power in Female Football Players
Morina, B., Višić, G., Antonić, D., Babić, M., Sporiš, G., Vlahović, T., Franić, M., Franjko, I., Tomac, Z., & Akman, O. (2025) · Annals of Applied Sport Science · doi:10.61186/aassjournal.1428
Revdal, A. (2014) · BIBSYS Brage (BIBSYS (Norway))
Bystad, M., Rydland, S., Bugge, C., Høgmo, S., Brøndbo, B., Jacobsen, R., García-Fernández, L., Rodríguez–Jiménez, R., Romero-Ferreiro, V., & Wynn, R. (2026) · Trials · doi:10.1186/s13063-026-09472-2 · Cited by 1
Bankolé, S. L. C. (2014) · theses.fr (ABES) · doi:10.70675/0d4d5dd2z8b73z4599zbeb1zf674fd67620b
Sosner, P. (2016) · theses.fr (ABES) · doi:10.70675/9ecbe77bz7010z478az871eze93a2a11acde
Chen, K., Yin, L., Yin, T., Lv, Y., & Yu, L. (2026) · Journal of Hypertension · doi:10.1097/hjh.0000000000004405
Wang, Y., Tan, Q., Zhong, J., Zhang, C., Wang, Y., Gao, W., & Li, M. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1904753
Hernandez, J. (2015) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/p5mt-nr61
Metadata
- Authors
- Tjønna, A. E., Leinan, I. M., Bartnes, A. T., Jenssen, B. M., Gibala, M. J., Winett, R. A., & Wisløff, U.
- Affiliations
- Norwegian University of Science and Technology (NO)
- McMaster University (CA)
- Virginia Tech (US)
- Corresponding author
- Tjønna, Arnt Erik
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-05-29
- Volume
- 8
- Issue
- 5
- Pages
- e65382
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3667025
- OpenAlex
- W2045717221
- Cited by
- 167
- References
- 44
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 10 · 2023: 12 · 2022: 17 · 2021: 18 · 2020: 9 · 2019: 12 · 2018: 14 · 2017: 12 · 2016: 19 · 2015: 16 · 2014: 16 · 2013: 4
- FWCI
- 43.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- BIBSYS Brage (BIBSYS (Norway)) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
- VTechWorks (Virginia Tech) (submittedVersion, cc-by)
- Funders
- Norges Forskningsråd
- St. Olavs Hospital Universitetssykehuset i Trondheim
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Keywords
- high-intensity interval training, VO2max, training volume, cardiovascular risk factors, blood pressure, fasting blood glucose, oxidized LDL, fat mass, overweight men, time-efficient exercise
- MeSH terms
- Adipose Tissue, Adult, Blood Glucose, Blood Pressure, Cholesterol, Exercise Therapy, Fasting, Humans, Cholesterol, LDL, Male, Middle Aged, Oxygen Consumption, Running, Time Factors, Exercise, Treatment Outcome, Overweight
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
