Application of Concave Microwells to Pancreatic Tumor Spheroids Enabling Anticancer Drug Evaluation in a Clinically Relevant Drug Resistance Model

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Anti-Cancer Effect of IN-2001 in T47D Human Breast Cancer

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Microphysiological Analysis Platform of Pancreatic Islet β‐Cell Spheroids

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Chemoradiotherapy screening in a novel biomimetic polymer based pancreatic cancer model

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Fabrication of Concave Microwells and Their Applications in Micro-Tissue Engineering: A Review

Guo, W., Chen, Z., Feng, Z., Li, H., Zhang, M., Zhang, H., & Cui, X. Y. (2022) · Micromachines · doi:10.3390/mi13091555 · Cited by 24 · see citing works

An overview of bio-actuation in collagen hydrogels: a mechanobiological phenomenon

Hameed, P., & Manivasagam, G. (2021) · Biophysical Reviews · doi:10.1007/s12551-021-00804-x · Cited by 23 · see citing works

Pancreatic Cancer Organoids: An Emerging Platform for Precision Medicine?

Sereti, E., Papapostolou, I., & DIMAS, K. S. (2023) · Biomedicines · doi:10.3390/biomedicines11030890 · Cited by 22 · see citing works

Bioprinted research models of urological malignancy

Wang, G., Mao, X., Wang, W., Xiaolong, W., Li, S., & Wang, Z. (2024) · Exploration · doi:10.1002/exp.20230126 · Cited by 22 · see citing works

Assembly of breast cancer heterotypic spheroids on hyaluronic acid coated surfaces

Carvalho, M. P., Costa, E. C., & Correia, I. J. (2017) · Biotechnology Progress · doi:10.1002/btpr.2497 · Cited by 22 · see citing works

Leveraging and manufacturing in vitro multicellular spheroid-based tumor cell model as a preclinical tool for translating dysregulated tumor metabolism into clinical targets and biomarkers

Wang, T., Wang, L., Wang, G., & Zhuang, Y. (2020) · Bioresources and Bioprocessing · doi:10.1186/s40643-020-00325-7 · Cited by 21 · see citing works

Overcoming chemoresistance in prostate cancer with Chinese medicine Tripterygium wilfordii via multiple mechanisms

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Big genes are big mutagen targets: A connection to cancerous, spherical cells?

Parry, M. L., Ramsamooj, M., & Blanck, G. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.09.044 · Cited by 21 · see citing works

Homogeneous pancreatic cancer spheroids mimic growth pattern of circulating tumor cell clusters and macrometastases: displaying heterogeneity and crater-like structure on inner layer

Feng, H., Ou, B., Zhao, J., Yin, S., Lu, A., Oechsle, E., & Thasler, W. E. (2017) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-017-2434-2 · Cited by 20 · see citing works

IGF-2 coated porous collagen microwells for the culture of pancreatic islets.

Forget, A., Waibel, M., Rojas-Canales, D., Chen, S.-W., Kawazoe, N., Harding, F. J., Loudovaris, T., Coates, P. T., Blencowe, A., Chen, G., et al. (2017) · Journal of materials chemistry. B · doi:10.1039/c6tb02748b · Cited by 10 · see citing works

Polyethylene glycol molecular weight influences the ClearT2 optical clearing method for spheroids imaging by confocal laser scanning microscopy

Costa, E. C., Moreira, A. F., de Melo‐Diogo, D., & Correia, I. J. (2018) · Journal of Biomedical Optics · doi:10.1117/1.jbo.23.5.055003 · Cited by 18 · see citing works

The Diverse Applications of Pancreatic Ductal Adenocarcinoma Organoids

Low, R. R. J., Lim, W., Nguyen, P. M., Lee, B., Christie, M., Burgess, A. W., Gibbs, P., Grimmond, S. M., Hollande, F., & Putoczki, T. L. (2021) · Cancers · doi:10.3390/cancers13194979 · Cited by 16 · see citing works

Scalable Formation of Highly Viable and Functional Hepatocellular Carcinoma Spheroids in an Oxygen‐Permeable Microwell Device for Anti‐Tumor Drug Evaluation

He, J., Zhou, C., Xu, X., Zhou, Z., Danoy, M., Shinohara, M., Xiao, W., Zhu, D., Zhao, X., Feng, X., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202200863 · Cited by 17 · see citing works

Scaffold-free development of multicellular tumor spheroids with spatial characterization of structure and metabolic radial profiles

Bess, S. N., Smart, G. K., Igoe, M. J., & Muldoon, T. J. (2024) · In vitro models · doi:10.1007/s44164-024-00074-3 · Cited by 16 · see citing works

Two-Dimensional and Three-Dimensional Cell Culture and Their Applications

Ballav, S., Deshmukh, A. J., Siddiqui, S., Aich, J., & Basu, S. (2021) · Biochemistry · doi:10.5772/intechopen.100382 · Cited by 15 · see citing works

Characteristics of multicellular tumor spheroids formed by pancreatic cells expressing different adhesion molecules

Svirshchevskaya, E. V., Doronina, E., Grechikhina, M. V., Matushevskaya, E., Kotsareva, O. D., Fattakhova, G. V., Sapozhnikov, A. M., & Felix, K. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.01.034 · Cited by 15 · see citing works

Quenching Epigenetic Drug Resistance Using Antihypoxic Microparticles in Glioblastoma Patient‐Derived Chips

Baek, S., Yu, S. E., Deng, Y., Lee, Y. J., Lee, D. G., Kim, S., Yoon, S., Kim, H., Park, J., Lee, C. H., et al. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202102226 · Cited by 15 · see citing works

Flat cells come full sphere: Are mutant cytoskeletal-related proteins oncoprotein-monsters or useful immunogens?

Parry, M. L., & Blanck, G. (2015) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1073428 · Cited by 14 · see citing works

A Novel Approach to Evaluating Cancer Driver Gene Mutation Densities: Cytoskeleton-related Gene Candidates.

Fawcett, T. J., Parry, M. L., & Blanck, G. (2015) · PubMed · Cited by 13 · see citing works

Fabrication approaches for high-throughput and biomimetic disease modeling

Grubb, M., & Caliari, S. R. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.006 · Cited by 13 · see citing works

Differential protein expression and novel biomarkers related to 5-FU resistance in a 3D colorectal adenocarcinoma model

Lee, S., NAM, J. K., Park, J. K., Lee, J., Min, D. S., & Kuh, H. (2014) · Oncology Reports · doi:10.3892/or.2014.3337 · Cited by 13 · see citing works

Adult Stem Cells and Anticancer Therapy

Kalvelytė, A. V., Imbrasaitė, A., Krestnikova, N., & Stulpinas, A. (2017) · Advances in molecular toxicology · doi:10.1016/b978-0-12-812522-9.00004-x · Cited by 13 · see citing works

A simple microsphere‐based mold to rapidly fabricate microwell arrays for multisize 3D tumor culture

Li, Z., Guo, X., Sun, L., Xu, J., Liu, W., Li, T., & Wang, J. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.27257 · Cited by 13 · see citing works

Bioprinted Fibroblast Mediated Heterogeneous Tumor Microenvironment for Studying Tumor‐Stroma Interaction and Drug Screening

Chen, Y., Xue, Y., Yan, C., Jin, J., Liu, Y., Li, J., Han, S., & Liu, J. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202404642 · Cited by 11 · see citing works

Cellular context-dependent interaction between cancer and stellate cells in hetero-type multicellular spheroids of pancreatic tumor

Nam, S., Khawar, I. A., Park, J. K., Chang, S., & Kuh, H. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.05.101 · Cited by 10 · see citing works

Modeling human pancreatic ductal adenocarcinoma for translational research: current options, challenges, and prospective directions

Suri, R., Zimmerman, J. W., & Burkhart, R. A. (2020) · Annals of Pancreatic Cancer · doi:10.21037/apc-20-29 · Cited by 10 · see citing works

Multi-Inlet Spheroid Generator for High-Throughput Combinatorial Drug Screening Based on the Tumor Microenvironment

Han, S., Kim, S., Hong, H. K., Cho, Y. B., Moon, H. E., Paek, S. H., & Park, S. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c02439 · Cited by 10 · see citing works

A Paired Bead and Magnet Array for Molding Microwells with Variable Concave Geometries

Lee, G.-H., Suh, Y., & Park, J. Y. (2018) · Journal of Visualized Experiments · doi:10.3791/55548 · Cited by 8 · see citing works

Lab-on-a-brane for spheroid formation

Bianco, M., Zizzari, A. T., Priore, P., Moroni, L., Metrangolo, P., Frigione, M., Rella, R., Gaballo, A., & Arima, V. (2019) · Biofabrication · doi:10.1088/1758-5090/ab0813 · Cited by 8 · see citing works

Pitch-tunable pillar arrays for high-throughput culture and immunohistological analysis of tumor spheroids

Lee, D. W., Kang, J., Hwang, H. J., Oh, M.-S., Shin, B. C., Lee, M., & Kuh, H. (2018) · RSC Advances · doi:10.1039/c7ra09090k · Cited by 7 · see citing works

Understanding the Conundrum of Pancreatic Cancer in the Omics Sciences Era

Nicoletti, A., Paratore, M., Vitale, F., Negri, M., Quero, G., Esposto, G., Mignini, I., Alfieri, S., Gasbarrini, A., Zocco, M. A., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147623 · Cited by 6 · see citing works

Smart nanophotonics for enzyme-driven drug resistance sensing and controlled therapeutic release

Taha, B. A., Addie, A. J., Al-Rawi, M. A., Haider, A. J., Yadav, A. K., Bhatia, D. D., Jabir, M. S., Ibnaouf, K. H., & Arsad, N. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107488 · Cited by 5 · see citing works

Exploring the Role of Desmoplastic Physical Stroma in Pancreatic Cancer Progression Using a Three-Dimensional Collagen Matrix Model

Song, X., Nihashi, Y., Yamamoto, M., Setoyama, D., Kunisaki, Y., & Kida, Y. S. (2023) · Bioengineering · doi:10.3390/bioengineering10121437 · Cited by 5 · see citing works

Identifying drug resistant cancer cells using microbubble well arrays

Pu, Q., Spooner, R., & DeLouise, L. A. (2017) · Biomedical Microdevices · doi:10.1007/s10544-017-0160-9 · Cited by 5 · see citing works

Toxicity of organic and inorganic nickel in pancreatic cell cultures: Comparison to cadmium

Wallace, D., Djordjević, A. B., & Benton, A. (2020) · Arhiv za farmaciju · doi:10.5937/arhfarm70-29277 · Cited by 5 · see citing works

Model Selection for the Preclinical Development of New Drug–Radiotherapy Combinations

Singh, J., Hatcher, S. V., Ku, A. A., Ding, Z., Feng, F. Y.-C., Sharma, R. A., & Pfister, S. (2021) · Clinical Oncology · doi:10.1016/j.clon.2021.08.008 · Cited by 5 · see citing works

A promising breakthrough in pancreatic cancer research: The potential of spheroids as 3D models

Jamshidi, N., Jamshidi, N., Chahardehi, A. M., Shams, E., & Chaleshi, V. (2024) · Bioimpacts · doi:10.34172/bi.30241 · Cited by 4 · see citing works

Comparison of two- and three-dimensional cancer models for assessing potential cancer therapeutics

Xie, B., Teusch, N. E., & Mrsny, R. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-102983-1.00014-4 · Cited by 3 · see citing works

TG6002 oncolytic vaccinia virus and chemotherapy synergy: a promising strategy for pancreatic ductal adenocarcinoma

Foloppe, J., Farine, I., Pichon, C., Kempf, J., Hortelano, J., Moreau, B., Cochin, S., Takeda, A., Pessaux, P., & Erbs, P. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1656984 · Cited by 2 · see citing works

Analysis of a Cancer Stem Cell-Derived Single Colony Raised in a Microwell Array

Lei, K. F., Chen, Q.-E., Goh, A., & Pai, P. C. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c00209 · Cited by 2 · see citing works

Monte Carlo simulation‐guided design for size‐tuned tumor spheroid formation in 3D printed microwells

Eş, İ., Ionescu, A. T., Görmüş, B. M., İnci, F., Marques, M. P. C., Szita, N., & de la Torre, L. G. (2024) · Biotechnology Progress · doi:10.1002/btpr.3470 · Cited by 2 · see citing works

Fabrication of Three-Dimensional Complex Shape PDMS Microstencil Using Air-Knife System and their Cell Culture Application

Choi, J., Jin, H. K., Bae, J., & Kim, G. M. (2018) · Journal of the Korean Society for Precision Engineering · doi:10.7736/kspe.2018.35.1.111 · Cited by 1 · see citing works

Isolation and Characterization of Cancer Stem Cells (CSCs)

Nalini, N., & Pratima, B. J. (2020) · Springer eBooks · doi:10.1007/978-981-15-5120-8_3 · Cited by 1 · see citing works

Preclinical models in ovarian cancer

Bolland, D. E., & McLean, K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814704-7.00002-7 · Cited by 1 · see citing works

Establishment of patient‑derived lung tumorspheres and their response to internal irradiation by Auger electrons

Madsen, K. L., Langkjær, N., Gerke, O., Høilund‐Carlsen, P. F., & Olsen, B. B. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5324 · Cited by 1 · see citing works

Microfluidics Applications in Cancer Drug Delivery

Zhang, H., & Shen, Y. (2016) · Wiley eBooks · doi:10.1002/9783527694396.ch5 · Cited by 1 · see citing works

The Present and Future of the Cancer Microenvironment Bioprinting

Cho, M. J., Chi, B. H., Kim, M. J., Whang, Y. M., & Chang, I. H. (2017) · Journal of Urologic Oncology · doi:10.22465/kjuo.2017.15.3.103

Development of microfluidic microanalysis systems for cancer therapeutic screening

Sabhachandani (2017) · doi:10.17760/d20273201

Células dendríticas na imunoterapia de glicoblastoma: avaliação da resposta imune e da citotoxicidade de linfócitos T CD8>sup<+>/sup< isolados de pacientes contra esferóides tumorais autólogos

Chauca-Torres, N. E. (2019) · doi:10.11606/d.42.2019.tde-26112019-164558

Molecular mechanisms of YAP signalling in the context of cancer

Xie, B. (2019)

Análise comparativa de diferentes sistemas de cultivo tridimensionais para estabelecimento de um modelo in vitro de câncer de bexiga para ensaios de eficácia terapêutica

do Amaral, R. L. F. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.60.2020.tde-21092021-055958

Abstract 2722: Characteristics of pancreatic cancer spheroids as a model for anticancer efficacy test.

Yeon, S.-E., Lee, S., & Kuh, H. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-2722

3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

Longati, P., Jia, X., Eimer, J., Wagman, A., Witt, M.-R., Rehnmark, S., Verbeke, C., Toftgård, R., Löhr, M., & Heuchel, R. L. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-95 · Cited by 394 · see citing works

A spheroid-based 3-D culture model for pancreatic cancer drug testing, using the acid phosphatase assay

Wen, Z., Liao, Q., Hu, Y., You, L., Zhou, L., & Zhao, Y. (2013) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20132647 · Cited by 102 · see citing works

Stratified 3D Microtumors as Organotypic Testing Platforms for Screening Pancreatic Cancer Therapies

Monteiro, M. V., Gaspar, V. M., Mendes, L., Duarte, I. F., & Mano, J. F. (2021) · Small Methods · doi:10.1002/smtd.202001207 · Cited by 28 · see citing works

Chemosensitivity of pancreatic cancer cell in multicellular spheroids

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