Association between Sleep Duration and 24-Hour Urine Free Cortisol in the MrOS Sleep Study
Open accessAbstract
CONTEXT: Short sleep duration is associated with adverse health outcomes, but the mechanisms involved are unknown. It has been postulated that short sleep duration may elevate cortisol levels, but studies have had conflicting results. It is unclear whether these differing findings may be due to methodological issues, such as assessment of sleep duration. Specifically, objective versus subjective methods of measuring habitual sleep duration may account for the conflicting results found in epidemiological studies. OBJECTIVE: Our goal was to determine whether habitual sleep duration, measured objectively (by actigraphy) and subjectively (by self-report), was associated with 24-hour urine free cortisol (UFC), a measure of integrated cortisol secretion. Our secondary goal was to determine whether slow wave sleep (SWS, determined by polysomnography) was associated with 24-hour UFC. DESIGN/SETTING: Cross sectional study of community dwelling older men. PATIENTS/PARTICIPANTS: 325 men (mean age = 76.6 years, SD = 5.5) from the Portland site of the MrOS Sleep Study, who underwent 24-hour urine collection, polysomnography, actigraphy and sleep questionnaire. PRIMARY OUTCOME: 24-hour UFC. RESULTS: In this study of community dwelling older men, self-reported sleep duration was inversely related to 24-hour UFC levels. Participants reporting <5 hours of habitual sleep had an adjusted mean 24-hour UFC of 29.8 ug, compared to 28.0 ug in participants reporting >5 to <8 hours of sleep 25.5 ug in those reporting >8 hours of habitual sleep. However, sleep duration determined by actigraphy was not associated with 24-hour UFC in either univariable or multivariable regression models. SWS was not associated with 24-hour UFC. CONCLUSION: Objectively measured (i.e., actigraphic) sleep duration is not associated with 24-hour UFC in these community dwelling older men. This finding, together with prior studies, suggests that elevated levels of integrated cortisol secretion is not the mechanisms by which short sleep duration leads to adverse health outcomes.
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Sleep, testosterone and cortisol balance, and ageing men
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“This is consistent with another study of 325 community-dwelling men aged 65 years or more that reported no significant association between actigraphally-measured sleep duration and 24-h urinary free cortisol [76].”
ResultSleep Characteristics and Daytime Cortisol Levels in Older Adults
Morgan, E., Schumm, L. P., McClintock, M., Waite, L., & Lauderdale, D. S. (2017) · Sleep · doi:10.1093/sleep/zsx043 · Cited by 52 · see citing works
- Authors
- Rao, M. N., Blackwell, T., Redline, S., Punjabi, N. M., Barrett-Connor, E., Neylan, T. C., Stone, K. L., & Osteoporotic Fractures in Men (MrOS) Study Group
- Affiliations
- University of California, San Francisco (US)
- California Pacific Medical Center (US)
- Brigham and Women's Hospital (US)
- Johns Hopkins University (US)
- University of California San Diego (US)
- San Francisco VA Medical Center (US)
- Corresponding author
- Rao, Madhu N.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-09-27
- Volume
- 8
- Issue
- 9
- Pages
- e75205
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3815404
- OpenAlex
- W2151628176
- Cited by
- 15
- References
- 37
- Citations by year
- 2024: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 3 · 2017: 3 · 2015: 3 · 2014: 1
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (RR024140, AG027810)
- National Institute on Aging (U01 AR45580, U01-AG-18197, U01AG018197, U01 AR45632, U01AG027810, U01 AR45654, AG18197, U01 AR45614, U01 AR45583, AG027810, U01 AR45647)
- National Heart, Lung, and Blood Institute (HL070841, R01HL070847, U01 AR45583, R01 HL071194, R01 HL070848, R01 HL070847, R01 HL070842, R01 HL070841, R01 HL070837, R01 HL070838, and R01 HL070839, R01HL070839, U01 AR45654, K23HL096832, HL070842, HL070838, U01-AG027810, HL070847, HL070837, R01HL070838, HL071194, U01 AR45647, R01HL070841, R01HL070848, R01HL071194, U01 AR45632, R01HL070837, HL070848, R01HL070842, U01 AG18197, U01 AR45614, HL070839, U01 AR45580)
- National Cancer Institute
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (U01AR45614, U01-AR45632, U01 AR45647, U01AR045583, U01 AR-45583, AR45654, AR45614, U01-AR-45654, AR45647, U01AR045580, AR45583, U01AR045632, U01AR045654, U01AR045614, AR45580, U01AR045647, U01 AG18197, AR45632, U01AR45580)
- National Center for Research Resources (U01 AR45654, U01 AR45632, U01 AR45580, U01 AR45647, UL1RR024140, U01 AR45614, U01 AR45583, U01 AG18197, RR024140)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep duration, 24-hour urine free cortisol, cortisol secretion, actigraphy, self-reported sleep duration, slow-wave sleep, older men
- MeSH terms
- Aged, Aged, 80 and over, Cross-Sectional Studies, Humans, Hydrocortisone, Male, Risk Factors, Sleep, Fractures, Bone, Actigraphy, Self Report
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