Association Between Sleep Architecture and Measures of Body Composition
Open accessAbstract
STUDY OBJECTIVES: To determine whether slow wave sleep (SWS) is inversely associated with body mass index (BMI) and other measures of body composition. DESIGN: Cross-sectional, observational study. SETTING: Community-based. PARTICIPANTS: 2745 older men from the MrOS Sleep Study who completed polysomnography. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: SWS as a percentage of total sleep duration was obtained from in-home, overnight polysomnography. Measures of body composition including BMI, weight, waist circumference and total body fat mass were determined by standard techniques. Other covariates in the analysis were age, race/ethnicity, clinic site, physical activity, respiratory disturbance index (RDI), total sleep time, and sleep efficiency. In the multivariate analysis, there was a significant inverse association between quartiles of SWS and BMI (P-trend = 0.0095). Older men in the lowest quartile of SWS had an average BMI of 27.4 kg/m2, compared to 26.8 for those in the highest quartile of SWS. This association was attenuated in men with RDI > or = 15. Furthermore, participants in the lowest quartile of SWS had a 1.4-fold increased odds for obesity (P = 0.03, 95% CI 1.0, 1.8) compared to those in the highest quartile. A similar inverse association between SWS and waist circumference as well as weight was observed. REM sleep was not associated with measures of body composition. CONCLUSIONS: Independent of sleep duration, percentage time in SWS is inversely associated with BMI and other measures of body composition in this population of older men. Participants in the lowest quartile of SWS (compared to those in the highest quartile) are at increased risk for obesity.
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A polysomnography study of 2,700 men above the age of 65 years revealed an inverse relationship between slow-wave sleep duration and BMI or waist circumference.
“A polysomnography study, not included in these meta-analyses, of 2,700 men above the age of 65 years revealed an inverse relationship between slow-wave sleep (SWS) duration and BMI or waist circumference.15”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [15]
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Self-citation
- Authors
- Rao, M. N., Blackwell, T., Redline, S., Stefanick, M. L., Ancoli-Israel, S., Stone, K. L., & for the Osteoporotic Fractures in Men (MrOS) Study Group
- Affiliations
- University of California, San Francisco (US)
- California Pacific Medical Center (US)
- Case Western Reserve University (US)
- Stanford University (US)
- Department of Psychiatry, University of California, San Diego, San Diego, CA
- Corresponding author
- Rao, Madhu N.
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-04-01
- Volume
- 32
- Issue
- 4
- Pages
- 483-490
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC2663862
- OpenAlex
- W181637513
- Cited by
- 118
- References
- 46
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 2 · 2019: 8 · 2018: 10 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 7 · 2013: 13 · 2012: 12
- FWCI
- 15.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- SLEEP (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG008415, U01AG018197, U01AG027810)
- National Heart, Lung, and Blood Institute (R01HL070847, R01HL070839, HL070838, HL070837, R01HL070838, R01HL070841, R01HL070848, R01HL071194, R01HL070837, R01HL070842, HL070839)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (U01AR045583, U01AR045580, U01AR045632, U01AR045654, U01AR045614, U01AR045647)
- National Center for Research Resources (UL1RR024140)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Keywords
- slow-wave sleep, sleep architecture, body composition, body mass index, obesity, waist circumference, older men, REM sleep, respiratory disturbance index
- MeSH terms
- Adipose Tissue, Aged, Aged, 80 and over, Body Composition, Humans, Male, Obesity, Signal Processing, Computer-Assisted, Sleep Apnea Syndromes, Sleep Stages, Sleep, REM, Cohort Studies, Absorptiometry, Photon, Body Mass Index, Polysomnography, Waist-Hip Ratio
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