Effects of 72 Hour Sleep Deprivation on Urinary Cortisol and Indices of Metabolism
Abstract
Cortisol, urea, glucose, electrolytes, and other compounds were measured in five consecutive 24 h urine collections during a 72 h sleep deprivation study in six young men. Urine was collected during a 24 h predeprivation day, 3 days of sleep deprivation, and a recovery day. Whereas urinary cortisol decreased only slightly, marked changes in other urinary constituents were observed. During sleep deprivation, urinary urea rose markedly, glucose decreased, and urinary electrolytes decreased. These data indicate that sleep deprivation under ad lib food and water conditions can cause disturbances in normal metabolism.
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Some authors have reported no change or even a slight decrease in cortisol levels after one or several nights of total sleep deprivation.
“Indeed, some authors have reported no change [41, 43, 74, 75] or even a slight decrease in cortisol levels [76, 77] after one or several nights of total sleep deprivation.”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [77]
The decrease in plasma or urinary cortisol found by Kant et al. and Åkerstedt et al. occurred after 48 hours or more of prolonged wakefulness.
“Notably, the decrease in plasma or urinary cortisol found by Kant et al. [77] and Åkerstedt et al. [76] occurred after 48 hours or more of prolonged wakefulness.”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [77]
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- Authors
- Kant, G. J., Genser, S. G., Thorne, D. R., Pfalser, H. L., & Mougey, E. H.
- Affiliations
- Walter Reed Army Institute of Research (US)
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 1984-09
- Volume
- 7
- Issue
- 2
- Pages
- 142-146
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W2437631391
- Cited by
- 52
- References
- 13
- Citations by year
- 2025: 1 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 4
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- SLEEP (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, urinary cortisol, urinary urea, urine glucose, urinary electrolytes, metabolism, recovery from sleep deprivation
- MeSH terms
- Adolescent, Adult, Blood Glucose, Electrolytes, Energy Metabolism, Humans, Hydrocortisone, Male, Sleep Deprivation, Urea
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