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Potential Role of the Bovine Rumen Microbiome in Modulating Milk Composition and Feed Efficiency
Open accessAbstract
Ruminants are completely dependent on their microbiota for feed digestion and consequently, their viability. It is therefore tempting to hypothesize a connection between the composition and abundance of resident rumen bacterial taxa and the physiological parameters of the host. Using a pyrosequencing approach, we characterized the rumen bacterial community composition in 15 dairy cows and their physiological parameters. We analyzed the degree of divergence between the different animals and found that some physiological parameters, such as milk yield and composition, are highly correlated with the abundance of various bacterial members of the rumen microbiome. One apparent finding was a strong correlation between the ratio of the phyla Firmicutes to Bacteroidetes and milk-fat yield. These findings paralleled human studies showing similar trends of increased adiposity with an increase in Bacteroidetes. This correlation remained evident at the genus level, where several genera showed correlations with the animals' physiological parameters. This suggests that the bacterial community has a role in shaping host physiological parameters. A deeper understanding of this process may allow us to modulate the rumen microbiome for better agricultural yield through bacterial community design.
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“Jami et al. (2014) also reported a positive correlation between RFI and the uncultured rumen bacterium RF39,”
From Addressing global ruminant agricultural challenges through understanding the rumen microbiome: past, present, and future (2018) · cites this paper as Jami et al., 2014
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Adhikari, B., Téllez‐Isaías, G., Jiang, T., Wooming, B., & Kwon, Y. M. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.596933 · Cited by 10
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“These findings might be endorsed by the nutrient composition of forages and grazing patterns, as higher OM contents increase the growth of these fibrolytic bacteria.”
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Inclusion of Camelina sativa Seeds in Ewes’ Diet Modifies Rumen Microbiota
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“Considering the fact that acetate and butyrate have a direct effect on maintaining adequate quantities of milk fat, multiple studies examined whether production traits correlated with change in microbial abundance (Jami et al. 2014; Jewell et al. 2015; Lima et al. 2015).”
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Parasites, Drugs and Captivity: Blastocystis-Microbiome Associations in Captive Water Voles
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Genotype-associated heritable rumen bacteria can be a stable microbiota passed to the offspring
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de Freitas, A. S., Gan, F. C., de David, D. B., & Roesch, L. F. W. (2022) · PLoS ONE · doi:10.1371/journal.pone.0279386 · Cited by 8
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BackgroundIncreased Yearling Weight Gain Is Associated with a Distinct Faecal Microbial Profile
Maslen, B. N., Duff, C. J., Clark, S., van der Werf, J. H. J., White, J. D., & Pant, S. D. (2023) · Animals · doi:10.3390/ani13193062 · Cited by 11
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Influence of maternal factors on the rumen microbiome and subsequent host performance1
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Metagenomics-Based Analysis of Candidate Lactate Utilizers from the Rumen of Beef Cattle
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“Moreover, 454-sequencing data from Brulc et al. (2009) revealed high individual differences across three bulls fed only hay for the percentage of Bacteroidetes in the SAM fraction of the rumen ranging from 5–27%.”
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“milk production [12] and is mainly governed by the ratio of grain and fibre [13].”
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“Specifically, many of the changes were identified within the phylum Firmicutes between different efficient animals, which has been shown to affect energy harvest (25).”
BackgroundAssociations of rumen and rectum bacteria with the sustained productive performance of dairy cows
Yang, J. M., Li, Y., Sun, M., Zhang, Y., Guo, S., Zhou, D. F., Lin, P., Wang, A., & Jin, Y. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1565034 · Cited by 7
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“…to the fact that Sika deer typically inhabit cold and high-altitude regions [43], where a high ratio of Firmicutes to Bacteroidetes is advantageous for fat deposition, helping animals adapt to severe cold cli-Animals mates [44], thereby enhancing their resilience to these challenging conditions.”
BackgroundGonzález-Gragera, E., García-López, J. D., Boutine, A., García-Marín, M. L., Fonollá, J., Gil-Martínez, L., Fernández, I., Martínez‐Bueno, M., & Baños, A. (2024) · Foods · doi:10.3390/foods13193165 · Cited by 7
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Clemmons, B. A., Mulon, P., Anderson, D. E., Ault-Seay, T. B., Henniger, M. T., Schneider, L. G., Staton, M. E., Voy, B. H., Donohoe, D. R., Campagna, S. R., et al. (2022) · Ruminants · doi:10.3390/ruminants2020019 · Cited by 7
Darwin, D., Humaira, T. H., & Muliawati, A. (2022) · Journal of Applied Biology & Biotechnology · doi:10.7324/jabb.2022.10s108 · Cited by 7
“The diversities in rumen microbiota may be related to cattle production and health characteristics including milk production and milk composition, feed efficiency, methane generation, and ruminal acidosis [5-8].”
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“…in the rumen interact with the host, regulate the nutrient metabolism of the organism, participate in the material transport process, and play an important role in the organism’s immune media, which could feedback affect the feed utilization rate and the growth performance of the host [10,11].”
BackgroundRecent Application Technologies of Rumen Microbiome Is the Key to Enhance Feed Fermentation
Islam, M., & Lee, S. (2018) · JoLS Journal of Life Sciences · doi:10.5352/jls.2018.28.10.1244 · Cited by 7
Revolution in Rumen Microbiology
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“Therefore, researchers have already suggested the potential role of rumen microbiota in modulating fat profiles in cow milk (Vlaeminck et al., 2006; Jami et al., 2014; Ferlay et al., 2017).”
BackgroundLuecke, S. M., Aryee, G., Holman, D. B., Schmidt, K. N., King, L. E., Crouse, M. S., Ward, A. K. K., Dahlen, C. R., Caton, J. S. S., & Amat, S. (2024) · Animal Microbiome · doi:10.1186/s42523-024-00335-2 · Cited by 7
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“This relationship was described with potential in the bovine rumen microbiome modulating feed efficiency and milk production performance (Jami et al. 2014 ).”
Fraga, M., Fernández-Ciganda, S., Cajarville, C., Martinez, M. M., Abin‐Carriquiry, J. A., & Zunino, P. (2015) · Annals of Microbiology · doi:10.1007/s13213-015-1077-2 · Cited by 6
“The potential to modulate the ruminal microbiota in order to obtain better productive results now begins to be a reality (Jami et al. 2014), and this work represents an approach to understand possible ways to use native microorganisms for that purpose.”
BackgroundResultCaptivity restructures the gut microbiota of François' langurs (Trachypithecus francoisi)
Mo, F., Li, Y., Liu, Z., Zheng, J., Nong, D., Liang, J., Li, Y., & Huang, Z. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1166688 · Cited by 6
“In this study, captive langurs had a higher relative abundance of Bacteroidetes that facilitate the decomposition of polysaccharides and proteins (Fernando et al., 2010; Jami et al., 2014).”
BackgroundFloridia, V., Russo, N., D’Alessandro, E., Lopreiato, V., Pino, A., Amato, A., Liotta, L., Caggia, C., & Randazzo, C. L. (2023) · Microbiological Research · doi:10.1016/j.micres.2023.127510 · Cited by 6
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Shah, S. A. U. R., Hao, Y., Tang, B., Ahmad, M., He, D., Nabi, G., Zheng, J., Wan, X., Wang, C., & Wang, K. (2025) · Environmental Research · doi:10.1016/j.envres.2025.121082 · Cited by 7
Functional Metagenomics from the Rumen Environment—A Review
Bekele, W., Zegeye, A., Simachew, A., & Assefa, G. (2021) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2021.125009 · Cited by 6
The role of microbiota in animal health and productivity: misinterpretations and limitations
Bajagai, Y. S., Trotter, M. G., WILLIAMS, T. M., Costa, D. F. A., Whitton, M. M., Ren, X., Wilson, C., & Stanley, D. (2022) · Animal Production Science · doi:10.1071/an21515 · Cited by 6
Temporal Changes in the Faecal Microbiota of Beef Cattle on Feedlot Placement
Maslen, B. N., Gray, L.-A., Ghorashi, S. A., White, J. D., Campbell, M. A., & Pant, S. D. (2022) · Animals · doi:10.3390/ani12192500 · Cited by 6
“For example, studies have shown that milk yield and composition are significantly correlated to the type and abundance of rumen microbiota in dairy cattle [10].”
ResultImproving the Inference of Co-Occurrence Networks in the Bovine Rumen Microbiome
Zheng, H., Wang, H., Dewhurst, R. J., & Roehe, R. (2018) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2018.2879342 · Cited by 6
“rumen, ruminants cannot function properly [5].”
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“Furthermore, increased relative abundance of Firmicutes enhanced energy harvesting in bovine and played a crucial role in increasing fat deposition in cows and feed efficiency in steers [41,42].”
BackgroundRumen microbial genomics: from cells to genes (and back to cells)
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Effects of Diet on Human Gut Microbiome and Subsequent Influence on Host Physiology and Metabolism
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“Studies have shown that Prevotellaceae produce mainly acetate and succinate [74] and are negatively correlated with growth rates [75] and production performance [76,77] in ruminants.”
BackgroundResultIntegrated metagenomics and metabolomics analyses revealed biomarkers in β-casein A2A2-type cows
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“Prevotella7 has also been implicated in modulating the immune response and inflammatory processes within the GIT, potentially influencing GIT morphology and function (Jami et al., 2014).”
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“The ratio of Firmicutes to Bacteroidetes has been correlated with milk fat yield (Jami et al., 2014).”
BackgroundVasco, K. A., Hansen, Z. A., Schilmiller, A. L., Bowcutt, B., Carbonell, S. L., Ruegg, P. L., Quinn, R. A., Zhang, L., & Manning, S. D. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1364637 · Cited by 4
“The presence of Bi fi dobacterium , for example, has been linked to higher milk-fat yields (Jami et al., 2014), while genus Prevotella (phylum Bacteroidetes) has been connected to metabolic pathways integral to protein and fat content in milk as well as the production of volatile fatty acids (Wu et…”
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“A previous study revealed negative correlations between two microorganisms, Crococcus and Ruminobacter, and milk yield and milk quality, which is in agreement with the findings of the present study [48].”
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“The Firmicutes/Bacteroidetes ratio in the gut microbiota has been linked to energy efficiency in animals, including mice, pigs, cows, and humans (Jami et al., 2014; Turnbaugh et al., 2006; Zhao et al., 2015).”
Min, B. R., Lourençon, R. V., Nagaraju, I., Pitta, D., Ismael, H., Abdo, H., Chaudhary, S., Hilaire, M., Kanyi, V., Solaiman, S. G., et al. (2025) · Journal of Animal Science · doi:10.1093/jas/skaf260 · Cited by 4
The Role of Feed Additives in Enhancing Ruminant Performance and Sustainability
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Effects of Artemisia argyi Aqueous Extract on Rumen Fermentation Parameters and Microbiota in Lambs
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Comparative Assessment of Rumen Microbial Diversity in Cattle and Buffaloes
Malik, P. K., Trivedi, S., Kolte, A. P., Sejian, V., Mech, A., Biswas, S., Bhattar, A. V. K., Mohapatra, A., & Bhatta, R. (2021) · Springer eBooks · doi:10.1007/978-981-16-9836-1_19 · Cited by 4
Metadata
- Authors
- Jami, E., White, B. A., & Mizrahi, I.
- Affiliations
- Tel Aviv University (IL)
- University of Illinois Urbana-Champaign (US)
- Agricultural Research Organization (IL)
- Corresponding author
- Mizrahi, Itzhak
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-01-22
- Volume
- 9
- Issue
- 1
- Pages
- e85423
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3899005
- OpenAlex
- W2042473229
- Cited by
- 588
- References
- 29
- Citations by year
- 2026: 26 · 2025: 46 · 2024: 78 · 2023: 54 · 2022: 67 · 2021: 82 · 2020: 55 · 2019: 46 · 2018: 38 · 2017: 47 · 2016: 22 · 2015: 20 · 2014: 7
- FWCI
- 63.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Ruminant Nutrition and Digestive Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- rumen microbiome, dairy cattle, milk composition, milk yield, feed efficiency, rumen bacterial community, Firmicutes/Bacteroidetes ratio, milk fat yield, host-microbe interactions, rumen bacteria
- MeSH terms
- Animals, Animal Feed, Animal Nutritional Physiological Phenomena, Bacteria, Cattle, DNA, Bacterial, Fats, Female, Milk, Phylogeny, RNA, Ribosomal, 16S, Rumen, Sequence Analysis, DNA, Bacteroidetes, Host-Pathogen Interactions, Microbiota
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