Cited by 592Ruminant Nutrition and Digestive PhysiologyGut microbiota and healthAnimal Nutrition and Physiology

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Potential Role of the Bovine Rumen Microbiome in Modulating Milk Composition and Feed Efficiency

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Jami, Elie, White, Bryan A., Mizrahi, Itzhak·2014·PLoS ONE

DOI 10.1371/journal.pone.0085423PMC PMC3899005

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Abstract

Ruminants are completely dependent on their microbiota for feed digestion and consequently, their viability. It is therefore tempting to hypothesize a connection between the composition and abundance of resident rumen bacterial taxa and the physiological parameters of the host. Using a pyrosequencing approach, we characterized the rumen bacterial community composition in 15 dairy cows and their physiological parameters. We analyzed the degree of divergence between the different animals and found that some physiological parameters, such as milk yield and composition, are highly correlated with the abundance of various bacterial members of the rumen microbiome. One apparent finding was a strong correlation between the ratio of the phyla Firmicutes to Bacteroidetes and milk-fat yield. These findings paralleled human studies showing similar trends of increased adiposity with an increase in Bacteroidetes. This correlation remained evident at the genus level, where several genera showed correlations with the animals' physiological parameters. This suggests that the bacterial community has a role in shaping host physiological parameters. A deeper understanding of this process may allow us to modulate the rumen microbiome for better agricultural yield through bacterial community design.

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“Analysis of rumen microbiome using high throughput sequencing technologies has expanded our understanding of rumen microbial communities (Jami et al., 2014).”
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“…the content of Bacteroidetes and the ratio of Firmicutes/Bacteroides (Fernando et al., 2010), and consequently the G+S cattle-yak could absorb energy-related nutrients more effectively and maintain their metabolic balance in the low-temperature environment (Murphy et al., 2010; Jami et al., 2014).”
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(2016) · PeerJ · doi:10.7287/peerj.1599v0.2/reviews/2
Peer Review #1 of "Comparative analysis of the metabolically active microbial communities in the rumen of dromedary camels under different feeding systems using total rRNA sequencing (v0.6)"
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Peer Review #3 of "Comparative analysis of the metabolically active microbial communities in the rumen of dromedary camels under different feeding systems using total rRNA sequencing (v0.1)"
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Peer Review #2 of "Comparative analysis of the metabolically active microbial communities in the rumen of dromedary camels under different feeding systems using total rRNA sequencing (v0.1)"
(2020) · PeerJ · doi:10.7287/peerj.10184v0.1/reviews/2
Peer Review #2 of "A comparison of rumen microbial profiles in dairy cows as retrieved by 454 Roche and Ion Torrent (PGM) sequencing platforms (v0.1)"
(2016) · PeerJ · doi:10.7287/peerj.1599v0.1/reviews/2
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“Jami et al. (2014) state that Bacteroidetes degrade starch, hemicellulose, pectin and protein, while Firmicutes degrade cellulose.”
Background
Characterization of the rumen epithelial microbiota of cattle and other ruminants through bioinformatics approaches: Discovering core microbiota, gene expression during sub-acute ruminal acidosis, and functional capabilities of novel metagenome assembled genomes
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“Jami, et al. 33 found that the microbial community is closely linked to the production traits of ruminants, highlighting the importance to study the composition of microbial community.”
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“Jami et al. (11) found a number of rumen-associated genera with strong correlations to milk yield, but in our data set, we were unable to identify any significant correlations between milk yield and the most abundant genera, which may be due to a number of factors, such as the inclusion of oral microbes in the data se…”
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“Indeed, higher proportions of Firmicutes/ Bacteroidetes were closely related to greater energetic efficiency in different species, including swine (Turnbaugh et al. 2006; Ley et al. 2007; Jami et al. 2014; Zhao et al. 2015; Xu et al. 2016).”
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Additional file 1 of Dynamic changes of rumen microbiota and serum metabolome revealed increases in meat quality and growth performances of sheep fed bio-fermented rice straw
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Additional file 7 of Postbiotics from Saccharomyces cerevisiae fermentation stabilize microbiota in rumen liquid digesta during grain-based subacute ruminal acidosis (SARA) in lactating dairy cows
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Additional file 3 of Characterization of rumen microbiome and immune genes expression of crossbred beef steers with divergent residual feed intake phenotypes
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Additional file 1 of Characterization of rumen microbiome and immune genes expression of crossbred beef steers with divergent residual feed intake phenotypes
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Additional file 5 of Dynamic changes of rumen microbiota and serum metabolome revealed increases in meat quality and growth performances of sheep fed bio-fermented rice straw
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Additional file 1 of Postbiotics from Saccharomyces cerevisiae fermentation stabilize microbiota in rumen liquid digesta during grain-based subacute ruminal acidosis (SARA) in lactating dairy cows
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Additional file 2 of Dynamic changes of rumen microbiota and serum metabolome revealed increases in meat quality and growth performances of sheep fed bio-fermented rice straw
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Additional file 5 of Postbiotics from Saccharomyces cerevisiae fermentation stabilize microbiota in rumen liquid digesta during grain-based subacute ruminal acidosis (SARA) in lactating dairy cows
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Additional file 2 of Postbiotics from Saccharomyces cerevisiae fermentation stabilize microbiota in rumen liquid digesta during grain-based subacute ruminal acidosis (SARA) in lactating dairy cows
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Additional file 9 of Ruminal resistome of dairy cattle is individualized and the resistotypes are associated with milking traits
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Additional file 2 of Characterization of rumen microbiome and immune genes expression of crossbred beef steers with divergent residual feed intake phenotypes
Taiwo, G., Morenikeji, O. B., Idowu, M. D., Sidney, T. S., Ajiboye, A. O., Cervantes, A. P., Peters, S., & Ogunade, I. M. (2024) · Figshare · doi:10.6084/m9.figshare.25347222
Additional file 7 of Ruminal resistome of dairy cattle is individualized and the resistotypes are associated with milking traits
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Additional file 2 of An artificial intelligence approach of feature engineering and ensemble methods depicts the rumen microbiome contribution to feed efficiency in dairy cows
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Additional file 1 of Multi-omics revealed the long-term effect of ruminal keystone bacteria and the microbial metabolome on lactation performance in adult dairy goats
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Additional file 12 of Ruminal resistome of dairy cattle is individualized and the resistotypes are associated with milking traits
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Additional file 3 of Dynamic changes of rumen microbiota and serum metabolome revealed increases in meat quality and growth performances of sheep fed bio-fermented rice straw
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Additional file 11 of Ruminal resistome of dairy cattle is individualized and the resistotypes are associated with milking traits
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Additional file 8 of Ruminal resistome of dairy cattle is individualized and the resistotypes are associated with milking traits
Xue, M.-Y., Xie, Y.-Y., Zhong, Y.-F., Liu, J., Guan, L. L., & Sun, H.-Z. (2021) · Figshare · doi:10.6084/m9.figshare.13889404
Additional file 4 of Dynamic changes of rumen microbiota and serum metabolome revealed increases in meat quality and growth performances of sheep fed bio-fermented rice straw
Kyawt, Y. Y., Aung, M., Xu, Y., Sun, Z., Zhou, Y., Zhu, W., Padmakumar, V., Tan, Z., & Cheng, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26686641
Additional file 3 of Postbiotics from Saccharomyces cerevisiae fermentation stabilize microbiota in rumen liquid digesta during grain-based subacute ruminal acidosis (SARA) in lactating dairy cows
Guo, J., Zhang, Z., Guan, L. L., Yoon, I., Plaizier, J. C., & Khafipour, E. (2024) · Figshare · doi:10.6084/m9.figshare.26745650
Additional file 4 of Postbiotics from Saccharomyces cerevisiae fermentation stabilize microbiota in rumen liquid digesta during grain-based subacute ruminal acidosis (SARA) in lactating dairy cows
Guo, J., Zhang, Z., Guan, L. L., Yoon, I., Plaizier, J. C., & Khafipour, E. (2024) · Figshare · doi:10.6084/m9.figshare.26745653
Additional file 10 of Ruminal resistome of dairy cattle is individualized and the resistotypes are associated with milking traits
Xue, M.-Y., Xie, Y.-Y., Zhong, Y.-F., Liu, J., Guan, L. L., & Sun, H.-Z. (2021) · Figshare · doi:10.6084/m9.figshare.13889368
Additional file 6 of Postbiotics from Saccharomyces cerevisiae fermentation stabilize microbiota in rumen liquid digesta during grain-based subacute ruminal acidosis (SARA) in lactating dairy cows
Guo, J., Zhang, Z., Guan, L. L., Yoon, I., Plaizier, J. C. B., & Khafipour, E. (2024) · Figshare · doi:10.6084/m9.figshare.26745659
Additional file 1 of Bacillus subtilis and Macleaya cordata extract regulate the rumen microbiota associated with enteric methane emission in dairy cows
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“These adjustments also influence nutrient partitioning between maintenance and production functions, thereby promoting milk production (Castillo et al., 2025a, 2025b; Castillo et al., 2000; Jami et al., 2014; Lucy et al., 2013).”
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“The presence of a high-abundance shared component should therefore not be interpreted as direct evidence of ecological stability or resilience 13,24–26 .”
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“The pathways for de novo fatty acid synthesis in the mammary gland are largely supported by acetate and butyrate, which are derived from ruminal fermentation of dietary fiber [44].”

Authors: Jami, E., White, B. A., & Mizrahi, I.
Affiliations: Tel Aviv University (IL)
University of Illinois Urbana-Champaign (US)
Agricultural Research Organization (IL)
Corresponding author: Mizrahi, Itzhak
ORCID: Jami, Elie
White, Bryan A.
Mizrahi, Itzhak
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2014-01-22
Volume: 9
Issue: 1
Pages: e85423
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0085423
PMC: PMC3899005
OpenAlex: W2042473229
Cited by: 588
References: 29
Citations by year: 2026: 26 · 2025: 46 · 2024: 78 · 2023: 54 · 2022: 67 · 2021: 82 · 2020: 55 · 2019: 46 · 2018: 38 · 2017: 47 · 2016: 22 · 2015: 20 · 2014: 7
FWCI: 63.79
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Figshare (submittedVersion, cc-by)
Topics: Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Ruminant Nutrition and Digestive Physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords: rumen microbiome, dairy cattle, milk composition, milk yield, feed efficiency, rumen bacterial community, Firmicutes/Bacteroidetes ratio, milk fat yield, host-microbe interactions, rumen bacteria
MeSH terms: Animals, Animal Feed, Animal Nutritional Physiological Phenomena, Bacteria, Cattle, DNA, Bacterial, Fats, Female, Milk, Phylogeny, RNA, Ribosomal, 16S, Rumen, Sequence Analysis, DNA, Bacteroidetes, Host-Pathogen Interactions, Microbiota

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Potential Role of the Bovine Rumen Microbiome in Modulating Milk Composition and Feed Efficiency

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