Cited by 592Ruminant Nutrition and Digestive PhysiologyGut microbiota and healthAnimal Nutrition and Physiology

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Potential Role of the Bovine Rumen Microbiome in Modulating Milk Composition and Feed Efficiency

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Jami, Elie, White, Bryan A., Mizrahi, Itzhak·2014·PLoS ONE

DOI 10.1371/journal.pone.0085423PMC PMC3899005

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Abstract

Ruminants are completely dependent on their microbiota for feed digestion and consequently, their viability. It is therefore tempting to hypothesize a connection between the composition and abundance of resident rumen bacterial taxa and the physiological parameters of the host. Using a pyrosequencing approach, we characterized the rumen bacterial community composition in 15 dairy cows and their physiological parameters. We analyzed the degree of divergence between the different animals and found that some physiological parameters, such as milk yield and composition, are highly correlated with the abundance of various bacterial members of the rumen microbiome. One apparent finding was a strong correlation between the ratio of the phyla Firmicutes to Bacteroidetes and milk-fat yield. These findings paralleled human studies showing similar trends of increased adiposity with an increase in Bacteroidetes. This correlation remained evident at the genus level, where several genera showed correlations with the animals' physiological parameters. This suggests that the bacterial community has a role in shaping host physiological parameters. A deeper understanding of this process may allow us to modulate the rumen microbiome for better agricultural yield through bacterial community design.

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“Обилие представителей Bacteroidetes и Firmicutes в рубце молочных коров подтверждается результатами других авторов, полученными ранее (28-30), однако доля представителей Bacteroidetes, детектированных в нашем исследовании, была значительно выше по сравнению с данными этих исследователей.”
Boosting the potential of cattle breeding using molecular biology, genetics, and bioinformatics approaches – a review
Čechová, M., & Andrlíková, M. (2021) · Acta Veterinaria Brno · doi:10.2754/avb202190020145 · Cited by 1
“The microbiome undoubtedly influences the health and disease of an individual, as evidenced in a number of recent studies (Jami et al. 2014; Malmuthuge and Guan 2017; Young et al. 2020).”
Background
Using a multi-omics approach to explore potential associations with rumen content and serum of cows with different milk production levels based on genomic predicted transmitting ability for milk and phenotypic milk production
Ravelo, A. D., Ferm, P., Guo, Y., Omontese, B. O., Morley, P. S., Chen, C., Noyes, N. R., & Caixeta, L. S. (2024) · PLoS ONE · doi:10.1371/journal.pone.0305674 · Cited by 2
Investigating the regulatory effect of Shen Qi Bu Qi powder on the gastrointestinal flora and serum metabolites in calves
Yang, H., Ren, J., Ji, P., Zhang, X., Mai, Z., Li, C., Zhao, N., Ma, T., Zhu, X., Hua, Y., et al. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1443712 · Cited by 1
“Both Firmicutes and Bacteroidetes are key players in the fermentation of ﬁ ber and the degradation of carbohydrates, producing various cellulases to hydrolyze macromolecular compounds such as cellulose and sugar (Jami et al., 2014; Xie et al., 2023).”
Background
Characterizing the hindgut microbiome in healthy and ketotic cows
Ju, Z., Li, R., Liu, W., Jiang, Q., Wang, J., Zhang, Y., Wang, X., Xiao, Y., Yang, C., Wei, X., et al. (2024) · All Life · doi:10.1080/26895293.2024.2393854 · Cited by 1
The effect of different forages on rumen microbiota and milk production performance in Holstein dairy cows
Wang, S. H., Liao, H. H., Chia-Xin, L., Chen, H.-M., Chen, L.-Y., Chuang, S.-T., & Hsu, J. (2024) · Czech Journal of Animal Science · doi:10.17221/86/2024-cjas · Cited by 1
Correlating Feed Efficiency with Ruminal Bacterial, Fungal, and Archaeal Community Composition in Dairy Cows over Two Lactations
Scheftgen, A. J., Skarlupka, J. H., Jewell, K. A., & Suen, G. (2025) · Dairy · doi:10.3390/dairy6010008 · Cited by 1
“These taxa are dominant in the rumen and have been previously associated with MPE [7,35,36].”
Rumen Microbial Ecology And Rumen-Derived Fatty Acids: Determinants Of And Relationship To Dairy Cow Production Performance
Cersosimo, L. M. (2017) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont) · Cited by 1
Microbiomes Associated with Animals: Implications for Livestock and Animal Production
Mantovani, H. C., Lopes, D. R. G., Bento, C. B. P., & de Oliveira, M. N. (2017) · Springer eBooks · doi:10.1007/978-3-319-59997-7_4 · Cited by 1
Metagenomics and its relevance to animal diseases and gut health
Kolte, A. P., Dhali, A., Malik, P. K., PAL, D., & Bhatta, R. (2020) · Indian Journal of Animal Health · doi:10.36062/ijah.59.2spl.2020.36-49 · Cited by 1
Effects of Supplementation with Saccharomyces cerevisiae and Its Fermentation Products on Production Performance and Its Mechanism in Perinatal Dairy Cows
Lin, X., Li, K., Ju, L., Xu, H., Jiang, Y. Q., Hou, Q., Hu, Z., Wang, Y., & Wang, Z. (2021) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2021.127013 · Cited by 1
Farm Animals and Pets—Impact on Gut Microbiota
Golić, N., & Đokić, J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00102-9 · Cited by 1
Milk And Resistance Exercise: What Are The Real Factors That Can Limit The Intake?
Nicastro, H. (2016) · Journal of Nutritional Health & Food Science · doi:10.15226/jnhfs.2016.00158 · Cited by 1
Effect of galangal essential oils on rumen microbial population and biodiversity on in vitro rumen fermentation
Daning, D. R. A., Widyobroto, B. P., Yusiati, L. M., & Hanim, C. (2022) · Indonesian Journal of Biotechnology · doi:10.22146/ijbiotech.66680 · Cited by 1
“According to Jami et al. (2014), Bacteriodetes is the most dominant type of bacteria in the rumen, responsible for degrading several nutrients such as carbohydrates and protein.”
Background
Current Status of Practical Applications: Probiotics in Dairy Cattle
Jeni, R. E., Osorio-Doblado, A. M., Feldmann, K. P., Lourenco, J. M., Bu, D., & Callaway, T. R. (2023) · Springer eBooks · doi:10.1007/978-3-031-40512-9_12 · Cited by 1
Genetic control of methane emission, feed efficiency and metagenomics in dairy cattle
Difford, G. F. (2018) · doi:10.18174/458036 · Cited by 1
“…studies have detected 1 General introduction 38 significant associations between numerous OTUs, species or higher taxonomic levels in dairy cattle (Jami et al., 2014; Jewell et al., 2015; Shabat et al., 2016) and beef cattle (Guan et al., 2008; Hernandez-Sanabria et al., 2010; Myer et al., 2015).”
Background
A batch culture study of the rumen bacterial community and the fermentative digestion of forage in cattle
McDermott, K. (2018) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York) · Cited by 1
Multi-Omics Study of The Salivary Modulation of The Rumen MicrobiomePreprint
Palma‐Hidalgo, J. M., Belanche, A., Jiménez, E., Martín-García, A. I., Newbold, C. J., Denman, S. E., & Yáñez-Ruíz, D. R. (2022) · Research Square · doi:10.21203/rs.3.rs-1167950/v1 · Cited by 1
“The rumen microbial diversity and function largely in uence many animal traits such as the e ciency of utilization of feeds and the environmental impact through methane emissions (Jami et al., 2014).”
Background
Characterization of bovine vaginal microbiota and its relationship with host fertility, health, and productionPreprint
Brulin, L., Ducrocq, S., Even, G., Sanchez, M.-P., Martel, S., Merlin, S., Audebert, C., Croiseau, P., & Estellé, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.13.571514 · Cited by 1
“As production is often linked to the digestive tract [74, 75], maybe these genera reflected the gut microbiota without being responsible for the differences of performances and were a proxy of the gut microbiota.”
Background
Exploring the biological basis of residual feed intake in beef cattle using multi-Omics analysis.
Taiwo, G. A. (2023) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.12281 · Cited by 1
Characterization of the dairy cattle rumen microbial communities in response to long term supplementation of a sodium-saccharin based sweetener during normal physiological and heat stress conditions
Koester, L. R. (2022) · doi:10.31274/td-20240329-140 · Cited by 1
Assembly and maturation of calf gut microbiome from neonate to post-puberty
Kim, H. S., Lee, J., Whon, T. W., & Bae, J. (2025) · Scientific Data · doi:10.1038/s41597-025-04677-7 · Cited by 1
“Bacteria are the predominant microbes in the rumen ( > 91% of the whole microbiome) 1 , and adult ruminants fed indi-gestible plant materials are larg™ely dependent on their ruminal microbiome for feed digestion 2,3 .”
Rumen Microbial Community Profiling as a Tool to Study Ruminant Production
Janssen, P. H., Kittelmann, S., Henderson, G., & Seedorf, H. (2014) · Proceedings of the New Zealand Society of Animal Production
The influence of viral and bacterial community diversity on pathogenic E. coli prevalence in pre-harvest cattle
Chopyk, J. (2025) · Library, Museums and Press - UDSpace (University of Delaware) · doi:10.58088/51xf-6s50
Dinâmica do microbioma ruminal de ovinos (Ovis aries) e sua relação com a degradação de biomassa
Romagnoli, E. M. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.11.2016.tde-07062016-171940
“Em ruminantes, Jami et al. (2014) reportaram que o aumento de Firmicutes em vacas leiteras esta positivamente correlacionado com a porcentagem de gordura no leite.”
Background
Feed Effic iency And The M icrobiota Of The Alimentary Tract
Hruska, L., Freetly, H. C., & Myer, P. R. (2016)
112 Vaginal and uterine bacterial communities in postpartum lactating cows
Clemmons, B. A., Dantas, F. G., Franco, G. A., Reese, S. T., Adeyosoye, O. I., Smith, T. P. L., Myer, P. R., & Pohler, K. G. (2017) · Journal of Animal Science · doi:10.2527/asasmw.2017.112
Metagenoma do microbioma do rúmen de ovinos e prospecção de genes degradadores de biomassa vegetal
Kmit, M. C. P. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.11.2018.tde-01082018-110114
Interrelations between feed, host and rumen microbiota in dairy cows
Schären, M. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7412
Examination Of Bovine Rumen Fluid And Milk Fat Globule Membrane Proteome Dynamics
Honan, M. C. (2019) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
Avaliação da associação entre microbioma fecal e eficiência alimentar em bovinos da raça Angus
Marcilli, G. M. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.74.2019.tde-04122019-120843
Effects of feeding strategy and duration of the dry period on the rumen microbiota of dairy cows
Khazanehei, H., Li, S., Khafipour, E., & Plaizier, J. C. B. (2019) · Canadian Journal of Animal Science · doi:10.1139/cjas-2019-0035
“As a result, during the first 7 wk of lactation, the ratio between the relative abundances of Firmicutes and the abundances of Bacteroidetes in rumen fluid increased more during the SHORT treatment than during the CONV treatment.”
BackgroundInfluential
Integration between healthy and microbiome in holstein cows immediately after calving
Castro-Tardón, D. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.10.2020.tde-04062020-091318
“JAMI et al (2014) have evaluated a connection between the composition and abundance of resident GI bacterial taxa and the physiological parameters in healthy Holstein Friesian lactating cows.”
BackgroundInfluential
Peer Review #2 of "Supplementary feeding of cattle-yak in the cold season alters rumen microbes, volatile fatty acids, and expression of SGLT1 in the rumen epithelium (v0.2)"
(2021) · PeerJ · doi:10.7287/peerj.11048v0.2/reviews/2
Peer Review #2 of "Supplementary feeding of cattle-yak in the cold season alters rumen microbes, volatile fatty acids, and expression of SGLT1 in the rumen epithelium (v0.1)"
(2021) · PeerJ · doi:10.7287/peerj.11048v0.1/reviews/2
High-throughput Methods Redefine the Rumen Microbiome and Its Relationship with Nutrition and Metabolism
Juan, J. (2014)
A Review on Steering System for Cars
Vinod, M., & Deepak, J. (2019) · Journal of Emerging Technologies and Innovative Research
The effects of heat stress and feed restriction on the microbiome of lactating dairy cows
Witzke, M. C. (2020) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/86548
Quantitative Analysis of Bacterial Genes Expression as Prognostic Markers of Metabolic Disorders with the Aim of the Dairy Cattle’s Health Monitoring
Laptev, G., Yildirim, E. A., Il'ina, L. A., Филиппова, В., Brazhnik, E. A., Novikova, N., Tiurina, D. G., Tarlavin, N. V., & Ponomareva, E. S. (2021) · Smart innovation, systems and technologies · doi:10.1007/978-981-16-3349-2_3
Taxonomic Profiling of the Lumen and Epimural Surface of the Duodenum, Rumen and Ileum Using a Cannulated Bovine Model
Stockler, R. M. (2021)
Peer Review #1 of "A cross-sectional study of the nasal and fecal microbiota of sows from different health status within six commercial swine farms (v0.3)"
(2021) · PeerJ · doi:10.7287/peerj.12120v0.3/reviews/1
Peer Review #1 of "A cross-sectional study of the nasal and fecal microbiota of sows from different health status within six commercial swine farms (v0.1)"
(2021) · PeerJ · doi:10.7287/peerj.12120v0.1/reviews/1
Peer Review #1 of "A cross-sectional study of the nasal and fecal microbiota of sows from different health status within six commercial swine farms (v0.4)"
(2021) · PeerJ · doi:10.7287/peerj.12120v0.4/reviews/1
Peer Review #1 of "A cross-sectional study of the nasal and fecal microbiota of sows from different health status within six commercial swine farms (v0.5)"
(2021) · PeerJ · doi:10.7287/peerj.12120v0.5/reviews/1
Peer Review #1 of "A cross-sectional study of the nasal and fecal microbiota of sows from different health status within six commercial swine farms (v0.2)"
(2021) · PeerJ · doi:10.7287/peerj.12120v0.2/reviews/1
“The microbiome is defined as the microbial community within or on a body site and is known to play an important role in human and animal health (Round & Mazmanian, 2009; Young, 2017; Nowland et al., 2019) and animal production (Jami, White & Mizrahi, 2014).”

Authors: Jami, E., White, B. A., & Mizrahi, I.
Affiliations: Tel Aviv University (IL)
University of Illinois Urbana-Champaign (US)
Agricultural Research Organization (IL)
Corresponding author: Mizrahi, Itzhak
ORCID: Jami, Elie
White, Bryan A.
Mizrahi, Itzhak
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2014-01-22
Volume: 9
Issue: 1
Pages: e85423
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0085423
PMC: PMC3899005
OpenAlex: W2042473229
Cited by: 588
References: 29
Citations by year: 2026: 26 · 2025: 46 · 2024: 78 · 2023: 54 · 2022: 67 · 2021: 82 · 2020: 55 · 2019: 46 · 2018: 38 · 2017: 47 · 2016: 22 · 2015: 20 · 2014: 7
FWCI: 63.79
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Figshare (submittedVersion, cc-by)
Topics: Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Ruminant Nutrition and Digestive Physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords: rumen microbiome, dairy cattle, milk composition, milk yield, feed efficiency, rumen bacterial community, Firmicutes/Bacteroidetes ratio, milk fat yield, host-microbe interactions, rumen bacteria
MeSH terms: Animals, Animal Feed, Animal Nutritional Physiological Phenomena, Bacteria, Cattle, DNA, Bacterial, Fats, Female, Milk, Phylogeny, RNA, Ribosomal, 16S, Rumen, Sequence Analysis, DNA, Bacteroidetes, Host-Pathogen Interactions, Microbiota

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Potential Role of the Bovine Rumen Microbiome in Modulating Milk Composition and Feed Efficiency

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