White matter tract damage in the behavioral variant of frontotemporal and corticobasal dementia syndromes
Open accessAbstract
The phenotypes of the behavioral variant of frontotemporal dementia and the corticobasal syndrome present considerable clinical and anatomical overlap. The respective patterns of white matter damage in these syndromes have not been directly contrasted. Beyond cortical involvement, damage to white matter pathways may critically contribute to both common and specific symptoms in both conditions. Here we assessed patients with the behavioral variant of frontotemporal dementia and corticobasal syndrome with whole-brain diffusion tensor imaging to identify the white matter networks underlying these pathologies. Twenty patients with the behavioral variant of frontotemporal dementia, 19 with corticobasal syndrome, and 15 healthy controls were enrolled in the study. Differences in tract integrity between (i) patients and controls, and (ii) patients with the corticobasal syndrome and the behavioral variant of frontotemporal dementia were assessed with whole brain tract-based spatial statistics and analyses of regions of interest. Behavioral variant of frontotemporal dementia and the corticobasal syndrome shared a pattern of bilaterally decreased white matter integrity in the anterior commissure, genu and body of the corpus callosum, corona radiata and in the long intrahemispheric association pathways. Patients with the behavioral variant of frontotemporal dementia showed greater damage to the uncinate fasciculus, genu of corpus callosum and forceps minor. In contrast, corticobasal syndrome patients had greater damage to the midbody of the corpus callosum and perirolandic corona radiata. Whereas several compact white matter pathways were damaged in both the behavioral variant of frontotemporal dementia and corticobasal syndrome, the distribution and degree of white matter damage differed between them. These findings concur with the distinctive clinical manifestations of these conditions and may improve the in vivo neuroanatomical and diagnostic characterization of these disorders.
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Raw structural connectivity models showed alterations in the uncinate fasciculus, superior longitudinal fasciculus, corpus callosum, dentatorubrothalamic tract, and inferior fronto-occipital fasciculus.
“we found alterations in the uncinate fasciculus (Agosta et al., 2012; Daianu et al., 2016; Iaccarino et al., 2015; Nguyen et al., 2013), superior longitudinal fasciculus (Agosta et al., 2012; Daianu et al., 2016), corpus callosum (Tovar-Moll et al., 2014), dentatorubrothalamic tract (Whitwell et al., 2011a), and inferior fronto-occipital fasciculus (Meijboom et al., 2017).”
From Multiclass characterization of frontotemporal dementia variants via multimodal brain network computational inference (2023) · cites this paper as Tovar-Moll et al., 2014
Subjects with CBS showed alterations in motor/parietal areas.
“Last, for the subjects with CBS, we found alterations in motor/parietal areas (Tovar-Moll et al., 2014; Whitwell et al., 2014)”
From Multiclass characterization of frontotemporal dementia variants via multimodal brain network computational inference (2023) · cites this paper as Tovar-Moll et al., 2014
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Cites
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,010 · see citing works
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589 · see citing works
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630 · see citing works
Cohen, J. (1992) · Psychological Bulletin · doi:10.1037//0033-2909.112.1.155 · Cited by 8,771 · see citing works
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568 · see citing works
Nonparametric permutation tests for functional neuroimaging: A primer with examples
Nichols, T. E., & Holmes, A. P. (2002) · Human Brain Mapping · doi:10.1002/hbm.1058 · Cited by 6,256 · see citing works
Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data
Smith, S. M., Jenkinson, M., Johansen-Berg, H., Rueckert, D., Nichols, T. E., Mackay, C., Watkins, K., Ciccarelli, O., Cader, M., Matthews, P., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.024 · Cited by 6,035 · see citing works
Nonrigid registration using free-form deformations: application to breast mr images
Rueckert, D., Sonoda, L. I., Hayes, C., Hill, D. L. G., Leach, M. O., & Hawkes, D. J. (1999) · IEEE Transactions on Medical Imaging · doi:10.1109/42.796284 · Cited by 5,265 · see citing works
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047 · see citing works
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
Minoshima, S., Giordani, B., Berent, S., Frey, K. A., Foster, N. L., & Kuhl, D. E. (1997) · Annals of Neurology · doi:10.1002/ana.410420114 · Cited by 1,802 · see citing works
A diffusion tensor imaging tractography atlas for virtual in vivo dissections.
CATANI, M., & THIEBAUTDESCHOTTEN, M. (2008) · Cortex · doi:10.1016/j.cortex.2008.05.004 · Cited by 1,642 · see citing works
Clinical and Pathological Diagnosis of Frontotemporal Dementia
McKhann, G. M. (2001) · Archives of Neurology · doi:10.1001/archneur.58.11.1803 · Cited by 1,475 · see citing works
DtiStudio: Resource program for diffusion tensor computation and fiber bundle tracking
Jiang, H., van Zijl, P. C. M., Kim, J., Pearlson, G. D., & Mori, S. (2006) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2005.08.004 · Cited by 999 · see citing works
Topography of the Human Corpus Callosum
LACOSTE, M. C. D., Kirkpatrick, J. B., & Ross, E. D. (1985) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198511000-00004 · Cited by 537 · see citing works
Frontal Paralimbic Network Atrophy in Very Mild Behavioral Variant Frontotemporal Dementia
Seeley, W. W., Crawford, R., Rascovsky, K., Kramer, J. H., Weiner, M., Miller, B. L., & Gorno-Tempini, M. L. (2008) · Archives of Neurology · doi:10.1001/archneurol.2007.38 · Cited by 506 · see citing works
Frontal lobe degeneration of non-Alzheimer type. I. Neuropathology
Brun, A. E. (1987) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(87)90021-5 · Cited by 396 · see citing works
Does corticobasal degeneration exist? A clinicopathological re-evaluation
Ling, H., O'Sullivan, S. S., Holton, J. L., Revesz, T., Massey, L. A., Williams, D. R., Paviour, D. C., & Lees, A. J. (2010) · Brain · doi:10.1093/brain/awq123 · Cited by 394 · see citing works
Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration
Rohrer, J. D., Lashley, T., Schott, J. M., Warren, J. D., Mead, S., Isaacs, A. M., Beck, J. A., Hardy, J., de Silva, R., Warrington, E. K., et al. (2011) · Brain · doi:10.1093/brain/awr198 · Cited by 359 · see citing works
The Neural Basis of Human Social Values: Evidence from Functional MRI
Zahn, R., Moll, J., Paiva, M., Garrido, G., Krueger, F., Huey, E. D., & Grafman, J. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn080 · Cited by 328 · see citing works
Self-citationThe corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia
KERTESZ, A. E., Martínez‐Lage, P., Davidson, W., & Muñoz, D. G. (2000) · Neurology · doi:10.1212/wnl.55.9.1368 · Cited by 304 · see citing works
Coenen, V. A., Schlaepfer, T. E., Maedler, B., & Panksepp, J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.12.009 · Cited by 246 · see citing works
Mechanism of disinhibition after brain lesions.
Starkstein, S., & Robinson, R. (1997) · Journal of Nervous and Mental Disease · doi:10.1097/00005053-199702000-00007 · Cited by 243 · see citing works
Frontal lobe degeneration of non-Alzheimer type.
Gustafson, L., Brun, A., & Passant, U. (1992) · PubMed · Cited by 241 · see citing works
Imaging correlates of pathology in corticobasal syndrome
Whitwell, J. L., Jack, C. R., Boeve, B. F., Parisi, J. E., Ahlskog, J. E., Drubach, D. A., Senjem, M. L., Knopman, D. S., Petersen, R. C., Dickson, D. W., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181feb2e8 · Cited by 241 · see citing works
Donahue, K. M., Krouwer, H. G. J., Rand, S. D., Pathak, A. P., Marszalkowski, C. S., Censky, S. C., & Prost, R. W. (2000) · Magnetic Resonance in Medicine · doi:10.1002/1522-2594(200006)43:6 · Cited by 241 · see citing works
Progression in Frontotemporal Dementia
Davies, R., Kipps, C., Mitchell, J., Kril, J. J., Halliday, G. M., & Hodges, J. R. (2006) · Archives of Neurology · doi:10.1001/archneur.63.11.1627 · Cited by 191 · see citing works
Migneco, O., Benoît, M., Koulibaly, P. M., Dygai, I., Bertogliati, C., Desvignes, P., Robert, P. H., Malandain, G., Bussiere, F., & Darcourt, J. (2001) · NeuroImage · doi:10.1006/nimg.2000.0741 · Cited by 191 · see citing works
White matter damage in frontotemporal lobar degeneration spectrum
Agosta, F., Scola, E., Canu, E., Marcone, A., Magnani, G., Sarro, L., Copetti, M., Caso, F., Cerami, C., Comi, G., et al. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr288 · Cited by 180 · see citing works
Olfactory deficit detected by fMRI in early Alzheimer's disease
Wang, J., Eslinger, P. J., Doty, R. L., Zimmerman, E. K., Grunfeld, R., Sun, X., Meadowcroft, M. D., Connor, J. R., Price, J. L., Smith, M. B. H., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.018 · Cited by 166 · see citing works
Frontotemporal dementia and related disorders: Deciphering the enigma
Josephs, K. A. (2008) · Annals of Neurology · doi:10.1002/ana.21426 · Cited by 166 · see citing works
Evidence of White Matter Changes on Diffusion Tensor Imaging in Frontotemporal Dementia
Borroni, B., Brambati, S. M., Agosti, C., Gipponi, S., Bellelli, G., Gasparotti, R., Garibotto, V., Luca, M. D., Scifo, P., Perani, D., et al. (2007) · Archives of Neurology · doi:10.1001/archneur.64.2.246 · Cited by 140 · see citing works
Aralaşmak, A., Ulmer, J. L., Koçak, M., Salvan, C. V., Hillis, A. E., & Yousem, D. M. (2006) · Journal of Computer Assisted Tomography · doi:10.1097/01.rct.0000226397.43235.8b · Cited by 139 · see citing works
Frontotemporal dementia as a neural system disease
Boccardi, M., Sabattoli, F., Laakso, M. P., Testa, C., Rossi, R., Beltramello, A., Soininen, H. S., & Frisoni, G. B. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.019 · Cited by 136 · see citing works
Profiles of white matter tract pathology in frontotemporal dementia
Mahoney, C. J., Ridgway, G. R., Malone, I. B., Downey, L. E., Beck, J., Kinnunen, K. M., Schmitz, N., Golden, H. L., Rohrer, J. D., Schott, J. M., et al. (2014) · Human Brain Mapping · doi:10.1002/hbm.22468 · Cited by 124 · see citing works
Executive dysfunction in frontotemporal dementia and corticobasal syndrome
Huey, E. D., Goveia, E., Paviol, S., Pardini, M., Krueger, F. W., Zamboni, G., Tierney, M., Wassermann, E. M., & Grafman, J. H. (2009) · Neurology · doi:10.1212/01.wnl.0000341781.39164.26 · Cited by 113 · see citing works
Self-citationAtrophy patterns in histologic vs clinical groupings of frontotemporal lobar degeneration
Pereira, J., Williams, G. B., Acosta‐Cabronero, J., Pengas, G., Spillantini, M. G., Xuereb, J. H., Hodges, J. R., & Nestor, P. J. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a55fa2 · Cited by 103 · see citing works
Frontotemporal Dementia: Therapeutic Interventions
Mendez, M. F. (2009) · Monographs in clinical neuroscience/Frontiers of neurology and neuroscience/Monographs in neural sciences · doi:10.1159/000197896 · Cited by 84 · see citing works
Hornberger, M., Shelley, B. P., Kipps, C. M., Piguet, O., & Hodges, J. R. (2009) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.163873 · Cited by 84 · see citing works
Distribution of brain atrophy in behavioral variant frontotemporal dementia
Kril, J. J., Macdonald, V., Patel, S., Png, F., & Halliday, G. M. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.02.003 · Cited by 83 · see citing works
Marchiafava-Bignami disease: literature review and case report.
Kohler, C. G., Ances, B. M., Coleman, A. R., et al. (2000) · PubMed · Cited by 78 · see citing works
Sajjadi, S., Acosta-Cabronero, J., Patterson, K., Diaz-de-Grenu, L. Z., Williams, G. B., & Nestor, P. (2013) · Brain : a journal of neurology · doi:10.1093/brain/awt118 · Cited by 63 · see citing works
Ventromedial temporal lobe anatomy, with comments on Alzheimer's disease and temporal injury
Hoesen, G. W. V. (1997) · Journal of Neuropsychiatry · doi:10.1176/jnp.9.3.331 · Cited by 55 · see citing works
Corticobasal degeneration: clinical aspects
Bak, T. H., & Hodges, J. R. (2008) · Handbook of clinical neurology · doi:10.1016/s0072-9752(07)01247-x · Cited by 49 · see citing works
Patterns of White Matter Atrophy in Frontotemporal Lobar Degeneration
Chao, L. L., Schuff, N., Clevenger, E. M., Mueller, S. G., Rosen, H. J., Gorno-Tempini, M. L., Kramer, J. H., Miller, B. L., & Weiner, M. W. (2007) · Archives of Neurology · doi:10.1001/archneur.64.11.1619 · Cited by 40 · see citing works
Involvement of motor pathways in corticobasal syndrome detected by diffusion tensor tractography
Boelmans, K., Kaufmann, J., Bodammer, N., Ebersbach, G., Behlau, G., Heinze, H., & Niehaus, L. (2008) · Movement Disorders · doi:10.1002/mds.22193 · Cited by 30 · see citing works
Frontotemporal Dementia/Pick's Disease
KERTESZ, A. E. (2004) · Archives of Neurology · doi:10.1001/archneur.61.6.969 · Cited by 26 · see citing works
Progress in Clinical Neurosciences: Frontotemporal Dementia-Pick's Disease
KERTESZ, A. E. (2006) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100004893 · Cited by 20 · see citing works
Yakovlev, P. I., Hamlin, H., & Sweet, W. H. (1950) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-195007000-00002 · Cited by 19 · see citing works
Seo, Y., Shinar, H., Morita, Y., & Navon, G. (1999) · Magnetic Resonance in Medicine · doi:10.1002/(sici)1522-2594(199909)42:3 · Cited by 19 · see citing works
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- [28]Smith SM, Jenkinson M, Johansen-Berg H, Rueckert D, Nichols TE, et al (2006) Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 31: 1487– 1505. 16624579
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Downey, L. E., Mahoney, C. J., Buckley, A. H., Golden, H. L., Henley, S. M., Schmitz, N., Schott, J. M., Simpson, I. J., Ourselin, S., Fox, N. C., et al. (2015) · NeuroImage: Clinical · doi:10.1016/j.nicl.2015.06.005 · Cited by 94 · see citing works
Kassubek, J., Müller, H.-P., Del Tredici, K., Hornberger, M., Schroeter, M. L., Müller, K., Anderl-Straub, S., Uttner, I., Grossman, M., Braak, H., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00047 · Cited by 23 · see citing works
Meijboom, R., Steketee, R. M. E., Ham, L. S., van der Lugt, A., van Swieten, J. C., & Smits, M. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160564 · Cited by 17 · see citing works
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- Authors
- Tovar-Moll, F., de Oliveira-Souza, R., Bramati, I. E., Zahn, R., Cavanagh, A., Tierney, M., Moll, J., & Grafman, J.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- King's College London (GB)
- National Institutes of Health (US)
- D’Or Institute for Research and Education (BR)
- Corresponding author
- Tovar-Moll, Fernanda
- Bramati, Ivanei Edson
- Zahn, Roland
- Cavanagh, Alyson
- Tierney, Michael
- Moll, Jorge
- Grafman, Jordan
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-07-23
- Volume
- 9
- Issue
- 7
- Pages
- e102656
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4108323
- OpenAlex
- W1993837705
- Cited by
- 30
- References
- 49
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 1
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- behavioral variant frontotemporal dementia, corticobasal syndrome, white matter injury, corpus callosum, uncinate fasciculus, forceps minor, corona radiata, anterior commissure, diffusion tensor imaging, tract-based spatial statistics, white matter integrity
- MeSH terms
- Aged, Analysis of Variance, Brain, Brain Mapping, Cerebral Cortex, Dementia, Female, Humans, Male, Middle Aged, Syndrome, Diffusion Tensor Imaging, Frontotemporal Dementia, White Matter
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