Cited by 17Dementia and Cognitive Impairment ResearchAdvanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity Studies

Differential hemispheric predilection of microstructural white matter and functional connectivity abnormalities between respectively semantic and behavioral variant frontotemporal dementia

Meijboom, Rozanna, Steketee, Rebecca M.E., Ham, Leontine S., van der Lugt, Aad, van Swieten, John C., Smits, Marion·2017·Journal of Alzheimer’s Disease

Abstract

Semantic dementia (SD) and behavioral variant frontotemporal dementia (bvFTD), subtypes of frontotemporal dementia, are characterized by distinct clinical symptoms and neuroimaging features, with predominant left temporal grey matter (GM) atrophy in SD and bilateral or right frontal GM atrophy in bvFTD. Such differential hemispheric predilection may also be reflected by other neuroimaging features, such as brain connectivity. This study investigated white matter (WM) microstructure and functional connectivity differences between SD and bvFTD, focusing on the hemispheric predilection of these differences. Eight SD and 12 bvFTD patients, and 17 controls underwent diffusion tensor imaging and resting state functional MRI at 3T. Whole-brain WM microstructure was assessed to determine distinct WM tracts affected in SD and bvFTD. For these tracts, diffusivity measures and lateralization indices were calculated. Functional connectivity was established for GM regions affected in early stage SD or bvFTD. Results of a direct comparison between SD and bvFTD are reported. Whole-brain WM microstructure abnormalities were more pronounced in the left hemisphere in SD and bilaterally- with a slight predilection for the right- in bvFTD. Lateralization of tract-specific abnormalities was seen in SD only, toward the left hemisphere. Functional connectivity of disease-specific regions was mainly decreased bilaterally in SD and in the right hemisphere in bvFTD. SD and bvFTD show WM microstructure…

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Crossref · 10.3233/jad-160564

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  • Increased connectivity values were detected in specific FTD variants: parietal lobe connections in bvFTD, frontal lobe in CBS, occipital lobe in PSP, and structural thalamic tract connectivity in bvFTD and svPPA.

    “We also detected increased connectivity values in specific FTD variants, for example, in the connections involving the parietal lobe in bvFTD (Meijboom et al., 2017; Whitwell et al., 2011b), the frontal lobe in CBS (Wolpe et al., 2014), occipital lobe in PSP (Whitwell et al., 2011a), and structural thalamic tract connectivity in bvFTD and svPPA.”
  • Functional ROI-to-ROI models showed alterations in fronto-temporal, intrafrontal, and precuneus-insula connectivity.

    “In line with previous studies, the functional ROI-to-ROI models showed alterations in fronto-temporal (Jastorff et al., 2016; Meijboom et al., 2017), intrafrontal (Dopper et al., 2014; Whitwell, 2019), and precuneus-insula (Whitwell et al., 2011b) connectivity.”

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Authors
Meijboom, R., Steketee, R. M. E., Ham, L. S., van der Lugt, A., van Swieten, J. C., & Smits, M.
Affiliations
  • Erasmus MC (NL)
  • Department of Radiology and Nuclear Medicine, Erasmus MC – University Medical Centre Rotterdam, The Netherlands
  • Department of Neurology, Erasmus MC – University Medical Centre Rotterdam, The Netherlands
Corresponding author
Smits, Marion
Venue
Journal of Alzheimer’s Disease
Published
2017-01-24
Volume
56
Issue
2
Pages
789-804
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W2568789352
Cited by
17
References
87
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 1
FWCI
1.58
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
  • Erasmus Universiteit Rotterdam
  • Erasmus+
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
semantic dementia, behavioral variant frontotemporal dementia
MeSH terms
Brain, Brain Mapping, Female, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Organ Size, Rest, Diffusion Tensor Imaging, Frontotemporal Dementia, White Matter, Gray Matter

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