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Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's Disease
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BIN1 isoforms 9 and 10 are ubiquitously expressed and are also detected in the brain.
“Isoforms 9 and 10 are ubiquitously expressed and are also detected in the brain [11].”
From BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology (2020) · cites this paper as [11]
BIN1 has 10 isoforms expressed in the central nervous system.
“BIN1 has 10 isoforms that are expressed in the Central Nervous System (CNS).”
From BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology (2020) · cites this paper as [11]
BIN1 isoforms are translated into proteins differently in neurons and astrocytes: cultured neurons mostly express isoforms 1, 3, 5 and 7 while cultured astrocytes express isoforms 2, 5, 9 and 10.
“It was reported that BIN1 isoforms are translated into proteins differently in neurons and astrocytes: cultured neurons mostly express isoforms 1, 3, 5 and 7 while cultured astrocytes express isoforms 2, 5, 9 and 10 [11].”
From BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology (2020) · cites this paper as [11]
Isoform 1 and 3 are expressed in neurons and isoform 2 in astrocytes.
“are consistent with previously published reports of isoform 1 and 3 expression in neurons and isoform 2 in astrocytes [11].”
From BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology (2020) · cites this paper as [11]
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Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance
Castellano, J. M., Kim, J., Stewart, F. R., Jiang, H., DeMattos, R. B., Patterson, B. W., Fagan, A. M., Morris, J. C., Mawuenyega, K. G., Cruchaga, C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002156 · Cited by 1,242 · cited 2×
“Because of previously reported effects of apoE genotype on brain amyloid burden [24], we also characterized subjects for their APOE variants.”
BackgroundClusterin inhibits apoptosis by interacting with activated Bax
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Apolipoprotein J: structure and tissue distribution
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Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains
Karch, C. M., Jeng, A. T., Nowotny, P., Cady, J., Cruchaga, C., & Goate, A. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050976 · Cited by 328
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Distribution of clusterin in Alzheimer brain tissue
McGeer, P. L., Kawamata, T., & Walker, D. G. (1992) · Brain Research · doi:10.1016/0006-8993(92)90071-g · Cited by 212 · cited 1×
“Induction of CLU mRNA is observed within pyramidal neurons of the hippocampus and the entorhinal cortex of AD patients [20,21], and CLU immunoreactivity is found in association with neutrophil threads, neurofibrillary tangles and amyloid plaques [20].”
BackgroundReplication of CLU, CR1, and PICALM Associations With Alzheimer Disease
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Functional and structural properties of lipid-associated apolipoprotein J (clusterin)
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Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration
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Metadata
- Authors
- Zhou, Y., Hayashi, I., Wong, J., Tugusheva, K., Renger, J. J., & Zerbinatti, C.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-07-22
- Volume
- 9
- Issue
- 7
- Pages
- e103187
- ISSN
- 1932-6203
- PMC
- PMC4106906
- Cited by
- 72
- References
- 12
- Language
- en
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