Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals
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In this study, we assess 34 of the most replicated genetic associations for Alzheimer's disease (AD) using data generated on Affymetrix SNP 6.0 arrays and imputed at over 5.7 million markers from a unique cohort of over 1600 neuropathologically defined AD cases and controls (1019 cases and 591 controls). Testing the top genes from the AlzGene meta-analysis, we confirm the well-known association with APOE single nucleotide polymorphisms (SNPs), the CLU, PICALM and CR1 SNPs recently implicated in unusually large data sets, and previously implicated CST3 and ACE SNPs. In the cases of CLU, PICALM and CR1, as well as in APOE, the odds ratios we find are slightly larger than those previously reported in clinical samples, consistent with what we believe to be more accurate classification of disease in the clinically characterized and neuropathologically confirmed AD cases and controls.
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The association of PICALM polymorphisms with late-onset AD has been reported by the majority of GWAS studies.
“The association of PICALM polymorphisms with late-onset AD has been reported by the majority of GWAS studies (94, 119, 236, 265, 298, 344, 528).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [119]
The Introduction reports that two large studies identified PICALM as a late-onset Alzheimer’s disease risk locus, and the Results report an association for PICALM in this cohort. The paper does not establish that a majority of GWAS studies reported the association. (LLM, conf=0.86)
Experimental — accuracy not yet measuredAPOE4 increases the risk for developing Alzheimer's disease by 2.5-4-fold in heterozygous carriers and 12-15-fold in homozygous carriers.
“APOE4 increases the risk for developing AD by 2.5-4-fold in heterozygous and 12-15-fold in homozygous carriers (Corder et al., 1993; Grupe et al., 2007; Corneveaux et al., 2010), however the risk is affected by factors such as sex or population ancestry (Belloy et al., 2023).”
From APOE genotype-dependent differences in human astrocytic energy metabolism (2025) · cites this paper as Corneveaux et al., 2010
The Introduction identifies APOE ε4 as a well-replicated risk factor for late-onset Alzheimer’s disease. The Results do not give the claimed 2.5–4-fold estimate for heterozygotes; for ε4 homozygotes, they report an odds ratio of about 20 in this cohort and cite about 13 from AlzGene. Thus the paper supports increased risk, but not both numerical ranges as stated. (LLM, conf=0.86)
Experimental — accuracy not yet measuredSome additional highly replicated AD risk genes include CR1, BIN1, and TREM2.
“Some additional highly replicated risk genes include CR1 , BIN1 , and TREM2 (94, 119, 219, 300, 344, 543).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [119]
Several GWAS studies have identified CLU as a significant genetic risk factor for sporadic AD.
“Several GWAS studies have identified CLU as a significant genetic risk factor for sporadic AD (94, 119, 236, 343).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [119]
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Cites
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089 · see citing works
Fast model-based estimation of ancestry in unrelated individuals
Alexander, D. H., Novembre, J., & Lange, K. (2009) · Genome Research · doi:10.1101/gr.094052.109 · Cited by 9,898 · see citing works
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works
A second generation human haplotype map of over 3.1 million SNPs
The International HapMap Consortium (2007) · Nature · doi:10.1038/nature06258 · Cited by 4,438 · see citing works
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268 · see citing works
Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.440 · Cited by 3,326 · see citing works
Self-citationStaging of alzheimer's disease-related neurofibrillary changes
Braak, H., & Braak, E. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00021-6 · Cited by 2,357 · see citing works
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
the European Alzheimer's Disease Initiative Investigators, Lambert, J.-C., Heath, S., Even, G., Campion, D., Sleegers, K., Hiltunen, M., Combarros, O., Zelenika, D., Bullido, M. J., et al. (2009) · Nature Genetics · doi:10.1038/ng.439 · Cited by 2,234 · see citing works
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
Bertram, L., McQueen, M. B., Mullin, K., Blacker, D., & Tanzi, R. E. (2007) · Nature Genetics · doi:10.1038/ng1934 · Cited by 1,857 · see citing works
Evans, D. A. (1989) · JAMA · doi:10.1001/jama.262.18.2551 · Cited by 1,627 · see citing works
Evans, D. A. (1989) · JAMA · doi:10.1001/jama.1989.03430180093036 · Cited by 1,226 · see citing works
Li, Y., Willer, C., Sanna, S., & Abecasis, G. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164242 · Cited by 990 · see citing works
Korn, J. M., Kuruvilla, F. G., McCarroll, S. A., Wysoker, A., Nemesh, J., Cawley, S., Hubbell, E., Veitch, J., Collins, P. J., Darvishi, K., et al. (2008) · Nature Genetics · doi:10.1038/ng.237 · Cited by 783 · see citing works
Evans, D. A., Funkenstein, H. H., Albert, M., Scherr, P. A., Cook, N. R., Chown, M. J., Hebert, L. E., Hennekens, C. H., & Taylor, J. O. (1989) · PubMed · Cited by 599 · see citing works
Coon, K. D., Myers, A. J., Craig, D. W., Webster, J. A., Pearson, J. V., Lince, D. H., Zismann, V. L., Beach, T. G., Leung, D., Bryden, L., et al. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0419 · Cited by 569 · see citing works
Self-citationGAB2 Alleles Modify Alzheimer's Risk in APOE ɛ4 Carriers
Reiman, E. M., Webster, J. A., Myers, A. J., Hardy, J., Dunckley, T., Zismann, V. L., Joshipura, K. D., Pearson, J. V., Hu-Lince, D., Huentelman, M. J., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.022 · Cited by 487 · see citing works
Self-citationA survey of genetic human cortical gene expression
Myers, A. J., Gibbs, J. R., Webster, J. A., Rohrer, K., Zhao, A., Marlowe, L., Kaleem, M., Leung, D., Bryden, L., Nath, P., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.16 · Cited by 479 · see citing works
Self-citationSlooter, A. J. C., Cruts, M., Kalmijn, S., Hofman, A., Breteler, M. M. B., Van Broeckhoven, C., & van Duijn, C. M. (1998) · Archives of Neurology · doi:10.1001/archneur.55.7.964 · Cited by 399 · see citing works
The National Alzheimer's Coordinating Center (NACC) Database: an Alzheimer disease database.
Beekly, D. L., Ramos, E. M., van Belle, G., Deitrich, W. D., Clark, A. D., Jacka, M. E., & Kukull, W. A. (2004) · PubMed · Cited by 345 · see citing works
Genetic Control of Human Brain Transcript Expression in Alzheimer Disease
Webster, J. A., Gibbs, J. R., Clarke, J., Ray, M., Zhang, W., Holmans, P., Rohrer, K., Zhao, A., Marlowe, L., Kaleem, M., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.03.011 · Cited by 304 · see citing works
Self-citationGenetic Aspects of Alzheimer Disease
Williamson, J., Goldman, J., & Marder, K. (2009) · The Neurologist · doi:10.1097/nrl.0b013e318187e76b · Cited by 299 · see citing works
The Number of Trait Loci in Late-Onset Alzheimer Disease
Daw, E. W., Payami, H., Nemens, E. J., Nochlin, D., Bird, T. D., Schellenberg, G. D., & Wijsman, E. M. (2000) · The American Journal of Human Genetics · doi:10.1086/302710 · Cited by 295 · see citing works
Angiotensin-Converting Enzyme Inhibitors and Cognitive Decline in Older Adults With Hypertension
Sink, K. M., Leng, X., Williamson, J. D., Kritchevsky, S. B., Yaffe, K. S., Kuller, L. H., Yaşar, S., Atkinson, H. H., Robbins, M. E. C., Psaty, B. M., et al. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.175 · Cited by 237 · see citing works
Cystatin C inhibits amyloid-β deposition in Alzheimer's disease mouse models
Mi, W., Pawlik, M., Sastre, M., Jung, S. S., Radvinsky, D. S., Klein, A. M., Sommer, J., Schmidt, S. D., Nixon, R. A., Mathews, P. M., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.29 · Cited by 189 · see citing works
Evans, D. A. (1997) · JAMA · doi:10.1001/jama.277.10.822 · Cited by 177 · see citing works
Non-familial Alzheimer's disease is mainly due to genetic factors
Ashford, J. W., & Mortimer, J. A. (2002) · Journal of Alzheimer s Disease · doi:10.3233/jad-2002-4307 · Cited by 153 · see citing works
Single-day apolipoprotein E genotyping
Crook, R., Hardy, J., & Duff, K. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90168-6 · Cited by 149 · see citing works
Self-citationApolipoprotein E ϵ4 and Incidence of Alzheimer Disease in a Community Population of Older Persons
Evans, D. A. (1997) · JAMA · doi:10.1001/jama.1997.03540340056033 · Cited by 102 · see citing works
Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles
Bennett, D. A., De Jager, P. L., Leurgans, S. E., & Schneider, J. A. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a2e87d · Cited by 93 · see citing works
Self-citationHypertension, Executive Dysfunction, and Progression to Dementia
Oveisgharan, S., & Hachinski, V. (2010) · Archives of Neurology · doi:10.1001/archneurol.2009.312 · Cited by 84 · see citing works
Cherbuin, N., Réglade‐Meslin, C., Kumar, R., Jacomb, P. A., Easteal, S., Christensen, H. M., Sachdev, P. S., & Anstey, K. J. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000229025 · Cited by 82 · see citing works
ApoE genotype is a risk factor in nonpresenilin early-onset alzheimer's disease families
Houlden, H., Crook, R., Backhovens, H., Prihar, G., Baker, M. C., Hutton, M., Rossor, M. N., Martin, J. J., Broeckhoven, C. V., & Hardy, J. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19980207)81:1 · Cited by 64 · see citing works
Genetic Variability in CLU and Its Association with Alzheimer's Disease
Guerreiro, R. J., Beck, J., Gibbs, J. R., Santana, I. J., Rossor, M. N., Schott, J. M., Nalls, M. A., Ribeiro, H. F., Santiago, B., Fox, N. C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009510 · Cited by 58 · see citing works
Self-citationGuo, Z., Fratiglioni, L., Viitanen, M. H., Lannfelt, L., Basun, H., Fastbom, J., & Winblad, B. G. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.3.225 · Cited by 53 · see citing works
Wray, S., & Noble, W. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2234-09.2009 · Cited by 42 · see citing works
Miniaturized sealed-tube allele-specific PCR
Hawkins, J. R., Khripin, Y., Valdes, A. M., & Weaver, T. A. (2002) · Human Mutation · doi:10.1002/humu.10060 · Cited by 42 · see citing works
Neurodegenerative Disorders and Cholesterol
Michikawa, M. (2004) · Current Alzheimer Research · doi:10.2174/1567205043331983 · Cited by 23 · see citing works
Webster, J., Reiman, E. M., Zismann, V., Joshipura, K. D., Pearson, J. V., Hu‐Lince, D., Huentelman, M. J., Craig, D. W., Coon, K. D., Beach, T., et al. (2010) · PubMed Central · Cited by 7 · see citing works
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Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works
Initiative, T. A. D. N., Hollingworth, P., CHARGE consortium, EADI1 consortium, Harold, D., Sims, R., Gerrish, A., Lambert, J.-C., Carrasquillo, M. M., Abraham, R., et al. (2011) · Nature Genetics · doi:10.1038/ng.803 · Cited by 1,997 · see citing works
Self-citationβ-Amyloid accumulation in the human brain after one night of sleep deprivation
Shokri-Kojori, E., Wang, G.-J., Wiers, C. E., Demiral, S. B., Guo, M., Kim, S. W., Lindgren, E., Ramirez, V., Zehra, A., Freeman, C., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721694115 · Cited by 893 · see citing works
Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
Ressler, K. J., Mercer, K. B., Bradley, B., Jovanovic, T., Mahan, A., Kerley, K., Norrholm, S. D., Kilaru, V., Smith, A. K., Myers, A. J., et al. (2011) · Nature · doi:10.1038/nature09856 · Cited by 800 · see citing works
Self-citationAPOE and Alzheimer disease: a major gene with semi-dominant inheritance
Genin, E., Hannequin, D., Wallon, D., Sleegers, K., Hiltunen, M., Combarros, O., Bullido, M. J., Engelborghs, S., De Deyn, P., Berr, C., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.52 · Cited by 714 · see citing works
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
Prinz, M., Priller, J., Sisodia, S. S., & Ransohoff, R. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2923 · Cited by 674 · see citing works
Jones, L., Holmans, P. A., Hamshere, M. L., Harold, D., Moskvina, V., Ivanov, D., Pocklington, A., Abraham, R., Hollingworth, P., Sims, R., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013950 · Cited by 606 · see citing works
Self-citationTREM2, microglia, and neurodegenerative diseases
Yeh, F. L., Hansen, D. V., & Sheng, M. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.03.008 · Cited by 440 · see citing works
Autophagy and the cell biology of age-related disease
Leidal, A. M., Levine, B., & Debnath, J. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0235-8 · Cited by 424 · see citing works
High complement levels in astrocyte‐derived exosomes of Alzheimer disease
Goetzl, E. J., Schwartz, J. B., Abner, E. L., Jicha, G. A., & Kapogiannis, D. (2018) · Annals of Neurology · doi:10.1002/ana.25172 · Cited by 369 · see citing works
Doens, D., & Fernández, P. L. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-48 · Cited by 348 · see citing works
Genetic insights in Alzheimer's disease
Bettens, K., Sleegers, K., & Broeckhoven, C. V. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70259-4 · Cited by 326 · see citing works
Alzheimer’s disease: analyzing the missing heritability
Ridge, P. G., Mukherjee, S., Crane, P. K., Kauwe, J. S. K., & Alzheimer’s Disease Genetics Consortium (2013) · PLoS ONE · doi:10.1371/journal.pone.0079771 · Cited by 328 · see citing works
Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau
Kang, S. S., Ebbert, M. T. W., Baker, K. E., Cook, C., Wang, X., Sens, J. P., Kocher, J.-P., Petrucelli, L., & Fryer, J. D. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20180653 · Cited by 260 · see citing works
Assessment of the genetic variance of late-onset Alzheimer's disease
Ridge, P. G., Hoyt, K. B., Boehme, K., Mukherjee, S., Crane, P. K., Haines, J. L., Mayeux, R., Farrer, L. A., Pericak-Vance, M. A., Schellenberg, G. D., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.02.024 · Cited by 236 · see citing works
Self-citationCommon variants at 12q14 and 12q24 are associated with hippocampal volume
Bis, J., Decarli, C., Smith, A., van der Lijn, F., Crivello, F., Fornage, M., Debette, S., Shulman, J. M., Schmidt, H., Srikanth, V., et al. (2012) · Nature Genetics · doi:10.1038/ng.2237 · Cited by 249 · see citing works
Self-citationEmerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease
Lewcock, J. W., Schlepckow, K., Di Paolo, G., Tahirovic, S., Monroe, K. M., & Haass, C. (2020) · Neuron · doi:10.1016/j.neuron.2020.09.029 · Cited by 221 · see citing works
Genetics of Alzheimer’s Disease
Chouraki, V. A., & Seshadri, S. S. (2014) · Advances in genetics · doi:10.1016/b978-0-12-800149-3.00005-6 · Cited by 208 · see citing works
Polygenic score prediction captures nearly all common genetic risk for Alzheimer's disease
Escott-Price, V., Shoai, M., Pither, R., Williams, J., & Hardy, J. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.07.018 · Cited by 183 · see citing works
Self-citationGenomic variants, genes, and pathways of Alzheimer's disease: An overview
Naj, A. C., & Schellenberg, G. D. (2016) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32499 · Cited by 178 · see citing works
Genetic risk prediction in complex disease
Jostins, L., & Barrett, J. C. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr378 · Cited by 179 · see citing works
Polygenic risk score analysis of pathologically confirmed Alzheimer disease
Escott‐Price, V., Myers, A., Huentelman, M. J., & Hardy, J. (2017) · Annals of Neurology · doi:10.1002/ana.24999 · Cited by 178 · see citing works
Self-citation<i>CR1</i> is associated with amyloid plaque burden and age‐related cognitive decline
Chibnik, L. B., Shulman, J. M., Leurgans, S. E., Schneider, J. A., Wilson, R. S., Tran, D., Aubin, C., Buchman, A. S., Heward, C. B., Myers, A. J., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22277 · Cited by 174 · see citing works
Self-citationThe Role of Clusterin in Alzheimer’s Disease: Pathways, Pathogenesis, and Therapy
Yu, J.-T., & Tan, L. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8237-1 · Cited by 174 · see citing works
Xiao, Q., Gil, S.-C., Yan, P., Wang, Y., Han, S., Gonzales, E., Perez, R., Cirrito, J. R., & Lee, J.-M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.338376 · Cited by 166 · see citing works
Hu, X., Pickering, E. H., Liu, Y. C., Hall, S., Fournier, H., Katz, E., DeChairo, B. M., John, S., Eerdewegh, P. V., Soares, H. D., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016616 · Cited by 161 · see citing works
Wojtas, A., Kang, S. S., Olley, B. M., Gatherer, M., Shinohara, M., Lozano, P. A., Liu, C., Kurti, A., Baker, K. E., Dickson, D. W., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1701137114 · Cited by 147 · see citing works
Koelewijn, L., Lancaster, T. M., Linden, D. E. J., Dima, D. C., Routley, B. C., Magazzini, L., Barawi, K., Brindley, L. M., Adams, R., Tansey, K. E., et al. (2019) · eLife · doi:10.7554/elife.36011 · Cited by 145 · see citing works
Giraldo, M., Lopera, F., Siniard, A. L., Corneveaux, J. J., Schrauwen, I., Carvajal, J., Muñoz, C., Ramirez-Restrepo, M., Gaiteri, C., Myers, A. J., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.016 · Cited by 147 · see citing works
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Self-citationCheng, X., Zhou, W., & Zhang, Y. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.10.002 · Cited by 133 · see citing works
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Yu, X., & Sun, S. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-274 · Cited by 126 · see citing works
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Genetic architecture of Alzheimer's disease
Neuner, S. M., TCW, J., & Goate, A. M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104976 · Cited by 126 · see citing works
Genome-wide association study of Alzheimer's disease with psychotic symptoms
Hollingworth, P., Sweet, R. A., Sims, R., Harold, D. H., Russo, G., Abraham, R., Stretton, A., Jones, N., Gerrish, A., Chapman, J., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.125 · Cited by 123 · see citing works
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Xu, W., Tan, L., & Yu, J. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8878-3 · Cited by 119 · see citing works
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Self-citationSchröder, N., Figueiredo, L. S., & de Lima, M. N. M. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121996 · Cited by 113 · see citing works
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Vitek, M. P., Araujo, J. A., Fossel, M., Greenberg, B. D., Howell, G. R., Rizzo, S. J. S., Seyfried, N. T., Tenner, A. J., Territo, P. R., Windisch, M., et al. (2020) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1002/trc2.12114 · Cited by 103 · see citing works
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Toro, C. A., Zhang, L., Cao, J., & Cai, D. (2019) · Brain Research · doi:10.1016/j.brainres.2019.05.031 · Cited by 97 · see citing works
Genetic variation at CR1 increases risk of cerebral amyloid angiopathy
Biffi, A., Shulman, J. M., Jagiella, J. M., Cortellini, L., Ayres, A. M., Schwab, K. M., Brown, D. L., Silliman, S. L., Selim, M. H., Worrall, B. B., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e3182452b40 · Cited by 97 · see citing works
Self-citationMyers, A., Williams, L. M., Gatt, J. M., McAuley, E. Z., Dobson‐Stone, C., Schofield, P. R., & Nemeroff, C. B. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.08.021 · Cited by 95 · see citing works
Self-citationGenetics of Alzheimer’s Disease
Ridge, P. G., Ebbert, M., & Kauwe, J. S. K. (2013) · BioMed Research International · doi:10.1155/2013/254954 · Cited by 96 · see citing works
Bettens, K., Brouwers, N., Engelborghs, S., Lambert, J., Rogaeva, E. A., Vandenberghe, R. R., Bastard, N. L., Pasquier, F., Vermeulen, S., Dongen, J. V., et al. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-3 · Cited by 94 · see citing works
TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism
Zheng, H., Cheng, B., Li, Y., Li, X., Chen, X., & Zhang, Y.-W. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00395 · Cited by 94 · see citing works
Lee, L., Sakurai, M., Matsuzaki, S., Arancio, O., & Fraser, P. E. (2013) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8257-7 · Cited by 89 · see citing works
Effect of Complement CR1 on Brain Amyloid Burden During Aging and Its Modification by APOE Genotype
Thambisetty, M., An, Y., Nalls, M., Sojkova, J., Swaminathan, S., Zhou, Y., Singleton, A. B., Wong, D. F., Ferrucci, L., Saykin, A. J., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.015 · Cited by 90 · see citing works
Self-citationRegulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease
Lee, L., Dale, E., Staniszewski, A., Zhang, H., Saeed, F., Sakurai, M., Fà, M., Orozco, I. J., Michelassi, F. E., Akpan, N., et al. (2014) · Scientific Reports · doi:10.1038/srep07190 · Cited by 90 · see citing works
A coding variant in CR1 interacts with APOE-ɛ4 to influence cognitive decline
Keenan, B. T., Shulman, J. M., Chibnik, L. B., Raj, T., Tran, D., Sabuncu, M. R., Initiative, T. A. D. N., Allen, A. N., Corneveaux, J. J., Hardy, J., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds054 · Cited by 93 · see citing works
Self-citationZhou, Y., Hayashi, I., Wong, J., Tugusheva, K., Renger, J. J., & Zerbinatti, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103187 · Cited by 86 · see citing works
Mattsson, N., Groot, C., Jansen, W. J., Landau, S. M., Villemagne, V. L., Engelborghs, S., Mintun, M. M., Lleo, A., Molinuevo, J. L., Jagust, W. J., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.009 · Cited by 88 · see citing works
Self-citationFonseca, M. I., Chu, S., Pierce, A. L., Brubaker, W. D., Hauhart, R. E., Mastroeni, D., Clarke, E. V., Rogers, J., Atkinson, J. P., & Tenner, A. J. (2016) · PLOS ONE · doi:10.1371/journal.pone.0149792 · Cited by 87 · see citing works
Chen, L. H., Kao, P. Y. P., Fan, Y., Ho, D. T. Y., Chan, C. S. Y., Yik, P. Y., Ha, J. C. T., Chu, L., & Song, Y. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.016 · Cited by 86 · see citing works
Zhu, X., Yu, J., Jiang, T., Wang, P., Cao, L., & Tan, L. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8723-8 · Cited by 84 · see citing works
Luchena, C., Zuazo-Ibarra, J., Alberdi, E. M., Matute, C., & Capetillo‐Zarate, E. (2018) · Mediators of Inflammation · doi:10.1155/2018/2530414 · Cited by 81 · see citing works
The role of Alzheimer's disease risk genes in endolysosomal pathways
Szabo, M. P., Mishra, S., Knupp, A., & Young, J. E. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105576 · Cited by 81 · see citing works
Carrasquillo, M. M., Belbin, O., Hunter, T. A., Ma, L., Bisceglio, G. D., Zou, F., Crook, J. E., Pankratz, V. S., Sando, S. B., Aasly, J. O., et al. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-54 · Cited by 82 · see citing works
Swaminathan, S., Huentelman, M. J., Corneveaux, J. J., Myers, A., Faber, K. M., Foroud, T., Mayeux, R. P., Shen, L., Kim, S., Turk, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050640 · Cited by 79 · see citing works
Self-citationSadikki, H., Fayossé, A., Cognat, E., Sabia, S., Engelborghs, S., Wallon, D., Alexopoulos, P., Blennow, K., Zetterberg, H., Parnetti, L., et al. (2019) · PLoS Medicine · doi:10.1371/journal.pmed.1003289 · Cited by 79 · see citing works
Alzheimer Risk Variant CLU and Brain Function During Aging
Thambisetty, M., Beason‐Held, L. L., An, Y., Kraut, M. A., Nalls, M. A., Hernandez, D. G., Singleton, A., Zonderman, A. B., Ferrucci, L., Lovestone, S., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.026 · Cited by 75 · see citing works
Self-citationSignaling pathways regulating neuron–glia interaction and their implications in Alzheimer's disease
Lian, H., & Zheng, H. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13424 · Cited by 75 · see citing works
Using genetics to enable studies on the prevention of Alzheimer's disease
Crenshaw, D. G., Gottschalk, W. K., Lutz, M. W., Grossman, I., Saunders, A. M., Burke, J. R., Welsh-Bohmer, K. A., Brannan, S. K., Burns, D. K., & Roses, A. D. (2013) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2012.222 · Cited by 70 · see citing works
Complement activation as a biomarker for Alzheimer's disease
Aiyaz, M., Lupton, M. K., Proitsi, P., Powell, J. F., & Lovestone, S. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.07.023 · Cited by 69 · see citing works
Alzheimer’s Disease: A Clinical Practice-Oriented Review
Alves, L., Correia, A. S., Miguel, R., Alegria, P., & Bugalho, P. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00063 · Cited by 69 · see citing works
Sumoylation in Synaptic Function and Dysfunction
Schorova, L., & Martin, S. (2016) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2016.00009 · Cited by 68 · see citing works
The PICALM Protein Plays a Key Role in Iron Homeostasis and Cell Proliferation
Scotland, P., Heath, J. L., Conway, A. E., Porter, N. B., Armstrong, M. B., Walker, J. A., Klebig, M. L., Lavau, C., & Wechsler, D. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044252 · Cited by 67 · see citing works
Alzheimer's risk variants in the clusterin gene are associated with alternative splicing
Szymanski, M., Wang, R., Bassett, S. S., & Avramopoulos, D. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.17 · Cited by 68 · see citing works
Neuropathology and cognitive performance in self-reported cognitively healthy centenarians
Ganz, A. B., Beker, N., Hulsman, M., Sikkes, S. A. M., NBB, Scheltens, P., Smit, A. B., Rozemüller, A. J. M., Hoozemans, J. J. M., & Holstege, H. H. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0558-5 · Cited by 66 · see citing works
Tan, L., Wang, H.-F., Tan, M., Tan, C., Zhu, X., Miao, D., Yu, W.-J., Jiang, T., Tan, L., Yu, J., et al. (2016) · Scientific Reports · doi:10.1038/srep26027 · Cited by 63 · see citing works
Novel targets in Alzheimer’s disease: A special focus on microglia
Balducci, C., & Forloni, G. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.01.017 · Cited by 61 · see citing works
Antipsychotic pharmacogenomics in first episode psychosis: a role for glutamate genes
Stevenson, J. M., Reilly, J. L., Harris, M. S. H., Patel, S., Weiden, P. J., Prasad, K. M. R., Badner, J. A., Nimgaonkar, V. L., Keshavan, M. S., Sweeney, J. A., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.10 · Cited by 60 · see citing works
The Correlation between Inflammatory Biomarkers and Polygenic Risk Score in Alzheimer’s Disease
Morgan, A. R., Touchard, S., O’Hagan, C., Sims, R., Majounie, E., Escott‐Price, V., Jones, L., Williams, J. H., & Morgan, B. P. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160889 · Cited by 59 · see citing works
Targeting Alzheimer's disease with gene and cell therapies
Loera‐Valencia, R., Piras, A., Ismail, M.-A.-M., Manchanda, S., Eyjolfsdottir, H., Saido, T. C., Johansson, J., Eriksdotter, M., Winblad, B. G., & Nilsson, P. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12759 · Cited by 57 · see citing works
Olgiati, P., Politis, A. M., Papadimitriou, G. N., Ronchi, D. D., & Serretti, A. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/832379 · Cited by 57 · see citing works
Genetics of Alzheimer’s Disease: the Importance of Polygenic and Epistatic Components
Raghavan, N. S., & Tosto, G. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0787-1 · Cited by 55 · see citing works
The Role of ABCA1 Gene Sequence Variants on Risk of Alzheimer's Disease
Lupton, M. K., Proitsi, P., Lin, K., Hamilton, G., Daniilidou, M., Tsolaki, M., & Powell, J. F. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-131121 · Cited by 55 · see citing works
Lazarczyk, M. J., Hof, P. R., Bouras, C., & Giannakopoulos, P. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-127 · Cited by 55 · see citing works
Clusterin in neurological disorders: Molecular perspectives and clinical relevance
Charnay, Y., Imhof, A., Vallet, P. G., Kövari, E., Bouras, C., & Giannakopoulos, P. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.05.006 · Cited by 53 · see citing works
Ridge, P. G., Maxwell, T. J., Corcoran, C. D., Norton, M. C., Tschanz, J. T., O’Brien, E., Kerber, R. A., Cawthon, R., Munger, R. G., & Kauwe, J. S. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045134 · Cited by 52 · see citing works
Beck, T. N., Nicolas, E., Kopp, M. C., & Golemis, E. A. (2014) · Oncoscience · doi:10.18632/oncoscience.64 · Cited by 50 · see citing works
HENA, heterogeneous network-based data set for Alzheimer’s disease
Sügis, E., Dauvillier, J., Leontjeva, A., Adler, P., Hindie, V., Moncion, T., Collura, V., Daudin, R., Loe-Mie, Y., Hérault, Y., et al. (2019) · Scientific Data · doi:10.1038/s41597-019-0152-0 · Cited by 50 · see citing works
What does heritability of Alzheimer’s disease represent?
Baker, E. A., Leonenko, G., Schmidt, K. M., Hill, M., Myers, A., Shoai, M., de Rojas, I., Tesi, N., Holstege, H. H., van der Flier, W. M., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281440 · Cited by 50 · see citing works
Self-citationMeta-analysis of the Association between Alzheimer Disease and Variants in GAB2, PICALM, and SORL1
Wang, Z., Lei, H., Zheng, M., Li, Y., Cui, Y., & Hao, F. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9546-y · Cited by 49 · see citing works
Initial Assessment of the Pathogenic Mechanisms of the Recently Identified Alzheimer Risk Loci
Holton, P., Ryten, M., Nalls, M., Trabzuni, D., Weale, M. E., Hernandez, D., Crehan, H., Gibbs, J. R., Mayeux, R., Haines, J. L., et al. (2013) · Annals of Human Genetics · doi:10.1111/ahg.12000 · Cited by 48 · see citing works
Self-citationCheng, X., Cui, X., Zheng, Y., Zhang, G., Li, P., Huang, H., Zhao, Y., Bo, X., Wang, S., Zhou, W., et al. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00065 · Cited by 48 · see citing works
Implication of common and disease specific variants in CLU, CR1, and PICALM
Ferrari, R., Moreno, J. H., Minhajuddin, A., O’Bryant, S. E., Reisch, J., Barber, R. C., & Momeni, P. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.01.110 · Cited by 47 · see citing works
Alzheimer’s genes in microglia: a risk worth investigating
Sudwarts, A., & Thinakaran, G. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00679-4 · Cited by 46 · see citing works
Hippocampal Function in Healthy Carriers of theCLUAlzheimer's Disease Risk Variant
Erk, S., Meyer‐Lindenberg, A., von Boberfeld, C. O., Esslinger, C., Schnell, K., Kirsch, P., Mattheisen, M., Mühleisen, T. W., Cichon, S., Witt, S. H., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4960-11.2011 · Cited by 45 · see citing works
Deák, F., Freeman, W. M., Ungvari, Z. I., Csiszár, A., & Sonntag, W. E. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv206 · Cited by 44 · see citing works
Systems healthcare: a holistic paradigm for tomorrow
Fiandaca, M. S., Mapstone, M. E., Connors, E. E., Jacobson, M., Monuki, E. S., Malik, S., Macciardi, F. M., & Federoff, H. J. (2017) · BMC Systems Biology · doi:10.1186/s12918-017-0521-2 · Cited by 45 · see citing works
Association of Parkinson Disease Risk Loci With Mild Parkinsonian Signs in Older Persons
Shulman, J. M., Yu, L., Buchman, A. S., Evans, D. A., Schneider, J. A., Bennett, D. A., & Jager, P. L. D. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.6222 · Cited by 43 · see citing works
Self-citationState of Play in Alzheimer’s Disease Genetics
Zhu, J.-B., Tan, C., Tan, L., & Yu, J. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170062 · Cited by 43 · see citing works
Single cell transcriptomes and multiscale networks from persons with and without Alzheimer’s disease
Wang, Q., Antone, J., Alsop, E. B., Reiman, R. A., Funk, C. C., Bendl, J. M., Dudley, J. T., Liang, W. S., Karr, T. L., Roussos, P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49790-0 · Cited by 44 · see citing works
Self-citationJohansson, J. U., Brubaker, W. D., Javitz, H. S., Bergen, A. W., Nishita, D., Trigunaite, A., Crane, A., Ceballos, J., Mastroeni, D., Tenner, A. J., et al. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.04.003 · Cited by 43 · see citing works
The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target
Petyuk, V., Chang, R. R., Ramirez‐Restrepo, M., Beckmann, N. D., Henrion, M., Piehowski, P., Zhu, K., Wang, S., Clarke, J., Huentelman, M. J., et al. (2018) · Brain · doi:10.1093/brain/awy215 · Cited by 39 · see citing works
Self-citation
- Authors
- Corneveaux, J. J., Myers, A. J., Allen, A. N., Pruzin, J. J., Ramirez, M., Engel, A., Nalls, M. A., Chen, K., Lee, W., Chewning, K., Villa, S. E., Meechoovet, H. B., Gerber, J. D., Frost, D., Benson, H. L., O'Reilly, S., Chibnik, L. B., Shulman, J. M., Singleton, A. B., Craig, D. W., Van Keuren-Jensen, K. R., Dunckley, T., Bennett, D. A., De Jager, P. L., Heward, C., Hardy, J., Reiman, E. M., & Huentelman, M. J.
- Affiliations
- Translational Genomics Research Institute (US)
- University of Miami (US)
- Banner Alzheimer’s Institute (US)
- Brigham and Women's Hospital (US)
- National Institutes of Health (US)
- Rush University Medical Center (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Corresponding author
- Huentelman, Matthew J.
- ORCID
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-06-09
- Volume
- 19
- Issue
- 16
- Pages
- 3295-3301
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- PMC
- PMC2908469
- OpenAlex
- W2147719183
- Cited by
- 237
- References
- 38
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 11 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 13 · 2019: 12 · 2018: 23 · 2017: 15 · 2016: 16 · 2015: 17 · 2014: 18 · 2013: 21 · 2012: 34
- FWCI
- 19.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Molecular Genetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- University of Miami
- Rush University
- Alzheimer's Society
- Alzheimer's Research Trust
- National Institute for Health and Care Research (P30AG10161)
- Newcastle University (G0400074)
- Stichting MS Research
- Newcastle upon Tyne Hospitals NHS Foundation Trust
- North Bristol NHS Trust
- Universitat de Barcelona
- Hersenstichting
- National Institutes of Health (1k01ag024079-01a2, AG19610)
- Medical Research Council (G0400074)
- NIHR Newcastle Biomedical Research Centre
- National Institute on Aging (P30-AG 10161, P30-AG-19610, P50AG005144, AG-034504, P30AG028377, U01AG016976, K01-AG-024079, R01AG034504, AG-19610, P50AG016570, K08AG034290, P50AG005128, R01AG015819, P30AG010161, AG031581, R01AG031581, Z01AG000950, P50AG005681, P50AG008671, P30AG019610, P50AG005146, P50AG005136, P50AG005134)
- National Institute of Mental Health (P50MH060451)
- National Institute of Neurological Disorders and Stroke (R01NS059873, NS059873, P30 AG19610, P50NS039764)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- Alzheimer's disease, genetic association, complement receptor 1, clusterin, PICALM, apolipoprotein E, CST3, ACE, single nucleotide polymorphisms, genetic risk variants, imputation
- MeSH terms
- Alzheimer Disease, Apolipoproteins E, Gene Frequency, Genotype, Humans, Cohort Studies, Odds Ratio, Receptors, Complement 3b, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Monomeric Clathrin Assembly Proteins, Clusterin, Genome-Wide Association Study
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