Physical disability, anxiety and depression in people with MS: an internet-based survey via the UK MS Register
Open accessAbstract
INTRODUCTION: People with Multiple Sclerosis are known to have a relatively high prevalence of both anxiety and depression. Studies of the relationship between physical disability and mental health in people with MS have reported mixed results, showing the need for further work. METHODS: Between May 2011 and April 2012, 4516 people completed the MSIS-29 (v.1) and HADS scales via the dedicated internet site of the UK MS Register within a 7 day time window. These responses were linked with basic demographic and descriptive data and analysed in SPSS (v.20). RESULTS: The proportions of people experiencing anxiety or depression increased with physical disability such that 38.0% of respondents with low, and 66.7% with high disability reported at least mild anxiety, and 17.1% of people with low, and 71.7% with high disability experienced at least mild depression. The multiple regression model explained 18.4% of the variance in anxiety with MSIS-29-PHYS score being the strongest predictor of anxiety. The model for depression explained 37.8% of the variance with MSIS-29-PHYS score being the strongest predictor. Some of the other variables included showed negative associations with anxiety and depression, indicating that the influence of physical disability on mental wellbeing could be underestimated. CONCLUSIONS: This study indicates that there is a positive relationship between physical disability and anxiety and depression, that physical disability impacts on anxiety and depression to differing extents, and that the effects vary with gender, age, disease course and disease duration. We have shown that physical disability is a predictor of anxiety and depression, and that other factors may mask the extent of this effect. Whether the causes of anxiety and depression are reactive, organic or a combination, it is essential that mental wellbeing is given due attention in caring for people with MS so that all their health needs can be met.
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Anxiety negatively impacts quality of life, physical disability, and sleep quality in persons with multiple sclerosis.
“As with depression, anxiety negatively impacts quality of life (Dubayova et al., 2013”
From Systematic review and meta-analysis of interventions for depression and anxiety in persons with multiple sclerosis (2016) · cites this paper as Jones et al., 2014
The Results and Conclusions report an association between physical disability and anxiety in people with MS, but identify disability as a predictor of anxiety—not anxiety as a cause of disability. The Introduction notes low quality-of-life scores in people with MS without linking them to anxiety, and the retrieved passages do not address sleep quality. (LLM, conf=0.87)
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Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
EuroQol: a new facility for the measurement of health-related quality of life
(1990) · Health Policy · doi:10.1016/0168-8510(90)90421-9 · Cited by 15,736 · see citing works
Depression and quality of life in older persons: A review
Sivertsen, H., Bjørkløf, G. H., Engedal, K., Selbæk, G., & Helvik, A.-S. (2015) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000437299 · Cited by 14,152 · see citing works
The validity of the Hospital Anxiety and Depression Scale
Bjelland, I., Dahl, A. A., Haug, T. T., & Neckelmann, D. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(01)00296-3 · Cited by 9,779 · cited 1× · see citing works
“15), using $8 as the threshold for indicating likely caseness [37,38].”
MethodThe Hospital Anxiety And Depression Scale.
(2003) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-1-29 · Cited by 2,391 · see citing works
The Multiple Sclerosis Impact Scale (MSIS-29): A new patient-based outcome measure
Hobart, J. (2001) · Brain · doi:10.1093/brain/124.5.962 · Cited by 1,120 · see citing works
Krupp, L., Alvarez, L., LaRocca, N. G., & Lc, S. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520280085020 · Cited by 999 · see citing works
Normative data for the HADS from a large non-clinical sample
Crawford, J. R., Henry, J. D., Crombie, C., & Taylor, E. P. (2001) · British Journal of Clinical Psychology · doi:10.1348/014466501163904 · Cited by 815 · cited 1× · see citing works
“Previous studies involving the general population and people with MS, have shown that anxiety and depression differ with various factors [27,34].”
BackgroundDepression in multiple sclerosis: a review
Siegert, R. J. (2005) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.054635 · Cited by 718 · see citing works
The SAIL databank: linking multiple health and social care datasets
Lyons, R. A., Jones, K. H., John, G., Brooks, C. J., Verplancke, J.-P., Ford, D. V., Brown, G., & Leake, K. (2009) · BMC Medical Informatics and Decision Making · doi:10.1186/1472-6947-9-3 · Cited by 638 · see citing works
Egede, L. E. (2007) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2007.06.002 · Cited by 638 · see citing works
Hobart, J., & Cano, S. (2009) · Health Technology Assessment · doi:10.3310/hta13120 · Cited by 621 · see citing works
The SAIL Databank: building a national architecture for e-health research and evaluation
Ford, D. V., Jones, K. H., Verplancke, J.-P., Lyons, R. A., John, G., Brown, G., Brooks, C. J., Thompson, S., Bodger, O. G., Couch, T., et al. (2009) · BMC Health Services Research · doi:10.1186/1472-6963-9-157 · Cited by 563 · see citing works
Chwastiak, L., Ehde, D. M., Gibbons, L. E., Sullivan, M., Bowen, J. D., & Kraft, G. H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.11.1862 · Cited by 555 · see citing works
Validation of the Hospital anxiety and depression scale for use with multiple sclerosis patients
Honarmand, K., & Feinstein, A. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458509347150 · Cited by 436 · see citing works
Catalogue of EQ-5D Scores for the United Kingdom
Sullivan, P. W., Slejko, J. F., Sculpher, M. J., & Ghushchyan, V. H. (2011) · Medical Decision Making · doi:10.1177/0272989x11401031 · Cited by 364 · see citing works
Bruce, J. M., Hancock, L. M., Arnett, P., & Lynch, S. (2010) · Journal of behavioral medicine · doi:10.1007/s10865-010-9247-y · Cited by 297 · see citing works
Depression in multiple sclerosis.
Minden, S., Orav, J., & Reich, P. (1987) · General Hospital Psychiatry · doi:10.1016/0163-8343(87)90052-1 · Cited by 267 · see citing works
Patten, S. B., Williams, J. V. A., Lavorato, D. H., Modgill, G., Jetté, N., & Eliasziw, M. (2008) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2008.05.001 · Cited by 257 · see citing works
Depression and anxiety amongst multiple sclerosis patients
Beiske, A. G., Svensson, E., Sandanger, I., Czujko, B., Pedersen, E. D., Aarseth, J. H., & Myhr, K. M. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.02041.x · Cited by 257 · see citing works
Depression and anxiety in multiple sclerosis. A clinical and MRI study in 95 subjects
Zorzon, M., de Masi, R., Nasuelli, D., Ukmar, M., Pozzi Mucelli, R., Cazzato, G., Bratina, A., & Zivadinov, R. (2001) · Journal of Neurology · doi:10.1007/s004150170184 · Cited by 249 · cited 1× · see citing works
“Fewer studies have been conducted on anxiety in people with MS, but it has been observed that anxiety is also of high prevalence and that it can affect the family members as well [10,11,27,48].”
BackgroundDepression in multiple sclerosis: Review and theoretical proposal
Arnett, P. A., Barwick, F. H., & BEENEY, J. E. (2008) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617708081174 · Cited by 243 · see citing works
Brain MRI lesions and atrophy are related to depression in multiple sclerosis
Bakshi, R., Czarnecki, D., Shaikh, Z. A., Priore, R. L., Janardhan, V., Kaliszky, Z., & Kinkel, P. R. (2000) · Neuroreport · doi:10.1097/00001756-200004270-00003 · Cited by 230 · see citing works
Jones, K. H., Ford, D. V., Jones, C., Dsilva, R., Thompson, S., Brooks, C. J., Heaven, M. L., Thayer, D. S., McNerney, C., & Lyons, R. A. (2014) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2014.01.003 · Cited by 218 · see citing works
Jones, K. H., Ford, D. V., Jones, P. A., John, A., Middleton, R. M., Lockhart-Jones, H., Osborne, L. A., & Noble, J. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041910 · Cited by 190 · see citing works
LYNCH, S. G., Kroencke, D. C., & Denney, D. R. (2001) · Multiple Sclerosis Journal · doi:10.1177/135245850100700611 · Cited by 190 · see citing works
Marrie, R. A., Salter, A. R., Tyry, T. M., Fox, R. J., & Cutter, G. (2013) · Journal of Medical Internet Research · doi:10.2196/jmir.2466 · Cited by 155 · see citing works
Psychological aspects of multiple sclerosis
Sá, M. J. (2008) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2007.10.001 · Cited by 155 · see citing works
Depression, cognitive impairment and social stress in multiple sclerosis
Gilchrist, A., & Creed, F. H. (1994) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(94)90115-5 · Cited by 127 · see citing works
Treatment of depression for patients with multiple sclerosis in neurology clinics
Mohr, D. C., Hart, S. L., Fonareva, I., & Tasch, E. S. (2006) · Multiple Sclerosis Journal · doi:10.1191/135248506ms1265oa · Cited by 126 · see citing works
Dahl, O. P., Stordal, E., Lydersen, S., & Midgard, R. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458509351542 · Cited by 117 · see citing works
Janssens, A. C., Buljevac, D., van Doorn, P. A., van der Meché, F. G., Polman, C. H., Passchier, J., & Hintzen, R. Q. (2006) · Multiple Sclerosis Journal · doi:10.1177/1352458506070935 · Cited by 107 · see citing works
Rasch analysis of the Multiple Sclerosis Impact Scale (MSIS-29)
Ramp, M., Khan, F., Misajon, R., & Pallant, J. (2009) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-7-58 · Cited by 95 · see citing works
da Silva, A. M., Vilhena, E., Lopes, A., Santos, E., Gonçalves, M. A., Pinto, C., Moreira, I., Mendonça, D., & Cavaco, S. (2011) · Journal of Neurological Sciences · doi:10.1016/j.jns.2011.03.042 · Cited by 86 · see citing works
Jones, K. H., Ford, D. V., Jones, P. A., John, A. M., Middleton, R., Lockhart-Jones, H. M., Peng, J. C., Osborne, L. A., & Noble, J. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065640 · Cited by 80 · see citing works
Haase, R., Schultheiß, T., Kempcke, R., Thomas, K., & Ziemssen, T. (2012) · Journal of Medical Internet Research · doi:10.2196/jmir.2133 · Cited by 77 · see citing works
Ford, D. V., Jones, K. H., Middleton, R., Lockhart-Jones, H. M., Maramba, I. D. C., Noble, J. G., Osborne, L. A., & Lyons, R. A. (2012) · BMC Medical Informatics and Decision Making · doi:10.1186/1472-6947-12-73 · Cited by 74 · see citing works
Antidepressant use in multiple sclerosis: epidemiologic study of a large community sample
Cetin, K., Johnson, K. L., Ehde, D. M., Kuehn, C. M., Amtmann, D., & Kraft, G. H. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458507077864 · Cited by 58 · see citing works
Gray, O., McDonnell, G. V., & Hawkins, S. (2008) · Multiple Sclerosis Journal · doi:10.1177/1352458508096872 · Cited by 57 · see citing works
The public and the Internet: Multifaceted drives for seeking health information
Boot, C. R. L., & Meijman, F. J. (2010) · Health Informatics Journal · doi:10.1177/1460458210364786 · Cited by 48 · see citing works
The Multiple Sclerosis Impact Scale (MSIS-29)
Hobart, J. C. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511975363.004 · Cited by 40 · see citing works
Jones, K. H., Ford, D. V., Jones, P. A., John, A. M., Middleton, R., Lockhart-Jones, H. M., Peng, J. C., Osborne, L. A., & Noble, J. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055422 · Cited by 32 · see citing works
Lynch, S. G., Kroencke, D. C., & Denney, D. R. (2001) · Multiple Sclerosis Journal · doi:10.1191/135245801701566998 · Cited by 30 · see citing works
A Platform for the Remote Conduct of Gene-Environment Interaction Studies
Gallacher, J., Collins, R., Elliott, P., Palmer, S., Burton, P. R., Mitchell, C., John, G., & Lyons, R. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054331 · Cited by 25 · see citing works
Elderly, novice users and health information web sites: issues of accessibility and usability.
Good, A., Stokes, S., & Jerrams-Smith, J. (2007) · PubMed · Cited by 21 · see citing works
Commentary on ‘Disability outcome measures in multiple sclerosis clinical trials’
Noble, J. G., Osborne, L. A., Jones, K. H., Middleton, R., & Ford, D. V. (2012) · Multiple Sclerosis Journal · doi:10.1177/1352458512457847 · Cited by 19 · see citing works
Michalski, D., Liebig, S., Thomae, E., Singer, S., Hinz, A., & Bergh, F. T. (2010) · Mental Illness · doi:10.4081/mi.2010.e5 · Cited by 17 · see citing works
Osborne, L. A., Noble, J. G., Lockhart-Jones, H. M., Middleton, R., Thompson, S., Maramba, I. D. C., Jones, K. H., & Ford, D. V. (2012) · International Journal of Healthcare Information Systems and Informatics · doi:10.4018/jhisi.2012070103 · Cited by 16 · see citing works
Desirability and expectations of the UK MS Register: Views of people with MS
Osborne, L. A., Middleton, R., Jones, K. H., Ford, D. V., & Noble, J. G. (2013) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2013.07.005 · Cited by 10 · see citing works
Outcome measures for multiple sclerosis
Osborne, L. A., Noble, J. G., Maramba, I. D. C., Jones, K. H., Middleton, R., Lyons, R. A., Ford, D. V., & Reed, P. (2013) · Physical Therapy Reviews · doi:10.1179/1743288x13y.0000000094 · Cited by 7 · see citing works
Identifying and Addressing the Barriers to the Use of an Internet-Register for Multiple Sclerosis
Osborne, L. A., Lockhart-Jones, H. M., Middleton, R., Thompson, S., Maramba, I. D. C., Jones, K. H., Ford, D. V., & Noble, J. G. (2013) · International Journal of Healthcare Information Systems and Informatics · doi:10.4018/jhisi.2013010101 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
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Effects of music and music therapy on mood in neurological patients
Raglio, A. (2015) · World Journal of Psychiatry · doi:10.5498/wjp.v5.i1.68 · Cited by 213 · see citing works
Fiest, K. M., Walker, J. R., Bernstein, C. N., Graff, L. A., Zarychanski, R., Abou-Setta, A. M., Patten, S. B., Sareen, J., Bolton, J. M., Marriott, J. J., et al. (2016) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2015.10.004 · Cited by 198 · see citing works
Wolinsky, J. S., Arnold, D. L., Brochet, B., Hartung, H.-P., Montalban, X., Naismith, R. T., Manfrini, M., Overell, J., Koendgen, H., Sauter, A., et al. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30342-2 · Cited by 150 · see citing works
Affective immunology: where emotions and the immune response converge
D’Acquisto, F. (2017) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2017.19.1/fdacquisto · Cited by 108 · see citing works
Henry, A., Tourbah, A., Camus, G., Deschamps, R., Mailhan, L., Castex, C., Gout, O., & Montreuil, M. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2018.09.039 · Cited by 95 · see citing works
Razazian, N., Yavari, Z., Farnia, V., Azizi, A., Kordavani, L., Bahmani, D. S., Holsboer‐Trachsler, E., & Brand, S. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000834 · Cited by 85 · see citing works
Psychiatric disorders in multiple sclerosis
Sparaco, M., Lavorgna, L., & Bonavita, S. (2019) · Journal of Neurology · doi:10.1007/s00415-019-09426-6 · Cited by 79 · see citing works
Kotterba, S., Neußer, T., Norenberg, C., Bussfeld, P., Gläser, T., Dörner, M., & Schürks, M. (2018) · BMC Neurology · doi:10.1186/s12883-018-1113-5 · Cited by 63 · see citing works
the Swiss Multiple Sclerosis Registry, Steinemann, N., Kühle, J., Calabrese, P., Kesselring, J., Disanto, G., Merkler, D., Pot, C., Ajdacic‐Gross, V., Rodgers, S., et al. (2018) · BMC Neurology · doi:10.1186/s12883-018-1118-0 · Cited by 61 · see citing works
Depression and cognitive deficits as long‐term consequences of thrombotic thrombocytopenic purpura
Falter, T., Schmitt, V., Herold, S., Weyer, V., von Auer, C., Wagner, S., Hefner, G., Beutel, M. E., Lackner, K. J., Lämmle, B., et al. (2017) · Transfusion · doi:10.1111/trf.14060 · Cited by 58 · see citing works
Willingham, T. B., Stowell, J. F., Collier, G., & Backus, D. A. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21010079 · Cited by 54 · see citing works
A Dataset of Students’ Mental Health and Help-Seeking Behaviors in a Multicultural Environment
Nguyen, M., Ho, M., Nguyen, Q.-Y. T., & Vuong, Q. (2019) · Data · doi:10.3390/data4030124 · Cited by 51 · see citing works
Gill, S., Santo, J., Blair, M., & Morrow, S. A. (2019) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.18010011 · Cited by 46 · see citing works
Ribbons, K., Lea, R. A., Schofield, P. W., & Lechner‐Scott, J. (2016) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.16050085 · Cited by 33 · see citing works
A Framework of Care in Multiple Sclerosis, Part 2
Newsome, S. D., Aliotta, P. J., Bainbridge, J. L., Bennett, S. E., Cutter, G., Fenton, K. M., LUBLIN, F. D., Northrop, D. E., Rintell, D. J., Walker, B. D., et al. (2017) · International Journal of MS Care · doi:10.7224/1537-2073.2016-062 · Cited by 30 · see citing works
Raffel, J., Wallace, A., Gveric, D. O., Reynolds, R., Friede, T., & Nicholas, R. S. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002346 · Cited by 25 · see citing works
Butzkueven, H., Spelman, T. D., Horáková, D., Hughes, S., Solaro, C. M., Izquierdo, G., Havrdová, E., Grand’Maison, F., Prat, A., Girard, M., et al. (2021) · European Journal of Neurology · doi:10.1111/ene.14824 · Cited by 23 · see citing works
Heffer-Rahn, P., & Fisher, P. L. (2018) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.11.014 · Cited by 22 · see citing works
Pan, Y., Huang, Y., Zhang, H., Tang, Y., & Wang, C. (2022) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2022.102862 · Cited by 22 · see citing works
Sakız, H. (2021) · Journal of Community Psychology · doi:10.1002/jcop.22676 · Cited by 22 · see citing works
Giovannoni, G., Kappos, L., Seze, J. D., Hauser, S. L., Overell, J. R., Koendgen, H., Manfrini, M., Wang, Q., & Wolinsky, J. S. (2021) · European Journal of Neurology · doi:10.1111/ene.14823 · Cited by 19 · see citing works
Individual Face-to-Face Cognitive Behavioural Therapy in Multiple Sclerosis: A Qualitative Study
Gottberg, K., Chruzander, C., Backenroth, G., Johansson, S., Ahlström, G., & Ytterberg, C. (2016) · Journal of Clinical Psychology · doi:10.1002/jclp.22288 · Cited by 18 · see citing works
Kleiter, I., Lang, M., Jeske, J., Norenberg, C., Stollfuß, B., & Schürks, M. (2017) · BMC Neurology · doi:10.1186/s12883-017-0953-8 · Cited by 17 · see citing works
Moriuchi, E. (2023) · Journal of Social Marketing · doi:10.1108/jsocm-05-2022-0111 · Cited by 16 · see citing works
Papeix, C., Gambotti, L., Assouad, R., Ewenczyck, C., Tanguy, M., Pineau, F., Houis, M.-C., Mazevet, D., Maillart, É., & Lubetzki, C. (2015) · Multiple Sclerosis Journal - Experimental Translational and Clinical · doi:10.1177/2055217315608864 · Cited by 16 · see citing works
Uccelli, M. M., Traversa, S., & Ponzio, M. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.07.039 · Cited by 15 · see citing works
Jacinto, M., Frontini, R., Matos, R. M. N., & Antunes, R. (2021) · Healthcare · doi:10.3390/healthcare9081047 · Cited by 15 · see citing works
Tanarsuwongkul, S., Liu, J., Spaulding, M., Perea-Schmittle, K., Lohman, M. C., & Wang, Q. (2025) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796024000866 · Cited by 14 · see citing works
Behavioral Neurology of Multiple Sclerosis and Autoimmune Encephalopathies.
Moghadasi, A., Pourmand, S., Sharifian, M., Minagar, A., & Sahraian, M. (2016) · Neurologic clinics · doi:10.1016/j.ncl.2015.08.002 · Cited by 13 · see citing works
Briones‐Buixassa, L., Milà, R., Arrufat, F., Aragonès, J. M., Bufill, E., Luminet, O., & Moss-Morris, R. E. (2017) · Journal of Health Psychology · doi:10.1177/1359105317692142 · Cited by 14 · see citing works
Lei, C., Chen, H., & Chen, K. (2023) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2202040 · Cited by 12 · see citing works
The relationship between dimensions of mental health and alexithymia in multiple sclerosis patients
Christopoulos, A. L., Πούλιος, Α., & Pavlopoulos, V. (2020) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102525 · Cited by 12 · see citing works
Montanari, E., Rottoli, M., Maimone, D., Confalonieri, P. A., Plewnia, K., Frigo, M., Francia, A., Pala, A., Losignore, N. A., Ragonese, P., et al. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.02.047 · Cited by 11 · see citing works
Yalachkov, Y., Anschütz, V., Jakob, J., Schaller, M., Schäefer, J. H., Reiländer, A., Friedauer, L., Behrens, M., & Foerch, C. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.719088 · Cited by 10 · see citing works
Merkt, H., Bahmani, D. S., Calabrese, P., Naegelin, Y., Gerber, M., Pühse, U., Holsboer‐Trachsler, E., & Brand, S. (2017) · Perceptual and Motor Skills · doi:10.1177/0031512517711851 · Cited by 10 · see citing works
Chireh, B., Essien, S. K., & Novik, N. (2021) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2021.100290 · Cited by 9 · see citing works
Baker, D., Anandhakrishnan, A., Tuite-Dalton, K., Lockhart-Jones, H. M., Middleton, R., Ford, D. V., Crowe, C., & Giovannoni, G. (2016) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2016.09.007 · Cited by 9 · see citing works
Remote testing of vitamin D levels across the UK MS population—A case control study
Vickaryous, N. K., Jitlal, M., Jacobs, B. M., Middleton, R., Chandran, S., MacDougall, N., Giovannoni, G., & Dobson, R. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241459 · Cited by 7 · see citing works
Dinamika psikologis penyintas Pulung Gantung di Gunung Kidul
Budiarto, S., Sugiarto, R., & Putrianti, F. G. (2020) · Jurnal Psikologi Ulayat · doi:10.24854/jpu112 · Cited by 6 · see citing works
Chireh, B., Essien, S. K., D'Arcy, C., Gyan, C., & Ankrah, M. (2024) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2024.100720 · Cited by 6 · see citing works
Sreedhar, P., Patil, S. S., Nagarathna, R., Singh, A., & Nibedita, K. S. (2021) · Annals of Neurosciences · doi:10.1177/09727531211023754 · Cited by 6 · see citing works
Saleh, K. A., Ahmed, W. A. M., Alrashedi, H., Alkubati, S. A., almoliky, M. A., Alrubaiee, G. G., Alqalah, T. A. H., Albani, G. F., Laradhi, A. O., & Altryfy, M. H. (2025) · Frontiers in Psychology · doi:10.3389/fpsyg.2025.1517340 · Cited by 5 · see citing works
Factors Associated with Depression and Anxiety Severity in Multiple Sclerosis Patients
Seferoğlu, M., Koca, N., Sıvacı, A. Ö., & Yurtoğulları, Ş. (2021) · Journal of Multiple Sclerosis Research · doi:10.4274/jmsr.galenos.2022.2021-10-2 · Cited by 5 · see citing works
Burch, A. E., Morasco, B. J., & Petry, N. M. (2015) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2015.06.006 · Cited by 5 · see citing works
Atikasari, A. F., & Imanti, V. (2019) · al-Balagh Jurnal Dakwah dan Komunikasi · doi:10.22515/balagh.v4i1.1608 · Cited by 5 · see citing works
Anderson, R. K. (2018) · Lincoln (University of Nebraska) · Cited by 5 · see citing works
Marlina, M., Mahdi, A., & Karneli, Y. (2023) · The Journal of Adult Protection · doi:10.1108/jap-10-2022-0024 · Cited by 4 · see citing works
Castro, S. E. L., Blanco, V., Otero, P., López, L., & Vázquez, F. L. (2020) · Revista Iberoamericana de Psicología y Salud · doi:10.23923/j.rips.2020.02.037 · Cited by 4 · see citing works
Depression during multiple sclerosis relapse: relation to disability and relapse severity
Šabanagić-Hajrić, S., Suljić, E., & Sulejmanpasic-Arslanagic, G. (2015) · Medicinski Glasnik · doi:10.17392/839-16 · Cited by 4 · see citing works
Montgomery, S., Green, L., Karoui, H., Nicholas, R. S., & Loh, J. (2022) · Journal of Medical Economics · doi:10.1080/13696998.2022.2161746 · Cited by 4 · see citing works
Tingkat Depresi Ditinjau dari Latar Belakang Penyebab Kecacatan pada Penyandang Tuna Daksa
Arianti, E. F., & Partini, P. (2017) · Indigenous Jurnal Ilmiah Psikologi · doi:10.23917/indigenous.v2i2.5680 · Cited by 3 · see citing works
Alsuwailem, R. I. (2022) · doi:10.31219/osf.io/u7r9x · Cited by 3 · see citing works
Wellbeing measurement among adults with Charcot-Marie-Tooth disease
Rule, P. D., Wolk, M. W., & Hill, P. L. (2024) · Health Care Transitions · doi:10.1016/j.hctj.2024.100053 · Cited by 2 · see citing works
Depression among individuals with disabilities: a community-based cross-sectional study in Nepal
Ghimire, A., & Mishra, D. K. K. (2025) · BMJ Open · doi:10.1136/bmjopen-2023-082955 · Cited by 2 · see citing works
Mahboobi, M., Khashandish, A., Moghadasi, A. N., Sahraian, M. A., Hidaji, M. B., & Etesam, F. (2022) · Current Journal of Neurology · doi:10.18502/cjn.v20i4.8347 · Cited by 2 · see citing works
Mental health of persons with disabilities during the COVID-19 pandemic in Bangladesh
Faruk, M. O., Siddik, M. A. B., Chowdhury, K. U. A., Bari, N., Hossain, M. S., Noor, S., Alam, M. R., Akter, T., Adams, B., Thikeo, M., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0322218 · Cited by 2 · see citing works
Rosa, L., Scandurra, C., Chiodi, A., Petracca, M., Costabile, T., Lauro, F., Moccia, M., Carotenuto, A., Maldonato, N., Morra, V. B., et al. (2022) · Journal of clinical psychology in medical settings · doi:10.1007/s10880-022-09849-w · Cited by 2 · see citing works
Psychiatric Symptoms and Disorders in Multiple Sclerosis: Review
Sönmez, İ., Mut, S. E., & BOZKURT, A. (2016) · Turkiye Klinikleri Journal of Neurology · doi:10.5336/neuro.2016-51118 · Cited by 2 · see citing works
Craft, C. L., Islam, T., Berard, J. A., & Walker, L. A. S. (2025) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2025.106720 · Cited by 1 · see citing works
The Role of Metacognition in Emotional Distress in People with Multiple Sclerosis
Heffer-Rahn, P. (2017) · University of Liverpool · doi:10.17638/03009731
DEPRESSION AMONG INDIVIDUALS HAVING LOWER LIMB PHYSICAL DISABILITY
Faraz, M. N., Sultan, S. M., Khan, S. A., Shakirullah, & Hameed, W. (2020) · Khyber Medical University Journal · doi:10.35845/kmuj.2020.19735
Frequency of depression amongst patients with lower limbs physical disability
Rasool, G., & Tareen, Z. (2022) · International Journal of Health Sciences · doi:10.53730/ijhs.v6ns10.13962
Hrynevych, K., & Kopchak, O. O. (2025) · INTERNATIONAL NEUROLOGICAL JOURNAL · doi:10.22141/2224-0713.21.5.2025.1195
The Lithuanian multiple sclerosis registry: current framework and quality challenges
Isačenko, J., Musneckienė, D., Kizlaitienė, R., Giedraitienė, N., Kizlaitis, R., Malcienė, L., Jatuzis, D., Kaubrys, G., & Rastenytė, D. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1728596
Faruk, M. O., Anik, A. I., Chowdhury, K. U. A., Hasan, M. T., Koly, K. N., Anjum, A., & Sarker, S. (2026) · Asia Pacific Journal of Counselling and Psychotherapy · doi:10.1080/21507686.2026.2673569
Mühlenbrock, P., Winter, P., Axhausen, F., Wolff, S., Juenemann, M. B., Krämer, H. H., Kampling, H., Kruse, J., Zara, S., & Pfeuffer, S. (2026) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2026.107279
Isidoro-Cabañas, E., & Pérez-Mármol, J. M. (2026) · Adapted Physical Activity Quarterly · doi:10.1123/apaq.2025-0146
Kibria, G., Hawlader, M. D. H., Nabi, M. H., Fatme, S. M. A. H., Ahmed, S., Habib, M. M., Alif, S. M., & Hossain, A. (2026) · Health Science Reports · doi:10.1002/hsr2.73184
- Authors
- Jones, K. H., Jones, P. A., Middleton, R. M., Ford, D. V., Tuite-Dalton, K., Lockhart-Jones, H., Peng, J., Lyons, R. A., John, A., & Noble, J. G.
- Affiliations
- Swansea University (GB)
- Corresponding author
- Jones, Kerina H.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-08-25
- Volume
- 9
- Issue
- 8
- Pages
- e104604
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4143231
- OpenAlex
- W2109576398
- Cited by
- 69
- References
- 50
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 10 · 2016: 6 · 2015: 7
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Multiple Sclerosis Society
- Medical Research Council (MR/K006525/1)
- Economic and Social Research Council (ES/L007444/1)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- multiple sclerosis, physical disability, anxiety, depression, mental health, MSIS-29, Hospital Anxiety and Depression Scale, disability severity, disease duration, clinical course, gender differences, age differences
- MeSH terms
- Adult, Anxiety, Depression, Female, Humans, Male, Middle Aged, Models, Theoretical, Multiple Sclerosis, Registries, Regression Analysis, Cohort Studies, Prevalence
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