Functional reorganization of the default mode network across chronic pain conditions
Open accessAbstract
Chronic pain is associated with neuronal plasticity. Here we use resting-state functional magnetic resonance imaging to investigate functional changes in patients suffering from chronic back pain (CBP), complex regional pain syndrome (CRPS) and knee osteoarthritis (OA). We isolated five meaningful resting-state networks across the groups, of which only the default mode network (DMN) exhibited deviations from healthy controls. All patient groups showed decreased connectivity of medial prefrontal cortex (MPFC) to the posterior constituents of the DMN, and increased connectivity to the insular cortex in proportion to the intensity of pain. Multiple DMN regions, especially the MPFC, exhibited increased high frequency oscillations, conjoined with decreased phase locking with parietal regions involved in processing attention. Both phase and frequency changes correlated to pain duration in OA and CBP patients. Thus chronic pain seems to reorganize the dynamics of the DMN and as such reflect the maladaptive physiology of different types of chronic pain.
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Depression, anxiety, and distress are among the strongest and most robust psychosocial predictors of transition from acute to chronic pain.
“psychosocial variables such as depression, anxiety, and distress are among the most potent and robust predictors of the transition from acute to chronic pain 13–18.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [17]
Developing an enduring pain condition substantially increases vulnerability for a later diagnosis of an affective disorder.
“the development of an enduring pain condition confers a substantially increased vulnerability for the subsequent diagnosis of an affective disorder”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [17]
Longitudinal observational research supports a strong bidirectional link between mood disorders and persistent pain.
“longitudinal, observational research supports a strong bidirectional link between mood disorders and persistent pain”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [17]
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Pain-Evoked Reorganization in Functional Brain Networks
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- Authors
- Baliki, M. N., Mansour, A. R., Baria, A. T., & Apkarian, A. V.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Apkarian, A. Vania
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-09-02
- Volume
- 9
- Issue
- 9
- Pages
- e106133
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4152156
- OpenAlex
- W2045895137
- Cited by
- 532
- References
- 54
- Citations by year
- 2026: 36 · 2025: 42 · 2024: 48 · 2023: 45 · 2022: 57 · 2021: 39 · 2020: 56 · 2019: 43 · 2018: 47 · 2017: 50 · 2016: 42 · 2015: 24 · 2014: 2
- FWCI
- 21.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS35115, R01NS035115)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- chronic pain, default mode network, chronic back pain, complex regional pain syndrome, knee osteoarthritis, resting-state functional connectivity, medial prefrontal cortex, insula, high-frequency oscillations, phase locking, attention, pain duration, neuroplasticity
- MeSH terms
- Adult, Aged, Female, Humans, Male, Middle Aged, Nerve Net, Neural Pathways, Rest, Case-Control Studies, Prefrontal Cortex, Young Adult, Chronic Pain
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