The Effects of Lifestyle Interventions on (Long-Term) Weight Management, Cardiometabolic Risk and Depressive Symptoms in People with Psychotic Disorders: A Meta-Analysis

Bruins, Jojanneke; Jörg, Frederike; Bruggeman, Richard; Slooff, Cees; Corpeleijn, Eva; Pijnenborg, Marieke

doi:10.1371/journal.pone.0112276

Cited by 129Schizophrenia research and treatmentObesity, Physical Activity, DietEating Disorders and Behaviors

The Effects of Lifestyle Interventions on (Long-Term) Weight Management, Cardiometabolic Risk and Depressive Symptoms in People with Psychotic Disorders: A Meta-Analysis

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Bruins, Jojanneke, Jörg, Frederike, Bruggeman, Richard, Slooff, Cees, Corpeleijn, Eva, Pijnenborg, Marieke·2014·PLoS ONE

DOI 10.1371/journal.pone.0112276PMC PMC4256304

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Abstract

AIMS: The aim of this study was to estimate the effects of lifestyle interventions on bodyweight and other cardiometabolic risk factors in people with psychotic disorders. Additionally, the long-term effects on body weight and the effects on depressive symptoms were examined. MATERIAL AND METHODS: We searched four databases for randomized controlled trials (RCTs) that compared lifestyle interventions to control conditions in patients with psychotic disorders. Lifestyle interventions were aimed at weight loss or weight gain prevention, and the study outcomes included bodyweight or metabolic parameters. RESULTS: The search resulted in 25 RCTs -only 4 were considered high quality- showing an overall effect of lifestyle interventions on bodyweight (effect size (ES) = -0.63, p<0.0001). Lifestyle interventions were effective in both weight loss (ES = -0.52, p<0.0001) and weight-gain-prevention (ES = -0.84, p = 0.0002). There were significant long-term effects, two to six months post-intervention, for both weight-gain-prevention interventions (ES = -0.85, p = 0.0002) and weight loss studies (ES = -0.46, p = 0.02). Up to ten studies reported on cardiometabolic risk factors and showed that lifestyle interventions led to significant improvements in waist circumference, triglycerides, fasting glucose and insulin. No significant effects were found for blood pressure and cholesterol levels. Four studies reported on depressive symptoms and showed a significant effect (ES = -0.95, p = 0.05). CONCLUSION: Lifestyle interventions are effective in treating and preventing obesity, and in reducing cardiometabolic risk factors. However, the quality of the studies leaves much to be desired.

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Interventions with long-term follow-up are warranted, since there are no reasons to believe that changes in metabolic risk factors occur faster in patients with severe mental disorders than the general population.
“Interventions with long-term follow-up are also warranted, since there are no reasons to believe that changes in metabolic risk factors occur faster in patients with severe mental disorders than the general population 18 .”
From The CHANGE trial: no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity (2016) · cites this paper as [18]
Weight reduction is the most used outcome in trials of behavioural interventions, and the evidence is reported to be favourable, although long-term trials are missing.
“Weight reduction is the most used outcome [46][47][48][49][50][51][52][53][54][55] and the evidence is reported to be favourable 17 , although long-term trials are missing 18 .”
From The CHANGE trial: no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity (2016) · cites this paper as [18]

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Multi-modal weight control intervention for people with persistent mental disorders.
Melamed, Y., Stein-Reisner, O., Gelkopf, M., Levi, G., Sivan, T., Ilievici, G., Rosenberg, R., Weizman, A., & Bleich, A. (2008) · Psychiatric Rehabilitation Journal · doi:10.2975/31.3.2008.194.200 · Cited by 52 · cited 1× · see citing works
“A screening of the articles and their references initially resulted in 32 eligible studies that were discussed within the research group (JB, FJ, EC, MP), which led to the exclusion of seven more studies: in five of these studies the participants were not randomly assigned to the experimental or the control group [38–…”
A healthy lifestyle intervention for middle-aged and older schizophrenia patients with diabetes mellitus: A 6-month follow-up analysis
McKibbin, C. L., Golshan, S., Griver, K., Andren, K. A. K., & Wykes, T. L. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2009.09.039 · Cited by 51 · cited 2× · see citing works
“Seven studies reported follow up data between two and six months after the completion of the intervention [20–26].”
Depressive Symptoms in the Early Course of Schizophrenia: Relationship to Familial Psychiatric Illness
Subotnik, K. L., Nuechterlein, K. H., Asarnow, R. F., Fogelson, D. L., Goldstein, M. J., & Talovic, S. A. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.11.1551 · Cited by 49 · cited 1× · see citing works
“Last, none of the available meta-analyses reported on the effects of lifestyle interventions on depressive symptoms, although it has been widely recognized that patients with psychotic disorders often suffer from comorbid depressive symptoms [27–29], and that increased physical activity in these patients has been asso…”
Weight Loss Intervention for People With Serious Mental Illness: A Randomized Controlled Trial of the RENEW Program
Brown, C. E., Goetz, J. R., & Hamera, E. K. (2011) · Psychiatric Services · doi:10.1176/ps.62.7.pss6207_0800 · Cited by 48 · see citing works
Weight change by baseline BMI from three-year observational data: findings from the Worldwide Schizophrenia Outpatient Health Outcomes Database
Bushe, C., Slooff, C. J., Haddad, P. M., & Karagianis, J. L. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881112473789 · Cited by 45 · cited 1× · see citing works
“Among the patients who were already overweight or obese (BMI $ 25 kg/m 2 ) at baseline this percentage was 12–42% [6].”
Self-citation
Weight Loss Intervention for People With Serious Mental Illness: A Randomized Controlled Trial of the RENEW Program
Brown, C. E. (2011) · Psychiatric Services · doi:10.1176/appi.ps.62.7.800 · Cited by 43 · see citing works
Weight change in treatment with olanzapine and a psychoeducational approach
Scocco, P., Longo, R., & Caon, F. (2005) · Eating Behaviors · doi:10.1016/j.eatbeh.2005.08.003 · Cited by 39 · see citing works
Appropriate intervention strategies for weight gain induced by olanzapine: A randomized controlled study
Milano, W. D., Grillo, F., Mastro, A. D., Rosa, M. D., Sanseverino, B., Petrella, C., & Capasso, A. (2007) · Advances in Therapy · doi:10.1007/bf02850000 · Cited by 36 · cited 1× · see citing works
“Interventions were performed in the United States of America [22, 25, 50–55], South-America [21], Canada [48], the United Kingdom [45, 46], Spain [56, 57], Italy [47, 49, 58], Sweden [59], Switzerland [24], the Netherlands [60], Australia [23], Korea [61], Thailand [62], Taiwan [63] and China [64].”
The Scandinavian Solutions for Wellness study - a two-arm observational study on the effectiveness of lifestyle intervention on subjective well-being and weight among persons with psychiatric disorders
Porsdal, V., Beal, C., Kleivenes, O. K., Martinsen, E. W., Lindström, E., Nilsson, H., & Svanborg, P. (2010) · BMC Psychiatry · doi:10.1186/1471-244x-10-42 · Cited by 35 · cited 1× · see citing works
“A screening of the articles and their references initially resulted in 32 eligible studies that were discussed within the research group (JB, FJ, EC, MP), which led to the exclusion of seven more studies: in five of these studies the participants were not randomly assigned to the experimental or the control group [38–…”
Remission of metabolic syndrome following a 15-week low-calorie lifestyle change program for weight loss
Lundgren, J. D., Malcolm, R., Binks, M., & O'Neil, P. M. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.225 · Cited by 28 · cited 1× · see citing works
“In one study a significant effect for lifestyle interventions on systolic blood pressure was reported [67]; a finding that could not be replicated in our meta-analysis.”
Pilot study of the efficacy of an educational programme to reduce weight, on overweight and obese patients with chronic stable schizophrenia
García, C. I., TOIMIL-IGLESIAS, A., & ALONSO-VILLA, M. J. (2010) · Journal of Psychiatric and Mental Health Nursing · doi:10.1111/j.1365-2850.2010.01590.x · Cited by 25 · see citing works
Can a brief health promotion intervention delivered by mental health key workers improve clients' physical health: A randomized controlled trial
Brown, S. W., & Smith, E. (2009) · Journal of Mental Health · doi:10.3109/09638230802522460 · Cited by 24 · cited 4× · see citing works
“All studies report randomization, but only 10 studies describe the randomization process [21, 22, 45, 46, 52, 56, 57, 59, 62, 64].”
Influential
Primary care-based educational interventions to decrease risk factors for metabolic syndrome for adults with major psychotic and/or affective disorders: a systematic review
Nover, C. H., & Jackson, S. S. (2013) · Systematic Reviews · doi:10.1186/2046-4053-2-116 · Cited by 19 · cited 2× · see citing works
“To date, several studies have examined the effectiveness of different lifestyle interventions in patients with psychotic disorders; numerous randomized controlled trials (RCTs) as well as a number of meta-analyses [15–17] and systematic reviews have been published [14, 18, 19].”
Solutions for Wellness: Results of a Manualized Psychoeducational Program for Adults with Psychiatric Disorders
Vreeland, B., Minsky, S. K., Gara, M. A., Toto, A. M., Kosseff, C., Verna, M., & Haytas, L. A. (2010) · American Journal of Psychiatric Rehabilitation · doi:10.1080/15487761003673032 · Cited by 16 · see citing works
Effects of Auricular Acupressure on Body Weight Parameters in Patients with Chronic Schizophrenia
Ching, H.-Y., Wu, S.-L., Chen, W., & Hsieh, C. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/151737 · Cited by 12 · cited 1× · see citing works
“…the research group (JB, FJ, EC, MP), which led to the exclusion of seven more studies: in five of these studies the participants were not randomly assigned to the experimental or the control group [38–42], and the two other studies did not meet the criteria of a lifestyle intervention [43, 44].”
The prevalence and predictive validity of early depressive symptoms in the course of schizophrenia
Wassink, T. H., Rose, S., Flaum, M. A., & Andreasen, N. C. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(97)82072-5 · Cited by 3 · see citing works
45 – Non-pharmacological management of weight gain: A national, multicentric study for schizophrenia and severe mental disorders patients
Attux, C. R. D. F., Martini, L. C., de Araújo, C. M., Roma, A. M., Mullan, E. M., Baptista, B. P., Pimentel, F. A., Castro, P. L., Camargo, M. G., Canguçu, D. F., et al. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2007.12.112 · Cited by 2 · see citing works

Flagged first, then by citations

Research works printed but not linked: 2

[66]Zukley LM (2008) The effects of a structured lifestyle intervention program in conjunction with dietary supplementation on weight loss and risk factors for the metabolic syndrome. Dissertation Abstracts International: Section B: The Sciences and Engineering 68.
[68]Yalom ID, Leszcz M (2005) The theory and practice of group psychotherapy (5th ed.). New York, NY US: Basic Books.

Sorted by citations

American Association of Clinical Endocrinologists and American College of Endocrinology Comprehensive Clinical Practice Guidelines For Medical Care of Patients with Obesity
Garvey, W. T., Mechanick, J. I., Brett, E. M., Garber, A. J., Hurley, D. L., Jastreboff, A. M., Nadolsky, K., Pessah-Pollack, R., & Plodkowski, R. (2016) · Endocrine Practice · doi:10.4158/ep161365.gl · Cited by 1,914 · see citing works
Antipsychotic-associated weight gain: management strategies and impact on treatment adherence
Dayabandara, M., Hanwella, R., Ratnatunga, S. S., Seneviratne, S., Suraweera, C. U., & de Silva, V. A. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s113099 · Cited by 377 · see citing works
“There was no significant effect on blood pressure or cholesterol.(55) An RCT comparing an early behavioral intervention with routine care in preventing AIWG in drug-naive first-episode psychosis patients found that the behavioral intervention group gained significantly less weight (mean =4.”
Background
BAP guidelines on the management of weight gain, metabolic disturbances and cardiovascular risk associated with psychosis and antipsychotic drug treatment
Cooper, S. J., Reynolds, G. P., order):, W. E. C.-A. (. A., Barnes, T., England, E., Haddad, P., Heald, A., Holt, R., Lingford-Hughes, A., Osborn, D., et al. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116645254 · Cited by 292 · see citing works
“An increasing number of studies have demonstrated the effectiveness of lifestyle intervention for people receiving antipsychotic medication (Bruins et al., 2014; Caemmerer et al., 2012).”
Background
The impact of pharmacological and non‐pharmacological interventions to improve physical health outcomes in people with schizophrenia: a meta‐review of meta‐analyses of randomized controlled trials
Vancampfort, D., Firth, J., Correll, C. U., Solmi, M., Siskind, D., De Hert, M., Carney, R., Koyanagi, A., Carvalho, A. F., Gaughran, F., et al. (2019) · World Psychiatry · doi:10.1002/wps.20614 · Cited by 227 · see citing works
Update on weight-gain caused by antipsychotics: a systematic review and meta-analysis
Barton, B. B., Segger, F., Fischer, K., Obermeier, M., & Musil, R. (2020) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2020.1713091 · Cited by 216 · see citing works
Solving a weighty problem: Systematic review and meta-analysis of nutrition interventions in severe mental illness
Teasdale, S. B., Ward, P. B., Rosenbaum, S., Samaras, K., & Stubbs, B. (2017) · British Journal of Psychiatry · doi:10.1192/bjp.bp.115.177139 · Cited by 198 · see citing works
Lifestyle interventions for weight loss among overweight and obese adults with serious mental illness: A systematic review and meta-analysis
Naslund, J. A., Whiteman, K. L., McHugo, G. J., Aschbrenner, K. A., Marsch, L. A., & Bartels, S. J. (2017) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2017.04.003 · Cited by 176 · see citing works
“…interventions for promoting physical activity and healthy eating among people with serious mental illness [17,18], and meta-analyses have demonstrated potential effectiveness of lifestyle interventions of short duration (≤ 6 months) for achieving weight loss in this high-risk group [19–21].”
The CHANGE trial: no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity
Speyer, H., Christian Brix Nørgaard, H., Birk, M., Karlsen, M., Storch Jakobsen, A., Pedersen, K., Hjorthøj, C., Pisinger, C., Gluud, C., Mors, O., et al. (2016) · World Psychiatry · doi:10.1002/wps.20318 · Cited by 153 · see citing works
Lifestyle Interventions for Weight Management in People With Serious Mental Illness: A Systematic Review With Meta-Analysis, Trial Sequential Analysis, and Meta-Regression Analysis Exploring the Mediators and Moderators of Treatment Effects
Speyer, H., Jakobsen, A. S., Westergaard, C., Nørgaard, H. C. B., Pisinger, C., Krogh, J., Hjorthøj, C., Nordentoft, M., Gluud, C., Correll, C. U., et al. (2019) · Psychotherapy and Psychosomatics · doi:10.1159/000502293 · Cited by 116 · see citing works
Diet and Psychosis: A Scoping Review
Aucoin, M., LaChance, L., Cooley, K., & Kidd, S. A. (2018) · Neuropsychobiology · doi:10.1159/000493399 · Cited by 114 · see citing works
A review of the nutritional challenges experienced by people living with severe mental illness: a role for dietitians in addressing physical health gaps.
Teasdale, S., Samaras, K., Wade, T., Jarman, R., & Ward, P. (2017) · Journal of human nutrition and dietetics (Print) · doi:10.1111/jhn.12473 · Cited by 79 · see citing works
Exercise, diet and educational interventions for metabolic syndrome in persons with schizophrenia: A systematic review
Gurusamy, J., Gandhi, S., Dinakaran, D., Venkatasubramanian, G., & Marimuthu, P. (2018) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2018.06.018 · Cited by 96 · see citing works
Lifestyle Interventions and Prevention of Suicide
Berardelli, I., Corigliano, V., Hawkins, M., Comparelli, A., Erbuto, D., & Pompili, M. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00567 · Cited by 75 · see citing works
“Moreover, lifestyle behaviors are involved in the pathogenesis of medical and severe psychiatric disorders such as depression and psychosis (8, 9), increasing the risk of suicide (10).”
Background
Mental health starts with physical health: current status and future directions of non-pharmacological interventions to improve physical health in first-episode psychosis
Gates, J., Killackey, E., Phillips, L., & Álvarez-Jiménez, M. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00213-8 · Cited by 72 · see citing works
Improving physical health of patients with severe mental disorders: a critical review of lifestyle psychosocial interventions
Rosa, C. D., Sampogna, G., Luciano, M., Vecchio, V. D., Pocai, B., Borriello, G., Giallonardo, V., Savorani, M., Pinna, F., Pompili, M., et al. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1325321 · Cited by 68 · see citing works
“Interventions were considered appropriate if they included an informative component on healthy nutrition, physical activity sessions, and/or a psychological intervention aimed at weight loss or weight gain prevention [29]; 3) studies aiming to improve patients’ physical status (evaluated in terms of body mass index –…”
Background
A nutrition intervention is effective in improving dietary components linked to cardiometabolic risk in youth with first-episode psychosis
Teasdale, S. B., Ward, P. B., Rosenbaum, S., Watkins, A., Curtis, J., Kalucy, M., & Samaras, K. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516001033 · Cited by 69 · see citing works
Effect of lifestyle coaching versus care coordination versus treatment as usual in people with severe mental illness and overweight: Two-years follow-up of the randomized CHANGE trial
Jakobsen, A. S., Speyer, H., Nørgaard, H. C. B., Karlsen, M., Birk, M., Hjorthøj, C. R., Mors, O. N., Krogh, J., Gluud, C. N., Pisinger, C. H., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185881 · Cited by 61 · see citing works
‘That red flag on your file’: misinterpreting physical symptoms as mental illness
Happell, B., Ewart, S. B., Bocking, J., Platania‐Phung, C., & Stanton, R. (2016) · Journal of Clinical Nursing · doi:10.1111/jocn.13355 · Cited by 53 · see citing works
EPA guidance on lifestyle interventions for adults with severe mental illness: A meta-review of the evidence
Maurus, I., Wagner, S. A., Spaeth, J., Vogel, A., Muenz, S., Seitz, V., von Philipsborn, P., Solmi, M., Firth, J., Stubbs, B., et al. (2024) · European Psychiatry · doi:10.1192/j.eurpsy.2024.1766 · Cited by 51 · see citing works
“…of various combinations of physical activity programs [39, 49 – 61], dietary changes including nutrition education and counselling [38, 39, 50 – 65], psychoeduca-tional, motivational or cognitive behavioural techniques to modify behaviour towards healthier lifestyle choices [38, 49, 51,…”
Effectiveness of Interventions for Weight Loss for People With Serious Mental Illness: A Systematic Review and Meta-Analysis
Brown, C., Geiszler, L. C., Lewis, K., & Arbesman, M. (2018) · American Journal of Occupational Therapy · doi:10.5014/ajot.2018.033415 · Cited by 31 · see citing works
“One difference was the magnitude of the effect size, with Bruins et al. (2014) finding a greater effect.”
Influential
The Effectiveness of Pharmacological and Non-Pharmacological Interventions for Improving Glycaemic Control in Adults with Severe Mental Illness: A Systematic Review and Meta-Analysis
Taylor, J., Stubbs, B., Hewitt, C. E., Ajjan, R., Alderson, S. L., Gilbody, S. M., Holt, R. I. G., Hosalli, P., Hughes, T. E., Kayalackakom, T., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0168549 · Cited by 47 · see citing works
“Bruins et al ., [7] found a significant improvement in fasting glucose levels with lifestyle interventions (standardised MD = -0.24, 95% CI, [-0.32, -0.10]; p = 0.001; n = 8 studies; I 2 = 0”
Influential
The Effect of Lifestyle Interventions on Anxiety, Depression and Stress: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Amiri, S., Mahmood, N., Javaid, S. F., & Khan, M. A. (2024) · Healthcare · doi:10.3390/healthcare12222263 · Cited by 42 · see citing works
Multimodal lifestyle intervention using a web-based tool to improve cardiometabolic health in patients with serious mental illness: results of a cluster randomized controlled trial (LION)
Looijmans, A., Jörg, F., Bruggeman, R., Schoevers, R. A., & Corpeleijn, E. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2310-5 · Cited by 35 · see citing works
“Key features of the intervention were: [1] patient readiness for behaviour change was not a prerequisite for starting the intervention, [2] patients decided what lifestyle behaviour would be targeted and created their own lifestyle plan, [3] the intervention addressed diet and physical exercise and incorporated behavi…”
BackgroundSelf-citation
Multiple physical healthcare needs among outpatients with schizophrenia: findings from a health examination study
Eskelinen, S., Sailas, E. S., Joutsenniemi, K., Holi, M. M., Koskela, T., & Suvisaari, J. (2017) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2017.1319497 · Cited by 34 · see citing works
“This supports the idea of the more rigorous prevention of obesity, which is also achievable among patients using antipsychotic drugs (28,29).”
Background
Patient-reported outcomes of lifestyle interventions in patients with severe mental illness: a systematic review and meta-analysis
Pape, L. M., Adriaanse, M. C., Kol, J., van Straten, A., & van Meijel, B. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-03854-x · Cited by 34 · see citing works
“We observed a trend of studies from the Asian region showing larger effect sizes, which is consistent with other systematic reviews [12, 73].”
Result
Effectiveness of a community‐based nurse‐led lifestyle‐modification intervention for people with serious mental illness and metabolic syndrome
Guijarro, S. F., Pomarol‐Clotet, E., Muñoz, M. C. R., García, C. M., López, E. N. E., Guijarro, R., Pérez, L. C., & Cuadra, M. A. R. (2019) · International Journal of Mental Health Nursing · doi:10.1111/inm.12644 · Cited by 32 · see citing works
Impact of lifestyle modification on some components of metabolic syndrome in persons with severe mental disorders: A meta-analysis.
Singh, V. K., Karmani, S., Malo, P., Virupaksha, H. G., Muralidhar, D., Venkatasubramanian, G., & Muralidharan, K. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.06.066 · Cited by 28 · see citing works
Online physical activity interventions for mental disorders: A systematic review
Rosenbaum, S., Newby, J. M., Steel, Z., Andrews, G., & Ward, P. B. (2015) · Internet Interventions · doi:10.1016/j.invent.2015.04.001 · Cited by 29 · see citing works
“Examples of successful physical activity and lifestyle interventions for people experiencingmental illness are increasing (Bruins et al., 2014;Daumit et al., 2013),with growing interest in the role of physical therapists and exercise physiologists to facilitate the delivery of such interventions (Rosenbaum et al.”
Background
Parity of esteem: Addressing the inequalities between mental and physical healthcare
Mitchell, A. J., Hardy, S., & Shiers, D. (2017) · BJPsych Advances · doi:10.1192/apt.bp.114.014266 · Cited by 30 · see citing works
“Interventions have focused on smoking cessation, weight management, glucose control or broader lifestyle intervention in depression/ anxiety and SMI (Barnett 2008; Park 2013; Bruins 2014; Vancampfort 2016; Taylor 2017).”
Dietary modification in the treatment of schizophrenia spectrum disorders: A systematic review
Aucoin, M., LaChance, L., Clouthier, S. N., & Cooley, K. (2020) · World Journal of Psychiatry · doi:10.5498/wjp.v10.i8.187 · Cited by 30 · see citing works
Persistent Low Rates of Treatment of Metabolic Risk Factors in People With Psychotic Disorders
Bruins, J., Pijnenborg, G. H. M., van den Heuvel, E. R., Visser, E., Corpeleijn, E., Bartels‐Velthuis, A. A., Bruggeman, R., & Jörg, F. (2017) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.16m10831 · Cited by 30 · see citing works
Self-citation
Metabolic syndrome in patients with schizophrenia: Underlying mechanisms and therapeutic approaches (Review)
Manta, A., Georganta, A., Roumpou, A., Zoumpourlis, V., Spandidos, D. A., Rizos, E. N., & Peppa, Μ. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13479 · Cited by 38 · see citing works
“In contrast to standard therapy, behavioral life‑ style programs that enhance diet and physical exercise may decrease the effects of APA induced weight gain, leading to a 3 kg and 1 kg/m 2 weight and BMI reduction, respectively (148,150,151).”
Nonpharmacological Interventions for the Treatment of Cardiometabolic Risk Factors in People With Schizophrenia—A Systematic Review
Tumiel, E., Wichniak, A., Jarema, M., & Lew‐Starowicz, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00566 · Cited by 29 · see citing works
The Impact of Pharmacological and Non-Pharmacological Interventions to Improve Physical Health Outcomes in People With Schizophrenia: A Meta-Review of Meta-Analyses of Randomized Controlled Trials
Vancampfort, D., Firth, J., Correll, C. U., Solmi, M., Siskind, D. J., Binder, M. D., Carney, R., Koyanagi, A., Carvalho, A. F., Gaughran, F., et al. (2021) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.19103 · Cited by 29 · see citing works
Mental health clinician attitudes to the provision of preventive care for chronic disease risk behaviours and association with care provision
Bartlem, K. M., Bowman, J., Ross, K., Freund, M., Wye, P. M., McElwaine, K., Gillham, K. E., Doherty, E. L., Wolfenden, L., & Wiggers, J. H. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-0763-3 · Cited by 29 · see citing works
“Such lifestyle interventions have further been shown to positively impact mental health outcomes, including reducing psychiatric symptoms [4, 12, 13].”
Background
Feasibility and acceptability of a student-led lifestyle (diet and exercise) intervention within a residential rehabilitation setting for people with severe mental illness, go heart (group occupation, health, exercise and rehabilitation treatment)
Korman, N., Fox, H., Skinner, T., Dodd, C., Suetani, S., Chapman, J., Parker, S., Dark, F., Collins, C., Rosenbaum, S., et al. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00319 · Cited by 27 · see citing works
Effects of a lifestyle intervention on psychosocial well-being of severe mentally ill residential patients: ELIPS, a cluster randomized controlled pragmatic trial
Stiekema, A. P. M., Looijmans, A., van der Meer, L., Bruggeman, R., Schoevers, R. A., Corpeleijn, E., & Jörg, F. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.02.053 · Cited by 25 · see citing works
“Lifestyle interventions can improve cardiometabolic risk factors such as waist circumference, triglycerides and fasting glucose in psychotic patients (Bruins et al., 2014).”
BackgroundSelf-citation
Early Intervention in Psychosis: Effectiveness and Implementation of a Combined Exercise and Health Behavior Intervention Within Routine Care
Smith, J., Griffiths, L., Band, M., Hird-Smith, R., Williams, B., Bold, J., Bradley, E., Dilworth, R., & Horne, D. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.577691 · Cited by 25 · see citing works
The First Episode Psychosis Services Fidelity Scale 1.0: Review and Update
Addington, D. E. (2021) · Schizophrenia Bulletin Open · doi:10.1093/schizbullopen/sgab007 · Cited by 25 · see citing works
“75 Monitoring of extrapyramidal side effects such as akathisia and tardive dyskinesia can lead to evidence-supported strategies to reduce these side effects.”
One-year efficacy of a lifestyle behavioural intervention on physical and mental health in people with severe mental disorders: results from a randomized controlled trial
Luciano, M., Sampogna, G., D’Ambrosio, E., Rampino, A., Amore, M., Calcagno, P., Rossi, A., Rossi, R., Carmassi, C., Dell’Osso, L., et al. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01684-w · Cited by 25 · see citing works
“Some of these lifestyle interventions effectively reduce Body Mass Index (BMI), body weight [8, 9], triglyceride levels and fasting glucose [10].”
Background
Schizophrenia and pregnancy: a national register-based follow-up study among Finnish women born between 1965 and 1980
Simoila, L., Isometsä, E. T., Gissler, M., Suvisaari, J., Halmesmäki, E., & Lindberg, N. (2019) · Archives of Women s Mental Health · doi:10.1007/s00737-019-0948-0 · Cited by 24 · see citing works
Contemporary approaches in mental health rehabilitation
van der Meer, L., & Wunderink, C. (2018) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796018000343 · Cited by 24 · see citing works
“A review of studies of lifestyle interventions for people with psychotic disorders by Bruins et al. (2014) concluded that they are effective in helping people to lose weight and preventing weight gain and therefore play an important role in preventing and treating obesity.”
Background
A meta-analysis of the overall effect of mHealth physical activity interventions for weight loss and the moderating effect of behavioral change theories, techniques, and mobile technologies
Qin, Y., Wang, X., & Namkoong, K. (2021) · Mobile Media & Communication · doi:10.1177/20501579211054929 · Cited by 22 · see citing works
Motivational theory-based interventions on health of people with several mental illness: A systematic review and meta-analysis.
Romain, A., Bernard, P., Akrass, Z., St-Amour, S., Lachance, J.-P., Hains-Monfette, G., Atoui, S., Kingsbury, C., Dubois, E., Karelis, A., et al. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.05.049 · Cited by 19 · see citing works
Comparative efficacy of lifestyle intervention strategies targeting weight outcomes in people with psychosis: a systematic review and network meta-analysis.
Mucheru, D., Hanlon, M.-C., McEvoy, M., Thakkinstian, A., & MacDonald-Wicks, L. (2019) · The JBI Database of Systematic Reviews and Implementation Reports · doi:10.11124/jbisrir-2017-003943 · Cited by 17 · see citing works
Design of the Lifestyle Interventions for severe mentally ill Outpatients in the Netherlands (LION) trial; a cluster randomised controlled study of a multidimensional web tool intervention to improve cardiometabolic health in patients with severe mental illness
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“Lifestyle interventions have been shown to be effective in the reduction of body weight [8] and cardiometabolic risk factors such as waist circumference, triglycerides and fasting glucose in adults with SMI [9, 10].”
BackgroundSelf-citation
Using the transtheoretical model to predict physical activity level of overweight adults with serious mental illness
Romain, A. J., & Abdel‐Baki, A. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.08.093 · Cited by 21 · see citing works
“ISMI are more likely to have obesity (Manu et al., 2015), and die prematurely because of metabolic complications (Almeida et al., 2014), and PA appears to be an effective strategy to manage them (Bruins et al., 2014; Chalfoun et al., 2015; Firth et al., 2015).”
Changing the obesogenic environment to improve cardiometabolic health in residential patients with a severe mental illness: cluster randomised controlled trial
Looijmans, A., Stiekema, A. P. M., Bruggeman, R., van der Meer, L., Stolk, R. P., Schoevers, R. A., Jörg, F., & Corpeleijn, E. (2017) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.117.199315 · Cited by 21 · see citing works
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Effects of a telehealth-delivered Mediterranean diet intervention in adults with Rheumatoid Arthritis (MEDRA): a randomised controlled trial
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“Several studies have demonstrated that participating in behavioural lifestyle interventions often lead weight loss [55].”
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Interventions to Promote the Utilization of Physical Health Care for People with Severe Mental Illness: A Scoping Review
Strunz, M., Jiménez, N. P., Gregorius, L., Hewer, W., Pollmanns, J., Viehmann, K., & Jacobi, F. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20010126 · Cited by 19 · see citing works
“However, this is an important factor, since changes in physical health often improve gradually and behavioral changes tend to vanish [106,107].”
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Health Effects of an Individualized Lifestyle Intervention for People with Psychotic Disorders in Psychiatric Outpatient Services: A Two Year Follow-up
Blomqvist, M., Ivarsson, A., Carlsson, I., Sandgren, A., & Jormfeldt, H. (2019) · Issues in Mental Health Nursing · doi:10.1080/01612840.2019.1642425 · Cited by 20 · see citing works
“A recently published meta-analysis has showed that lifestyle interventions have impacted the reduction and prevention of obesity and on decreasing cardio-metabolic risk factors except blood pressure and cholesterol levels (Bruins et al., 2014).”
Background
Psychosocial therapies in severe mental illness: update on evidence and recommendations
Gühne, U., Weinmann, S., Riedel-Heller, S. G., & Becker, T. (2020) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000618 · Cited by 19 · see citing works
“with effects of weight loss interventions [50,53].”
Background
Predictors of competitive employment in individuals with severe mental illness: results from an observational, cross-sectional study in Germany
Gühne, U., Pabst, A., Kösters, M., Hasan, A., Falkai, P., Kilian, R., Allgöwer, A., Ajayi, K., Baumgärtner, J., Brieger, P., et al. (2022) · Journal of Occupational Medicine and Toxicology · doi:10.1186/s12995-022-00345-3 · Cited by 19 · see citing works
Among Inpatients, Posttraumatic Stress Disorder Symptom Severity Is Negatively Associated With Time Spent Walking
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“For example ensuring individualized and targeted exercise programming, addressing social support, facilitating goal setting, and ensuring adequate opportunity for participation in exercise while attending inpatient treatment may help promote physical activity participation among this vulnerable population (Bruins et a…”
Background
Dietary Intake, Adherence to Mediterranean Diet and Lifestyle-Related Factors in People with Schizophrenia
Costa, R., Teasdale, S. B., Abreu, S., Bastos, T. C. L., Probst, M., Rosenbaum, S., Ward, P. B., & Corredeira, R. (2019) · Issues in Mental Health Nursing · doi:10.1080/01612840.2019.1642426 · Cited by 17 · see citing works
“Concerning that, and due to the role of healthy diet on weight lost, insulin resistance, dyslipidemia, and hypertension (Bonfioli, Berti, Goss, Muraro, & Burti, 2012; Bruins et al., 2014; Wu, Wang, Bai, Huang, & Lee, 2007), traditional dietary patterns with proven benefits on health may be recommended for people with…”
Background
Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries
Mishu, M. P., Uphoff, E., Aslam, F., Philip, S., Wright, J. M., Tirbhowan, N., Ajjan, R., Azdi, Z. A., Stubbs, B., Churchill, R. C., et al. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013281.pub2 · Cited by 16 · see citing works
Collaborative, individualised lifestyle interventions are acceptable to people with first episode psychosis; a qualitative study
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Background
Improving cardiovascular health and quality of life in people with severe mental illness: study protocol for a randomised controlled trial
Battersby, M., Kidd, M. R., Licinio, J., Aylward, P. E., Baker, A., Ratcliffe, J., Quinn, S. J., Castle, D. J., Zabeen, S., Fairweather‐Schmidt, A. K., et al. (2018) · Trials · doi:10.1186/s13063-018-2748-7 · Cited by 15 · see citing works
Interventions for preventing type 2 diabetes in adults with mental disorders in low and middle income countries
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“For example, in a meta-analysis of lifestyle interventions for people with SMI [11], only eight of 25 included studies measured the effect on glycaemic parameters and only four measured depressive symptoms, despite the fact that diabetes is associated with increased depres-”
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Superwellness Program: a cognitive-behavioral therapy-based group intervention to reduce weight gain in patients treated with antipsychotic drugs
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Cardiovascular disease lifestyle risk factors in people with psychosis: a cross-sectional study
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“Uncontrolled hyperglycaemia can however still progress to type 2 diabetes, therefore, it is important that this risk is mitigated through lifestyle intervention [64].”
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Barriers and facilitators of effective health education targeting people with mental illness: a theory-based ethnographic study
Hempler, N. F., Pals, R., Pedersbæk, L., & Costa, P. D. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1924-3 · Cited by 11 · see citing works
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A 12-Week Evidence-Based Education Project to Reduce Cardiovascular and Metabolic Risk in Adults With Serious Mental Illness in the Integrated Care Setting
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“…al., 2013; Naslund et al., 2016; Olker et al., 2016; Richards et al., 2016; Verhaeghe et al., 2013), significant reductions in waist circumference (Bruins et al., 2014; Caemmerer et al., 2012; Fernández-San-Martín et al., 2014, Gill et al., 2016), reductions in blood pressure (Bauer et al., 2016;…”
BackgroundResult
Factors to consider during the implementation of nutrition and physical activity trials for people with psychotic illness into an Australian community setting
Mucheru, D., Ashby, S., Hanlon, M., McEvoy, M., & MacDonald‐Wicks, L. K. (2020) · BMC Health Services Research · doi:10.1186/s12913-020-05629-0 · Cited by 13 · see citing works
Exercise as a novel treatment option to address cardiometabolic dysfunction associated with PTSD
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Effect of a nurse‐led intervention program on the physical health and quality of life of individuals with severe mental illness
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Olanzapine-samidorphan combination tablets for the treatment of schizophrenia and bipolar I disorder - what is it, and will it be used?
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“treatment as usual, with little difference between specific interventions [95,96].”
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The effect of lifestyle interventions on depressive symptom severity in individuals with type-2 diabetes: A meta-analysis of randomized controlled trials
Koning, E., Grigolon, R. B., Breda, V., Gomes, F. A., Zucatti, K. P., Teixeira, P. P., Colpani, V., Gerchman, F., & Brietzke, E. M. (2023) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2023.111445 · Cited by 13 · see citing works
Bridge connection between depression and anxiety symptoms and lifestyles in Chinese residents from a network perspective
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Lithium or Valproate Adjunctive Therapy to Second-generation Antipsychotics and Metabolic Variables in Patients With Schizophrenia or Schizoaffective Disorder
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Antidepressant medication use and objectively measured physical activity and sedentary behaviors in adults: A cross-sectional analysis of a nationally representative sample of Canadian adults
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Die Effekte nicht-pharmakologischer, gesundheitsfördernder Interventionen bei Menschen mit schweren psychischen Erkrankungen
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“Die Anzahl an eingeschlossenen Studien mit randomisierten kontrollierten Studiendesign in den einzelnen vollständig berücksichtigten Übersichtsarbeiten variiert zwischen 10 [58] und 25 RCTs [55].”
BackgroundInfluential
A longitudinal study about the impact of an inclusive sports program in people with a diagnosis of schizophrenia
Mullor, D., Cangas, A. J., Gallego, J., Aguilar-Parra, J. M., Rosado, A., & López, A. (2019) · Psychosis · doi:10.1080/17522439.2018.1559873 · Cited by 4 · see citing works
“(Brown, Goetz, &Hamera, 2011; Bruins et al., 2014; Carter-Morris & Faulkner, 2003; Daumit et al., 2013: Poulin et al., 2007; Skrinar, Huxley, Hutchinson, Menninger, & Glew, 2005).”
Result
The psychiatric, psychosocial and physical health profile of young people with early psychosis: Data from an early psychosis intervention service
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“…nursing intervention and group program offered concurrently as a combination of both individual and group-based healthy lifestyle interventions has been found to be more effective than either strategy in isolation (Bruins et al., 2014; Rosenbaum, Tiedemann, Sherrington, Curtis, & Ward, 2014).”
Method
Schizophrenia and Related Psychoses
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Co-prescription of metformin and antipsychotics in severe mental illness: a UK primary care cohort study
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Nurse-led lifestyle intervention in a cohort of schizophrenia patients treated with clozapine
Mallorquí, A., Oliveira, C., Ríos, J., Isla-Pera, M. P., Gil-Badenes, J., Amoretti, S., Bernardo, M., Vieta, E., Parellada, E., Garriga, M., et al. (2023) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2023.06.008 · Cited by 7 · see citing works
Integrated Review of Lifestyle Interventions Targeting Diet and Exercise in Early or First-Episode Psychosis
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Halting the Metabolic Complications of Antipsychotic Medication in Patients with a First Episode of Psychosis: How Far Can We Go with the Mediterranean Diet? A Pilot Study
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“These results are in agreement with those of several studies, such as those included in a meta-analysis [36] where no significant effects on the cholesterol levels of FEP patients were documented after dietary intervention [36].”
BackgroundResultInfluential
Weight gain under antipsychotic and mood stabilizing treatment: a narrative review about mechanisms and future options
Seiter, H. T., Fellendorf, F. T., Popkova, D., & Reininghaus, E. Z. (2025) · International Journal of Bipolar Disorders · doi:10.1186/s40345-025-00397-4 · Cited by 7 · see citing works
“…exercise and/or psychological components) to control conditions in patients with psychotic disorders illustrated that these interventions were effective for both weight loss (effect size = − 0.52, p < 0.0001) and weight gain prevention (effect size = − 0.84, p = 0.0002) (Bruins et al. 2014).”
Influential
Associations of Depressive Symptoms and Cognition in the FINGER Trial: A Secondary Analysis of a Randomised Clinical Trial
Neuvonen, E., Lehtisalo, J., Ngandu, T., Levälahti, E., Antikaínen, R., Hänninen, T., Laatikainen, T. K., Lindström, J., Paajanen, T. I., Soininen, H. S., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11051449 · Cited by 6 · see citing works
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Effect of a 30-Month Health-Promoting Program on the Prevalence of Cardiovascular Risk Factors in Patients With First Episode Schizophrenia
Søgaard, H. J., Højlund, M., Elliott, A. F., Viuff, A. G., Vandborg, K., Viuff, J. H., Munk‐Jørgensen, P., & Hjorth, P. (2018) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000000708 · Cited by 5 · see citing works
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“When effective, lifestyle interventions in SMI patients mostly lead to small physical health improvements, and sustaining these improvements in the long term is a challenge (2).”
BackgroundSelf-citation
Qualitative analysis of the Meals, Mindfulness, & Moving Forward (M3) lifestyle programme: Cultivating a ‘safe space’ to start on a ‘new path’ for youth with early episode psychosis
Thompson, A., Senders, A., Seibel, C. L., Usher, C. T., Borgatti, A. C., Bodden, K., Calabrese, C., Hagen, K., David, J., BOURDETTE, D. N., et al. (2020) · Early Intervention in Psychiatry · doi:10.1111/eip.12913 · Cited by 5 · see citing works
“Controlled studies evaluating diet education, and physical activity in early psychosis report benefit in attenuated weight gain, weight loss, improved dietary choices and improved psychotic symptoms (Bonfioli, Berti, Goss, Muraro, & Burti, 2012; Bruins et al., 2014; Curtis et al., 2016; Firth, Carney, Elliott, et al.,…”
Background
The use of e-& mHealth technology-based interventions to improve modifiable lifestyle risk factors amongst individuals with severe mental illness (SMI): a scoping review
Gill, P., King, K., & Flego, A. (2022) · Australian Psychologist · doi:10.1080/00050067.2022.2107889 · Cited by 4 · see citing works
“, 2016) and reduction in other cardiometabolic risk factors such as waist circumference and blood pressure (Bruins et al., 2014; Cabassa et al., 2010; Daumit et al., 2013), while encouraging increased physical activity, reduction of alcohol consumption and smoking cessation (Naslund et al.”
Background
Effect of lifestyle modification intervention (LMI) on metabolic syndrome in schizophrenia in a residential mental health care setting–A mixed method study
Gurusamy, J., Gandhi, S., Dinakaran, D., Palaniappan, M., & Venkatasubramanian, G. (2024) · Schizophrenia Research · doi:10.1016/j.schres.2024.02.002 · Cited by 4 · see citing works
Effects of Long-Term Multimodal Psychosocial Treatment on Antipsychotic-Induced Metabolic Changes in Patients With First Episode Psychosis
Kuzman, M. R., Kuharić, D. B., Kekin, I., Makarić, P., Madžarac, Z., Makar, A. K., Mikulić, S. K., Bajić, Ž., Bistrović, P., Bonacin, D., et al. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00488 · Cited by 4 · see citing works
“While several interventions involving exercise proved to be efficient over a shorter period, this effect is lost over a longer period (19, 20).”
Background
Dietetic Prescriptions in Bipolar Disorder: Nutritional Strategies to Support Mood Stability and Reduce Relapse Risk—A Narrative Review
Marano, G., Marzo, E. M., Sfratta, G., Traversi, G., Capristo, E., Gaetani, E., & Mazza, M. (2026) · Life · doi:10.3390/life16010146 · Cited by 3 · see citing works
“Lifestyle interventions that include dietary counseling have shown effectiveness in reducing BMI, body weight, triglycerides, and fasting glucose [175,176], while also contributing to improvements in psychosocial well-being, quality of life, and symptom severity [177,178].”
Integrative Interventions for Improving Outcomes in Depression: A Narrative Review
Halma, M. T. J., Plothe, C., & Marik, P. E. (2024) · Psychology International · doi:10.3390/psycholint6020033 · Cited by 2 · see citing works
“We performed a literature search on lifestyle treatment for depression and found several reviews (Supplementary Table S3) [281–289].”
Method
Metabolic screen and intervene: improving mental health inpatient metabolic monitoring
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Effects of a Telehealth-Delivered Mediterranean Diet Intervention in Adults with Rheumatoid Arthritis (MEDRA): A Randomised Controlled TrialPreprint
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“Lifestyle changes, such as diet, physical activity, and altera - tions in behavioral habits, are the first-line intervention for the treatment of obesity and should also serve as the first step in counteracting APD-induced obesity [ 89, 90].”
The impact of educational lifestyle intervention on body weight and psychological health among overweight/obese patients with severe mental disorders
Zhang, M., Shi, J.-X., Li, H., Chen, R., Zheng, M., Yan, L.-J., Wu, N.-J., & He, Q. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.09.028 · Cited by 2 · see citing works
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Symptoms in People with Psychotic Disorders: A Meta-Analysis
Management, L.-T. W., Risk, C., Bruins, J., Bruggeman, R., Slooff, C. J., Corpeleijn, E., & Pijnenborg, M. (2016)
Self-citation
Health promotion lifestyle interventions for weight management in psychosis: a systematic review and meta-analysis of randomised controlled trials
Bonfioli, E., Berti, L., Goss, C., Muraro, F., & Burti, L. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-78 · Cited by 154 · see citing works
James Foulis Duncan (1812–1895)
Kelly, B. D. (2017) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.116.190538
Poster #T35 THE EFFECT OF LIFESTYLE TREATMENTS ON BODYWEIGHT CARDIOMETABOLIC RISK AND DEPRESSION IN PEOPLE WITH SEVERE MENTAL ILLNESS – A META-ANALYSIS
Bruins, J., Jörg, F., Bruggeman, R., Slooff, C. J., Corpeleijn, E., & Pijnenborg, G. H. M. (2014) · Schizophrenia Research · doi:10.1016/s0920-9964(14)70852-7 · Cited by 1 · see citing works
Self-citation
Comparative efficacy of lifestyle intervention strategies targeting weight outcomes in people with psychosis: a systematic review and network meta-analysis.
Mucheru, D., Hanlon, M.-C., McEvoy, M., Thakkinstian, A., & MacDonald-Wicks, L. (2019) · The JBI Database of Systematic Reviews and Implementation Reports · doi:10.11124/jbisrir-2017-003943 · Cited by 17 · see citing works

Authors: Bruins, J., Jörg, F., Bruggeman, R., Slooff, C., Corpeleijn, E., & Pijnenborg, M.
Affiliations: University Medical Center Groningen (NL)
Corresponding author: Bruins, Jojanneke
ORCID: Bruins, Jojanneke
Jörg, Frederike
Bruggeman, Richard
Corpeleijn, Eva
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2014-12-04
Volume: 9
Issue: 12
Pages: e112276
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0112276
PMC: PMC4256304
OpenAlex: W2118574085
Cited by: 129
References: 81
Citations by year: 2026: 4 · 2025: 6 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 13 · 2020: 16 · 2019: 15 · 2018: 16 · 2017: 18 · 2016: 8 · 2015: 6
FWCI: 1.47
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Figshare (submittedVersion, cc-by)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by)
Funders: Eli Lilly and Company
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords: lifestyle intervention, psychosis, weight management, weight loss, weight gain prevention, cardiometabolic risk, depressive symptoms, obesity, waist circumference, triglycerides, fasting blood glucose, insulin, blood pressure, cholesterol
MeSH terms: Blood Pressure, Body Weight, Depression, Humans, Insulin Resistance, Life Style, Obesity, Psychotic Disorders, Risk Factors, Weight Loss, Exercise, Body Mass Index

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The Effects of Lifestyle Interventions on (Long-Term) Weight Management, Cardiometabolic Risk and Depressive Symptoms in People with Psychotic Disorders: A Meta-Analysis

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