FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works

Abdominal Visceral and Subcutaneous Adipose Tissue Compartments: Association With Metabolic Risk Factors in the Framingham Heart Study

Fox, C. S., Massaro, J. M., Hoffmann, U., Pou, K. M., Maurovich-Horvat, P., Liu, C.-Y., Vasan, R. S., Murabito, J. M., Meigs, J. B., Cupples, L. A., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.675355 · Cited by 2,882 · see citing works

Brown and beige fat: Development, function and therapeutic potential

Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328 · see citing works

Subcutaneous and visceral adipose tissue: Structural and functional differences

Ibrahim, M. M. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00623.x · Cited by 2,238 · see citing works

FNDC5 and Irisin in Humans: I. Predictors of Circulating Concentrations in Serum and Plasma and II. mRNA Expression and Circulating Concentrations in Response to Weight Loss and Exercise

Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040 · see citing works

Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

Lee, P., Linderman, J. D., Smith, S., Brychta, R. J., Wang, J., Idelson, C., Perron, R. M., Werner, C. D., Phan, G. Q., Kammula, U. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.017 · Cited by 802 · see citing works

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

Cypess, A. M., White, A. P., Vernochet, C., Schulz, T. J., Xue, R., Sass, C. A., Huang, T. L., Roberts‐Toler, C., Weiner, L. S., Sze, C., et al. (2013) · Nature Medicine · doi:10.1038/nm.3112 · Cited by 662 · see citing works

FNDC5/irisin is not only a myokine but also an adipokine

Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Crujeiras, A. B., Seoane, L. M., Casanueva, F. F., & Pardo, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060563 · Cited by 612 · see citing works

Metabolic Obesity: The Paradox Between Visceral and Subcutaneous Fat

Publisher, B. S. P. B. S. (2006) · Current Diabetes Reviews · doi:10.2174/1573399810602040367 · Cited by 571 · see citing works

Neural innervation of white adipose tissue and the control of lipolysis

Bartness, T. J., Liu, Y., Shrestha, Y. B., & Ryu, V. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.04.001 · Cited by 358 · see citing works

Overexpression of Perilipin A and B Blocks the Ability of Tumor Necrosis Factor α to Increase Lipolysis in 3T3-L1 Adipocytes

Souza, S. C., de Vargas, L. M., Yamamoto, M. T., Lien, P., Franciosa, M. D., Moss, L. G., & Greenberg, A. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.38.24665 · Cited by 283 · see citing works

Pharmacological and nutritional agents promoting browning of white adipose tissue

Bonet, M. L., Oliver, P., & Palou, A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.12.002 · Cited by 276 · see citing works

Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue

Watt, M. J., Holmes, A. G., Pinnamaneni, S. K., GARNHAM, A. P., Steinberg, G. R., Kemp, B. E., & Febbraio, M. A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00361.2005 · Cited by 241 · see citing works

Irisin is inversely associated with intrahepatic triglyceride contents in obese adults

Zhang, H.-J., Zhang, X.-F., Ma, Z.-M., Pan, L.-L., Chen, Z., Han, H.-W., Han, C.-K., Zhuang, X.-J., Lu, Y., Li, X.-J., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.04.030 · Cited by 234 · see citing works

Modulation of Hormone-sensitive Lipase and Protein Kinase A-mediated Lipolysis by Perilipin A in an Adenoviral Reconstituted System

Souza, S. C., Muliro, K. V., Liscum, L., Lien, P., Yamamoto, M. T., Schaffer, J. E., Dallal, G. E., Wang, X., Kraemer, F. B., Obin, M. S., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108329200 · Cited by 228 · see citing works

Body Weight Set-Points: Determination and Adjustment

Keesey, R. E., & Hirvonen, M. D. (1997) · Journal of Nutrition · doi:10.1093/jn/127.9.1875s · Cited by 206 · see citing works

Endurance training-induced increase in circulating irisin levels is associated with reduction of abdominal visceral fat in middle-aged and older adults

Miyamoto-Mikami, E., Sato, K., Kurihara, T., Hasegawa, N., Fujie, S., Fujita, S., Sanada, K., Hamaoka, T., Tabata, I., & Iemitsu, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120354 · Cited by 143 · see citing works

Browning of white fat: does irisin play a role in humans?

Elsen, M., Raschke, S., & Eckel, J. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0189 · Cited by 128 · see citing works

Metabolic Adaptations in the Absence of Perilipin

Saha, P., Kojima, H., Martı́nez-Botas, J., Sunehag, A. L., & Chan, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405499200 · Cited by 104 · see citing works

Both Subcutaneous and Visceral Adipose Tissue Correlate Highly with Insulin Resistance in African Americans

Tulloch-Reid, M. K., Hanson, R. L., Sebring, N. G., Reynolds, J. C., Premkumar, A., Genovese, D. J., & Sumner, A. E. (2004) · Obesity Research · doi:10.1038/oby.2004.170 · Cited by 104 · see citing works

Diet quality is associated with circulating C-reactive protein but not irisin levels in humans

Park, K., Zaichenko, L., Peter, P. R., Davis, C. R., Crowell, J. A., & Mantzoros, C. S. (2013) · Metabolism · doi:10.1016/j.metabol.2013.10.011 · Cited by 90 · see citing works

Enhanced Adipose Afferent Reflex Contributes to Sympathetic Activation in Diet-Induced Obesity Hypertension

Xiong, X.-Q., Chen, W.-W., Han, Y., Zhou, Y.-B., Zhang, F., Gao, X.-Y., & Zhu, G.-Q. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.198002 · Cited by 85 · see citing works

Insulin signalling, exercise and cellular integrity

Kirwan, J. P., & Aguila, L. F. D. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311281 · Cited by 70 · see citing works

Hydrodynamic Delivery of mIL10 Gene Protects Mice From High-fat Diet-induced Obesity and Glucose Intolerance

Gao, M., Zhang, C., Ma, Y., Bu, L., Yan, L., & Liu, D. (2013) · Molecular Therapy · doi:10.1038/mt.2013.125 · Cited by 62 · see citing works

Adipose afferent reflex: sympathetic activation and obesity hypertension

Xiong, X., Chen, W., & Zhu, G. (2013) · Acta Physiologica · doi:10.1111/apha.12182 · Cited by 60 · see citing works

Set-Point Theory and Obesity

Farias, M. M., Cuevas, A. M., & Rodríguez, F. (2010) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2010.0090 · Cited by 60 · see citing works

Update on perilipin polymorphisms and obesity

Smith, C. E., & Ordovás, J. M. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00515.x · Cited by 60 · see citing works

Protein Tyrosine Phosphatase Epsilon Affects Body Weight by Downregulating Leptin Signaling in a Phosphorylation-Dependent Manner

Rousso-Noori, L., Knobler, H., Levy-Apter, E., Kuperman, Y., Neufeld-Cohen, A., Keshet, Y., Akepati, V. R., Klinghoffer, R. A., Chen, A., & Elson, A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.017 · Cited by 54 · see citing works

In vitro brown and “brite”/“beige” adipogenesis: Human cellular models and molecular aspects

Béranger, G. E., Karbiener, M., Barquissau, V., Pisani, D. F., Scheideler, M., Langin, D., & Amri, E. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.11.001 · Cited by 51 · see citing works

White and brown adipose stem cells: From signaling to clinical implications

Algire, C., Medříková, D., & Herzig, S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.10.001 · Cited by 47 · see citing works

Recent advances in bariatric/metabolic surgery: appraisal of clinical evidence

Wei-Jei, L., & Abdullah, A. (2015) · Journal of Biomedical Research · doi:10.7555/jbr.28.20140120 · Cited by 36 · see citing works

The effect of glucose concentration and sodium phenylbutyrate treatment on mitochondrial bioenergetics and ER stress in 3T3-L1 adipocytes

Tanis, R. M., Piroli, G. G., Day, S. D., & Frizzell, N. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.10.012 · Cited by 27 · see citing works

Metabolic bariatric surgery and type 2 diabetes mellitus: an endocrinologist’ s perspective

Sonali, G., Hong, C., Phong, C., & Tham, K. W. (2015) · Journal of Biomedical Research · doi:10.7555/jbr.29.20140127 · Cited by 24 · see citing works

Adipose tissue plasticity and new therapeutic targets

Enerbäck, S. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.242 · Cited by 20 · see citing works

The brain splits obesity and hypertension

Humphreys, M. H. (2011) · Nature Medicine · doi:10.1038/nm0711-782 · Cited by 12 · see citing works

Metabolic bariatric surgery and type 2 diabetes mellitus：an endocrinologist’s perspective

Sonali, S., Ganguly, Hồng, Chang, Tan, �., Phong, Ching, Lee, Kwang, Wei, et al. (2015) · Acta Scientiarum Naturalium Universitatis Sunyatseni · Cited by 12 · see citing works

Physiology and role of irisin in glucose homeostasis

Perakakis, N., Triantafyllou, G. A., Fernández-Real, J. M., Huh, J. Y., Park, K. H., Seufert, J., & Mantzoros, C. S. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.221 · Cited by 621 · see citing works

Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus

Cheng, L., Wang, J., Dai, H., Duan, Y., An, Y., Shi, L., Lv, Y., Li, H., Wang, C., Ma, Q., et al. (2021) · Adipocyte · doi:10.1080/21623945.2020.1870060 · Cited by 377 · see citing works

Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress

Bi, J., Zhang, J., Ren, Y., Du, Z., Li, Q., Wang, Y., Wei, S., Yang, L., Zhang, J., Liu, C., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.10.019 · Cited by 288 · see citing works

The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review

Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278 · see citing works

Irisin in metabolic diseases

Polyzos, S. A., Anastasilakis, A. D., Efstathiadou, Z. A., Makras, P., Perakakis, N., Kountouras, J., & Mantzoros, C. S. (2018) · Endocrine · doi:10.1007/s12020-017-1476-1 · Cited by 262 · see citing works

Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation

Ren, Y., Zhao, H., Yin, C., Lan, X., Wu, L., Du, X., Griffiths, H. R., & Gao, D. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.873699 · Cited by 260 · see citing works

Progress and Challenges in the Biology of FNDC5 and Irisin

Maak, S., Norheim, F., Drevon, C. A., & Erickson, H. P. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab003 · Cited by 247 · see citing works

The role of exercise-induced myokines in regulating metabolism

Huh, J. Y. (2018) · Archives of Pharmacal Research · doi:10.1007/s12272-017-0994-y · Cited by 242 · see citing works

Irisin exerts dual effects on browning and adipogenesis of human white adipocytes.

Zhang, Y., Xie, C., Wang, H., Foss, R. M., Clare, M., George, E., Li, S.-W., Katz, A. J., Cheng, H., Ding, Y.-S., et al. (2016) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00094.2016 · Cited by 187 · see citing works

The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction

Packer, M. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.06.055 · Cited by 190 · see citing works

New insights into the cellular activities of Fndc5/Irisin and its signaling pathways

Rabiee, F., Lachinani, L., Ghaedi, S., Nasr‐Esfahani, M. H., Megraw, T. L., & Ghaedi, K. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00413-3 · Cited by 178 · see citing works

Irisin Inhibits Hepatic Cholesterol Synthesis via AMPK-SREBP2 Signaling

Tang, H. W., Yu, R., Liu, S., Huwatibieke, B., Li, Z., & Zhang, W. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.02.041 · Cited by 151 · see citing works

FNDC5 Alleviates Hepatosteatosis by Restoring AMPK/mTOR-Mediated Autophagy, Fatty Acid Oxidation, and Lipogenesis in Mice

Liu, T., Xiong, X., Ren, X., Zhao, M., Shi, C., Wang, J., Zhou, Y., Zhang, F., Han, Y., Gao, X.-Y., et al. (2016) · Diabetes · doi:10.2337/db16-0356 · Cited by 135 · see citing works

Interleukin-15 facilitates muscle regeneration through modulation of fibro/adipogenic progenitors

Kang, X., Yang, M., Shi, Y., Xie, M., Zhu, M. P., Zheng, X., Zhang, C., Ge, Z., Bian, X., Lv, J.-T., et al. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0251-0 · Cited by 117 · see citing works

FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle

Varela-Rodríguez, B. M., Pena-Bello, L., Juiz-Valiña, P., Bretal, B. V., Cordido, F., & Sangiao‐Alvarellos, S. (2016) · Scientific Reports · doi:10.1038/srep29898 · Cited by 111 · see citing works

Role of Irisin in Myocardial Infarction, Heart Failure, and Cardiac Hypertrophy

Ho, M.-Y., & Wang, C. (2021) · Cells · doi:10.3390/cells10082103 · Cited by 109 · see citing works

β-aminoisobutyric acid attenuates hepatic endoplasmic reticulum stress and glucose/lipid metabolic disturbance in mice with type 2 diabetes

Shi, C.-X., Zhao, M.-X., Shu, X.-D., Xiong, X.-Q., Wang, J.-J., Gao, X.-Y., Chen, Q., Li, Y.-H., Kang, Y.-M., & Zhu, G.-Q. (2016) · Scientific Reports · doi:10.1038/srep21924 · Cited by 108 · see citing works

An update on the role of irisin in the regulation of endocrine and metabolic functions

Mahgoub, M., D’Souza, C. M., Darmaki, R. S. A., Baniyas, M. M. Y. H., & Adeghate, E. A. (2018) · Peptides · doi:10.1016/j.peptides.2018.03.018 · Cited by 109 · see citing works

Irisin, a fascinating field in our times

Bao, J., She, Q.-Y., Hu, P., Jia, N., & Li, A. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.06.003 · Cited by 102 · see citing works

Is irisin the new player in exercise-induced adaptations or not? A 2017 update

Fatouros, I. G. (2017) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-0674 · Cited by 91 · see citing works

The Role of Irisin in Alzheimer’s Disease

Kim, O. Y., & Song, J. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7110407 · Cited by 90 · see citing works

The Role of Exercise, Diet, and Cytokines in Preventing Obesity and Improving Adipose Tissue

ATAKAN, M. M., Koşar, Ş. N., Güzel, Y., Tin, H. T., & Yan, X. (2021) · Nutrients · doi:10.3390/nu13051459 · Cited by 94 · see citing works

Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process

Zhang, H., Wu, X., Liang, J., Kirberger, M., & Chen, N. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101680 · Cited by 88 · see citing works

Acute Anaerobic Exercise Affects the Secretion of Asprosin, Irisin, and Other Cytokines – A Comparison Between Sexes

Więcek, M., Szymura, J., Maciejczyk, M., Kantorowicz, M., & Szyguła, Z. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01782 · Cited by 83 · see citing works

Increased Expression of Meteorin-Like Hormone in Type 2 Diabetes and Obesity and Its Association with Irisin

AlKhairi, I., Cherian, P., Abu-Farha, M., Madhoun, A. A., Nizam, R., Melhem, M., Jamal, M., Al-Sabah, S., Ali, H., Tuomilehto, J., et al. (2019) · Cells · doi:10.3390/cells8101283 · Cited by 82 · see citing works

The Potential Role of Contraction-Induced Myokines in the Regulation of Metabolic Function for the Prevention and Treatment of Type 2 Diabetes

Carson, B. P. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00097 · Cited by 83 · see citing works

Irisin ameliorates hepatic glucose/lipid metabolism and enhances cell survival in insulin-resistant human HepG2 cells through adenosine monophosphate-activated protein kinase signaling

So, W. Y., & Leung, P. S. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.07.022 · Cited by 83 · see citing works

High irisin levels are associated with better glycemic control and bone health in children with Type 1 diabetes

Faienza, M. F., Brunetti, G., Sanesi, L., Colaianni, G., Celi, M., Piacente, L., D’Amato, G., Schipani, E., Colucci, S. C., & Grano, M. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.03.046 · Cited by 82 · see citing works

From Obesity to Hippocampal Neurodegeneration: Pathogenesis and Non-Pharmacological Interventions

Lee, T. H.-Y., & Yau, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010201 · Cited by 76 · see citing works

Impact of Lipotoxicity on Tissue “Cross Talk” and Metabolic Regulation

Montgomery, M. K., Nardo, W. D., & Watt, M. J. (2019) · Physiology · doi:10.1152/physiol.00037.2018 · Cited by 78 · see citing works

Adropin and irisin in arterial hypertension, diabetes mellitus and chronic kidney disease

Maciorkowska, M., Musiałowska, D., & Małyszko, J. (2019) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/104551 · Cited by 72 · see citing works

Transcriptomic Analysis of Single Isolated Myofibers Identifies miR-27a-3p and miR-142-3p as Regulators of Metabolism in Skeletal Muscle

Chemello, F., Grespi, F., Zulian, A., Cancellara, P., Hébert-Chatelain, É., Martini, P. G. V., Bean, C., Alessio, E., Buson, L., Bazzega, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.105 · Cited by 72 · see citing works

Irisin alleviates FFA induced β-cell insulin resistance and inflammatory response through activating PI3K/AKT/FOXO1 signaling pathway

Zheng, S., Chen, N., Kang, X.-J., Hu, Y., & Shi, S. (2021) · Endocrine · doi:10.1007/s12020-021-02875-y · Cited by 69 · see citing works

Decreased Concentration of Irisin Is Associated with Poor Functional Outcome in Ischemic Stroke

Tu, W., Qiu, H., Cao, J., Liu, Q., Zeng, X., & Zhao, J.-Z. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0651-2 · Cited by 67 · see citing works

Factors mediating exercise‐induced organ crosstalk

Sabaratnam, R., Wojtaszewski, J. F. P., & Højlund, K. (2022) · Acta Physiologica · doi:10.1111/apha.13766 · Cited by 69 · see citing works

Irisin Exerts Inhibitory Effect on Adipogenesis Through Regulation of Wnt Signaling

Ma, E. B., Sahar, N.-E., Jeong, M., & Huh, J. Y. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01085 · Cited by 69 · see citing works

FNDC5 attenuates obesity-induced cardiac hypertrophy by inactivating JAK2/STAT3-associated inflammation and oxidative stress

Geng, Z., Fan, W., Zhou, B. R., Ye, C., Tong, Y., Zhou, Y., & Xiong, X. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1857-8 · Cited by 62 · see citing works

Association of Serum Irisin Concentrations with Presence and Severity of Coronary Artery Disease

Deng, W. (2016) · Medical Science Monitor · doi:10.12659/msm.897376 · Cited by 62 · see citing works

Fndc5 loss‐of‐function attenuates exercise‐induced browning of white adipose tissue in mice

Xiong, Y., Wu, Z., Zhang, B., Wang, C., Mao, F., Liu, X., Hu, K., Sun, X., Jin, W. L., & Kuang, S. (2019) · The FASEB Journal · doi:10.1096/fj.201801754rr · Cited by 63 · see citing works

Adipose–Muscle Crosstalk in Age-Related Metabolic Disorders: The Emerging Roles of Adipo-Myokines

Fang, P., She, Y., Yu, M., Min, W., Shang, W., & Zhang, Z. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101829 · Cited by 62 · see citing works

Disordered metabolism in mice lacking irisin

Luo, Y., Qiao, X., Ma, Y., Deng, H., Xu, C. C., & Xu, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-74588-7 · Cited by 60 · see citing works

The Effect of Irisin as a Metabolic Regulator and Its Therapeutic Potential for Obesity

Li, H., Wang, F., Mu, Y., Sun, J., Zhao, Y. C., & Tang, D. (2021) · International Journal of Endocrinology · doi:10.1155/2021/6572342 · Cited by 59 · see citing works

Uncovering the Role of p38 Family Members in Adipose Tissue Physiology

Leiva, M., Matesanz, N., Pulgarín-Alfaro, M., Nikolić, I., & Sabio, G. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.572089 · Cited by 58 · see citing works

Lack of Adipocyte-Fndc5/Irisin Expression and Secretion Reduces Thermogenesis and Enhances Adipogenesis

Pérez-Sotelo, D., Roca-Rivada, A., de la Torre, I. B., Baltar, J., Castro, A. I., Domínguez, E., Collado, M., Casanueva, F. F., & Pardo, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-16602-z · Cited by 59 · see citing works

FNDC5: A novel player in metabolism and metabolic syndrome.

Cao, R. Y., Zheng, H., Redfearn, D., & Yang, J. (2019) · Biochimie · doi:10.1016/j.biochi.2019.01.001 · Cited by 49 · see citing works

Irisin and Incretin Hormones: Similarities, Differences, and Implications in Type 2 Diabetes and Obesity

Marrano, N., Biondi, G., Borrelli, A., Cignarelli, A., Perrini, S., Laviola, L., Giorgino, F., & Natalicchio, A. (2021) · Biomolecules · doi:10.3390/biom11020286 · Cited by 56 · see citing works

Serum irisin levels are associated with adverse cardiovascular outcomes in patients with acute myocardial infarction

Hsieh, C., Ho, M.-Y., Wen, M., Chen, C., Hsieh, M., Lin, C., Yeh, J., Tsai, M., Yang, C., Wu, V. C., et al. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.11.072 · Cited by 56 · see citing works

Adipose Tissue Secretion Pattern Influences β-Cell Wellness in the Transition from Obesity to Type 2 Diabetes

Biondi, G., Marrano, N., Borrelli, A., Rella, M., Palma, G., CALDERONI, I., Siciliano, E., Lops, P., Giorgino, F., & Natalicchio, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105522 · Cited by 54 · see citing works

Association between Irisin, hs-CRP, and Metabolic Status in Children and Adolescents with Type 2 Diabetes Mellitus

Elizondo‐Montemayor, L., González-Gil, A. M., Tamez‐Rivera, O., Toledo‐Salinas, C., Peschard-Franco, M., Rodríguez-Gutiérrez, N. A., Silva‐Platas, C., & García‐Rivas, G. (2019) · Mediators of Inflammation · doi:10.1155/2019/6737318 · Cited by 55 · see citing works

Serum irisin level in myocardial infarction patients with or without heart failure

El-Mottaleb, N. A. A., Galal, H. M., Maghraby, K., & Gadallah, A. I. (2019) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2018-0736 · Cited by 52 · see citing works

Potential exerkines for physical exercise-elicited pro-cognitive effects: Insight from clinical and animal research

Lee, T. H.-Y., Formolo, D. A., Kong, T., Lau, S. W.-Y., Ho, C. S.-L., Leung, R. Y. H., Hung, F. H.-Y., & Yau, S. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.06.002 · Cited by 49 · see citing works

Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions

Wang, T., Zhou, D., & Hong, Z. (2025) · MedComm · doi:10.1002/mco2.70030 · Cited by 46 · see citing works

Glucocorticoid receptor positively regulates transcription of FNDC5 in the liver

Kim, H. K., Jeong, Y. J., Song, I.-S., Noh, Y. H., Seo, K. W., Kim, M., & Han, J. (2017) · Scientific Reports · doi:10.1038/srep43296 · Cited by 49 · see citing works

Irisin lowers blood pressure by activating the Nrf2 signaling pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats.

Huo, C.-J., Yu, X.-J., Sun, Y.-J., Li, H.-B., Su, Q., Bai, J., Li, Y., Liu, K.-L., Qi, J., Zhou, S., et al. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.114953 · Cited by 39 · see citing works

Fibronectin type III domain containing 5 attenuates NLRP3 inflammasome activation and phenotypic transformation of adventitial fibroblasts in spontaneously hypertensive rats

Ling, L., Chen, D., Tong, Y., Zang, Y.-H., Ren, X., Zhou, Y., Qi, X., Chen, Q., Li, Y., Kang, Y., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001654 · Cited by 45 · see citing works

The Physiological Role of Irisin in the Regulation of Muscle Glucose Homeostasis

Yano, N., Zhao, Y., & Zhao, T. C. (2021) · Endocrines · doi:10.3390/endocrines2030025 · Cited by 46 · see citing works

Irisin in goldfish ( Carassius auratus ): Effects of irisin injections on feeding behavior and expression of appetite regulators, uncoupling proteins and lipoprotein lipase, and fasting-induced changes in FNDC5 expression

Butt, Z. D., Hackett, J. D., & Volkoff, H. (2017) · Peptides · doi:10.1016/j.peptides.2017.02.003 · Cited by 44 · see citing works

Mechanistic complexities of bone loss in Alzheimer’s disease: a review

Frame, G., Bretland, K. A., & Dengler-Crish, C. M. (2020) · Connective Tissue Research · doi:10.1080/03008207.2019.1624734 · Cited by 44 · see citing works

FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway

Zhou, B. R., Qiu, Y., Wu, N., Chen, A., Zhou, Y., Chen, Q., Kang, Y., Li, Y., & Zhu, G. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6384803 · Cited by 43 · see citing works

The Role of Peptide Hormones Discovered in the 21st Century in the Regulation of Adipose Tissue Functions

Kolodziejski, P. A., Pruszyńska‐Oszmałek, E., Wojciechowicz, T., Sassek, M., Leciejewska, N., Jasaszwili, M., Billert, M., Małek, E., Szczepankiewicz, D., Misiewicz-Mielnik, M., et al. (2021) · Genes · doi:10.3390/genes12050756 · Cited by 43 · see citing works

Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders

Pervin, S., Reddy, S. T., & Singh, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.653179 · Cited by 42 · see citing works

Synergistic effect of carnosine on browning of adipose tissue in exercised obese rats; a focus on circulating irisin levels

Schaalan, M. F., Ramadan, B. K., & Elwahab, A. H. A. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26370 · Cited by 42 · see citing works

Inhibition of miR-135a-5p attenuates vascular smooth muscle cell proliferation and vascular remodeling in hypertensive rats

Ye, C., Tong, Y., Wu, N., Wan, G.-W., Zheng, F., Chen, J., Lei, J., Zhou, H., Chen, A., Wang, J., et al. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00608-x · Cited by 42 · see citing works

Irisin alleviates obesity-induced bone loss by inhibiting interleukin 6 expression via TLR4/MyD88/NF-κB axis in adipocytes

Zhang, Y.-S., He, X., Wang, K., Xue, Y., Hu, S.-H., Jin, Y.-S., Zhu, G., Rui, Y.-J., & Shi, Q. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.04.013 · Cited by 49 · see citing works

The effects of royal jelly and tocotrienol‐rich fraction on impaired glycemic control and inflammation through irisin in obese rats

Irandoost, P., Alamdari, N. M., Saidpour, A., Shidfar, F., Roshanravan, N., Jafarabadi, M. A., Farsi, F., Hanjani, N. A., & Vafa, M. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13493 · Cited by 40 · see citing works

FNDC5 inhibits foam cell formation and monocyte adhesion in vascular smooth muscle cells via suppressing NFκB-mediated NLRP3 upregulation

Zang, Y.-H., Chen, D., Zhou, B. R., Chen, A., Wang, J., Gao, X.-Y., Chen, Q., Li, Y., Kang, Y., & Zhu, G. (2019) · Vascular Pharmacology · doi:10.1016/j.vph.2019.106579 · Cited by 40 · see citing works

Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre‐symptomatic female but not male htau mice

Bretland, K. A., Lin, L., Bretland, K. M., Smith, M. A., Fleming, S. M., & Crish, S. D. (2021) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12711 · Cited by 40 · see citing works

Serum irisin and its regulation by hyperinsulinemia in women with polycystic ovary syndrome

Adamska, A., Karczewska‐Kupczewska, M., Łebkowska, A., Milewski, R. J., Górska, M., Otziomek, E., Nikołajuk, A., Wołczyński, S., & Kowalska, I. (2016) · Endocrine Journal · doi:10.1507/endocrj.ej16-0249 · Cited by 38 · see citing works

Norepinephrine acting on adventitial fibroblasts stimulates vascular smooth muscle cell proliferation via promoting small extracellular vesicle release

Ye, C., Zheng, F., Xu, T., Wu, N., Tong, Y., Xiong, X., Zhou, Y., Wang, J., Chen, Q., Li, Y., et al. (2022) · Theranostics · doi:10.7150/thno.70974 · Cited by 37 · see citing works

Adipocyte Mitochondria: Deciphering Energetic Functions across Fat Depots in Obesity and Type 2 Diabetes

Das, S., Mukhuty, A., Mullen, G. P., & Rudolph, M. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126681 · Cited by 39 · see citing works

Mechanism of CNS regulation by irisin, a multifunctional protein

Qi, J., Yang, L.-K., Wang, X., Wang, M., Li, X., Feng, B., Wu, Y., Liu, S., & Zhang, K. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.07.007 · Cited by 36 · see citing works

Relation of serum irisin level with metabolic and antropometric parameters in obese children

Çatlı, G., Küme, T., Tuhan, H., Anık, A., Çalan, Ö. G., Böber, E., & Abacı, A. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.07.019 · Cited by 34 · see citing works

Irisin protects macrophages from oxidized low density lipoprotein-induced apoptosis by inhibiting the endoplasmic reticulum stress pathway

Zheng, G., Li, H., Zhang, T., Yang, L., Yao, S., Chen, S., Zheng, M., Zhao, Q., & Tian, H. (2017) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2017.08.018 · Cited by 34 · see citing works

Whole-Body Cryotherapy Is an Effective Method of Reducing Abdominal Obesity in Menopausal Women with Metabolic Syndrome

Więcek, M., Szymura, J., Sproull, J., & Szyguła, Z. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092797 · Cited by 33 · see citing works

Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis

Li, H., Shen, J., Wu, T., Kuang, J., Liu, Q., Cheng, S., Pu, S., Chen, L., Li, R., Li, Y., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00548 · Cited by 33 · see citing works

Factors Associated with White Fat Browning: New Regulators of Lipid Metabolism

Zhang, P., He, Y., Wu, S., Li, X., Lin, X., Gan, M., Chen, L., Zhao, Y., Niu, L., Zhang, S., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147641 · Cited by 32 · see citing works

Irisin increases the expression of anorexigenic and neurotrophic genes in mouse brain

Natalicchio, A., Marrano, N., Biondi, G., Dipaola, L., Spagnuolo, R., Cignarelli, A., Perrini, S., Laviola, L., & Giorgino, F. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3238 · Cited by 31 · see citing works

Reduced plasma level of irisin in first trimester as a risk factor for the development of gestational diabetes mellitus

Wang, P., Ma, H.-H., Hou, X., Song, L., Song, X.-L., & Zhang, J.-F. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.05.038 · Cited by 31 · see citing works

Irisin Serum Levels in Metabolic Syndrome Patients Treated with Three Different Diets: A Post-Hoc Analysis from a Randomized Controlled Clinical Trial

Osella, A. R., Colaianni, G., Correale, M., Pesole, P. L., Bruno, I., Buongiorno, C., Deflorio, V., Leone, C. M., Colucci, S. C., Grano, M., et al. (2018) · Nutrients · doi:10.3390/nu10070844 · Cited by 31 · see citing works

Role of Irisin in Endocrine and Metabolic Disorders—Possible New Therapeutic Agent?

Leuștean, L., Preda, C., Teodoriu, L. C., Mihalache, L., Arhire, L. I., & Ungureanu, M.-C. (2021) · Applied Sciences · doi:10.3390/app11125579 · Cited by 33 · see citing works

Irisin and Energy Metabolism and the Role of Irisin on Metabolic Syndrome

Aladag, T., Moğulkoç, R., & Baltacı, A. K. (2023) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557523666230411105506 · Cited by 30 · see citing works

The saturated fatty acid palmitate induces insulin resistance through Smad3-mediated down-regulation of FNDC5 in myotubes

Guo, Q., Wei, X., Hu, H., Yang, D., Zhang, B., Fan, X., Liu, J., He, H., Oh, Y., Wu, Q., et al. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.10.077 · Cited by 30 · see citing works

Irisin and Chemerin Levels in Patients with Type 2 Diabetes Mellitus

Balaban, Y. (2019) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2019.442 · Cited by 30 · see citing works

Fibronectin type III domain-containing 5 in cardiovascular and metabolic diseases: a promising biomarker and therapeutic target

Zhang, X., Hu, C., Wu, H., Ma, Z., & Tang, Q. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00557-5 · Cited by 30 · see citing works

Irisin alleviates obesity-related spermatogenesis dysfunction via the regulation of the AMPKα signalling pathway

Yang, M., Dai, H., Luo, L., & Yang, J. (2021) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00821-1 · Cited by 30 · see citing works

Exercise-regulated lipolysis: Its role and mechanism in health and diseases

Zhu, J., & Guo, L. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.11.031 · Cited by 31 · see citing works

Hepatic Klf10-Fh1 axis promotes exercise-mediated amelioration of NASH in mice

Luo, H.-Y., Mu, W.-J., Chen, M., Zhu, J., Li, Y., Li, S., Yan, L.-J., Li, R.-Y., Yin, M.-T., Li, X., et al. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155916 · Cited by 28 · see citing works

Mechanisms of altered bone remodeling in children with type 1 diabetes

Brunetti, G., D’Amato, G., Santis, S. D., Grano, M., & Faienza, M. F. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i7.997 · Cited by 27 · see citing works

The modulatory effects of irisin on asprosin, leptin, glucose levels and lipid profile in healthy and obese male and female rats

Özcan, S., Ülker, N., Bulmuş, Ö., Yardımcı, A., Özcan, M., & Canpolat, S. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1722706 · Cited by 26 · see citing works

Alcohol Consumption and Liver Metabolism in the Era of MASLD: Integrating Nutritional and Pathophysiological Insights

Acierno, C., Barletta, F., Caturano, A., Nevola, R., Sasso, F., Adinolfi, L., & Rinaldi, L. (2025) · Nutrients · doi:10.3390/nu17132229 · Cited by 31 · see citing works

The Acute Effects of Swimming Exercise on PGC-1α-FNDC5/Irisin-UCP1 Expression in Male C57BL/6J Mice

Cho, E., Jeong, D. Y., Kim, J. G., & Lee, S. (2021) · Metabolites · doi:10.3390/metabo11020111 · Cited by 25 · see citing works

Asprosin, a novel glucogenic adipokine: a potential therapeutic implication in diabetes mellitus

Hekım, M. G., Keleştemur, M. M., Bulmuş, F. G., Bılgın, B., Bulut, F., Gökdere, E., Ozdede, M. R., Keleştimur, H., Canpolat, S., & Özcan, M. (2021) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2021.1894178 · Cited by 26 · see citing works

The Potential of Irisin as a Therapeutic for Diabetes

Leung, P. S. (2017) · Future Medicinal Chemistry · doi:10.4155/fmc-2017-0035 · Cited by 25 · see citing works

Exercise and Metabolic Health: The Emerging Roles of Novel Exerkines

Yazgan, B., Türkel, İ., Özerkliğ, B., ATAKAN, M. M., Aktitiz, S., & Koşar, Ş. N. (2022) · Current Protein and Peptide Science · doi:10.2174/1389203723666220629163524 · Cited by 25 · see citing works

Irisin Regulates the Functions of Hepatic Stellate Cells

Dong, H. N., Park, S. Y., Le, C. T., Choi, D.-H., & Cho, E.-H. (2020) · Endocrinology and Metabolism · doi:10.3803/enm.2020.658 · Cited by 23 · see citing works

Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice

Jiang, S., Piao, L., Ma, E. B., Ha, H., & Huh, J. Y. (2021) · Biomolecules · doi:10.3390/biom11020322 · Cited by 23 · see citing works

Ferulic Acid Stimulates Adipocyte-Specific Secretory Proteins to Regulate Adipose Homeostasis in 3T3-L1 Adipocytes

Kuppusamy, P., Soundharrajan, I., Hwang, I. H., Kim, D., & Choi, K. C. (2021) · Molecules · doi:10.3390/molecules26071984 · Cited by 23 · see citing works

DR-region of Na+/K+-ATPase is a target to ameliorate hepatic insulin resistance in obese diabetic mice

Sun, H., Cao, L., Zhu, M., Wu, Z., Shen, C., Nie, X.-W., & Bian, J. (2020) · Theranostics · doi:10.7150/thno.46053 · Cited by 22 · see citing works

miR-31-5p Promotes Oxidative Stress and Vascular Smooth Muscle Cell Migration in Spontaneously Hypertensive Rats via Inhibiting FNDC5 Expression

Zhou, B. R., Wu, L., Zheng, F., Wu, N., Chen, A., Zhou, H., Chen, J., Chen, Q., Li, Y., Kang, Y., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9081009 · Cited by 22 · see citing works

Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice

Jiang, S., Piao, L., Ma, E. B., Ha, H., & Huh, J. Y. (2021) · Biomolecules · doi:10.3390/biom11020322 · Cited by 23 · see citing works

FNDC5 and Irisin in Humans: I. Predictors of Circulating Concentrations in Serum and Plasma and II. mRNA Expression and Circulating Concentrations in Response to Weight Loss and Exercise

Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040 · see citing works

Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance

Moreno-Navarrete, J. M., Ortega, F., Serrano, M., Guerra, E., Pardo, G., Tinahones, F., Ricart, W., & Fernández-Real, J. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2749 · Cited by 788 · see citing works

FNDC5: A novel player in metabolism and metabolic syndrome.

Cao, R. Y., Zheng, H., Redfearn, D., & Yang, J. (2019) · Biochimie · doi:10.1016/j.biochi.2019.01.001 · Cited by 49 · see citing works

Irisin Is Regulated by CAR in Liver and Is a Mediator of Hepatic Glucose and Lipid Metabolism.

Mo, L., Shen, J., Liu, Q.-H., Zhang, Y., Kuang, J.-Y., Pu, S.-Y., Cheng, S., Zou, M., Jiang, W., Jiang, C.-T., et al. (2016) · Molecular Endocrinology · doi:10.1210/me.2015-1292 · Cited by 87 · see citing works