Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis
Open accessAbstract
PICALM (Phosphatidyl Inositol Clathrin Assembly Lymphoid Myeloid protein) is a ubiquitously expressed protein that plays a role in clathrin-mediated endocytosis. PICALM also affects the internalization and trafficking of SNAREs and modulates macroautophagy. Chromosomal translocations that result in the fusion of PICALM to heterologous proteins cause leukemias, and genome-wide association studies have linked PICALM Single Nucleotide Polymorphisms (SNPs) to Alzheimer's disease. To obtain insight into the biological role of PICALM, we performed gene expression studies of PICALM-deficient and PICALM-expressing cells. Pathway analysis demonstrated that PICALM expression influences the expression of genes that encode proteins involved in cholesterol biosynthesis and lipoprotein uptake. Gas Chromatography-Mass Spectrometry (GC-MS) studies indicated that loss of PICALM increases cellular cholesterol pool size. Isotopic labeling studies revealed that loss of PICALM alters increased net scavenging of cholesterol. Flow cytometry analyses confirmed that internalization of the LDL receptor is enhanced in PICALM-deficient cells as a result of higher levels of LDLR expression. These findings suggest that PICALM is required for cellular cholesterol homeostasis and point to a novel mechanism by which PICALM alterations may contribute to disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PICALM has been shown to be involved in lipid/cholesterol metabolism in Drosophila glia and HEK293 cells.
“Although PICALM has been shown to be involved in lipid/cholesterol metabolism in Drosophila glia and HEK293 cells13,36”
From PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia (2025) · cites this paper as [36]
PICALM's role in lipid/cholesterol metabolism has been reported in Drosophila glia and HEK293 cells.
“its role in lipid/cholesterol metabolism has been reported in Drosophila glia and HEK293 cells13,36”
From PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia (2025) · cites this paper as [36]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works
Lipid rafts and signal transduction
Simons, K., & Toomre, D. K. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 6,252 · see citing works
Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.440 · Cited by 3,326 · see citing works
SNAREs — engines for membrane fusion
Jahn, R., & Scheller, R. H. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2002 · Cited by 2,635 · see citing works
Plat-E: an efficient and stable system for transient packaging of retroviruses
MORITA, S., Kojima, T., & Kitamura, T. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301206 · Cited by 1,660 · see citing works
Cellular cholesterol trafficking and compartmentalization
Ikonen, E. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2336 · Cited by 1,455 · see citing works
Goldstein, J. L., & Brown, M. S. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.179564 · Cited by 1,344 · see citing works
Role of cholesterol and lipid organization in disease
Maxfield, F. R., & Tabas, I. A. (2005) · Nature · doi:10.1038/nature04399 · Cited by 1,297 · see citing works
Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease
Seshadri, S. (2010) · JAMA · doi:10.1001/jama.2010.574 · Cited by 1,219 · see citing works
Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts
Ehehalt, R., Keller, P., Haass, C., Thiele, C., & Simons, K. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200207113 · Cited by 1,103 · see citing works
Dietschy, J. M., & Turley, S. D. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r400004-jlr200 · Cited by 1,095 · see citing works
Fassbender, K. C., Simons, M., Bergmann, C., Stroick, M., Lütjohann, D., Keller, P., Runz, H., Kühl, S., Bertsch, T., von Bergmann, K., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081620098 · Cited by 1,078 · see citing works
Brain Cholesterol: Long Secret Life Behind a Barrier
Björkhem, I., & Meaney, S. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000120374.59826.1b · Cited by 1,044 · see citing works
Linking lipids to Alzheimer's disease: cholesterol and beyond
Di Paolo, G., & Kim, T.-W. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3012 · Cited by 972 · see citing works
Ford, M. G. J., Pearse, B. M. F., Higgins, M. K., Vallis, Y., Owen, D. J., Gibson, A., Hopkins, C. R., Evans, P. R., & McMahon, H. T. (2001) · Science · doi:10.1126/science.291.5506.1051 · Cited by 727 · see citing works
Versatile retroviral vectors for potential use in gene therapy.
Hawley, R. G., Lieu, F. H., Fong, A. Z. C., & Hawley, T. S. (1994) · PubMed · Cited by 652 · see citing works
Cholesterol Sensing, Trafficking, and Esterification
Chang, T., Chang, C. C. Y., Ohgami, N., & Yamauchi, Y. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104656 · Cited by 633 · see citing works
A loss-of-function RNA interference screen for molecular targets in cancer
Ngo, V. N., Davis, R. E., Lamy, L., Yu, X., Zhao, H. G., Lenz, G., Lam, L. T., Davé, S. S., Yang, L., Powell, J. I., et al. (2006) · Nature · doi:10.1038/nature04687 · Cited by 606 · see citing works
Regulation of Sterol Synthesis in Eukaryotes
Espenshade, P. J., & Hughes, A. L. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130315 · Cited by 593 · see citing works
Radhakrishnan, A., Goldstein, J. L., McDonald, J. G., & Brown, M. S. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.008 · Cited by 561 · see citing works
Analysis of Clathrin-mediated Endocytosis of Epidermal Growth Factor Receptor by RNA Interference
Huang, F., Khvorova, A., Marshall, W., & Sorkin, A. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400046200 · Cited by 460 · see citing works
Zhang, B., Koh, Y. H., Beckstead, R. B., Budnik, V., Ganetzky, B., & Bellen, H. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80664-9 · Cited by 434 · see citing works
Jun, G. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.201 · Cited by 422 · see citing works
Lavau, C., Szilvassy, S. J., Slany, R. K., & Cleary, M. L. (1997) · The EMBO Journal · doi:10.1093/emboj/16.14.4226 · Cited by 401 · see citing works
Self-citationSong, B., Sever, N., & DeBose‐Boyd, R. A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.009 · Cited by 368 · see citing works
Qi, Y., Wang, J. K. T., McMillian, M., & Chikaraishi, D. M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-04-01217.1997 · Cited by 330 · see citing works
Yu, L., York, J., von Bergmann, K., Lütjohann, D., Cohen, J. C., & Hobbs, H. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301311200 · Cited by 323 · see citing works
Tebar, F., Bohlander, S. K., & Sorkin, A. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.8.2687 · Cited by 320 · see citing works
GATHER: a systems approach to interpreting genomic signatures
Chang, J. T., & Nevins, J. R. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl483 · Cited by 314 · see citing works
Dreyling, M. H., Martinez-Climent, J. A., Zheng, M., Mao, J., Rowley, J. D., & Bohlander, S. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4804 · Cited by 310 · see citing works
Impaired Autophagy in the Lipid-Storage Disorder Niemann-Pick Type C1 Disease
Sarkar, S., Carroll, B., Buganim, Y., Maetzel, D., Ng, A. H. M., Cassady, J. P., Cohen, M. A., Chakraborty, S., Wang, H., Spooner, E., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.042 · Cited by 291 · see citing works
PICALM modulates autophagy activity and tau accumulation
Moreau, K., Fleming, A., Imarisio, S., Lopez Ramirez, A., Mercer, J. L., Jimenez-Sanchez, M., Bento, C. F., Puri, C., Zavodszky, E., Siddiqi, F., et al. (2014) · Nature Communications · doi:10.1038/ncomms5998 · Cited by 281 · see citing works
Self-citationLiscum, L., & Faust, J. R. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45483-x · Cited by 245 · see citing works
Corneveaux, J. J., Myers, A. J., Allen, A. N., Pruzin, J. J., Ramirez, M., Engel, A., Nalls, M. A., Chen, K., Lee, W., Chewning, K., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq221 · Cited by 237 · see citing works
Mechanisms for cellular cholesterol transport: Defects and human disease
Ikonen, E. (2006) · Physiological Reviews · doi:10.1152/physrev.00022.2005 · Cited by 229 · see citing works
Regulation of cholesterol homeostasis
Goedeke, L., & Fernandez-Hernando, C. F. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0857-5 · Cited by 216 · see citing works
ENTH/ANTH proteins and clathrin-mediated membrane budding
Legendre, V., Wasiak, S., Hussain, N. K., Angers, A., & McPherson, P. S. (2003) · Journal of Cell Science · doi:10.1242/jcs.00928 · Cited by 205 · see citing works
An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Williams, K. J., Argus, J. P., Zhu, Y., Wilks, M. Q., Marbois, B. N., York, A. G., Kidani, Y., Pourzia, A. L., Akhavan, D., Lisiero, D. N., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0382-t · Cited by 197 · see citing works
Self-citationThe Molecular Basis for the Endocytosis of Small R-SNAREs by the Clathrin Adaptor CALM
Miller, S. E., Sahlender, D. A., Graham, S. C., Höning, S., Robinson, M. S., Peden, A. A., & Owen, D. J. (2011) · Cell · doi:10.1016/j.cell.2011.10.038 · Cited by 192 · see citing works
The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH
Maurer, M. E., & Cooper, J. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.03217 · Cited by 191 · see citing works
Suri, C., Fung, B., Tischler, A. S., & Chikaraishi, D. M. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-03-01280.1993 · Cited by 181 · see citing works
Cholesterol Accumulates in Senile plaques of Alzheimer Disease patients and in Transgenic APPswMice
Mori, T., Paris, D., Town, T., Rojiani, A. M., Sparks, D. L., DelleDonne, A., Crawford, F., Abdullah, L. I., Humphrey, J., Dickson, D. W., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.778 · Cited by 175 · see citing works
Zelcer, N., Sharpe, L. J., Loregger, A., Kristiana, I., Cook, E. C. L., Phan, L., Stevenson, J., & Brown, A. J. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01140-13 · Cited by 173 · see citing works
Xiao, Q., Gil, S.-C., Yan, P., Wang, Y., Han, S., Gonzales, E., Perez, R., Cirrito, J. R., & Lee, J.-M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.338376 · Cited by 166 · see citing works
Late Endosomal Cholesterol Accumulation Leads to Impaired Intra-Endosomal Trafficking
Sobo, K., Blanc, I., Luyet, P., Fivaz, M. L., Ferguson, C., Parton, R. G., Gruenberg, J. E., & van der Goot, F. G. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000851 · Cited by 157 · see citing works
Cholesterol metabolism in Huntington disease
Karasinska, J. M., & Hayden, M. R. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.132 · Cited by 154 · see citing works
Connections between SNAREs and autophagy
Moreau, K., Renna, M., & Rubinsztein, D. C. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.11.004 · Cited by 151 · see citing works
Lipid imbalance in the neurological disorder, Niemann‐Pick C disease
Vance, J. E. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.06.008 · Cited by 146 · see citing works
Effect of Clathrin Assembly Lymphoid Myeloid Leukemia Protein Depletion on Clathrin Coat Formation
Meyerholz, A., Hinrichsen, L., Groos, S., Esk, C., Brandes, G., & Ungewickell, E. J. (2005) · Traffic · doi:10.1111/j.1600-0854.2005.00355.x · Cited by 144 · see citing works
Evidence for CALM in Directing VAMP2 Trafficking
Harel, A., Wu, F., Mattson, M. P., Morris, C. M., & Yao, P. J. (2008) · Traffic · doi:10.1111/j.1600-0854.2007.00694.x · Cited by 144 · see citing works
Koo, S. J., Marković, S., Puchkov, D., Mahrenholz, C. C., Beceren‐Braun, F., Maritzen, T., Dernedde, J., Volkmer, R., Oschkinat, H., & Haucke, V. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107067108 · Cited by 142 · see citing works
Ando, K., Brion, J.-P., Stygelbout, V., Suain, V., Authelet, M., Dedecker, R., Chanut, A., Lacor, P., Lavaur, J., Sazdovitch, V., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1111-z · Cited by 136 · see citing works
Tang, X., Lucas, J. E., Chen, J. L.-Y., LaMonte, G., Wu, J., Wang, M. C., Koumenis, C., & Chi, J. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-2076 · Cited by 126 · see citing works
Self-citationDefective cholesterol trafficking in Niemann‐Pick C‐deficient cells
Peake, K., & Vance, J. E. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.04.047 · Cited by 123 · see citing works
The Role of PICALM in Alzheimer’s Disease
Xu, W., Tan, L., & Yu, J. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8878-3 · Cited by 119 · see citing works
Distribution and Expression of Picalm in Alzheimer Disease
Baig, S., Joseph, S. A., Tayler, H., Abraham, R., Owen, M. J., Williams, J., Kehoe, P. G., & Love, S. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181f52e01 · Cited by 115 · see citing works
Du, C., Redner, R. L., Cooke, M. P., & Lavau, C. (1999) · Blood · doi:10.1182/blood.v94.2.793 · Cited by 101 · see citing works
Self-citationBohlander, S. K., Muschinsky, V., Schrader, K., Siebert, R., Schlegelberger, B., Harder, L., Schemmel, V., Fonatsch, C., Ludwig, W., Hiddemann, W., et al. (2000) · Leukemia · doi:10.1038/sj.leu.2401614 · Cited by 97 · see citing works
Nucleocytoplasmic Shuttling of Endocytic Proteins
Vecchi, M., Polo, S., Poupon, V., van de Loo, J.-W., Benmerah, A., & Fiore, P. P. D. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.7.1511 · Cited by 96 · see citing works
Kanatsu, K., Morohashi, Y., Suzuki, M., Kuroda, H., Watanabe, T., Tomita, T., & Iwatsubo, T. (2014) · Nature Communications · doi:10.1038/ncomms4386 · Cited by 91 · see citing works
Garuti, R., Jones, C., Li, W., Michaely, P., Herz, J., Gerard, R. D., Cohen, J. C., & Hobbs, H. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509394200 · Cited by 89 · see citing works
Rab7 Is Functionally Required for Selective Cargo Sorting at the Early Endosome
Girard, E., Chmiest, D., Fournier, N., Johannes, L., Paul, J., Vedie, B., & Lamaze, C. (2013) · Traffic · doi:10.1111/tra.12143 · Cited by 87 · see citing works
Model equations for condensation biosynthesis using stable isotopes and radioisotopes
Kelleher, J. K., & Masterson, T. M. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.1.e118 · Cited by 86 · see citing works
ACAT inhibition and amyloid beta reduction
Bhattacharyya, R., & Kovacs, D. M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.04.003 · Cited by 71 · see citing works
The PICALM Protein Plays a Key Role in Iron Homeostasis and Cell Proliferation
Scotland, P., Heath, J. L., Conway, A. E., Porter, N. B., Armstrong, M. B., Walker, J. A., Klebig, M. L., Lavau, C., & Wechsler, D. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044252 · Cited by 67 · see citing works
Self-citationCalcium Phosphate Transfection
Kingston, R. E., Chen, C. A., & Okayama, H. (1997) · Current Protocols in Neuroscience · doi:10.1002/0471142301.nsa01cs01 · Cited by 65 · see citing works
Klebig, M. L., Wall, M. D., Potter, M. D., Rowe, E., Carpenter, D. A., & Rinchik, E. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432634100 · Cited by 62 · see citing works
Suzuki, M., Tanaka, H., Tanimura, A., Tanabe, K., Oe, N., Rai, S., Kon, S., Fukumoto, M., Takei, K., Abe, T., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031854 · Cited by 60 · see citing works
Gatza, M. L., Kung, H., Blackwell, K., Dewhirst, M. W., Marks, J. R., & Chi, J. (2011) · Breast Cancer Research · doi:10.1186/bcr2899 · Cited by 59 · see citing works
Self-citationMorgen, K., Ramı́rez, A., Frölich, L., Tost, H., Plichta, M. M., Kölsch, H., Rakebrandt, F., Rienhoff, O., Jessen, F., Peters, O., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.11.001 · Cited by 59 · see citing works
Calcium Phosphate Transfection
Kingston, R. E., Chen, C. A., & Okayama, H. (1999) · Current Protocols in Immunology · doi:10.1002/0471142735.im1013s31 · Cited by 59 · see citing works
Joe Goldstein and Mike Brown: from cholesterol homeostasis to new paradigms in membrane biology
Anderson, R. E. (2003) · Trends in Cell Biology · doi:10.1016/j.tcb.2003.08.007 · Cited by 48 · see citing works
A critical role for CRM1 in regulating HOXA gene transcription in CALM-AF10 leukemias
Conway, A. E., Haldeman, J. M., Wechsler, D. S., & Lavau, C. (2014) · Leukemia · doi:10.1038/leu.2014.221 · Cited by 47 · see citing works
Self-citationGirard, E., Paul, J., Fournier, N., Beaune, P. H., Johannes, L., Lamaze, C., & Vedie, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029042 · Cited by 43 · see citing works
Thomas, R. S., Lelos, M. J., Good, M. A., & Kidd, E. J. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.10.131 · Cited by 41 · see citing works
Robinet, P., Fradagrada, A., Monier, M., Marchetti, M., Cogny, A., MOATTI, N., Paul, J., Vedie, B., & Lamaze, C. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00435.x · Cited by 37 · see citing works
A CALM-derived nuclear export signal is essential for CALM-AF10–mediated leukemogenesis
Conway, A. E., Scotland, P., Lavau, C., & Wechsler, D. S. (2013) · Blood · doi:10.1182/blood-2012-06-435792 · Cited by 33 · see citing works
Self-citationEden, E. R., Sun, X.-M., Patel, D., & Soutar, A. K. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm232 · Cited by 26 · see citing works
Uncoupling the Functions of CALM in VAMP Sorting and Clathrin-Coated Pit Formation
Sahlender, D. A., Kozik, P., Miller, S. E., Peden, A. A., & Robinson, M. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064514 · Cited by 21 · see citing works
Sarkar, S., Maetzel, D., Korolchuk, V. I., & Jaenisch, R. (2014) · Autophagy · doi:10.4161/auto.28623 · Cited by 20 · see citing works
Reducing the Genotoxic Potential of Retroviral Vectors
Ramezani, A., Hawley, T. S., & Hawley, R. G. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-248-3_12 · Cited by 14 · see citing works
Rai, S., Tanaka, H., Suzuki, M., Ogoh, H., Taniguchi, Y., Morita, Y., Shimada, T., Tanimura, A., Matsui, K., Yokota, T., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109441 · Cited by 13 · see citing works
Abdelhaleem, M. M., Beimnet, K., Kirby-Allen, M. A., Naqvi, A., Hitzler, J. K., & Shago, M. (2006) · Leukemia · doi:10.1038/sj.leu.2404503 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
PICALM and Alzheimer’s Disease: An Update and Perspectives
Ando, K., Nagaraj, S., Küçükali, F., de Fisenne, M.-A., Kosa, A.-C., Doeraene, E., Lopez Gutierrez, L., Brion, J.-P., & Leroy, K. (2022) · Cells · doi:10.3390/cells11243994 · Cited by 104 · see citing works
Thomas, R. S., Henson, A., Gerrish, A., Jones, L., Williams, J., & Kidd, E. J. (2016) · BMC Neuroscience · doi:10.1186/s12868-016-0288-1 · Cited by 55 · see citing works
PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia
Kozlova, A., Zhang, S., Sudwarts, A., Zhang, H., Smirnou, S., Byeon, S. K., Thapa, C., Sun, X., Stephenson, K., Zhao, X., et al. (2025) · Nature · doi:10.1038/s41586-025-09486-x · Cited by 53 · see citing works
“Although PICALM has been shown to be involved in lipid/cholesterol metabolism in Drosophila glia and HEK293 cells 13,36 , its potential role in LD formation in MGs, especially its link to the LOAD-risk allele, has not been demonstrated.”
Impact of late-onset Alzheimer’s genetic risk factors on beta-amyloid endocytic production
Almeida, C. G., Mirfakhar, F. S., Perdigão, C., & Burrinha, T. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2825-9 · Cited by 48 · see citing works
Heath, L. M., Earls, J. C., Magis, A. T., Kornilov, S. A., Lovejoy, J. C., Funk, C. C., Rappaport, N., Logsdon, B. A., Mangravite, L. M., Kunkle, B. W., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-09825-2 · Cited by 24 · see citing works
Cell type-specific functions of Alzheimer's disease endocytic risk genes
Maninger, J., Nowak, K., Goberdhan, S., O’Donoghue, R., & Connor‐Robson, N. (2024) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2022.0378 · Cited by 21 · see citing works
Gene Expression Profiling as a Novel Diagnostic Tool for Neurodegenerative Disorders
Martínez-Iglesias, O. A., Naidoo, V., Carril, J. C., Seoane, S., Cacabelos, N., & Cacabelos, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065746 · Cited by 18 · see citing works
Towards a Unitary Hypothesis of Alzheimer’s Disease Pathogenesis
Area-Gómez, E., & Schon, E. (2024) · Journal of Alzheimer's Disease · doi:10.3233/jad-231318 · Cited by 16 · see citing works
Vacínová, G., Vejražková, D., Lukášová, P., Lischkova, O., Dvořáková, K., Rusina, R., Holmerová, I., Vaňková, H., Včelák, J., Bendlová, B., et al. (2017) · Molecular Biology Reports · doi:10.1007/s11033-017-4100-9 · Cited by 16 · see citing works
Guizar, P., Abdalla, A. L., Monette, A., Davis, K., Caballero, R. E., Niu, M., Liu, X., Ajibola, O., Murooka, T. T., Chen, L., et al. (2024) · iScience · doi:10.1016/j.isci.2024.110131 · Cited by 7 · see citing works
The Role of Genetics in Alzheimer's Disease and Parkinson's Disease
Porter, T., Gozt, A., Mastaglia, F. L., & Laws, S. M. (2019) · Wiley eBooks · doi:10.1002/9781119356752.ch15 · Cited by 7 · see citing works
Jorgenson, L. M., Knight, L. A., Widner, R. E., & Rucks, E. A. (2023) · Molecular and Cellular Biology · doi:10.1080/10985549.2023.2171695 · Cited by 2 · see citing works
Heath, L. M., Earls, J. C., Magis, A. T., Kornilov, S. A., Lovejoy, J. C., Funk, C. C., Rappaport, N., Logsdon, B. A., Mangravite, L. M., Kunkle, B. W., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1108842/v2 · Cited by 1 · see citing works
Heath, L. M., Earls, J. C., Magis, A. T., Kornilov, S. A., Lovejoy, J. C., Funk, C. C., Rappaport, N., Logsdon, B. A., Mangravite, L. M., Kunkle, B. W., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-1108842/v1
PICALM antibody | knockout validation | Sigma-Aldrich HPA019061
(2016) · Materials and Methods · doi:10.13070/ko.en.6.1699
PICALM :: MLLT10 translocated leukemia
Cullen, J. M., Nakatsugawa, A. C., Barton, N., Haines, H., Stein, G. S., Stein, J. L., Wechsler, D. S., & Heath, J. L. (2026) · FEBS Letters · doi:10.1002/1873-3468.70279
Self-citation
- Authors
- Mercer, J. L., Argus, J. P., Crabtree, D. M., Keenan, M. M., Wilks, M. Q., Chi, J.-T. A., Bensinger, S. J., Lavau, C. P., & Wechsler, D. S.
- Affiliations
- Duke University (US)
- University of California, Los Angeles (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Wechsler, Daniel S.
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-06-15
- Volume
- 10
- Issue
- 6
- Pages
- e0129776
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4467867
- OpenAlex
- W1548216896
- Cited by
- 17
- References
- 83
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Figshare (submittedVersion, cc-by)
- Funders
- Sontag Foundation
- National Institutes of Health
- University of California, Los Angeles
- National Institute of General Medical Sciences (T32GM007184, T32-GM008469, T32GM007754)
- National Institute of Allergy and Infectious Diseases (AI093768, R01AI093768)
- Hyundai Hope On Wheels
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- PICALM, clathrin-mediated endocytosis, cholesterol biosynthesis, lipoprotein uptake, macroautophagy, Alzheimer's disease
- MeSH terms
- Animals, Cell Line, Cholesterol, Homeostasis, Humans, Organ Specificity, Receptors, LDL, Gene Expression, Protein Transport, Monomeric Clathrin Assembly Proteins, RNA Interference, RNA, Small Interfering, Mice, Biosynthetic Pathways, Gene Knockout Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
