Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis
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Autophagy is an evolutionarily conserved pathway responsible for degradation of cytoplasmic material via the lysosome. Although autophagy has been reported to contribute to cell death, the underlying mechanisms remain largely unknown. In this study, we show that autophagy controls DNA fragmentation during late oogenesis in Drosophila melanogaster. Inhibition of autophagy by genetically removing the function of the autophagy genes atg1, atg13, and vps34 resulted in late stage egg chambers that contained persisting nurse cell nuclei without fragmented DNA and attenuation of caspase-3 cleavage. The Drosophila inhibitor of apoptosis (IAP) dBruce was found to colocalize with the autophagic marker GFP-Atg8a and accumulated in autophagy mutants. Nurse cells lacking Atg1 or Vps34 in addition to dBruce contained persisting nurse cell nuclei with fragmented DNA. This indicates that autophagic degradation of dBruce controls DNA fragmentation in nurse cells. Our results reveal autophagic degradation of an IAP as a novel mechanism of triggering cell death and thereby provide a mechanistic link between autophagy and cell death.
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During Drosophila oogenesis, the autophagic apparatus acts upstream of DNA fragmentation by promoting IAP degradation and caspase activation.
“while the autophagic apparatus acts upstream of DNA fragmentation by promoting IAP degradation and caspase activation [845, 846].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [845]
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- Authors
- Nezis, I. P., Shravage, B. V., Sagona, A. P., Lamark, T., Bjørkøy, G., Johansen, T., Rusten, T. E., Brech, A., Baehrecke, E. H., & Stenmark, H.
- Affiliations
- Oslo University Hospital (NO)
- University of Massachusetts Chan Medical School (US)
- UiT The Arctic University of Norway (NO)
- Høgskolen i Sør-Trøndelag (NO)
- Corresponding author
- Stenmark, Harald
- ORCID
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2010-08-16
- Volume
- 190
- Issue
- 4
- Pages
- 523-531
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2928014
- OpenAlex
- W2116991826
- Cited by
- 252
- References
- 38
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 12 · 2023: 18 · 2022: 8 · 2021: 14 · 2020: 16 · 2019: 15 · 2018: 12 · 2017: 19 · 2016: 18 · 2015: 25 · 2014: 26 · 2013: 18 · 2012: 18
- FWCI
- 10.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Cell Biology (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM079431, R01GM079431)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- autophagy, inhibitor of apoptosis proteins, DNA fragmentation, nurse cells, oogenesis, egg chamber, caspase-3 cleavage, Atg1, ATG13, Vps34, Atg8a, cell death, Drosophila melanogaster
- MeSH terms
- Autophagy-Related Proteins, Autophagy-Related Protein-1 Homolog, Animals, Autophagy, Drosophila melanogaster, Female, Oogenesis, Recombinant Fusion Proteins, Cell Death, Protein Serine-Threonine Kinases, Transgenes, Phosphatidylinositol 3-Kinases, Drosophila Proteins, Caspase 3, DNA Fragmentation
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