Cited by 282Alzheimer's disease research and treatmentsMemory and Neural MechanismsDementia and Cognitive Impairment Research

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A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice

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Wolf, Andrea, Bauer, Björn, Abner, Erin L., Ashkenazy-Frolinger, Tal, Hartz, Anika M. S.·2016·PLOS ONE

DOI 10.1371/journal.pone.0147733PMC PMC4726499

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Abstract

Transgenic Tg2576 mice overexpressing human amyloid precursor protein (hAPP) are a widely used Alzheimer's disease (AD) mouse model to evaluate treatment effects on amyloid beta (Aβ) pathology and cognition. Tg2576 mice on a B6;SJL background strain carry a recessive rd1 mutation that leads to early retinal degeneration and visual impairment in homozygous carriers. This can impair performance in behavioral tests that rely on visual cues, and thus, affect study results. Therefore, B6;SJL/Tg2576 mice were systematically backcrossed with 129S6/SvEvTac mice resulting in 129S6/Tg2576 mice that lack the rd1 mutation. 129S6/Tg2576 mice do not develop retinal degeneration but still show Aβ accumulation in the brain that is comparable to the original B6;SJL/Tg2576 mouse. However, comprehensive studies on cognitive decline in 129S6/Tg2576 mice are limited. In this study, we used two dementia mouse models on a 129S6 background--scopolamine-treated 129S6/SvEvTac mice (3-5 month-old) and transgenic 129S6/Tg2576 mice (11-13 month-old)-to establish a behavioral test battery for assessing learning and memory. The test battery consisted of five tests to evaluate different aspects of cognitive impairment: a Y-Maze forced alternation task, a novel object recognition test, the Morris water maze, the radial arm water maze, and a Y-maze spontaneous alternation task. We first established this behavioral test battery with the scopolamine-induced dementia model using 129S6/SvEvTac mice and then evaluated 129S6/Tg2576 mice using the same testing protocol. Both models showed distinctive patterns of cognitive impairment. Together, the non-invasive behavioral test battery presented here allows detecting cognitive impairment in scopolamine-treated 129S6/SvEvTac mice and in transgenic 129S6/Tg2576 mice. Due to the modular nature of this test battery, more behavioral tests, e.g. invasive assays to gain additional cognitive information, can easily be added.

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BackgroundMethodInfluential
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BackgroundMethod
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“Wolf, Bauer, Abner, Ashkenazy-Frolinger, and Hartz (2016), performed 5 days interval between novel object recognition and Morris water maze while delayed just 1 day between two water maze tasks (Wolf et al., 2016).”
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“, 2016) and novel object recognition (NOR) test (Wolf et al., 2016) were conducted in a square test box (40 × 40 × 40 cm3).”
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“T maze spontaneous alternation The T maze spontaneous alternation test was run according to the procedure reported by Wolf and colleagues [40].”
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“The spontaneous alternation Y-maze was used to evaluate the spatial working memory in 14-week-old mice as previously described with few modifications (38).”
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“From day to day reduction in escape latency represents reference memory in the first trail, while working memory is represented from first trial to second trial [57,59,60,61].”
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“The Y-maze forced alternation protocol was adapted from Wolf et al. [32].”
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“Y-maze spontaneous alternation test The Y-maze spontaneous alternation test is used as a behavioral test to assess learning and memory in rodents [30].”
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“A decrease in spontaneous alternation indicates a deficit in spatial working memory, which is a common cognitive impairment in AD [173].”
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“For this set of assessments (Figure 4), we used the Y maze, the novel object recognition (NOR), and the block test, designed to assess memory and learning [22].”
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“This test is used for the evaluation of novel medications for their impact on cognition [22].”
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“less than three arm entries during the first minute of the second Y-maze trial were also excluded (see SI Methods and (Wolf et al., 2016)).”
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“Behavioural experiments in mice have long been an important test and are widely practised worldwide [46, 58].”
Peptide-loaded chitosan nanoparticles improve mitochondrial and cognitive functions via inhibition of Aβ-ABAD interaction in Alzheimer’s disease
Youssef, Y. A., Tammam, S. N., El-Shenawy, B. M., Ilyas, S., Gad, A. A., Farag, K. S., Mathur, S., & Abdel-Kader, R. M. (2025) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2025.114778 · Cited by 12
Dangguijakyak-san ameliorates memory deficits in ovariectomized mice by upregulating hippocampal estrogen synthesis
Hwang, D., Kim, N., Choi, J. G., Kim, H. G., Kim, H., & Oh, M. S. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-2015-6 · Cited by 11
“To examine the effects of DJS-stimulated hippocampal estrogen on memory function, we performed NORT and Y-maze test, which measured cognitive function and spatial working memory of rodents [38].”
Rescuing Kv10.2 protein changes cognitive and emotional function in kainic acid-induced status epilepticus rats
Liu, Y., Duan, Y., Du, D., & Chen, F. (2020) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.106894 · Cited by 11
Postnatal therapeutic approaches in genetic neurodevelopmental disorders
Levy, G., & Barak, B. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.293133 · Cited by 11
“…1999, 2008; Moy et al., 2008), OCD (Burguière et al., 2015; Monteiro and Feng, 2016), cognition properties (Brooks et al., 2005; Crawley, 2008; Wolf et al., 2016), alterations in social behavior (Crawley, 1999, 2008; Moy et al., 2008; Netser et al., 2009), motor functions and anxiety…”
Background
Older Age: A Protective Factor Against Perceived Dignity-Related Distress in Patients With Advanced Cancer?
Pergolizzi, D., Monforte‐Royo, C., Balaguer, A., Porta-Sales, J., Rodríguez‐Prat, A., & Crespo, I. (2020) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2020.09.041 · Cited by 11
Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer’s disease
Chartampila, E., Elayouby, K. S., Leary, P., LaFrancois, J. J., Alcantara‐Gonzalez, D., Jain, S. S., Gerencer, K., Botterill, J. J., Ginsberg, S. D., & Scharfman, H. E. (2024) · eLife · doi:10.7554/elife.89889.4 · Cited by 10
Dapagliflozin mitigates cognitive deficits in a rat model of chronic restrained stress by addressing insulin resistance and mitochondrial dysfunction
Gamal, N., Bakly, W. M. S. E., Saad, S. S. T., El-Waseef, D. A. E.-D. A., El‐Shal, A. S., Morsy, W. E., & Magdy, Y. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04136-5 · Cited by 10
“Both Y maze and MWM tests are commonly used to assess memory and cognition deficits (Wolf et al. 2016).”
Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy
Bhatia, T. N., Clark, R. N., Needham, P. G., Miner, K. M., Jamenis, A. S., Eckhoff, E. A., Abraham, N., Hu, X., Wipf, P., Luk, K. C., et al. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01114-6 · Cited by 10
“Cognitive deficits were assessed by the Y-maze test [88] and anxiety-related behaviors were tested in an open field arena [87, 89, 90].”
Method
Low-molecular weight sulfated marine polysaccharides: Promising molecules to prevent neurodegeneration in mucopolysaccharidosis IIIA?
Veraldi, N., Quadri, I. D., van de Looij, Y., Modernell, L., Sinquin, C., Zykwinska, A., Tournier, B. B., Dalonneau, F., Li, H., Li, J., et al. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.121214 · Cited by 10
Tryptophan Improves Memory Independent of Its Role as a Serotonin Precursor: Potential Involvement of Microtubule Proteins
Yousefzadeh, S. A., Jarah, M., & Riazi, G. H. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01457-y · Cited by 10
“In line with the mentioned functions, microtubules provide a platform for information storage and memory consolidation in neurons (Dent and Baas 2014; Dent 2017; Kaganovsky and Wang 2016; Woolf 2006).”
Background
Phytogenic feed additive (PFA) standardized in labdane diterpens have a protective effect in Salmo salar against Piscirickettsia salmonis
Romero, A., Pérez, T., Santibáñez, N., Vega, M., & Miranda, P. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.736170 · Cited by 10
Immunodetection of rainbow trout IL-8 cleaved-peptide: Tissue bioavailability and potential antibacterial activity in a bacterial infection context
Sáenz-Martínez, D. E., Santana, P., Aróstica, M., Forero, J. C., Guzmán, F., & Mercado, L. A. (2021) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2021.104182 · Cited by 10
Neuroepigenetic alterations in the prefrontal cortex of type 2 diabetic mice through DNA hypermethylation
Fernandes, V., Sood, A., Preeti, K., Khatri, D. K., & Singh, S. B. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-08018-4 · Cited by 8
A Concomitant Muscle Injury Does Not Worsen Traumatic Brain Injury Outcomes in Mice
Sun, M., Brady, R. D., van der Poel, C., Apted, D., Semple, B. D., Church, J. E., O'Brien, T. J., McDonald, S. J., & Shultz, S. R. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01089 · Cited by 9
“Spatial cognition was assessed in Y-maze as previously described (26, 40).”
Method
Effect of Various Intermittent Fasting Protocols on Hyperglycemia-Induced Cognitive Dysfunction in Rats
Alfheeaid, H., Alhowail, A., Ahmed, F., Zaki, A., & Alkhaldy, A. (2023) · Brain Science · doi:10.3390/brainsci13020165 · Cited by 11
“The Y-maze is a behavioral test used to assess the ability of an animal to recognize familiar places and its tendency to explore new pl ces [18].”
BackgroundMethod
Compulsive‐like eating of high‐fat high‐sugar food is associated with ‘addiction‐like’ glutamatergic dysfunction in obesity prone rats
Sketriené, D., Battista, D., Lalert, L., Kraiwattanapirom, N., Thai, H. N., Leeboonngam, T., Knackstedt, L. A., Nithianantharajah, J., Sumithran, P., Lawrence, A. J., et al. (2022) · Addiction Biology · doi:10.1111/adb.13206 · Cited by 10
“receptor mediated currents as compared to NMDA previously observed(5) but a body of literature exists demonstrating a role for NAc GluA2-lacking (presumably GluA1-containing) AMPAR in incubation of drug craving and enduring vulnerability to relapse.(9,16,32)”
Result
Effects of ELF-PEMF exposure on spontaneous alternation, anxiety, motor co-ordination and locomotor activity of adult wistar rats and viability of C6 (Glial) cells in culture
Tekam, C. K. S., Majumdar, S., Kumari, P., Prajapati, S. K., Sahi, A. K., Shinde, S., Singh, R., Samaiya, P. K., Patnaik, R., Krishnamurthy, S., et al. (2022) · Toxicology · doi:10.1016/j.tox.2022.153409 · Cited by 9
Evaluation of molecular mechanisms responsible for in vivo anti-Alzheimer’s property of Euphorbia cotinifolia methanol extract
Saadullah, M., Fakhar-e-alam, M., Muzammil, S., Asif, M., Siddique, M. H., Rashad, M., Atif, M. M., Sayyid, A. H., & Afzal, M. (2023) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2023.102785 · Cited by 9
Behavioral Phenotyping in Developmental Neurotoxicology—Simple Approaches Using Unconditioned Behaviors in Rodents
Graham, D. L., Meyer, J. S., & Stanwood, G. D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809405-1.00025-0 · Cited by 9
Comparative Behavioral Correlation of High and Low-Performing Mice in the Forced Swim Test
Valencia, S. T., Gonzales, E. L., Adil, K. J., Jeon, S. J., Kwon, K. J., Cho, K. S., & Shin, C. Y. (2019) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2018.210 · Cited by 9
Acute Fasting Does Not Induce Cognitive Impairment in Mice
Zheng, H., Ton, H. T., Yang, L., Liufu, N., Dong, Y., Zhang, Y., & Xie, Z. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00896 · Cited by 9
“These results indicated that the acute fasting enhanced the spatial recognition memory of the mice as compared to the control condition, consistent with the findings from the other studies (Rayatnia et al., 2011; Wolf et al., 2016).”
Result
Modulation of the cognitive impairment associated with Alzheimer’s disease by valproic acid: possible drug repurposing
Sorial, M. E. S., Abdelghany, R. M., & Sayed, N. S. E. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01695-0 · Cited by 8
“Percentage of time spent in and the percentage of visits to the novel arm were calculated (Martini et al. 2014; Sanderson et al. 2009; Wolf et al. 2016).”
Handling and novel object recognition modulate fear response and endocannabinoid signaling in nucleus basalis magnocellularis
de Tena, I. B., Moreno‐Rodríguez, M., Llorente‐Ovejero, A., Benito, S. M., Martínez‐Gardeazabal, J., Onandia‐Hinchado, I., Manuel, I., Giménez‐Llort, L., & Rodríguez‐Puertas, R. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15642 · Cited by 6
“…et al., 2010; McIlwain et al., 2001; von Kortzfleisch et al., 2019), the use of behavioral batteries that include several consecutive tests is a usual approach for the evaluation of fear, anxiety, cognition, and learning in rodents (Blanchard et al., 2003; Wolf et al., 2016; You et al., 2019).”
Background
Prenatal Cafeteria Diet Primes Anxiety-like Behavior Associated to Defects in Volume and Diffusion in the Fimbria-fornix of Mice Offspring
Cruz-Carrillo, G., Trujillo-Villarreal, L. A., Ángeles-Valdéz, D., Concha, L., Garza‐Villarreal, E. A., & Camacho‐Morales, A. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.12.021 · Cited by 8
Novel pyrrole based CB2 agonists: New insights on CB2 receptor role in regulating neurotransmitters' tone
Micco, S. D., Ciaglia, T., Salviati, E., Michela, P., Kostrzewa, M., Musella, S., Moriello, A. S., Sarno, V. D., Smaldone, G., Matteo, F. D., et al. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116298 · Cited by 8
Subarachnoid hemorrhage in C57BL/6J mice increases motor stereotypies and compulsive-like behaviors
Nanegrungsunk, D., Ragozzino, M. E., Xu, H., Haselton, K. J., & Paisansathan, C. (2020) · Neurological Research · doi:10.1080/01616412.2020.1841481 · Cited by 8
Leucine Carboxyl Methyltransferase 1 Overexpression Protects Against Cognitive and Electrophysiological Impairments in Tg2576 APP Transgenic Mice
Gnanaprakash, M., Staniszewski, A., Zhang, H., Pitstick, R., Kavanaugh, M. P., Arancio, O., & Nicholls, R. E. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-200462 · Cited by 9
“impairments caused by the rd1 mutation and to exhibit more consistent behavioral performance than animals maintained in the original mixed B6;SJL background [52, 53].”
Background
A PDK-1 Allosteric Agonist Improves Spatial Learning and Memory in a ΒAPP/PS-1 Transgenic Mouse-High Fat Diet Intervention Model of Alzheimer's DiseasePreprint
Querfurth, H. W., Slitt, A. L., DiCamillo, A., Surles, N. O., DeBoef, B., & Lee, H. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4105279 · Cited by 8
Vitamin D3 supplementation improves spatial memory, muscle function, pain score, and modulates different functional physiological biomarkers in vitamin D3 deficiency diet (VDD)-induced rats model
Trivedi, M. K., Branton, A., Trivedi, D., Mondal, S. C., & Jana, S. (2023) · BMC Nutrition · doi:10.1186/s40795-023-00767-0 · Cited by 7
“The novelty test was used to determine the time spent and the number of entries in each arm [12].”
Method
Behavioral and Neurophysiological Implications of Pathological Human Tau Expression in Serotonin Neurons
Khan, N. S., Isaza, J. U., Rouhi, N., Jamani, N. F., Jabeen, S., Gill, A. K., Tsutsui, M., Visser, F., & Sargin, D. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00626 · Cited by 8
N-Acetylcysteine Attenuates Aβ-Mediated Oxidative Stress, Blood–Brain Barrier Leakage, and Renal Dysfunction in 5xFAD Mice
Ontawong, A., Nehra, G., Maloney, B. J., Vaddhanaphuti, C. S., Bauer, B., & Hartz, A. M. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094352 · Cited by 7
“Specific luminal NBD-CSA fluorescence was determined as the difference between the total luminal fluorescence and fluorescence in the presence of the P-gp specific inhibitor PSC833 (5 µ M final concentration).”
Self-citation
MicroRNA210 Suppresses Mitochondrial Metabolism and Promotes Microglial Activation in Neonatal Hypoxic–Ischemic Brain Injury
Hu, S. X., Lopez-Robles, Y., Shen, G., Liu, E., Zhang, L., & Ma, Q. (2025) · Cells · doi:10.3390/cells14151202 · Cited by 7
“The data were analyzed via NIH ImageJ software 1.54e with the MouBeAT plugin [34] by an investigator blinded to experimental groups.”
Augmented impulsive behavior in febrile seizure-induced mice
Remonde, C. G., Gonzales, E. L., Adil, K. J., Jeon, S. J., & Shin, C. Y. (2022) · Toxicological Research · doi:10.1007/s43188-022-00145-1 · Cited by 7
9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer’s disease neuropathology and neuroinflammation in Alzheimer’s disease-like mouse models
Twitto‐Greenberg, R., Zaltsman, S. L., Michaelson, D. M., Liraz, O., Lubitz, I., Atrakchi, D., Shemesh, C., Ashery, U., Cooper, I., Harari, A., et al. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.09.005 · Cited by 7
Diet-induced hyperhomocysteinemia causes sex-dependent deficiencies in offspring musculature and brain function
Suszyńska-Zajczyk, J., Witucki, Ł., Perła‐Kaján, J., & Jakubowski, H. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1322844 · Cited by 7
Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer’s disease
Chartampila, E., Elayouby, K. S., Leary, P., LaFrancois, J. J., Alcantara‐Gonzalez, D., Jain, S. S., Gerencer, K., Botterill, J. J., Ginsberg, S. D., & Scharfman, H. E. (2024) · eLife · doi:10.7554/elife.89889 · Cited by 19
“…used to evaluate cognitive deficits in >9 months-408 old Tg2576 mouse model (i.e., Morris Water Maze, Radial Arm Water Maze, Y-409 Maze; (Yassine et al., 2013; A. Wolf et al., 2016)), provided an opportunity to capture cognitive deficits in animals as young as three months-old (Duffy et al., 2015).”
Diethyl nitrosamine-induces neurobehavioral deficit, oxido-nitrosative stress in rats' brain: a neuroprotective role of diphenyl diselenide
Owumi, S. E., Chimezie, J., Emmanuel, P. D., Okeibuno, A. C., & Owoeye, O. (2024) · BMC Neuroscience · doi:10.1186/s12868-024-00922-8 · Cited by 8
Cpne5 is Involved in Regulating Rodent Anxiety Level
Ding, X., Wang, H., Lü, Q., Hu, Z., Feng, S., Wu, Y., Yang, H., Wu, H., Fan, W., & Fan, M. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12674 · Cited by 7
“To investigate the role of Cpne5, 11 female homozygotes and seven female wild-type mice from littermate were used to perform behavioral test, including open field (OF), Y-maze, novelty recognition (NR), light–dark box (LDB), elevated plus maze (EPM), and elevated platform (EP) task [7].”
Method
A Novel Thermal-Visual Place Learning Paradigm for Honeybees (Apis mellifera)
Scheiner, R., Frantzmann, F., Jäger, M., Mitesser, O., Helfrich‐Förster, C., & Pauls, D. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00056 · Cited by 7
“…a link to vertebrate studies because setups like the Morris Water Maze or the Radial Arm Maze have been used there for many years to study place learning and spatial tasks related to both basic and applied, clinical research (Savonenko et al., 2005; Vorhees and Williams, 2006; Wolf et al., 2016).”
Background
Salt as a non-caloric behavioral modifier: A review of evidence from pre-clinical studies
Beaver, J. N., & Gilman, T. L. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.007 · Cited by 7
Effect of combination therapy with pramipexole and n-acetylcysteine on global cerebral ischemic reperfusion injury in rats.
Danduga, R. C. S. R., Reddy, D. S., Seshadri, S. M., Has, K. S. S., & Kola, P. K. (2018) · Europe PMC (PubMed Central) · doi:10.22038/ijbms.2018.22647.5756 · Cited by 7
“Percentage of spontaneous alternations (%SA) was calculated using the formula (15)”
Method
Patient-derived monoclonal LGI1 autoantibodies elicit seizures, behavioral changes and brain MRI abnormalities in rodent models
Upadhya, M. A., Stumpf, A., O'Brien-Cairney, J., Gómez, C. C., Döring, J. H., Hoffmann, J., Mueller, S. G., Fukata, Y., van Hoof, S., Dhangar, D., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.02.019 · Cited by 7
“Behavioral tests were conducted between days 10 and 14 after surgery following established protocols (Jurek et al., 2019; Wolf et al., 2016) All tasks were performed and assessed by trained experimenters under blinded conditions and contained Open Field (locomotion and anxiety), Rotarod (motor…”
Neurobehavioral and Neuropathological Alterations Induced by Nickel Sulphate Toxicity in Rats: Molecular Mechanisms and Prophylaxis with Curcumin Supplementation
Mehanna, S., Hassan, N. H., Ibrahim, M. A., Mohammed, F. F., & Hassanen, E. I. (2025) · Biological Trace Element Research · doi:10.1007/s12011-025-04654-6 · Cited by 6
“Several brain regions influence this behavior, including the hippocampus, prefrontal cortex, and basal forebrain [43].”
An 8-cage imaging system for automated analyses of mouse behavior
Hernández, T. D. R., Joshi, N. R., Gore, S. V., Kreiling, J. A., & Créton, R. (2023) · Scientific Reports · doi:10.1038/s41598-023-35322-1 · Cited by 6
“A ‘Summary’ table shows the following 15 behaviors in table format: (1) M1 = movement during 1st hour, (2) MD = movement during daytime (average of hours 2–6), (3) M7 = movement in the 7th hour (1st hour of nighttime), (4) MN = movement during nighttime (average of hours 8–12), (5) N-D = The difference between nightti…”
Background
Allosteric inhibition of phosphodiesterase 4D induces biphasic memory-enhancing effects associated with learning-activated signaling pathways
Jino, K., Miyamoto, K., Kanbara, T., Unemura, C., Horiguchi, N., & Ago, Y. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06510-8 · Cited by 6
“In a previous study by Burgin et al. (2010), the intravenous administration of D159687 led to pro-cognitive effects in a dose-dependent manner (0.03–0.1 µg/kg for the scopolamine-impaired Y-maze test and 0.3–10 µg/ kg for the novel object recognition test), rather than having a bell-shaped effect.”
Influential
Eye Drop Instillation of the Rac1 Modulator CNF1 Attenuates Retinal Gliosis and Ameliorates Visual Performance in a Rat Model of Hypertensive Retinopathy
Matteucci, A., Ricceri, L., Fabbri, A., Fortuna, A., Travaglione, S., Guidotti, M., Martinelli, A., Villa, M., Pricci, F., Maroccia, Z., et al. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.05.021 · Cited by 5
Ethanol Exacerbates the Alzheimer’s Disease Pathology in the 5xFAD Mouse Model
Mohammed, H. E., Nelson, J. C., & Marshall, S. A. (2024) · Neuroglia · doi:10.3390/neuroglia5030020 · Cited by 5
“…such as an NOR task with multiple familiar objects, should be performed in the future; additionally, a more comprehensive battery of behavioral assessments that measure cognitive flexibility should be performed to truly assess whether ethanol may accelerate AD-related cognitive decline [44,75,76].”
Elevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion
Russart, K. L. G., Huk, D. J., Nelson, R. J., & Kirschner, L. S. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.12.012 · Cited by 4
“Therefore, this task is a sensitive measure of spatial memory (Wolf et al., 2016).”
Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
Park, K.-M., Kim, J., Choi, I., & Cho, K. (2020) · Journal of Visualized Experiments · doi:10.3791/60751 · Cited by 5

Authors: Wolf, A., Bauer, B., Abner, E. L., Ashkenazy-Frolinger, T., & Hartz, A. M. S.
Affiliations: University of Minnesota, Duluth (US)
University of Kentucky (US)
Corresponding author: Hartz, Anika M. S.
ORCID: Bauer, Björn
Abner, Erin L.
Hartz, Anika M. S.
Venue: PLOS ONE
Publisher: Public Library of Science (PLoS)
Published: 2016-01-25
Volume: 11
Issue: 1
Pages: e0147733
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0147733
PMC: PMC4726499
OpenAlex: W2426168356
Cited by: 281
References: 89
Citations by year: 2026: 16 · 2025: 20 · 2024: 28 · 2023: 37 · 2022: 30 · 2021: 33 · 2020: 37 · 2019: 28 · 2018: 40 · 2017: 6 · 2016: 6
FWCI: 21.46
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
UKnowledge (University of Kentucky) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Funders: University of Kentucky (P30 AG028383, AG028383)
National Institute on Aging (AG-028383, P30AG028383, R01AG039621)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: mouse models of Alzheimer's disease, amyloid precursor protein overexpression, retinal degeneration, scopolamine-induced dementia, cognitive impairment, learning and memory, novel object recognition, Morris water maze, radial arm water maze, spontaneous alternation, amyloid-beta pathology
MeSH terms: Animals, Behavior, Animal, Male, Memory, Mice, Transgenic, Maze Learning, Mice

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A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice

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