The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Colonization with enterotoxigenic Bacteroides fragilis is associated with early-stage colorectal neoplasia
Open accessAbstract
BACKGROUND: Enterotoxigenic Bacteroides fragilis (ETBF) is a toxin-producing bacteria thought to possibly promote colorectal carcinogenesis by modulating the mucosal immune response and inducing epithelial cell changes. Here, we aim to examine the association of colonic mucosal colonization with ETBF and the presence of a range of lesions on the colonic neoplastic spectrum. METHODS: Mucosal tissue from up to four different colonic sites was obtained from a consecutive series of 150 patients referred for colonoscopy. The presence and relative abundance of the B. fragilis toxin gene (bft) in each tissue sample was determined using quantitative PCR, and associations with clinicopathological characteristics were analysed. FINDINGS: We found a high concordance of ETBF between different colonic sites (86%). Univariate analysis showed statistically significant associations between ETBF positivity and the presence of low-grade dysplasia (LGD), tubular adenomas (TA), and serrated polyps (P-values of 0.007, 0.027, and 0.007, respectively). A higher relative abundance of ETBF was significantly associated with LGD and TA (P-values of < 0.0001 and 0.025, respectively). Increased ETBF positivity and abundance was also associated with left-sided biopsies, compared to those from the right side of the colon. CONCLUSION: Our results showing association of ETBF positivity and increased abundance with early-stage carcinogenic lesions underlines its importance in the development of colorectal cancer, and we suggest that detection of ETBF may be a potential marker of early colorectal carcinogenesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Higher proportions of patients with familial adenomatous polyposis42 or sporadic premalignant lesions had intestinal mucosa that tested positive for ETBF than of controls.41”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [41]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2015) · International Journal of Cancer · doi:10.1002/ijc.29210 · Cited by 28,766
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399
Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043
Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812
The keystone-pathogen hypothesis
Hajishengallis, G., Darveau, R. P., & Curtis, M. A. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2873 · Cited by 1,790
A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects
Tjalsma, H., Boleij, A., Marchesi, J. R., & Dutilh, B. E. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2819 · Cited by 903
Gut microbiota imbalance and colorectal cancer
Gagnière, J. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i2.501 · Cited by 890
Microbes, Microbiota, and Colon Cancer
Sears, C. L., & Garrett, W. S. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.007 · Cited by 853
Tumour-associated and non-tumour-associated microbiota in colorectal cancer
Flemer, B., Lynch, D. B., Brown, J. M. R., Jeffery, I. B., Ryan, F. J., Claesson, M. J., O'Riordain, M., Shanahan, F., & O'Toole, P. W. (2017) · Gut · doi:10.1136/gutjnl-2015-309595 · Cited by 804
Microbiota organization is a distinct feature of proximal colorectal cancers
Dejea, C. M., Wick, E. C., Hechenbleikner, E. M., White, J. R., Mark Welch, J. L., Rossetti, B. J., Peterson, S. N., Snesrud, E. C., Borisy, G. G., Lazarev, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406199111 · Cited by 700
Flagged first, then by citations
Research works printed but not linked: 1
- 2015, Selected Cancer 2012, 2013, 2014
Cited by
Sorted by citations
Items 201–230 of 230
Irrazábal, T. (2018) · TSpace (University of Toronto)
Gut Microbiota and Colorectal Cancer
Zeuner, A., Angelis, M. L. D., & Francescangeli, F. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00029-2
The role of intestinal microbiota in the colorectal carcinogenesis
Cardelle‐Cobas, A., Vázquez, B. I., Rocha, J. L., Franco, C., Poza, M., Lago, N. M., & Aparicio, L. M. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-90055-3.00036-3
Messing, E. M. (2021) · Bladder Cancer · doi:10.3233/blc-229000
Arora, R., Hermann, A., & Wargo, J. A. (2019) · Springer eBooks · doi:10.1007/978-1-4614-7147-9_41
Bacteremia and colon cancer: Causality or coincidence?
Corredoira, J., & Ayuso, B. (2022) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/j.eimc.2022.02.003
Microbiome and Cancer Metastasis
White, M. G., Wargo, J. A., & McQuade, J. L. (2022) · Springer eBooks · doi:10.1007/978-3-030-93084-4_73
Alberca, G. G. F. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2020.tde-13012022-153608
Data from The Microbiome and Cancer: Creating Friendly Neighborhoods and Removing the Foes Within
Parida, S., & Sharma, D. (2023) · doi:10.1158/0008-5472.c.6512508.v1
Shields, C. E. D., White, J. R., Chung, L., Wenzel, A. N., Hicks, J. L., Tam, A. J., Chan, J. L., Dejea, C. M., Fan, H., Michel, J. H., et al. (2023) · doi:10.1158/2159-8290.c.6549334.v1
Shields, C. E. D., White, J. R., Chung, L., Wenzel, A. N., Hicks, J. L., Tam, A. J., Chan, J. L., Dejea, C. M., Fan, H., Michel, J. H., et al. (2023) · doi:10.1158/2159-8290.c.6549334
Mikrobiom und gastrointestinale Erkrankungen
Ammer‐Herrmenau, C., & Hamm, J. (2023) · Springer Reference Medizin · doi:10.1007/978-3-642-54676-1_578-1
Pace, G. M., Costantino, A., Festa, B. M., Giannitto, C., Franzese, C., Spriano, G., Bossi, P., & VIRGILIO, A. D. (2023) · Otorhinolaryngology · doi:10.23736/s2724-6302.23.02511-2
Shagaleeva, O. Y., Pobeguts, O. V., Kashatnikova, D. A., Kardonsky, D. A., Vorob'eva, E. M., Silantiev, A. S., Efimov, B. A., Matyushkina, D. S., Vanyushkina, A., & Zakharzhevskaya, N. B. (2024) · Research Square · doi:10.21203/rs.3.rs-3970402/v1
Micro-nano Plastics: Development of Carcinogenicity
Chatterjee, A., Goswami, R., Chatterjee, P., Ramavat, A., & Santos, J. (2025) · Sustainable development goals series · doi:10.1007/978-981-96-5047-7_22
Oliero, M., Hajjar, R., Cuisiniere, T., Fragoso, G., Calvé, A., Dagbert, F., Loungnarath, R., Sebajang, H., Schwenter, F., Wassef, R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26557955
Libera, K. D., Adamowicz, E. M., Muehlbauer, A. L., Priya, S., Alazizi, A., Luca, F., & Blekhman, R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.26.700635
Role of the microbiome on epigenetic changes in pancreatic and colon cancers
Patel, M., Alsaleh, T., & George, J. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27765-8.00004-7
Role of the gut microbiome in the development of colorectal cancer
Shanbhag, A. P. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40483-2.00040-6
Srinivas, P., Adebomi, V., Markiewicz, S. M., Wang, K., Chac, D., Lindenauer, K., Huber, N., Tao, Z., Luong, P., Rettie, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.22.733822
Dang, J. T., Lee, Y., Wills, M. V., Brown, J. M., Madsen, K., & Mocanu, V. (2026) · British journal of surgery · doi:10.1093/bjs/znag082
Colonic mucus attenuates Bacteroides fragilis virulence in vitro
Dawson, K. L., Day, A. S., & Keenan, J. I. (2026) · Anaerobe · doi:10.1016/j.anaerobe.2026.103070
Self-citationIONESCU, V.-A., Gheorghe, G., Turculet, C. Ş., Georgescu, T. F., Bratu, M. R., Baban, I.-A., Mambet, C., Diaconu, C. C., Enache, V., Dragu, L. D., et al. (2026) · Biomedicines · doi:10.3390/biomedicines14081741
Microbiome and Diseases: Colorectal Cancer
Zeißig, S., Jokisch, F., Peuker, K., & Janssen, K. (2026) · Springer eBooks · doi:10.1007/978-3-032-26410-7_15
Microbiome-based strategies to overcome chemoresistance: Probiotics and prebiotics in cancer therapy
Kotthapalli, P., Joji, D., & Archer, A. C. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33206-7.00003-0
Deng, J., Chen, D., Shen, S., Zhou, Y., Cui, H., Qiu, Y., Li, Q., & Hu, Y. (2026) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1014844
Dietary exposures, microbial ecology and carcinogenesis: An integrated review
Kang, X., Soh, W. S., & Wong, S. H. (2026) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2026.102155
Monaghan, T. M., Polytarchou, C., Hatziapostolou, M., & Nateri, A. S. (2026) · Targetome · doi:10.48130/targetome-0026-0051
Metadata
- Authors
- Purcell, R. V., Pearson, J., Aitchison, A., Dixon, L., Frizelle, F. A., & Keenan, J. I.
- Affiliations
- University of Otago (NZ)
- Corresponding author
- Purcell, Rachel V.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-02-02
- Volume
- 12
- Issue
- 2
- Pages
- e0171602
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5289627
- OpenAlex
- W2583680774
- Cited by
- 230
- References
- 30
- Citations by year
- 2026: 18 · 2025: 21 · 2024: 20 · 2023: 27 · 2022: 28 · 2021: 27 · 2020: 36 · 2019: 31 · 2018: 18 · 2017: 4
- FWCI
- 10.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- enterotoxigenic Bacteroides fragilis, colorectal neoplasia, colorectal carcinogenesis, low-grade dysplasia, tubular adenoma, serrated polyps, left-sided colon
- MeSH terms
- Adult, Aged, Aged, 80 and over, Bacterial Toxins, Bacteroides fragilis, Bacteroides Infections, Colon, Female, Humans, Intestinal Mucosa, Male, Metalloendopeptidases, Middle Aged, Colorectal Neoplasms, Polymerase Chain Reaction, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
