Cited by 230Colorectal Cancer Screening and DetectionGut microbiota and healthClostridium difficile and Clostridium perfringens research

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Colonization with enterotoxigenic Bacteroides fragilis is associated with early-stage colorectal neoplasia

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Purcell, Rachel V., Pearson, John, Aitchison, Alan, Dixon, Liane, Frizelle, Frank A., Keenan, Jacqueline I.·2017·PLoS ONE

DOI 10.1371/journal.pone.0171602PMC PMC5289627

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Abstract

BACKGROUND: Enterotoxigenic Bacteroides fragilis (ETBF) is a toxin-producing bacteria thought to possibly promote colorectal carcinogenesis by modulating the mucosal immune response and inducing epithelial cell changes. Here, we aim to examine the association of colonic mucosal colonization with ETBF and the presence of a range of lesions on the colonic neoplastic spectrum. METHODS: Mucosal tissue from up to four different colonic sites was obtained from a consecutive series of 150 patients referred for colonoscopy. The presence and relative abundance of the B. fragilis toxin gene (bft) in each tissue sample was determined using quantitative PCR, and associations with clinicopathological characteristics were analysed. FINDINGS: We found a high concordance of ETBF between different colonic sites (86%). Univariate analysis showed statistically significant associations between ETBF positivity and the presence of low-grade dysplasia (LGD), tubular adenomas (TA), and serrated polyps (P-values of 0.007, 0.027, and 0.007, respectively). A higher relative abundance of ETBF was significantly associated with LGD and TA (P-values of < 0.0001 and 0.025, respectively). Increased ETBF positivity and abundance was also associated with left-sided biopsies, compared to those from the right side of the colon. CONCLUSION: Our results showing association of ETBF positivity and increased abundance with early-stage carcinogenic lesions underlines its importance in the development of colorectal cancer, and we suggest that detection of ETBF may be a potential marker of early colorectal carcinogenesis.

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Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2015) · International Journal of Cancer · doi:10.1002/ijc.29210 · Cited by 28,766
Cancer-related inflammation
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399
Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812
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Gagnière, J. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i2.501 · Cited by 890
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Sears, C. L., & Garrett, W. S. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.007 · Cited by 853
Tumour-associated and non-tumour-associated microbiota in colorectal cancer
Flemer, B., Lynch, D. B., Brown, J. M. R., Jeffery, I. B., Ryan, F. J., Claesson, M. J., O'Riordain, M., Shanahan, F., & O'Toole, P. W. (2017) · Gut · doi:10.1136/gutjnl-2015-309595 · Cited by 804
Microbiota organization is a distinct feature of proximal colorectal cancers
Dejea, C. M., Wick, E. C., Hechenbleikner, E. M., White, J. R., Mark Welch, J. L., Rossetti, B. J., Peterson, S. N., Snesrud, E. C., Borisy, G. G., Lazarev, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406199111 · Cited by 700

Show all 30 references

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Garraway, K., Johannes, C. M., Bryan, A., Peauroi, J. R., Rossi, G., Zhang, M., Wang, C., Allenspach, K., & Jergens, A. E. (2018) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.15291 · Cited by 30
The Impact of the Gut Microbiome on Colorectal Cancer
Maisonneuve, C., Irrazábal, T., Martín, A., Girardin, S. E., & Philpott, D. J. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030617-050240 · Cited by 30
Characterization of Mucosal Dysbiosis of Early Colonic Neoplasia
Hong, B., Ideta, T., Lemos, B. S., Igarashi, Y., Tan, Y., DiSiena, M., Mo, A., Birk, J. W., Forouhar, F., Devers, T. J., et al. (2019) · npj Precision Oncology · doi:10.1038/s41698-019-0101-6 · Cited by 33
Antibiotic use and colorectal neoplasia: a systematic review and meta-analysis
Aneke-Nash, C. S., Yoon, G. H., Du, M., & Liang, P. S. (2021) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2021-000601 · Cited by 33
Local Breast Microbiota: A “New” Player on the Block
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Retracted
Increasing Incidence of Young-Onset Colorectal Carcinoma A 3-Country Population Analysis
Chittleborough, T. J., Gutlic, I., Pearson, J. F., Watson, A. J. M., Bhatti, L. A., Buchwald, P., Potter, J. D., Wakeman, C. J., Eglinton, T., & Frizelle, F. (2020) · Diseases of the Colon & Rectum · doi:10.1097/dcr.0000000000001631 · Cited by 28
Self-citation
Gut Microbiota and Immune Responses
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Nutritional Interventions Targeting Gut Microbiota during Cancer Therapies
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Effect of gut microbiota in the colorectal cancer and potential target therapy
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Lawrence, G. W., Begley, M., Cotter, P. D., & Guinane, C. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030924 · Cited by 25
Fusobacterium nucleatum in biopsied tissues from colorectal cancer patients and alcohol consumption in Korea
Kim, M., Lee, S., Choi, S., Lee, H., Kwon, S. S., Byun, J., Kim, Y. A., Rhee, K., Choi, J. R., Kim, T. I., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-76467-7 · Cited by 25
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Microbiome in drug resistance to colon cancer
Pandey, K. R., & Umar, S. (2021) · Current Opinion in Physiology · doi:10.1016/j.cophys.2021.100472 · Cited by 24
Application and development of noninvasive biomarkers for colorectal cancer screening: a systematic review
Song, D., Wang, F., Ju, Y., He, Q., Sun, T., Deng, W., Ding, R., Zhang, C., Xu, Q., Qi, C., et al. (2023) · International Journal of Surgery · doi:10.1097/js9.0000000000000260 · Cited by 26
The Microbiome-Immune Axis Therapeutic Effects in Cancer Treatments
Son, Y. M., & Kim, J. (2022) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2208.08002 · Cited by 23
The role of adjuvant probiotics to attenuate intestinal inflammatory responses due to cancer treatments
Thomsen, M., Clarke, S. J., & Vitetta, L. (2018) · Beneficial Microbes · doi:10.3920/bm2017.0172 · Cited by 23
The Complex Puzzle of Interactions Among Functional Food, Gut Microbiota, and Colorectal Cancer
Mendonça, L. A. B. M., Ferreira, R. D. S., Guimarães, R. D. C. A., de Castro, A. P., Franco, O. L., Matias, R., & Carvalho, C. M. E. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00325 · Cited by 23

Authors: Purcell, R. V., Pearson, J., Aitchison, A., Dixon, L., Frizelle, F. A., & Keenan, J. I.
Affiliations: University of Otago (NZ)
Corresponding author: Purcell, Rachel V.
ORCID: Purcell, Rachel V.
Pearson, John
Aitchison, Alan
Frizelle, Frank A.
Keenan, Jacqueline I.
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2017-02-02
Volume: 12
Issue: 2
Pages: e0171602
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0171602
PMC: PMC5289627
OpenAlex: W2583680774
Cited by: 230
References: 30
Citations by year: 2026: 18 · 2025: 21 · 2024: 20 · 2023: 27 · 2022: 28 · 2021: 27 · 2020: 36 · 2019: 31 · 2018: 18 · 2017: 4
FWCI: 10.73
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Keywords: enterotoxigenic Bacteroides fragilis, colorectal neoplasia, colorectal carcinogenesis, low-grade dysplasia, tubular adenoma, serrated polyps, left-sided colon
MeSH terms: Adult, Aged, Aged, 80 and over, Bacterial Toxins, Bacteroides fragilis, Bacteroides Infections, Colon, Female, Humans, Intestinal Mucosa, Male, Metalloendopeptidases, Middle Aged, Colorectal Neoplasms, Polymerase Chain Reaction, Young Adult

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Colonization with enterotoxigenic Bacteroides fragilis is associated with early-stage colorectal neoplasia

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