Identification of genome-wide targets of Olig2 in the adult mouse spinal cord using ChIP-Seq
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In jawed vertebrates, oligodendrocytes (OLs) are the myelin-producing glial cells responsible for ensheathment of axons within the central nervous system and are also crucial for remyelination following injury or disease. Olig2 is a crucial factor in the specification and differentiation of oligodendrocyte precursor cells (OPCs) that give rise to mature, myelin-producing OLs in the developing and postnatal CNS; however, its role in adulthood is less well understood. To investigate the role Olig2 plays in regulating gene expression in the adult OL lineage in a physiologically-relevant context, we performed chromatin immunoprecipitation followed by next generation sequencing analysis (ChIP-Seq) using whole spinal cord tissue harvested from adult mice. We found that many of the Olig2-bound sites were associated with genes with biological processes corresponding to OL differentiation (Nkx2.2, Nkx6.2, and Sip1), myelination and ensheathment (Mbp, Cldn11, and Mobp), as well as cell cycle and cytoskeletal regulation. This suggests Olig2 continues to play a critical role in processes related to OL differentiation and myelination well into adulthood.
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Several motifs were enriched in Olig2 single-cell CUT&Tag, including CAGMTG similar to the previously identified Olig2 motif.
“We found several motifs enriched in the Olig2 scCUT&Tag, including motif CAGMTG, similar to the previously identified CAGMTG/CAGCTG motif specific for Olig2 (Figure 5h) in mouse33 and rat34 respectively.”
From Single-cell CUT&Tag profiles histone modifications and transcription factors in complex tissues (2021) · cites this paper as [34]
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Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607 · see citing works
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386 · see citing works
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382 · see citing works
Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction
Ye, J., Coulouris, G., Zaretskaya, I., Cutcutache, I., Rozen, S., & Madden, T. (2012) · BMC Bioinformatics · doi:10.1186/1471-2105-13-134 · Cited by 6,133 · see citing works
Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875 · see citing works
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029 · see citing works
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129 · see citing works
VISTA: computational tools for comparative genomics
Frazer, K. A., Pachter, L. S., Poliakov, A., Rubin, E. M., & Dubchak, I. L. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh458 · Cited by 2,791 · see citing works
ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia
Landt, S. G., Marinov, G. K., Kundaje, A., Kheradpour, P., Pauli, F., Batzoglou, S., Bernstein, B. E., Bickel, P., Brown, J. B., Cayting, P., et al. (2012) · Genome Research · doi:10.1101/gr.136184.111 · Cited by 2,033 · see citing works
Mi, H., Huang, X., Muruganujan, A., Tang, H., Mills, C., Kang, D. S., & Thomas, P. D. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1138 · Cited by 1,985 · see citing works
Helix-Loop-Helix Proteins: Regulators of Transcription in Eucaryotic Organisms
Massari, M. E., & Murre, C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.2.429-440.2000 · Cited by 1,800 · see citing works
Oligodendroglia metabolically support axons and contribute to neurodegeneration
Lee, Y., Morrison, B. M., Li, Y., Lengacher, S., Farah, M. H., Hoffman, P. N., Liu, Y., Tsingalia, A., Jin, L., Zhang, P.-W., et al. (2012) · Nature · doi:10.1038/nature11314 · Cited by 1,664 · see citing works
Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
Marques, S., Zeisel, A., Codeluppi, S., van Bruggen, D., Mendanha Falcão, A., Xiao, L., Li, H., Häring, M., Hochgerner, H., Romanov, R. A., et al. (2016) · Science · doi:10.1126/science.aaf6463 · Cited by 1,246 · see citing works
Lu, Q. R., Sun, T., Zhu, Z.-M., Ma, N., García, M., Stiles, C., & Rowitch, D. (2002) · Cell · doi:10.1016/s0092-8674(02)00678-5 · Cited by 1,064 · see citing works
The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification
Zhou, Q., & Anderson, D. J. (2002) · Cell · doi:10.1016/s0092-8674(02)00677-3 · Cited by 1,059 · see citing works
Dawson, M. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00210-0 · Cited by 927 · see citing works
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
Suvà, M. L., Rheinbay, E., Gillespie, S. M., Patel, A. P., Wakimoto, H., Rabkin, S. D., Riggi, N., Chi, A. S., Cahill, D. P., Nahed, B. V., et al. (2014) · Cell · doi:10.1016/j.cell.2014.02.030 · Cited by 927 · see citing works
Stolt, C. C., Rehberg, S., Ader, M., Lommes, P., Riethmacher, D., Schachner, M., Bartsch, U., & Wegner, M. (2002) · Genes & Development · doi:10.1101/gad.215802 · Cited by 685 · see citing works
Zhang, B., Arun, G., Mao, Y. S., Lazar, Z., Hung, G., Bhattacharjee, G., Xiao, X., Booth, C. J., Wu, J., Zhang, C., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.06.003 · Cited by 598 · see citing works
Oligodendrocyte Development and PlasticityPreprint
Bergles, D. E., & Richardson, W. D. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020453 · Cited by 573 · see citing works
Dicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination
Dugas, J. C., Cuellar, T. L., Scholze, A., Ason, B., Ibrahim, A., Emery, B., Zamanian, J. L., Foo, L. C., McManus, M. T., & Barres, B. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.027 · Cited by 527 · see citing works
Ligon, K., Huillard, E., Mehta, S., Kesari, S., Liu, H.-Y., Alberta, J., Bachoo, R., Kane, M., Louis, D., DePinho, R., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.009 · Cited by 525 · see citing works
Takebayashi, H., Nabeshima, Y., Yoshida, S., Chisaka, O., Ikenaka, K., & Nabeshima, Y. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00926-0 · Cited by 500 · see citing works
Protective and therapeutic role for αB-crystallin in autoimmune demyelination
Ousman, S., Tomooka, B. H., van Noort, J., Wawrousek, E., O'Conner, K., Hafler, D., Sobel, R., Robinson, W., & Steinman, L. (2007) · Nature · doi:10.1038/nature05935 · Cited by 491 · see citing works
Rapid Conduction and the Evolution of Giant Axons and Myelinated Fibers
Hartline, D. K., & Colman, D. R. (2007) · Current Biology · doi:10.1016/j.cub.2006.11.042 · Cited by 478 · see citing works
Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice
Fruttiger, M., Karlsson, L. K., Hall, A. C., Abramsson, A., Calver, A. R., Boström, H., Willetts, K. E., Bertold, C.-H., Heath, J. K., Betsholtz, C., et al. (1999) · Development · doi:10.1242/dev.126.3.457 · Cited by 440 · see citing works
Oligodendrocyte-Encoded HIF Function Couples Postnatal Myelination and White Matter Angiogenesis
Yuen, T. J., Silbereis, J. C., Griveau, A., Chang, S. M., Daneman, R., Fancy, S. P. J., Zahed, H., Maltepe, E., & Rowitch, D. H. (2014) · Cell · doi:10.1016/j.cell.2014.04.052 · Cited by 433 · see citing works
Regulation of Oligodendrocyte Development and Myelination by Glucose and Lactate
Rinholm, J. E., Hamilton, N. B., Kessaris, N., Richardson, W. D., Bergersen, L. H., & Attwell, D. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3516-10.2011 · Cited by 383 · see citing works
Olig2 Targets Chromatin Remodelers to Enhancers to Initiate Oligodendrocyte Differentiation
Yu, Y., Chen, Y., Kim, B., Wang, H., Zhao, C., He, X., Liu, L., Liu, W., Wu, L. M. N., Mao, M., et al. (2013) · Cell · doi:10.1016/j.cell.2012.12.006 · Cited by 375 · see citing works
Control of oligodendrocyte differentiation by theNkx2.2homeodomain transcription factor
Qi, Y. B., Cai, J., Wu, Y., Wu, R., Lee, J. D., Fu, H. Q., Rao, M. S., Sussel, L., Rubenstein, J. L. R., & Qiu, M. S. (2001) · Development · doi:10.1242/dev.128.14.2723 · Cited by 356 · see citing works
Self-citationMultiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain.
Vallstedt, A., Klos, J. M., & Ericson, J. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.026 · Cited by 346 · see citing works
Cai, J., Qi, Y., Hu, X.-M., Tan, M., Liu, Z., Zhang, J.-S., Li, Q., Sander, M., & Qiu, M.-S. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.028 · Cited by 345 · see citing works
CNS Myelin Wrapping Is Driven by Actin Disassembly
Zuchero, J. B., Fu, M.-M., Sloan, S. A., Ibrahim, A., Olson, A., Zaremba, A., Dugas, J. C., Wienbar, S., Caprariello, A. V., Kantor, C., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.06.011 · Cited by 335 · see citing works
Functional Genomic Analysis of Oligodendrocyte Differentiation
Dugas, J. C., Tai, Y. C., Speed, T. P., Ngai, J., & Barres, B. A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2572-06.2006 · Cited by 324 · see citing works
Pringle, N. P., Yu, W., Guthrie, S., Roelink, H., Lumsden, A., Peterson, A. C., & Richardson, W. D. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0142 · Cited by 281 · see citing works
Li, W., Zhang, B., Tang, J., Cao, Q., Wu, Y., Wu, C. A., Guo, J., Ling, E., & Liang, F. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4181-06.2007 · Cited by 265 · see citing works
Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors
Orentas, D. M., Hayes, J. E., Dyer, K. L., & Miller, R. H. (1999) · Development · doi:10.1242/dev.126.11.2419 · Cited by 265 · see citing works
A Role for the Helix-Loop-Helix Protein Id2 in the Control of Oligodendrocyte Development
Wang, S., Sdrulla, A. D., Johnson, J. E. B., Yokota, Y., & Barres, B. A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00237-9 · Cited by 261 · see citing works
A High-Resolution Enhancer Atlas of the Developing Telencephalon
Visel, A., Taher, L., Girgis, H., May, D., Golonzhka, O., Hoch, R. V., McKinsey, G. L., Pattabiraman, K., Silberberg, S. N., Blow, M. J., et al. (2013) · Cell · doi:10.1016/j.cell.2012.12.041 · Cited by 257 · see citing works
Myelinogenesis and Axonal Recognition by Oligodendrocytes in Brain Are Uncoupled in Olig1-Null Mice
Xin, M., Yue, T., Ma, Z.-Y., Wu, F.-F., Gow, A., & Lu, Q. R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3034-04.2005 · Cited by 253 · see citing works
Identification of Dynamically Regulated MicroRNA and mRNA Networks in Developing Oligodendrocytes
Lau, P., Verrier, J. D., Nielsen, J. A., Johnson, K. R., Notterpek, L., & Hudson, L. D. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1932-08.2008 · Cited by 252 · see citing works
Lecca, D., Trincavelli, M. L., Gelosa, P., Sironi, L., Ciana, P., Fumagalli, M., Villa, G. C. F., Verderio, C., Grumelli, C., Guerrini, U., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003579 · Cited by 227 · see citing works
Nawaz, S., Sánchez, P., Schmitt, S., Snaidero, N., Mitkovski, M., Velte, C., Brückner, B., Alexopoulos, I., Czopka, T., Jung, S. Y., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.05.013 · Cited by 214 · see citing works
A crucial role for Olig2 in white matter astrocyte development
Cai, J., Chen, Y., Cai, W.-H., Hurlock, E. C., Wu, H., Kernie, S. G., Parada, L. F., & Lu, Q. R. (2007) · Development · doi:10.1242/dev.02847 · Cited by 203 · see citing works
The Id4 HLH protein and the timing of oligodendrocyte differentiation
Kondo, T., & Raff, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.9.1998 · Cited by 203 · see citing works
Tripathi, R. B., Clarke, L. E., Burzomato, V., Kessaris, N., Anderson, P. N., Attwell, D., & Richardson, W. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6474-10.2011 · Cited by 199 · see citing works
Masahira, N., Takebayashi, H., Ono, K., Watanabe, K., Ding, L., Furusho, M., Ogawa, Y., Nabeshima, Y., Álvarez-Buylla, A., Shimizu, K., et al. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.02.029 · Cited by 182 · see citing works
Lee, J., Gravel, M., Zhang, R., Thibault, P., & Braun, P. E. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200411047 · Cited by 175 · see citing works
Self-citationmiR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS
Wang, H., Moyano, A. L., Ma, Z., Deng, Y., Lin, Y., Zhao, C., Zhang, L., Jiang, M., He, X., Ma, Z., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.03.001 · Cited by 174 · see citing works
The origin of the myelination program in vertebrates
Zalc, B., Goujet, D. F., & Colman, D. (2008) · Current Biology · doi:10.1016/j.cub.2008.04.010 · Cited by 166 · see citing works
Weng, Q.-J., Chen, Y., Wang, H.-B., Xu, X., Yang, B., He, Q., Shou, W., Chen, Y., Higashi, Y., van den Berghe, V., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.12.021 · Cited by 165 · see citing works
Mehta, S. V., Huillard, E., Kesari, S., Maire, C. L., Golebiowski, D., Harrington, E. P., Alberta, J. A., Kane, M., Theisen, M., Ligon, K. L., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.01.035 · Cited by 158 · see citing works
Demyelination in spinal cord injury
Waxman, S. G. (1989) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(89)90072-5 · Cited by 155 · see citing works
Zhao, C., Deng, Y., Liu, L., Yu, K., Zhang, L., Wang, H., He, X., Wang, J., Lu, C., Wu, L. N., et al. (2016) · Nature Communications · doi:10.1038/ncomms10883 · Cited by 154 · see citing works
Bifulco, M., Laezza, C., Stingo, S., & Wolff, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042678799 · Cited by 147 · see citing works
Thurnherr, T., Benninger, Y., Wu, X., Chrostek, A., Krause, S. M., Nave, K.-A., Franklin, R. J. M., Brakebusch, C., Suter, U., & Relvas, J. B. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2158-06.2006 · Cited by 142 · see citing works
AXONAL TRANSECTION IN THE LESIONS OF MULTIPLE SCLEROSIS
Rapp, D., Eterson, J. O. P., Ansohoff, R. I. M. R., Udick, R. I. R., & Örk, S. V. M. (1998) · Cited by 141 · see citing works
Küspert, M., Hammer, A., Bösl, M., & Wegner, M. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq951 · Cited by 136 · see citing works
He, D., Wang, J., Lu, Y., Deng, Y., Zhao, C., Xu, L., Chen, Y., Hu, Y., Zhou, W., & Lu, Q. R. (2016) · Neuron · doi:10.1016/j.neuron.2016.11.044 · Cited by 135 · see citing works
Chen, Y., Miles, D., Hoang, T., Shi, J., Hurlock, E., Kernie, S., & Lu, Q. R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3545-08.2008 · Cited by 112 · see citing works
Ou, Z., Sun, Y., Li, L., You, N., Liu, X., Li, H., Ma, Y., Cao, L., Han, Y., Liu, M., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0898-16.2016 · Cited by 91 · see citing works
Oligodendrocyte precursors originate from both the dorsal and the ventral parts of the spinal cord
Cameron-Curry, P., & Douarin, N. M. L. (1995) · Neuron · doi:10.1016/0896-6273(95)90009-8 · Cited by 90 · see citing works
Dong, X., Chen, K., Durán, R. C., You, Y., Sloan, S. A., Zhang, Y., Zong, S., Cao, Q., Barres, B. A., & Wu, J. Q. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005669 · Cited by 82 · see citing works
The transcriptome of mouse central nervous system myelin
Thakurela, S., Garding, A., Jung, R. B., Müller, C., Goebbels, S., White, R., Werner, H. B., & Tiwari, V. K. (2016) · Scientific Reports · doi:10.1038/srep25828 · Cited by 81 · see citing works
Embryonic stem cell-based system for mapping developmental transcriptional programs
Mazzoni, E. O., Mahony, S., Iacovino, M., Morrison, C. A., Mountoufaris, G., Closser, M., Whyte, W. A., Young, R. A., Kyba, M., Gifford, D. K., et al. (2011) · Europe PMC (PubMed Central) · doi:10.1038/nmeth.1775 · Cited by 79 · see citing works
Awatramani, R., Scherer, S. S., Grinspan, J. B., Collarini, E. J., Skoff, R. P., O’Hagan, D., Garbern, J. Y., & Kamholz, J. A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-17-06657.1997 · Cited by 74 · see citing works
Reynaud, C., Fabre, S., & Jalinot, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000465200 · Cited by 72 · see citing works
Leukodystrophies: recent developments in genetics, molecular biology, pathogenesis and treatment*
Berger, J., Moser, H. W., & Forss‐Petter, S. (2001) · Current Opinion in Neurology · doi:10.1097/00019052-200106000-00007 · Cited by 64 · see citing works
Fan, H., Chen, L.-X., Qu, X., Ren, C., Wu, X., Dong, F., Zhang, B., Gao, D., & Yao, R. (2017) · Scientific Reports · doi:10.1038/srep41407 · Cited by 62 · see citing works
Changes in CLIP3 expression after sciatic nerve injury in adult rats
Deng, X., Wei, H., Lou, D., Sun, B., Chen, H., Zhang, Y., & Wang, Y. (2012) · Journal of Molecular Histology · doi:10.1007/s10735-012-9450-y · Cited by 11 · see citing works
Septins in the glial cells of the nervous system
Patzig, J., Dworschak, M. S., Martens, A., & Werner, H. B. (2013) · Biological Chemistry · doi:10.1515/hsz-2013-0240 · Cited by 10 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [11]Pringle NP, Yu WP, Guthrie S, Roelink H, Lumsden A, Peterson AC, et al Determination of neuroepithelial cell fate: induction of the OL lineage by ventral midline cells and sonic hedgehog. Dev Biol. 1996; 177(1): 30– 42. doi: 10.1006/dbio.1996.0142 8660874 · DOI
Cited by
Sorted by citations
Single-cell CUT&Tag profiles histone modifications and transcription factors in complex tissues
Bartosovic, M., Kabbe, M., & Castelo-Branco, G. (2021) · Nature Biotechnology · doi:10.1038/s41587-021-00869-9 · Cited by 483 · see citing works
Seixas, A. I., Azevedo, M. M., de Faria, J. P., Fernandes, D. C., Pinto, I. M., & Relvas, J. B. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2915-8 · Cited by 40 · see citing works
Regulators of Oligodendrocyte DifferentiationPreprint
Emery, B., & Wood, T. L. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041358 · Cited by 35 · see citing works
Yang, F., Guan, Y., Feng, X. M., Rolfs, A., Schlüter, H., & Luo, J. (2019) · Molecular Brain · doi:10.1186/s13041-019-0440-9 · Cited by 30 · see citing works
Arx Expression Suppresses Ventralization of the Developing Dorsal Forebrain
Lim, Y., Cho, I.-T., Shi, X., Grinspan, J., Cho, G., & Golden, J. (2019) · Scientific Reports · doi:10.1038/s41598-018-36194-6 · Cited by 19 · see citing works
Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179
Li, Y., Lim, C., Dismuke, T., Malawsky, D. S., Oasa, S., Bruce, Z. C., Offenhäuser, C., Baumgartner, U., D’Souza, R. C. J., Edwards, S. L., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-54861-3 · Cited by 23 · see citing works
Evolutionary Origins of the Oligodendrocyte Cell Type and Adaptive Myelination
Hines, J. H. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.757360 · Cited by 16 · see citing works
Chowdhury, R., Wang, Y., Campbell, M., Goderie, S. K., Doyle, F., Tenenbaum, S. A., Kusek, G., Kiehl, T. R., Ansari, S. A., Boles, N. C., et al. (2021) · Development · doi:10.1242/dev.199376 · Cited by 17 · see citing works
Manipulating Adult Neural Stem and Progenitor Cells with G-Quadruplex Ligands
Goldberg, D. C., Fones, L., Vivinetto, A. L., Caufield, J. T., Ratan, R. R., & Cave, J. W. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00194 · Cited by 17 · see citing works
Single-cell profiling of histone modifications in the mouse brainPreprint
Bartošovič, M., Kabbe, M., & Castelo‐Branco, G. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.02.279703 · Cited by 15 · see citing works
c‐Abl‐induced Olig2 phosphorylation regulates the proliferation of oligodendrocyte precursor cells
Zhang, J., Sun, J.-G., Xing, X., Wu, R.-R., Zhou, L., Zhang, Y., Yuan, F., Wang, S., & Yuan, Z.-Q. (2022) · Glia · doi:10.1002/glia.24157 · Cited by 7 · see citing works
Kremp, M., Aberle, T., Sock, E., Bohl, B., Hillgärtner, S., Winkler, J., & Wegner, M. (2024) · Glia · doi:10.1002/glia.24538 · Cited by 3 · see citing works
Li, Y.-C., Dismuke, T., Lim, C., Bruce, Z. C., Offenhäuser, C., Baumgartner, U., Maybury, M., D'Souza, R. C. J., Hassall, T., Wainwright, B., et al. (2022) · bioRxiv · doi:10.1101/2022.02.14.480293 · Cited by 2 · see citing works
Olig2 knockdown alleviates hypoxic-ischemic brain damage in newborn rats.
Yang, L., & Cui, H. (2021) · PubMed · doi:10.14670/hh-18-344
- Authors
- Darr, A. J., Danzi, M. C., Brady, L., Emig-Agius, D., Hackett, A., Golshani, R., Warner, N., Lee, J., Lemmon, V. P., & Tsoulfas, P.
- Affiliations
- University of Miami (US)
- Illumina (United States) (US)
- Corresponding author
- Tsoulfas, Pantelis
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-10-19
- Volume
- 12
- Issue
- 10
- Pages
- e0186091
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5648140
- OpenAlex
- W2765807992
- Cited by
- 14
- References
- 71
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 1
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institutes of Health (HD057632)
- National Multiple Sclerosis Society (PP-1510-06517)
- Buoniconti Fund to Cure Paralysis
- The Miami Project to Cure Paralysis
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- Olig2, oligodendrocytes, oligodendrocyte precursor cells, spinal cord, Nkx2.2, NKX6-2, ZEB2, myelin genes, cell cycle regulation, cytoskeleton regulation, transcriptional regulation
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Homeobox Protein Nkx-2.2, Animals, Male, Mice, Inbred C57BL, Myelin Sheath, Spinal Cord, Genome, Chromatin Immunoprecipitation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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