A systematic review of the 60 year literature: Effects of outreach programs in supporting historically marginalized and first-generation, low-income students in healthcare education
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We have reviewed over 60 years of studies on healthcare education outreach programs that are aimed to support first-generation, low-income, as well as underrepresented racial and ethnic minority groups (historically marginalized students) to pursue pre-health professions. As a systematic literature review, we present the challenges studies on healthcare education outreach programs had as three main categories: 1) Design , 2) Evaluation , and 3) Analysis . 1) Designs of studies on healthcare education outreach programs often lacked theoretical foundations whereby a) the interventions did not present theories underlying a causal mechanism of inequity in health professions; and/or 1b) the defined outcome measures were not clearly aligned with the problem the intervention tried to address. 2) Evaluations of studies on healthcare education outreach programs were not always conducted effectively whereby: 2a) controlled groups were commonly absent for comparison with the intervention group; and/or 2b) post measures were solely used without pre-measures. 3) Analyses of studies on healthcare education outreach programs were not adequate whereby: 3a) the response rates and effect size were commonly low; and/or 3b) qualitative results commonly did not supplement quantitative results. Overall, our findings reveal studies on healthcare education outreach programs have common challenges that hinder the reliability of their effects supporting historically marginalized students in pursuing pre-health professions. To address such challenges with studies on healthcare education outreach programs aimed at supporting historically marginalized students, we created a decision flow chart for researchers to ask themselves: 1) how is the design guided by theoretical goals; 2) how are measurements used to evaluate success; and 3) how does the analysis lead to reliable results?
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The absence of a control group limits causal inference and attribution of observed outcomes directly to program participation.
“The absence of a control group also reflects broader challenges in healthcare education outreach research, where most published evaluations lack matched comparison groups, limiting causal inference and attribution of observed outcomes directly to program participation [14].”
From The Clinical Mentorship Program: a mixed-methods evaluation of a community-based medical education pathway program for high school students (2026) · cites this paper as [14]
Most published evaluations in healthcare education outreach research lack matched comparison groups.
“where most published evaluations lack matched comparison groups”
From The Clinical Mentorship Program: a mixed-methods evaluation of a community-based medical education pathway program for high school students (2026) · cites this paper as [14]
Other reviews have focused on identifying barriers and protective factors or on critiquing the methodology and quality of existing programs, noting flaws and challenges in their design, evaluation, and analysis.
“Other reviews have focused on identifying barriers and protective factors or on critiquing the methodology and quality of existing programs, noting flaws and challenges in their design, evaluation, and analysis [32].”
From Efficacy of Early Exposure Medical Programs for Underrepresented Students: A Systematic Review (2026) · cites this paper as [32]
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Cites
From the Achievement Gap to the Education Debt: Understanding Achievement in U.S. Schools
Ladson-Billings, G. (2006) · Educational Researcher · doi:10.3102/0013189x035007003 · Cited by 3,211 · cited 1× · see citing works
“As mentioned previously, historically marginalized students face disproportionate education disparity when compared to their counterparts [59]; consequently, academic preparedness is a salient feature to consider for structuring healthcare education outreach programs.”
BackgroundTheobald, E. J., Hill, M. J., Tran, E., Agrawal, S., Arroyo, E. N., Behling, S., Chambwe, N., Cintrón, D. L., Cooper, J. D., Dunster, G., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916903117 · Cited by 1,387 · see citing works
The Distinctions Between Theory, Theoretical Framework, and Conceptual Framework
Varpio, L., Paradis, E., Uijtdehaage, S., & Young, M. (2020) · Academic Medicine · doi:10.1097/acm.0000000000003075 · Cited by 681 · see citing works
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Hunt, V. M., Cheng, J., de Lomba, W. C., & Warrier, S. (2026) · BMC Medical Education · doi:10.1186/s12909-026-09852-x
Efficacy of Early Exposure Medical Programs for Underrepresented Students: A Systematic Review
Jaganathan, N., Guntaka, R., Goel, V., Odo, N., Sun, Z., & Arthur, M. E. (2026) · Cureus · doi:10.7759/cureus.109396
- Authors
- Jenkins, E., Nardo, J. E., & Salehi, S.
- Affiliations
- Stanford University (US)
- Corresponding author
- Nardo, Jocelyn Elizabeth
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2022-12-01
- Volume
- 17
- Issue
- 12
- Pages
- e0278453
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC9714932
- OpenAlex
- W4310522395
- Cited by
- 19
- References
- 3
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 4 · 2023: 2
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Social Sciences › Gender Studies › Diversity and Career in Medicine
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Medical Education and Admissions
- Social Sciences › Education › Higher Education Research Studies
- Keywords
- first-generation college students, low-income students, historically marginalized students, intervention design, program evaluation, outcome measures, research reliability
- MeSH terms
- Delivery of Health Care, Ethnicity, Humans, Minority Groups, Students, Reproducibility of Results
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