The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient
Open accessAbstract
There is intense interest in developing curative interventions for HIV. How such a cure will be quantified and defined is not known. We applied a series of measurements of HIV persistence to the study of an HIV-infected adult who has exhibited evidence of cure after allogeneic hematopoietic stem cell transplant from a homozygous CCR5Δ32 donor. Samples from blood, spinal fluid, lymph node, and gut were analyzed in multiple laboratories using different approaches. No HIV DNA or RNA was detected in peripheral blood mononuclear cells (PBMC), spinal fluid, lymph node, or terminal ileum, and no replication-competent virus could be cultured from PBMCs. However, HIV RNA was detected in plasma (2 laboratories) and HIV DNA was detected in the rectum (1 laboratory) at levels considerably lower than those expected in ART-suppressed patients. It was not possible to obtain sequence data from plasma or gut, while an X4 sequence from PBMC did not match the pre-transplant sequence. HIV antibody levels were readily detectable but declined over time; T cell responses were largely absent. The occasional, low-level PCR signals raise the possibility that some HIV nucleic acid might persist, although they could also be false positives. Since HIV levels in well-treated individuals are near the limits of detection of current assays, more sensitive assays need to be developed and validated. The absence of recrudescent HIV replication and waning HIV-specific immune responses five years after withdrawal of treatment provide proof of a clinical cure.
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Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
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Self-citationRecovery of replication-competent HIV despite prolonged suppression of plasma viremia
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Self-citationQuantification of latent tissue reservoirs and total body viral load in HIV-1 infection
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Self-citationHigh Level of Coreceptor-independent HIV Transfer Induced by Contacts between Primary CD4 T Cells
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Cited by
The end of AIDS: HIV infection as a chronic disease
Deeks, S. G., Lewin, S. R., & Havlir, D. V. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61809-7 · Cited by 2,063
Self-citationReplication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
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Self-citationHIV infection: epidemiology, pathogenesis, treatment, and prevention
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International AIDS Society global scientific strategy: towards an HIV cure 2016
International AIDS Society Towards a Cure Working Group, Deeks, S. G., Lewin, S. R., Ross, A. L., Ananworanich, J., Benkirane, M., Cannon, P., Chomont, N., Douek, D., Lifson, J. D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4108 · Cited by 425
Self-citationResearch priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021
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Metadata
- Authors
- Yukl, S. A., Boritz, E., Busch, M., Bentsen, C., Chun, T.-W., Douek, D., Eisele, E., Haase, A., Ho, Y.-C., Hütter, G., Justement, J. S., Keating, S., Lee, T.-H., Li, P., Murray, D., Palmer, S., Pilcher, C., Pillai, S., Price, R. W., Rothenberger, M., Schacker, T., Siliciano, J., Siliciano, R., Sinclair, E., Strain, M., Wong, J., Richman, D., & Deeks, S. G.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-05-09
- Volume
- 9
- Issue
- 5
- Pages
- e1003347
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2065379504
- Cited by
- 291
- References
- 6
- FWCI
- 20.00
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yukl, S. A., Boritz, E., Busch, M., Bentsen, C., Chun, T.-W., Douek, D., Eisele, E., Haase, A., Ho, Y.-C., Hütter, G., Justement, J. S., Keating, S., Lee, T.-H., Li, P., Murray, D., Palmer, S., Pilcher, C., Pillai, S., Price, R. W., . . . Deeks, S. G. (2013). Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1003347
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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