AMP-Activated Protein Kinase is Highly Expressed in Neurons in the Developing Rat Brain and Promotes Neuronal Survival Following Glucose Deprivation

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

Mattson, M. P., Cheng, B., Davis, D. G., Bryant, K., Lieberburg, I. M., & Rydel, R. E. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00376.1992 · Cited by 1,633

The AMP‐Activated Protein Kinase: Fuel Gauge of the Mammalian Cell?

Hardie, D. G., & Carling, D. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00259.x · Cited by 1,317

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

Hawley, S. A., Davison, M., Woods, A., Davies, S. P., Beri, R. K., Carling, D., & Hardie, D. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27879 · Cited by 1,264

5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?

Corton, J. M., Gillespie, J. G., Hawley, S. A., & Hardie, D. G. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20498.x · Cited by 1,232

Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase

Endres, M., Laufs, U., Huang, Z., Nakamura, T., Huang, P. L., Moskowitz, M. A., & Liao, J. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8880 · Cited by 957

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

Wang, H., Rapp, U. R., & Reed, J. C. (1996) · Cell · doi:10.1016/s0092-8674(00)81383-5 · Cited by 769

Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

Kruman, I. I., Bruce‐Keller, A. J., Bredesen, D. E., Waeg, G., & Mattson, M. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05089.1997 · Cited by 721

Mammalian AMP-activated protein kinase subfamily

Stapleton, D., Mitchelhill, K. I., Gao, G., Widmer, J., Michell, B. J., Teh, T., House, C. M., Fernandez, C. S., Cox, T., Witters, L. A., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.2.611 · Cited by 652

Neurotrophic Factors Attenuate Glutamate‐Induced Accumulation of Peroxides, Elevation of Intracellular Ca 2+ Concentration, and Neurotoxicity and Increase Antioxidant Enzyme Activities in Hippocampal Neurons

Mattson, M. P., Lovell, M. A., Furukawa, K., & Markesbery, W. R. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65041740.x · Cited by 615

A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis

Carling, D., Zammit, V. A., & Hardie, D. G. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80292-2 · Cited by 599

5′‐AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP‐activated protein kinase. Studies using bacterially expressed human protein phosphatase‐2C α and native bovine protein phosphatase‐2A c

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Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

Mark, R. J., Hensley, K., Butterfield, D. A., & Mattson, M. P. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-09-06239.1995 · Cited by 553

Dealing with energy demand: the AMP-activated protein kinase

Kemp, B. E., Mitchelhill, K. I., Stapleton, D., Michell, B. J., Chen, Z., & Witters, L. A. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01340-1 · Cited by 521

Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell‐permeable activator of AMP‐activated protein kinase

Sullivan, J. E., Brocklehurst, K. J., Marley, A. E., Carey, F., Carling, D., & Beri, R. K. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01006-4 · Cited by 488

NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis

Cheng, B., & Mattson, M. P. (1991) · Neuron · doi:10.1016/0896-6273(91)90347-3 · Cited by 460

Secreted Forms of β-Amyloid Precursor Protein Protect Hippocampal Neurons against Amyloid β-Peptide-Induced Oxidative Injury

Goodman, Y., & Mattson, M. P. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1107 · Cited by 449

Role of the AMP-activated protein kinase in the cellular stress response

Corton, J. M., Gillespie, J. G., & Hardie, D. G. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00070-1 · Cited by 423

AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic β cells, and may regulate insulin release

Salt, I. P., JOHNSON, G., Ashcroft, S. J. H., & Hardie, D. G. (1998) · Biochemical Journal · doi:10.1042/bj3350533 · Cited by 408

The early events of oxygen and glucose deprivation: setting the scene for neuronal death?

Martin, R. L., Lloyd, H., & Cowan, A. I. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90008-6 · Cited by 405

Contraction-induced Changes in Acetyl-CoA Carboxylase and 5′-AMP-activated Kinase in Skeletal Muscle

Vavvas, D., Apazidis, A., Saha, A. K., Gamble, J., Patel, A., Kemp, B. E., Witters, L. A., & Ruderman, N. B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.13255 · Cited by 395

Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase.

Mitchelhill, K. I., Stapleton, D., Gao, G., House, C. M., Michell, B. J., Katsis, F., Witters, L. A., & Kemp, B. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41951-x · Cited by 338

Dual regulation of the AMP‐activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle

Ponticos, M., Lu, Q. L., Morgan, J. E., Hardie, D. G., Partridge, T. A., & Carling, D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1688 · Cited by 317

The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase

Carling, D., & Grahame Hardie, D. (1989) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(89)90014-1 · Cited by 296

Phosphorylation of bovine hormone‐sensitive lipase by the AMP‐activated protein kinase

Garton, A. J., Campbell, D. G., Carling, D., Hardie, D. G., Colbran, R. J., & Yeaman, S. J. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb14548.x · Cited by 271

Cellular Distribution and Developmental Expression of AMP‐Activated Protein Kinase Isoforms in Mouse Central Nervous System

Turnley, A. M., Stapleton, D., Mann, R. J., Witters, L. A., Kemp, B. E., & Bartlett, P. F. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.721707.x · Cited by 270

Growth Factors Prevent Mitochondrial Dysfunction, Loss of Calcium Homeostasis, and Cell Injury, but Not ATP Depletion in Hippocampal Neurons Deprived of Glucose

Mattson, M. P., Zhang, Y., & Bose, S. C. (1993) · Experimental Neurology · doi:10.1006/exnr.1993.1066 · Cited by 265

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

Guo, Q., Fu, W., Xie, J., Luo, H., Sells, S. F., Geddes, J. W., Bondada, V., Rangnekar, V. M., & Mattson, M. P. (1998) · Nature Medicine · doi:10.1038/nm0898-957 · Cited by 260

AMP-activated Protein Kinase Inhibits the Glucose-activated Expression of Fatty Acid Synthase Gene in Rat Hepatocytes

Foretz, M., Carling, D., Guichard, C., Ferré, P., & Foufelle, F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.24.14767 · Cited by 256

Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP‐activated protein kinase

Henin, N., Vincent, M. F., Gruber, H. E., & Berghe, G. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.7.7737463 · Cited by 251

Characterization of 5′AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia

Kudo, N., Gillespie, J. G., Kung, L., Witters, L. A., Schulz, R., Clanachan, A. S., & Lopaschuk, G. D. (1996) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(96)00013-6 · Cited by 246

Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP‐activated protein kinase: A sensitive mechanism to protect the cell against ATP depletion

MOORE, F., WEEKES, J., & HARDIE, D. G. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16172.x · Cited by 223

Metyrapone, an Inhibitor of Glucocorticoid Production, Reduces Brain Injury Induced by Focal and Global Ischemia and Seizures

Smith‐Swintosky, V. L., Pettigrew, L. C., Sapolsky, R. M., Phares, C., Craddock, S. D., Brooke, S. M., & Mattson, M. P. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199607000-00008 · Cited by 182

Strong nuclear factor-?B-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic alzheimer's disease superior temporal lobe neocortex

Lukiw, W. J., & Bazan, N. G. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19980901)53:5 · Cited by 182

Effect of exercise intensity on skeletal muscle malonyl-CoA and acetyl-CoA carboxylase

Rasmussen, B. B., & Winder, W. W. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.4.1104 · Cited by 158

5-Amino-4-imidazolecarboxamide riboside (Z-riboside) metabolism in eukaryotic cells.

Sabina, R. L., Patterson, D., & HOLMES, E. W. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88943-8 · Cited by 146

Inhibition of Cholesterol Production but Not of Nonsterol Isoprenoid Products Induces Neuronal Cell Death

Michikawa, M., & Yanagisawa, K. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0722278.x · Cited by 140

The 5′‐AMP‐activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex

Leclerc, I., Kahn, A., & Doiron, B. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00745-5 · Cited by 137

4-Hydroxynonenal, a Product of Lipid Peroxidation, Damages Cholinergic Neurons and Impairs Visuospatial Memory in Rats

Bruce‐Keller, A. J., Li, Y., Lovell, M. A., Kraemer, P. J., Gary, D. S., Brown, R. R., Markesbery, W. R., & Mattson, M. P. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199803000-00007 · Cited by 133

Isoform-specific Purification and Substrate Specificity of the 5′-AMP-activated Protein Kinase

Michell, B. J., Stapleton, D., Mitchelhill, K. I., House, C. M., Katsis, F., Witters, L. A., & Kemp, B. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.45.28445 · Cited by 133

Non-catalytic - and -Subunit Isoforms of the 5′-AMP-activated Protein Kinase

Gao, G., Fernández, C., Stapleton, D., Auster, A. S., Widmer, J., Dyck, J. R. B., Kemp, B. E., & Witters, L. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.15.8675 · Cited by 129

Mammalian 5'-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase.

Stapleton, D., Gao, G., Michell, B. J., Widmer, J., Mitchelhill, K. I., Teh, T., House, C. M., Witters, L. A., & Kemp, B. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43879-3 · Cited by 122

Activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl Coenzyme A reductase kinase by adenosine 5′-monophosphate

Ferrer, A., Caelles, C., Massot, N., & Hegardt, F. G. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)91161-1 · Cited by 118

AMP‐activated protein kinase isoenzyme family: subunit structure and chromosomal location

Stapleton, D., Woollatt, E., Mitchelhill, K. I., Nicholl, J. K., Fernández, C., Michell, B. J., Witters, L. A., Power, D. A., Sutherland, G. R., & Kemp, B. E. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00569-3 · Cited by 117

Control of Hepatic Fatty Acid Oxidation by 5′-AMP-Activated Protein Kinase Involves a Malonyl-CoA-Dependent and a Malonyl-CoA-Independent Mechanism

Velasco, G., Geelen, M. J. H., & Guzmán, M. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.9784 · Cited by 115

Specificity determinants for the AMP‐activated protein kinase and its plant homologue analysed using synthetic peptides

Weekes, J., Ball, K. L., Caudwell, F. B., & Hardie, D. G. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80706-z · Cited by 107

Inhibition of Glucocorticoid-Induced Apoptosis with 5-Aminoimidazole-4-carboxamide Ribonucleoside, a Cell-Permeable Activator of AMP-Activated Protein Kinase

Stefanelli, C., Stanić, I., Bonavita, F., Flamigni, F., Pignatti, C., Guarnieri, C., & Caldarera, C. M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8154 · Cited by 85

Raf, but Not MEK or ERK, Is Sufficient for Differentiation of Hippocampal Neuronal Cells

Kuo, W., Abe, M. K., Rhee, J. M., Eves, E. M., McCarthy, S. A., Yan, M., Templeton, D. J., McMahon, M., & Rosner, M. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1458 · Cited by 84

Catalytic subunits of the porcine and rat 5′-AMP-activated protein kinase are members of the SNF1 protein kinase family

Gao, G., Widmer, J., Stapleton, D., Teh, T., Cox, T. M., Kemp, B. E., & Witters, L. A. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(94)00222-z · Cited by 82

Roles for mitotic history in the generation and degeneration of hippocampal neuroarchitecture

Mattson, M. P., Guthrie, P., Hayes, B., & Kater, S. B. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-04-01223.1989 · Cited by 63

Identification of Raf‐1 Ser621 kinase activity from NIH 3T3 cells as AMP‐activated protein kinase

Sprenkle, A. B., Davies, S. P., Carling, D., Hardie, D. G., & Sturgill, T. W. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00062-8 · Cited by 59

Sustained protection by acadesine against ischemia- and reperfusion-induced injury. Studies in the transplanted rat heart.

Galiñanes, M., Bullough, D. A., Mullane, K., & Hearse, D. J. (1992) · Circulation · doi:10.1161/01.cir.86.2.589 · Cited by 59

Acadesine and myocardial protection. Studies of time of administration and dose-response relations in the rat.

Galiñanes, M., Mullane, K., Bullough, D. A., & Hearse, D. J. (1992) · Circulation · doi:10.1161/01.cir.86.2.598 · Cited by 58

Bcl‐2, Raf‐1 and mitochondrial regulation of apoptosis

Wang, H., & Reed, J. C. (1998) · BioFactors · doi:10.1002/biof.5520080103 · Cited by 52

Acadesine extends the window of protection afforded by ischaemic preconditioning

Tsuchida, A., Yang, X.-M., Burckhartt, B., Mullane, K., Cohen, M. V., & Downey, J. M. (1994) · Cardiovascular Research · doi:10.1093/cvr/28.3.379 · Cited by 38

Characterization of the Mononickel Metallocenter in H134A Mutant Urease

Park, I., Michel, L. O., Pearson, M. A., Jabri, E., Karplus, P. A., Wang, S., Dong, J. C., Scott, R. A., Koehler, B. P., Johnson, M. K., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.31.18632 · Cited by 37

Timely administration of AICA riboside reduces reperfusion injury in rabbits

Kingma, J. G., Simard, D., & Rouleau, J. R. (1994) · Cardiovascular Research · doi:10.1093/cvr/28.7.1003 · Cited by 30

Differential effects of basic fibroblast growth factor, epidermal growth factor, transforming growth factor-?, and insulin-like growth factor-I on a hypothalamic gonadotropin-releasing hormone neuronal cell line

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Brain Damage Caused by Ischemia: Pathophysiological and Pharmacological Aspects

Rami, A., & Krieglstein, J. (1993) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000107292 · Cited by 18

5-aminoimidazole-4-carboxamide riboside (AICAr) administration reduces cerebral ischemic damage in the mongolian gerbil

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Protection against injury during ischemia and reperfusion by acadesine derivatives GP-1-468 and GP-1-668

Galiñanes, M., Zhai, X., Bullough, D. A., Mullane, K., & Hearse, D. J. (1995) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(95)70108-7 · Cited by 14

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Shaw, R. J., Kosmatka, M., Bardeesy, N., Hurley, R. L., Witters, L. A., DePinho, R. A., & Cantley, L. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308061100 · Cited by 1,797

AMPK in Health and Disease

Steinberg, G. R., & Kemp, B. E. (2009) · Physiological Reviews · doi:10.1152/physrev.00011.2008 · Cited by 1,668

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637

Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.009 · Cited by 1,589

Resveratrol stimulates AMP kinase activity in neurons

Dasgupta, B., & Milbrandt, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610068104 · Cited by 723

Meta-analysis of Alzheimer’s disease risk with obesity, diabetes, and related disorders

Profenno, L. A., Porsteinsson, A. P., & Faraone, S. V. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.02.013 · Cited by 718

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

Vingtdeux, V., Giliberto, L., Zhao, H., Chandakkar, P., Wu, Q., Simon, J. E., Janle, E. M., Lobo, J., Ferruzzi, M. G., Davies, P. J., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.060061 · Cited by 654

Metformin: An Old But Still the Best Treatment for Type 2 Diabetes

Rojas, L. B. A., & Gomes, M. B. (2013) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-5-6 · Cited by 567

AMPK at the Nexus of Energetics and Aging

Burkewitz, K., Zhang, Y., & Mair, W. B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.002 · Cited by 483

Neuroprotective action of resveratrol

Bastianetto, S., Ménard, C., & Quirion, R. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.09.011 · Cited by 423

Caloric restriction and intermittent fasting: Two potential diets for successful brain aging

Martin, B., Mattson, M. P., & Maudsley, S. R. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.04.002 · Cited by 405

AMPK inhibition in health and disease

Viollet, B., Horman, S., Leclerc, J., Lantier, L., Foretz, M., Billaud, M., Giri, S., & Andreelli, F. (2010) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2010.488215 · Cited by 383

AMP-activated protein kinase: new regulation, new roles?

Carling, D., Thornton, C., Woods, A., & Sanders, M. J. (2012) · Biochemical Journal · doi:10.1042/bj20120546 · Cited by 390

Glycolysis: a bioenergetic or a survival pathway?

Bolaños, J. P., Almeida, Á., & Moncada, S. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.10.006 · Cited by 374

The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β-oxidation

Buzzai, M., Bauer, D. E., Jones, R. G., DeBerardinis, R. J., Hatzivassiliou, G., Elstrom, R. L., & Thompson, C. B. (2005) · Oncogene · doi:10.1038/sj.onc.1208622 · Cited by 357

The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation

Mairet-Coello, G., Courchet, J., Pieraut, S., Courchet, V., Maximov, A., & Polleux, F. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.003 · Cited by 351

5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside Inhibits Cancer Cell Proliferation in Vitro and in Vivo via AMP-activated Protein Kinase

Rattan, R., Giri, S., Singh, A. K., & Singh, I. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507443200 · Cited by 347

Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke

McCullough, L. D., Zeng, Z., Li, H., Landree, L. E., McFadden, J., & Ronnett, G. V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409985200 · Cited by 333

Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis

Rutter, G. A., Xavier, G. D. S., & Leclerc, I. (2003) · Biochemical Journal · doi:10.1042/bj20030048 · Cited by 334

Brain Glucose Sensing, Counterregulation, and Energy Homeostasis

Marty, N., Dallaporta, M., & Thorens, B. (2007) · Physiology · doi:10.1152/physiol.00010.2007 · Cited by 344

Hypothalamic AMPK: a canonical regulator of whole-body energy balance

López, M., Nogueiras, R., Tena‐Sempere, M., & Diéguez, C. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.67 · Cited by 318

The Therapeutic Potential of Metformin in Neurodegenerative Diseases

Rotermund, C., Machetanz, G., & Fitzgerald, J. C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00400 · Cited by 313

C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase

Kim, E. K., Miller, I., Aja, S. M., Landree, L. E., Pinn, M. L., McFadden, J. M., Kuhajda, F. P., Moran, T. H., & Ronnett, G. V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402165200 · Cited by 313

AMPK in the brain: its roles in energy balance and neuroprotection

Ronnett, G. V., Ramamurthy, S., Kleman, A. M., Landree, L. E., & Aja, S. M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05916.x · Cited by 300

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies

Vingtdeux, V., Davies, P., Dickson, D. W., & Marambaud, P. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0759-x · Cited by 297

Energy metabolism in adult neural stem cell fate

Rafalski, V. A., & Brunet, A. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.10.007 · Cited by 293

5-Aminoimidazole-4-Carboxamide-1-β-4-Ribofuranoside Inhibits Proinflammatory Response in Glial Cells: A Possible Role of AMP-Activated Protein Kinase

Giri, S., Nath, N., Smith, B., Viollet, B., Singh, A. K., & Singh, I. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4288-03.2004 · Cited by 266

Lipid Processing in the Brain: A Key Regulator of Systemic Metabolism

Bruce, K. D., Zsombok, A., & Eckel, R. H. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00060 · Cited by 279

Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death

Chen, L., Xu, B., Liu, L., Luo, Y., Zhou, H., Chen, W., Shen, T., Han, X., Kontos, C. D., & Huang, S. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.032 · Cited by 252

AMP-activated Protein Kinase and p38 MAPK Activate O-GlcNAcylation of Neuronal Proteins during Glucose Deprivation

Cheung, W. D., & Hart, G. W. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801222200 · Cited by 248

AMPK: Potential Therapeutic Target for Ischemic Stroke

Jiang, S., Li, T. X., Ji, T., Yi, W., Yang, Z. P., Wang, S., Yang, Y., & Gu, C. (2018) · Theranostics · doi:10.7150/thno.25674 · Cited by 256

AMP‐activated protein kinase: a potential player in Alzheimer’s disease

Salminen, A., Kaarniranta, K., Haapasalo, A., Soininen, H. S., & Hiltunen, M. O. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07331.x · Cited by 224

Ghrelin: a hormone regulating food intake and energy homeostasis

Gil‐Campos, M., Aguilera, C. M., Cañete, R., & Gil, Á. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061787 · Cited by 218

Neuroprotective Effects of Adenosine Monophosphate- Activated Protein Kinase Inhibition and Gene Deletion in Stroke

Li, J., Zeng, Z., Viollet, B., Ronnett, G. V., & McCullough, L. D. (2007) · Stroke · doi:10.1161/strokeaha.107.490904 · Cited by 216

Leptin Stimulates Fatty Acid Oxidation and Peroxisome Proliferator-Activated Receptor α Gene Expression in Mouse C2C12 Myoblasts by Changing the Subcellular Localization of the α2 Form of AMP-Activated Protein Kinase

Suzuki, A., Okamoto, S., Lee, S. P., Saito, K., Shiuchi, T., & Minokoshi, Y. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02222-06 · Cited by 213

AMPK activation: Role in the signaling pathways of neuroinflammation and neurodegeneration

Peixoto, C. A., Oliveira, W. H. D., Araújo, S. M. D. R., & Nunes, A. K. S. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.08.013 · Cited by 196

Regulation of Glucose Transporter 3 Surface Expression by the AMP-Activated Protein Kinase Mediates Tolerance to Glutamate Excitation in Neurons

Weisová, P., Concannon, C. G., Devocelle, M., Prehn, J. H. M., & Ward, M. W. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0354-09.2009 · Cited by 161

Developing a head for energy sensing: AMP‐activated protein kinase as a multifunctional metabolic sensor in the brain

Ramamurthy, S., & Ronnett, G. V. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.110122 · Cited by 161

Effects of AMP-Activated Protein Kinase in Cerebral Ischemia

Li, J., & McCullough, L. D. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.255 · Cited by 165

AMPK in the brain: its roles in glucose and neural metabolism

Muraleedharan, R., & Dasgupta, B. (2021) · FEBS Journal · doi:10.1111/febs.16151 · Cited by 170

Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK

Li, Y., Munoz-Mayorga, D., Nie, Y., Kang, N., Tao, Y., Lagerwall, J., Pernaci, C., Curtin, G., Coufal, N. G., Mertens, J., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.03.014 · Cited by 160

Targeting AMPK Signaling as a Neuroprotective Strategy in Parkinson’s Disease

Curry, D. W., Stutz, B., Andrews, Z. B., & Elsworth, J. D. (2018) · Journal of Parkinson s Disease · doi:10.3233/jpd-171296 · Cited by 160

Activation of Cannabinoid CB2 Receptor–Mediated AMPK/CREB Pathway Reduces Cerebral Ischemic Injury

Choi, I.-Y., Ju, C., Jalin, A. M. A. A., Lee, D. I., Prather, P. L., & Kim, W.-K. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.11.024 · Cited by 157

Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease

Zhang, K., Zhu, S., Li, J., Jiang, T., Feng, L., Pei, J., Wang, G., Ouyang, L., & Liu, B. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.02.016 · Cited by 159

AMP kinase–mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis

Concannon, C. G., Tuffy, L. P., Weisová, P., Bonner, H. P., Dávila, D., Bonner, C., Devocelle, M. C., Strasser, A., Ward, M. W., & Prehn, J. H. M. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200909166 · Cited by 149

Berberine suppresses neuroinflammatory responses through AMP‐activated protein kinase activation in BV‐2 microglia

Lu, D., Tang, C., Chen, Y., & Wei, I. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22580 · Cited by 151

Potential Role for AMP-Activated Protein Kinase in Hypoglycemia Sensing in the Ventromedial Hypothalamus

McCrimmon, R. J., Fan, X., Ding, Y., Zhu, W., Jacob, R. J., & Sherwin, R. S. (2004) · Diabetes · doi:10.2337/diabetes.53.8.1953 · Cited by 153

Redox Homeostasis and Cellular Stress Response in Aging and Neurodegeneration

Calabrese, V., Cornelius, C., Mancuso, C., Lentile, R., Stella, A. M. G., & Butterfield, D. A. (2009) · Methods in molecular biology · doi:10.1007/978-1-60327-029-8_17 · Cited by 151

AICA riboside both activates AMP‐activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus

Gadalla, A. E., Pearson, T., Currie, A. J., Dale, N., Hawley, S. A., Sheehan, M., Hirst, W. D., Michel, A. D., Randall, A. D., Hardie, D. G., et al. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02253.x · Cited by 144

The role of LKB1 and AMPK in cellular responses to stress and damage

Alexander, A., & Walker, C. L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.010 · Cited by 145

Adiponectin is Protective against Oxidative Stress Induced Cytotoxicity in Amyloid-Beta Neurotoxicity

Chan, K., Lam, K. S. L., Cheng, O.-Y., Kwan, J., Ho, P. W., Cheng, K. K. Y., Chung, S. K., Ho, J. W.-M., Guo, V. Y., & Xu, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052354 · Cited by 143

Ghrelin, a gastrointestinal hormone, regulates energy balance and lipid metabolism

Lv, Y., Liang, T., Wang, G., & Li, Z. (2018) · Bioscience Reports · doi:10.1042/bsr20181061 · Cited by 144

AMPK: A cellular metabolic and redox sensor. A minireview

Shirwany, N. A. (2014) · Frontiers in bioscience · doi:10.2741/4218 · Cited by 143

Role of Neuronal Energy Status in the Regulation of Adenosine 5′-Monophosphate-Activated Protein Kinase, Orexigenic Neuropeptides Expression, and Feeding Behavior

Lee, K., Li, B., Xi, X., Suh, Y., & Martin, R. J. (2004) · Endocrinology · doi:10.1210/en.2004-0968 · Cited by 138

Leptin and the systems neuroscience of meal size control

Grill, H. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.10.005 · Cited by 138

AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3

King, T. D., Song, L., & Jope, R. S. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.03.005 · Cited by 137

5-Aminoimidazole-4-Carboxamide Ribonucleoside: A Novel Immunomodulator with Therapeutic Efficacy in Experimental Autoimmune Encephalomyelitis

Nath, N., Giri, S., Prasad, R. C., Salem, M. L., Singh, A. K., & Singh, I. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.566 · Cited by 136

AMP-Activated Protein Kinase Phosphorylates Retinoblastoma Protein to Control Mammalian Brain Development

Dasgupta, B., & Milbrandt, J. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.005 · Cited by 133

Expanding roles for AMP‐activated protein kinase in neuronal survival and autophagy

Poels, J., Spasić, M. R., Callaerts, P., & Norga, K. (2009) · BioEssays · doi:10.1002/bies.200900003 · Cited by 130

Fatty acid metabolism as a target for obesity treatment

Ronnett, G. V., KIM, E., Landree, L. E., & TU, Y. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.04.014 · Cited by 129

C75, a Fatty Acid Synthase Inhibitor, Modulates AMP-activated Protein Kinase to Alter Neuronal Energy Metabolism

Landree, L. E., Hanlon, A. L., Strong, D. W., Rumbaugh, G., Miller, I. M., Thupari, J. N., Connolly, E. C., Huganir, R. L., Richardson, C. A., Witters, L. A., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310991200 · Cited by 133

AMPK Activation by Oncogenesis Is Required to Maintain Cancer Cell Proliferation in Astrocytic Tumors

García, M. R., Foretz, M., Viollet, B., Prieto, A., Fraga, M., Costoya, J. A., & Señarís, R. M. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-0861 · Cited by 126

Reciprocal Inhibition of p53 and Nuclear Factor-κB Transcriptional Activities Determines Cell Survival or Death in Neurons

Culmsee, C., Siewe, J., Junker, V., Retiounskaia, M., Schwarz, S., Camandola, S., El-Metainy, S., Behnke, H., Mattson, M. P., & Krieglstein, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-24-08586.2003 · Cited by 147

AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo

Domise, M., Didier, S., Marinangeli, C., Zhao, H., Chandakkar, P., Buée, L., Viollet, B., Davies, P., Marambaud, P., & Vingtdeux, V. (2016) · Scientific Reports · doi:10.1038/srep26758 · Cited by 124

Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells

Hallows, K. R., Kobinger, G., Wilson, J. M., Witters, L. A., & Foskett, J. K. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00227.2002 · Cited by 121

Endurance factors improve hippocampal neurogenesis and spatial memory in mice

Kobilo, T., Yuan, C., & van Praag, H. (2011) · Learning & Memory · doi:10.1101/lm.2001611 · Cited by 114

5′-aminoimidazole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells

Garcia‐Gil, M., Pesi, R., Perna, S., Allegrini, S., Giannecchini, M., Camici, M., & Tozzi, M. G. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00836-9 · Cited by 112

Macrophage migration inhibitory factor (MIF) promotes cell survival and proliferation of neural stem/progenitor cells

Ohta, S., Misawa, A., Fukaya, R., Inoue, S., Kanemura, Y., Okano, H., Kawakami, Y., & Toda, M. (2012) · Journal of Cell Science · doi:10.1242/jcs.102210 · Cited by 110

AMP-Activated Protein Kinase (AMPK) Molecular Crossroad for Metabolic Control and Survival of Neurons

Spasić, M. R., Callaerts, P., & Norga, K. K. (2009) · The Neuroscientist · doi:10.1177/1073858408327805 · Cited by 109

A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion

Pan, D. A., & Hardie, D. G. (2002) · Biochemical Journal · doi:10.1042/bj20020703 · Cited by 112

Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family

Cho, S. H., Ahn, A., Bhargava, P., Lee, C., Eischen, C. M., McGuinness, O. P., & Boothby, M. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017082108 · Cited by 108

Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells

Peairs, A., Radjavi, A., Davis, S., Li, L., Ahmed, A. A., Giri, S., & Reilly, C. M. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.03924.x · Cited by 106

Chronic stress-induced memory deficits are reversed by regular exercise via AMPK-mediated BDNF induction

Kim, D.-M., & Leem, Y. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.03.019 · Cited by 109

Dietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain trauma

Sharma, S., Zhuang, Y., Ying, Z., Wu, A., & Gómez‐Pinilla, F. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.04.042 · Cited by 103

AMP-activated protein kinase is activated in Parkinson’s disease models mediated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Choi, J., Park, C., & Jeong, J. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.11.022 · Cited by 103

Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window

Lanzillotta, A., Pignataro, G., Branca, C., Cuomo, O., Sarnico, I., Benarese, M., Annunziato, L., Spano, P., & Pizzi, M. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.08.018 · Cited by 102

Mitochondrial dysfunction and Parkinson disease: a Parkin–AMPK alliance in neuroprotection

Hang, L., Thundyil, J., & Lim, K. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12820 · Cited by 103

Unpredictable chronic mild stress induces anxiety and depression-like behaviors and inactivates AMP-activated protein kinase in mice

Zhu, S., Wang, J., Zhang, Y., Li, V., Kong, J., He, J., & Li, X. (2014) · Brain Research · doi:10.1016/j.brainres.2014.06.002 · Cited by 101

Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation

Cai, Y., Martens, G. A., Hinke, S. A., Heimberg, H., PIPELEERS, D. G., & de Casteele, M. V. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.09.018 · Cited by 99

Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of α-synuclein oligomers and decrease of neurites

Jiang, P., Gan, M., Ebrahim, A. S., Castanedes‐Casey, M., Dickson, D. W., & Yen, S.-H. C. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.001 · Cited by 99

O-GlcNAc Protein Modification in Cancer Cells Increases in Response to Glucose Deprivation through Glycogen Degradation

Kang, J. G., Park, S., Ji, S., Jang, I., Park, S., Kim, H. S., Kim, S., Yook, J. I., Park, Y. I., Roth, J., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.026351 · Cited by 92

Synaptic Activity and Bioenergy Homeostasis: Implications in Brain Trauma and Neurodegenerative Diseases

Khatri, N., & Man, H. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00199 · Cited by 96

Oxidative stress modulates Sir2α in rat hippocampus and cerebral cortex

Wu, A., Ying, Z., & Gómez‐Pinilla, F. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04807.x · Cited by 92

5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNFα-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling

Su, R.-Y., Chao, Y., Chen, T., Huang, D.-Y., & Lin, W. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0800 · Cited by 90

Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis

Won, J., Im, Y., Kim, J., Singh, A. K., & Singh, I. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.081 · Cited by 92

Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots

Yang, S.-H., Li, W., Sumien, N., Forster, M. J., Simpkins, J. W., & Liu, R. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.10.005 · Cited by 89

Dorsal Hindbrain 5′-Adenosine Monophosphate-Activated Protein Kinase as an Intracellular Mediator of Energy Balance

Hayes, M. R., Skibicka, K. P., Bence, K. K., & Grill, H. J. (2008) · Endocrinology · doi:10.1210/en.2008-1319 · Cited by 87

AMP-Activated Protein Kinase: A New Beta-Cell Glucose Sensor?

Leclerc, I., & Rutter, G. A. (2004) · Diabetes · doi:10.2337/diabetes.53.suppl_3.s67 · Cited by 91

5-Aminoimidazole-4-carboxamide-ribonucleoside enhances oxidative stress-induced apoptosis through activation of nuclear factor-κB in mouse Neuro 2a neuroblastoma cells

Jung, J. E., Lee, J., Ha, J., Kim, S. S., Cho, Y. H., Baik, H. H., & Kang, I. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.10.012 · Cited by 86

Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: Potential utility in treatment of diabetes and heart disease

Hutchinson, D. S., Summers, R. J., & Bengtsson, T. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.05.008 · Cited by 88

Characterization of the AMP-activated protein kinase pathway in chickens

Proszkowiec‐Weglarz, M., Richards, M. P., Ramachandran, R., & McMurtry, J. P. (2005) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2005.10.009 · Cited by 89

A focused review on CB2 receptor-selective pharmacological properties and therapeutic potential of β-caryophyllene, a dietary cannabinoid

Hashiesh, H. M., Sharma, C., Goyal, S. N., Sadek, B. S., Jha, N. K., Kaabi, J. A., & Ojha, S. K. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111639 · Cited by 96

Adiponectin attenuates neuronal apoptosis induced by hypoxia-ischemia via the activation of AdipoR1/APPL1/LKB1/AMPK pathway in neonatal rats

Xu, N., Zhang, Y., Doycheva, D. M., Ding, Y. P., Zhang, Y., Tang, J., Guo, H., & Zhang, J. H. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.02.024 · Cited by 82

Role of 5′-Adenosine Monophosphate-Activated Protein Kinase in Cell Survival and Death Responses in Neurons

Weisová, P., Dávila, D., Tuffy, L. P., Ward, M. W., Concannon, C. G., & Prehn, J. H. M. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3544 · Cited by 83

Adiponectin protects rat hippocampal neurons against excitotoxicity

Qiu, G., Wan, R., Hu, J., Mattson, M. P., Spangler, E. L., Liu, S., Yau, S., Lee, T. M. C., Gleichmann, M., Ingram, D. K., et al. (2010) · AGE · doi:10.1007/s11357-010-9173-5 · Cited by 80

Intracerebroventricular Infusion of Glucose, Insulin, and the Adenosine Monophosphate-Activated Kinase Activator, 5-Aminoimidazole-4-Carboxamide-1-β- d -Ribofuranoside, Controls Muscle Glycogen Synthesis

Perrin, C., Knauf, C., & Burcelin, R. (2004) · Endocrinology · doi:10.1210/en.2004-0270 · Cited by 79

The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: implication for Krabbe Disease

Giri, S., Khan, M., Nath, N., Singh, I., & Singh, A. K. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05279.x · Cited by 78

Mesenchymal stem cell-derived extracellular vesicles promote microglial M2 polarization after subarachnoid hemorrhage in rats and involve the AMPK/NF-κB signaling pathway

Han, M., Cao, Y., Guo, X., Chu, X., Li, T., Xue, H., Xin, D., Yuan, L., Ke, H., Li, G., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111048 · Cited by 78

Involvement of AMP‐activated protein kinase in neuroinflammation and neurodegeneration in the adult and developing brain

Saito, M., Saito, M., & Das, B. C. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.01.007 · Cited by 75

AMPK in the brain: its roles in glucose and neural metabolism

Muraleedharan, R., & Dasgupta, B. (2021) · FEBS Journal · doi:10.1111/febs.16151 · Cited by 170

AMP-Activated Protein Kinase (AMPK) Molecular Crossroad for Metabolic Control and Survival of Neurons

Spasić, M. R., Callaerts, P., & Norga, K. K. (2009) · The Neuroscientist · doi:10.1177/1073858408327805 · Cited by 109

A Pharmacological Activator of AMP-Activated Protein Kinase Protects Hypoxic Neurons in a Concentration-Dependent Manner

Zhang, X., Gao, R.-K., Li, J., Qi, Y., Song, X., Zhao, L., Wang, H., Pu, Y., Xu, K., & Li, J. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0186-3 · Cited by 17

A Protective Partnership

Adler, E. M. (2007) · Science s STKE · doi:10.1126/stke.3702007tw31

Role of 5′-Adenosine Monophosphate-Activated Protein Kinase in Cell Survival and Death Responses in Neurons

Weisová, P., Dávila, D., Tuffy, L. P., Ward, M. W., Concannon, C. G., & Prehn, J. H. M. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3544 · Cited by 83