Cited by 29Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchProtease and Inhibitor Mechanisms

The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.

Progress Toward Identification of Protease Activity Involved in Proteolysis of Apolipoprotein E in Human Brain

Marques, Marcos A., Owens, Phillip A., Crutcher, Keith A.·2004·Journal of Molecular Neuroscience

DOI 10.1385/jmn:24:1:073

Open this paper in CoChat — free account

Abstract

Apolipoprotein E (apoE) genotype is the single most important genetic risk factor for the most common (sporadic) form of Alzheimer's disease (AD). Increasing evidence supports the hypothesis that the presence of the E4 isoform of this cholesterol-binding protein contributes directly to disease risk, age of onset, and severity of the neuropathology. For example, studies in transgenic mice demonstrate that apoE is necessary for the formation of plaques with neuritic pathology. The precise mechanism by which apoE contributes to the disease remains unknown. However, several lines of investigation from a number of laboratories now point to a role for proteolytic fragments of apoE in the formation of both plaques and tangles, the two pathological hallmarks of the disease. In particular, the C-terminal portion of apoE has been implicated in binding to amyloid and is localized to plaques. The N-terminal domain, on the other hand, is neurotoxic in culture and has been localized to, and implicated in the formation of, neurofibrillary tangles. These results suggest that inhibition of apoE proteolysis is a potential therapeutic strategy for AD. Using human brain homogenates, we have determined that proteolysis of apoE is greatest at acidic pH and can be inhibited by compounds targeting aspartic proteases. The feasibility of screening candidate inhibitors is supported by both ELISA and immunoblotting methods. Future studies will use a combination of in vitro and in vivo assays to test the…

Integrity signals

Registry

Crossref · 10.1385/jmn:24:1:073

Cites

74 of 74 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268
Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028
Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease
Namba, Y., Tomonaga, M., Kawasaki, H., Otomo, E., & Ikeda, K. (1991) · Brain Research · doi:10.1016/0006-8993(91)91092-f · Cited by 1,157
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
Holtzman, D. M., Bales, K. R., Tenkova, T., Fagan, A. M., Parsadanian, M., Sartorius, L. J., Mackey, B., Olney, J., McKeel, D., Wozniak, D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050004797 · Cited by 937
Senile dementia of the Alzheimer type
Terry, R. D., & Katzman, R. (1983) · Annals of Neurology · doi:10.1002/ana.410140502 · Cited by 839
Apolipoprotein E: Structure-Function Relationships
Weisgraber, K. H. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60642-7 · Cited by 830
Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.
Boyles, J. K., Pitas, R. E., Wilson, E., Mahley, R. W., & Taylor, J. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112130 · Cited by 829
Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro
Nathan, B. P., Bellosta, S., Sanan, D. A., Weisgraber, K. H., Mahley, R. W., & Pitas, R. E. (1994) · Science · doi:10.1126/science.8171342 · Cited by 795
Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E
Mahley, R. W., & Ji, Z.-S. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33334-4 · Cited by 693
Apolipoprotein E in animal models of CNS injury and in alzheimer's disease
Poirier, J. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90156-2 · Cited by 637
Expression of apolipoprotein E during nerve degeneration and regeneration.
Ignatius, M. J., Gebicke‐Haerter, P. J., Skene, J. H. P., Schilling, J., Weisgraber, K. H., Mahley, R. W., & Shooter, E. M. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.1125 · Cited by 571
Apolipoprotein E ∈4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases
Saunders, A. M., Roses, A. D., Pericak‐Vance, M. A., Dole, K. C., Strittmatter, W. J., Schmechel, D. E., Szymanski, M. H., McCown, N., Manwaring, M., Schmader, K. E., et al. (1993) · The Lancet · doi:10.1016/0140-6736(93)91709-u · Cited by 498
Apolipoprotein E is essential for amyloid deposition in the APP V717F transgenic mouse model of Alzheimer's disease
Bales, K. R., Verina, T., Cummins, D. J., Du, Y., Dodel, R. C., Saura, J., Fishman, C. E., DeLong, C. A., Piccardo, P., Petegnief, V., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15233 · Cited by 486
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons
Huang, Y., Liu, X. Q., Wyss-Coray, T., Brecht, W. J., Sanan, D. A., & Mahley, R. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151254698 · Cited by 392
Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors.
Mahley, R. W., Hui, D. Y., Innerarity, T. L., & Weisgraber, K. H. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110365 · Cited by 373
Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.
Holtzman, D. M., Pitas, R. E., Kilbridge, J., Nathan, B., Mahley, R. W., Bu, G., & Schwartz, A. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9480 · Cited by 349
Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease
Holtzman, D. M., Bales, K. R., Wu, S., Bhat, P., Parsadanian, M., Fagan, A. M., Chang, L. K., Sun, Y., & Paul, S. M. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6179 · Cited by 349
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice
Harris, F. M., Brecht, W. J., Xu, Q., Tesseur, I., Kekonius, L., Wyss-Coray, T., Fish, J. D., Masliah, E., Hopkins, P. C., Scearce-Levie, K., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1434398100 · Cited by 342
Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth
Bellosta, S., Nathan, B. P., Orth, M., Dong, L.-M., Mahley, R. W., & Pitas, R. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27063 · Cited by 313
Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains.
Wetterau, J. R., Aggerbeck, L. P., Rall, S. C., & Weisgraber, K. H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68778-2 · Cited by 293
The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments.
Innerarity, T. L., Friedlander, E. J., Rall, S. C., Weisgraber, K. H., & Mahley, R. W. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44180-9 · Cited by 276
The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization
Nathan, B. P., Chang, K.-C., Bellosta, S., Brisch, E., Ge, N., Mahley, R. W., & Pitas, R. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.34.19791 · Cited by 276
Exploring the Etiology of Alzheimer Disease Using Molecular Genetics
Lendon, C. L. (1997) · JAMA · doi:10.1001/jama.1997.03540340059034 · Cited by 274
Expression of Human Apolipoprotein E4 in Neurons Causes Hyperphosphorylation of Protein Tau in the Brains of Transgenic Mice
Tesseur, I. C., Dorpe, J. V., Spittaels, K., den Haute, C. V., Moechars, D., & LEUVEN, F. V. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64963-2 · Cited by 246
Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3.
Weisgraber, K. H., Rall, S. C., Mahley, R. W., Milne, R. W., Marcel, Y. L., & Sparrow, J. T. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35898-2 · Cited by 240
Untitled work
Lalazar (1989) · doi:10.1016/s0021-9258(18)81806-3 · Cited by 238
Apolipoprotein E: Binding to Soluble Alzheimer′s β-Amyloid
Wisniewski, T., Golabek, A., Matsubara, E., Ghiso, J., & Frangione, B. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1423 · Cited by 212
Apolipoprotein E4 Forms a Molten Globule
Morrow, J. A., Hatters, D. M., Lu, B., Höchtl, P., Oberg, K. A., Rupp, B., & Weisgraber, K. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204898200 · Cited by 204
Characterization of stable complexes involving apolipoprotein E and the amyloid β peptide in Alzheimer's disease brain
Näslund, J., Thyberg, J., Tjernberg, L. O., Wernstedt, C., Karlström, A. R., Bogdanović, N., Gandy, S., Lannfelt, L., Terenius, L. Y., & Nordstedt, C. (1995) · Neuron · doi:10.1016/0896-6273(95)90079-9 · Cited by 197
Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study
Han, S.-H., Einstein, G., Weisgraber, K. H., Strittmatter, W. J., Saunders, A. M., Pericak-Vance, M., Roses, A. D., & Schmechel, D. E. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199409000-00013 · Cited by 195
Behavioral phenotyping of GFAP-ApoE3 and -ApoE4 transgenic mice: ApoE4 mice show profound working memory impairments in the absence of Alzheimer’s-like neuropathology.
Hartman, R. E., Wozniak, D. F., Nardi, A., Olney, J. W., Sartorius, L., & Holtzman, D. M. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7715 · Cited by 157
Is Alzheimer's disease an apolipoprotein E amyloidosis?
Wisniewski, T., Lalowski, M., Golabek, A., Frangione, B., & Vogel, T. (1995) · The Lancet · doi:10.1016/s0140-6736(95)90701-7 · Cited by 155
Apolipoprotein E Is Present in Hippocampal Neurons without Neurofibrillary Tangles in Alzheimer's Disease and in Age-Matched Controls
Han, S., Hulette, C., Saunders, A. M., Einstein, G., Pericak‐Vance, M. A., Strittmatter, W. J., Roses, A. D., & Schmechel, D. E. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1108 · Cited by 155
Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity
Tolar, M., Keller, J. N., Chan, S., Mattson, M. P., Marques, M. A., & Crutcher, K. A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-16-07100.1999 · Cited by 148
Self-citation
CELLULAR AND MOLECULAR BIOLOGY OF ALZHEIMER'S DISEASE AND ANIMAL MODELS
Price, D. L., & Sisodia, S. S. (1994) · Annual Review of Medicine · doi:10.1146/annurev.med.45.1.435 · Cited by 132
Apolipoprotein E: A potent inhibitor of endothelial and tumor cell proliferation
Vogel, T., Guo, N., Guy, R., Drezlich, N., Krutzsch, H. C., Blake, D. A., Panet, A., & Roberts, D. D. (1994) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240540306 · Cited by 122
Chapter 29 Neuropathological changes in Alzheimer disease
Terry, R. D. (1994) · Progress in brain research · doi:10.1016/s0079-6123(08)61964-0 · Cited by 122
Expression of apolipoprotein E mRNA in rat microglia
Nakai, M., Kawamata, T., Taniguchi, T., Maeda, K., & Tanaka, C. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12716-6 · Cited by 121
Neurotoxicity of the 22 kDa Thrombin-Cleavage Fragment of Apolipoprotein E and Related Synthetic Peptides Is Receptor-Mediated
Tolar, M., Marques, M. A., Harmony, J. A. K., & Crutcher, K. A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05678.1997 · Cited by 114
Self-citation
APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress
COLTON, C., BROWN, C., COOK, D., NEEDHAM, L., XU, Q., CZAPIGA, M., SAUNDERS, A., SCHMECHEL, D., RASHEED, K., & VITEK, M. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00016-7 · Cited by 108
Apolipoprotein E Is Synthesized in the Retina by Müller Glial Cells, Secreted into the Vitreous, and Rapidly Transported into the Optic Nerve by Retinal Ganglion Cells
Amaratunga, A., Abraham, C. R., Edwards, R. B., Sandell, J. H., Schreiber, B. M., & Fine, R. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.10.5628 · Cited by 107
Quantitation of apoE Domains in Alzheimer Disease Brain Suggests a Role for apoE in Aß Aggregation
Cho, H. S., Hyman, B. T., Greenberg, S. M., & Rebeck, G. W. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.4.342 · Cited by 103
Cell-derived Apolipoprotein E (ApoE) Particles Inhibit Vascular Cell Adhesion Molecule-1 (VCAM-1) Expression in Human Endothelial Cells
Stannard, A. K., Riddell, D. R., Sacre, S. M., Tagalakis, A. D., Langer, C., von Eckardstein, A., Cullen, P., Athanasopoulos, T., Dickson, G., & Owen, J. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104812200 · Cited by 101
Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease
Buttini, M., Akeefe, H., Lin, C. J., Mahley, R. W., Pitas, R. E., Wyss‐Coray, T., & Mucke, L. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00069-5 · Cited by 98
A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicity
Marques, M. A., Tolar, M., Harmony, J. A. K., & Crutcher, K. A. (1996) · Neuroreport · doi:10.1097/00001756-199611040-00025 · Cited by 97
Self-citation
Health care utilization and costs of Alzheimer's disease: the role of co-morbid conditions, disease stage, and pharmacotherapy.
Fillit, H. M., Hill, J. W., & Futterman, R. (2002) · PubMed · Cited by 92
ApoE isoforms affect neuronal N-methyl-d-aspartate calcium responses and toxicity via receptor-mediated processes
Qiu, Z., Crutcher, K. A., Hyman, B. T., & Rebeck, G. W. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.017 · Cited by 87
Self-citation
Neuronal Apoptosis by Apolipoprotein E4 through Low-Density Lipoprotein Receptor-Related Protein and Heterotrimeric GTPases
Hashimoto, Y., Jiang, H., Niikura, T., Ito, Y., Hagiwara, A., Umezawa, K., Abe, Y., Murayama, Y., & Nishimoto, I. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08401.2000 · Cited by 86
β‐Amyloid Peptide Interacts Specifically with the Carboxyl‐Terminal Domain of Human Apolipoprotein E
Pillot, T., Goethals, M., Najib, J., Labeur, C., Lins, L., Chambaz, J., Brasseur, R., Vandekerckhove, J. S., & Rosseneu, M. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720230.x · Cited by 84
Lipoproteins of Special Significance in Atherosclerosis: Insights Provided by Studies of Type III Hyperlipoproteinemia
MAHLEY, R. W., INNERARITY, T. L., RALL, S. C., & WEISGRABER, K. H. (1985) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1985.tb11860.x · Cited by 75
Acute Hyperinsulinemia Decreases the Hepatic Secretion of Very-Low-Density Lipoprotein Apolipoprotein B-100 in NIDDM
Cummings, M. H., Watts, G. F., Umpleby, A. M., Hennessy, T. R., Kelly, J. M., Jackson, N. C., & Sönksen, P. H. (1995) · Diabetes · doi:10.2337/diab.44.9.1059 · Cited by 74
Apoprotein E-rich high density lipoproteins inhibit ovarian androgen synthesis.
Dyer, C. A., & Curtiss, L. K. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)38064-5 · Cited by 70
Isolation and Characterization of Apolipoproteins from Murine Microglia
Xu, Q., Li, Y., Cyras, C., Sanan, D. A., & Cordell, B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002796200 · Cited by 69
Synaptic loss is accompanied by an increase in synaptic area in the dentate gyrus of aged human apolipoprotein E4 transgenic mice
Cambon, K., Davies, H. A., & Stewart, M. G. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00065-8 · Cited by 63
Apolipoprotein E Inhibits Neointimal Hyperplasia after Arterial Injury in Mice
Zhu, B., Kuhel, D. G., Witte, D. P., & Hui, D. Y. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64823-7 · Cited by 61
Localization of a Domain in Apolipoprotein E with both Cytostatic and Cytotoxic Activity
Clay, M. A., Anantharamaiah, G. M., Mistry, M. J., Balasubramaniam, A., & Harmony, J. A. K. (1995) · Biochemistry · doi:10.1021/bi00035a020 · Cited by 58
Apolipoprotein-E degradation in human very low density lipoproteins by plasma protease(s): Chemical and biological consequences
Bradley, W. A., Gilliam, E. B., Gotto, A. M., & Gianturco, S. H. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(82)91927-1 · Cited by 52
Neurite Degeneration Elicited by Apolipoprotein E Peptides
Crutcher, K. A., Clay, M. A., Scott, S. A., Tian, X., Tolar, M., & Harmony, J. A. K. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1191 · Cited by 51
Self-citation
Perlecan Mediates the Antiproliferative Effect of Apolipoprotein E on Smooth Muscle Cells
Paka, L., Goldberg, I. J., Obunike, J. C., Choi, S. Y., Saxena, U., Goldberg, I. D., & Pillarisetti, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.51.36403 · Cited by 50
Expression of apolipoprotein E by cultured vascular smooth muscle cells is controlled by growth state.
Majack, R. A., Castle, C. K., Goodman, L. V., Weisgraber, K. H., Mahley, R. W., Shooter, E. M., & Gebicke-Haerter, P. J. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.3.1207 · Cited by 47
The Endosomal Trafficking of Apolipoprotein E3 and E4 in Cultured Human Brain Neurons and Astrocytes
DeKroon, R. M., & Armati, P. J. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0362 · Cited by 38
Molecular Determinants of the Interaction Between the C‐Terminal Domain of Alzheimer's β‐Amyloid Peptide and Apolipoprotein E α‐Helices
Lins, L., Thomas‐Soumarmon, A., Pillot, T., Vandekerckhove, J. S., Rosseneu, M., & Brasseur, R. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730758.x · Cited by 36
Functional Domains of Apolipoprotein E and Apolipoprotein B
Innerarity, T. L., Weisgraber, K. H., Rall, S. C., & Mahley, R. W. (1987) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1987.tb09903.x · Cited by 33
Distinct Apolipoprotein E Isoform Preference for Inhibition of Smooth Muscle Cell Migration and Proliferation
Zeleny, M., Swertfeger, D. K., Weisgraber, K. H., & Hui, D. Y. (2002) · Biochemistry · doi:10.1021/bi026202k · Cited by 33
A test of the cytosolic apolipoprotein E hypothesis fails to detect the escape of apolipoprotein E from the endocytic pathway into the cytosol and shows that direct expression of apolipoprotein E in the cytosol is cytotoxic
DeMattos, R. B., Thorngate, F. E., & Williams, D. L. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02464.1999 · Cited by 30
Amino-terminus truncated apolipoprotein E is the major species in amyloid deposits in Alzheimer's disease-affected brains: a possible role for apolipoprotein E in Alzheimer's disease
Aizawa, Y., Fukatsu, R., Takamaru, Y., Tsuzuki, K., Chiba, H., Kobayashi, K., Fujii, N., & Takahata, N. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00640-9 · Cited by 29
Apolipoprotein E (ApoE), a novel heparin-binding protein inhibits the development of Kaposi's sarcoma-like lesions in BALB/c nu/nu mice.
Browning, P. J., Roberts, D. D., Zabrenetzky, V. S., Bryant, J., Kaplan, M. P., Washington, R., Panet, A., Gallo, R. C., & Vogel, T. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.5.1949 · Cited by 27
Phosphorylation state of tau in the hippocampus of apolipoprotein E4 and E3 knock-in mice
Kobayashi, M., Ishiguro, K., Fukui, Y., Yokoyama, M., & Fujita, S. C. (2003) · Neuroreport · doi:10.1097/00001756-200304150-00008 · Cited by 23
Cellular and Molecular Biology of Lipoprotein Metabolism: Characterization of Lipoprotein Receptor-Ligand Interactions
Mahley, R. W., Innerarity, T. L., Weisgraber, K. H., Rall, S. C., Hui, D. Y., Lalazar, A., Boyles, J. K., Taylor, J. M., & Levy-Wilson, B. (1986) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1986.051.01.095 · Cited by 22
Apolipoprotein E-Related Neurotoxicity as a Therapeutic Target for Alzheimer's Disease
Marques, M. A., & Crutcher, K. A. (2003) · Journal of Molecular Neuroscience · doi:10.1385/jmn:20:3:327 · Cited by 17
Self-citation
Apolipoprotein E: Receptor Binding Properties
Weisgraber, K. H., Innerarity, T. L., Rall, S. C., & Mahley, R. W. (1985) · Springer eBooks · doi:10.1007/978-1-4613-2459-1_13 · Cited by 7
Receptor interactions controlling lipoprotein metabolism
Weisgraber, K. H., Innerarity, T. L., Rall, S. C., & Mahley, R. W. (1985) · Canadian Journal of Biochemistry and Cell Biology · doi:10.1139/o85-111 · Cited by 6
Economics, pharmacoeconomics and drug discovery for dementias
Fillit, H. M. (2002) · Drug Discovery Today · doi:10.1016/s1359-6446(02)02379-6 · Cited by 4
Molecular Biology of Alzheimer's Disease
Whitehouse, P. J., Landreth, G. E., & Younkin, S. G. (1993) · Elsevier eBooks · doi:10.1016/b978-0-12-462003-2.50008-0 · Cited by 3

Sorted by citations

Apolipoprotein E: From lipid transport to neurobiology
Hauser, P. S., Narayanaswami, V., & Ryan, R. O. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.09.001 · Cited by 320
Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence
Yamazaki, Y., Painter, M. M., Bu, G., & Kanekiyo, T. (2016) · CNS Drugs · doi:10.1007/s40263-016-0361-4 · Cited by 173
Apolipoprotein E and cholesterol in aging and disease in the brain
de Chaves, E. P., Narayanaswami, V., Christoffersen, C., & Nielsen, L. B. (2008) · Future Lipidology · doi:10.2217/17460875.3.5.505 · Cited by 164
Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation
Lanfranco, M. F., Sepulveda, J., Kopetsky, G., & Rebeck, G. W. (2021) · Glia · doi:10.1002/glia.23974 · Cited by 164
Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model
Huynh, T.-P. V., Wang, C., Tran, A. C., Tabor, G. T., Mahan, T. E., Francis, C. M., Finn, M. B., Spellman, R., Manis, M., Tanzi, R. E., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0337-1 · Cited by 139

See all 29

Authors: Marques, M. A., Owens, P. A., & Crutcher, K. A.
Affiliations: University of Cincinnati (US)
Corresponding author: Crutcher, Keith A.
ORCID: Crutcher, Keith A.
Venue: Journal of Molecular Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2004
Volume: 24
Issue: 1
Pages: 073-080
ISSN: 0895-8696 (ISSN-L)
DOI: 10.1385/jmn:24:1:073
OpenAlex: W2021255192
Cited by: 29
References: 74
Citations by year: 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 2
FWCI: 0.61
Type: journal article
Language: en
Open access: closed
Locations: Journal of Molecular Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Keywords: apolipoprotein E, Alzheimer's disease, aspartic protease, protease inhibitors, APOE ε4, amyloid plaques, neurofibrillary tangles, human brain, inhibitor screening, transgenic mouse model
MeSH terms: Alzheimer Disease, Animals, Apolipoproteins E, Brain, Drug Evaluation, Preclinical, Enzyme Inhibitors, Humans, Peptide Fragments, Peptide Hydrolases, Neurofibrillary Tangles, Plaque, Amyloid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Progress Toward Identification of Protease Activity Involved in Proteolysis of Apolipoprotein E in Human Brain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks