Is Alzheimer's disease an apolipoprotein E amyloidosis?

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

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Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8098 · Cited by 1,363 · see citing works

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

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Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

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Peptide Compositions of the Cerebrovascular and Senile Plaque Core Amyloid Deposits of Alzheimer′s Disease

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Apolipoprotein E4 allele in a population–based study of early–onset Alzheimer's disease

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Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro.

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ApoE genotype accounts for the vast majority of AD risk and AD pathology

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Apolipoprotein E structure: insights into function

Hatters, D. M., Peters-Libeu, C. A., & Weisgraber, K. H. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.06.008 · Cited by 583 · see citing works

Statins for the prevention of dementia

McGuinness, B., Craig, D., Bullock, R., & Passmore, P. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003160.pub3 · Cited by 490 · see citing works

Cerebral Amyloid Angiopathy: A Systematic Review

Biffi, A., & Greenberg, S. M. (2011) · Journal of Clinical Neurology · doi:10.3988/jcn.2011.7.1.1 · Cited by 444 · see citing works

Amyloid-β peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease

Yan, S. D., Zhu, H., Fu, J., Yan, S. F., Roher, A. E., Tourtellotte, W. W., Rajavashisth, T. B., Chen, X., Godman, G. C., Stern, D. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5296 · Cited by 427 · see citing works

Apolipoprotein e sets the stage: response to injury triggers neuropathology

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Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease

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Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β

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Apolipoprotein E: From lipid transport to neurobiology

Hauser, P. S., Narayanaswami, V., & Ryan, R. O. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.09.001 · Cited by 320 · see citing works

Human Apolipoprotein E4 Alters the Amyloid-β 40:42 Ratio and Promotes the Formation of Cerebral Amyloid Angiopathy in an Amyloid Precursor Protein Transgenic Model

Fryer, J. D., Simmons, K., Parsadanian, M., Bales, K. R., Paul, S. M., Sullivan, P. M., & Holtzman, D. M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5170-04.2005 · Cited by 278 · see citing works

Macromolecular Crowding Accelerates Amyloid Formation by Human Apolipoprotein C-II

Hatters, D. M., Minton, A. P., & Howlett, G. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110429200 · Cited by 276 · see citing works

Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid β peptides

TOKUDA, T., CALERO, M., MATSUBARA, E., VIDAL, R., KUMAR, A., PERMANNE, B., ZLOKOVIC, B., SMITH, J. D., LADU, M. J., ROSTAGNO, A., et al. (2000) · Biochemical Journal · doi:10.1042/bj3480359 · Cited by 272 · see citing works

Statins for the treatment of dementia

McGuinness, B., Craig, D., Bullock, R. A., Malouf, R. S., & Passmore, P. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007514.pub3 · Cited by 232 · see citing works

Oxidative Stress and Neurodegenerative Disorders

Sun, A. Y., & Chen, Y. (1998) · Journal of Biomedical Science · doi:10.1007/bf02255928 · Cited by 214 · see citing works

Statins for the prevention of dementia

McGuinness, B., Craig, D., Bullock, R., & Passmore, P. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003160.pub2 · Cited by 193 · see citing works

Amyloidosis and Alzheimer’s disease

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Characterization of stable complexes involving apolipoprotein E and the amyloid β peptide in Alzheimer's disease brain

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Biology of Aβ Amyloid in Alzheimer's Disease

Wısnıewskı, T., Ghiso, J. A., & Frangione, B. (1997) · Neurobiology of Disease · doi:10.1006/nbdi.1997.0147 · Cited by 185 · see citing works

Mechanism of Cerebral β-Amyloid Angiopathy: Murine and Cellular Models

Herzig, M. C., Nostrand, W. E. V., & Jucker, M. (2006) · Brain Pathology · doi:10.1111/j.1750-3639.2006.tb00560.x · Cited by 167 · see citing works

Apolipoprotein E and cholesterol in aging and disease in the brain

de Chaves, E. P., Narayanaswami, V., Christoffersen, C., & Nielsen, L. B. (2008) · Future Lipidology · doi:10.2217/17460875.3.5.505 · Cited by 164 · see citing works

Apolipoprotein E Markedly Facilitates Age-Dependent Cerebral Amyloid Angiopathy and Spontaneous Hemorrhage in Amyloid Precursor Protein Transgenic Mice

Fryer, J. D., Taylor, J. W., DeMattos, R. B., Bales, K. R., Paul, S. M., Parsadanian, M., & Holtzman, D. M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07889.2003 · Cited by 160 · see citing works

Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure

Zhong, N., & Weisgraber, K. H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r800009200 · Cited by 159 · see citing works

Genetic Modification of the Phenotypes Produced by Amyloid Precursor Protein Overexpression in Transgenic Mice

Carlson, G. A., Borchelt, D. R., Dake, A., Turner, S., Danielson, V., Coffin, J. D., Eckman, C., Meiners, J., Nilsen, S. P., Younkin, S. G., et al. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.11.1951 · Cited by 158 · see citing works

Amyloid-β immunisation for Alzheimer's disease

Wisniewski, T., & Konietzko, U. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70170-4 · Cited by 155 · see citing works

A Synthetic Peptide Blocking the Apolipoprotein E/β-Amyloid Binding Mitigates β-Amyloid Toxicity and Fibril Formation in Vitro and Reduces β-Amyloid Plaques in Transgenic Mice

Sadowski, M., Pankiewicz, J., Scholtzova, H., Ripellino, J. A., Li, Y., Schmidt, S. D., Mathews, P. M., Fryer, J. D., Holtzman, D. M., Sigurdsson, E. M., et al. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63355-x · Cited by 154 · see citing works

ole of apoE/Aβ Interactions in the Pathogenesis of Alzheimer's Disease and Cerebral Amyloid Angiopathy

Holtzman, D. M. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:2:147 · Cited by 143 · see citing works

Fibrillar Amyloid Protein Present in Atheroma Activates CD36 Signal Transduction

Medeiros, L. A., Khan, T., Khoury, J. B. E., Pham, C. L. L., Hatters, D. M., Howlett, G. J., Lopez, R., O’Brien, K. D., & Moore, K. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311735200 · Cited by 140 · see citing works

The Interaction between Apolipoprotein E and Alzheimer's Amyloid β-Peptide Is Dependent on β-Peptide Conformation

Golabek, A. A., Soto, C. A., Vogel, T., & Wısnıewskı, T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10602 · Cited by 137 · see citing works

The “Nonamyloidogenic” p3 Fragment (Amyloid β17-42) Is a Major Constituent of Down's Syndrome Cerebellar Preamyloid

Lalowski, M. M., Golabek, A. A., Lemere, C. A., Selkoe, D. J., Wı́sniewski, H. M., Beavis, R. C., Frangione, B., & Wısnıewskı, T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33623 · Cited by 134 · see citing works

APOE-amyloid interaction: Therapeutic targets

Wısnıewskı, T., & Drummond, E. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104784 · Cited by 125 · see citing works

Hypercholesterolaemia and vascular dementia

Appleton, J. P., Scutt, P., Sprigg, N., & Bath, P. M. (2017) · Clinical Science · doi:10.1042/cs20160382 · Cited by 127 · see citing works

The Early Events That Initiate β-Amyloid Aggregation in Alzheimer’s Disease

Zhang, X., Fu, Z., Meng, L., He, M., & Zhang, Z. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00359 · Cited by 122 · see citing works

Apolipoprotein E epsilon 4 allele decreases functional connectivity in Alzheimer's disease as measured by EEG coherence

Jelić, V., Julin, P., Shigeta, M., Nordberg, A. K., Lannfelt, L., Winblad, B. G., & Wahlund, L. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.63.1.59 · Cited by 118 · see citing works

The classification of amyloid deposits in clinicopathological practice

Röcken, C., SCHWOTZER, E. B., Linke, R., & Saeger, W. (1996) · Histopathology · doi:10.1111/j.1365-2559.1996.tb01416.x · Cited by 115 · see citing works

Conformational mimicry in Alzheimer's disease. Role of apolipoproteins in amyloidogenesis.

Wısnıewskı, T., Golabek, A. A., Kida, E., Wisniewski, K. E., & Frangione, B. (1995) · Europe PMC (PubMed Central) · Cited by 107 · see citing works

Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils

Hatters, D. M., Zhong, N., Rutenber, E., & Weisgraber, K. H. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.06.080 · Cited by 105 · see citing works

Quantitation of apoE Domains in Alzheimer Disease Brain Suggests a Role for apoE in Aß Aggregation

Cho, H. S., Hyman, B. T., Greenberg, S. M., & Rebeck, G. W. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.4.342 · Cited by 100 · see citing works

Electroencephalogram and Alzheimer’s Disease: Clinical and Research Approaches

Tsolaki, A., Kazis, D. A., Kompatsiaris, I. Y., Kosmidou, V. E., & Tsolaki, M. (2014) · International Journal of Alzheimer s Disease · doi:10.1155/2014/349249 · Cited by 101 · see citing works

The Molecular Chaperone, α-Crystallin, Inhibits Amyloid Formation by Apolipoprotein C-II

Hatters, D. M., Lindner, R. A., Carver, J. A., & Howlett, G. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105285200 · Cited by 100 · see citing works

Amyloid β binding proteins in vitro and in normal human cerebrospinal fluid

Golabek, A., Marques, M. A., Lalowski, M., & Wisniewski, T. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11565-7 · Cited by 99 · see citing works

Annexin 5 and apolipoprotein E2 protect against Alzheimer’s amyloid-β-peptide cytotoxicity by competitive inhibition at a common phosphatidylserine interaction site

Lee, G., Pollard, H. B., & Arispe, N. J. (2002) · Peptides · doi:10.1016/s0196-9781(02)00060-8 · Cited by 93 · see citing works

Association of human, rat, and rabbit apolipoprotein E with β‐amyloid

LaDu, M. J., Lukens, J. R., Reardon, C. A., & Getz, G. S. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970701)49:1

Statins for the treatment of dementia

McGuinness, B., O’Hare, J., Craig, D., Bullock, R. A., Malouf, R. S., & Passmore, P. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007514.pub2 · Cited by 92 · see citing works

Vascular abnormalities: the insidious pathogenesis of Alzheimer’s disease☆

Shi, J., Perry, G. L., Smith, M. A., & Friedland, R. P. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00119-6 · Cited by 86 · see citing works

Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain

Jones, P. B., Adams, K. W., Rozkalne, A., Spires-Jones, T. L., Hshieh, T. T., Hashimoto, T., von Armin, C. A. F., Mielke, M., Bacskai, B. J., & Hyman, B. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014586 · Cited by 84 · see citing works

Isolation of Cytochrome P450 Inhibitors from Strawberry Fruit, Fragaria ananassa

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Amyloid β40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice

Ji, Y., Permanne, B., Sigurdsson, E. M., Holtzman, D. M., & Wısnıewskı, T. (2001) · Journal of Alzheimer s Disease · doi:10.3233/jad-2001-3105 · Cited by 83 · see citing works

Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights

Das, M., & Gursky, O. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-17344-3_8 · Cited by 80 · see citing works

Apolipoprotein E: Essential Catalyst of the Alzheimer Amyloid Cascade

Potter, H., & Wısnıewskı, T. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/489428 · Cited by 80 · see citing works

Deposition of apolipoproteins E and J in senile plaques is topographically determined in both Alzheimer's disease and Down's syndrome brain

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Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations

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Glycation and Microglial Reaction in Lesions of Alzheimer's Disease

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Cerebral Amyloid Angiopathy: A Common Cause of Cerebral Hemorrhage

Pezzini, A., Zotto, E. D., Volonghi, I., Giossi, A., Costa, P., & Padovani, A. (2009) · Current Medicinal Chemistry · doi:10.2174/092986709788682047 · Cited by 76 · see citing works

Alzheimer amyloid-beta peptide forms denaturant-resistant complex with type epsilon 3 but not type epsilon 4 isoform of native apolipoprotein E.

Zhou, Z., Smith, J. D., Greengard, P., & Gandy, S. (1996) · PubMed Central · Cited by 71 · see citing works

Can Statins Prevent or Help Treat Alzheimer's Disease?

McGuinness, B., & Passmore, P. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091570 · Cited by 67 · see citing works

Amyloid β 1-42 deposits do not lead to Alzheimer's neuritic plaques in aged dogs

Wısnıewskı, T., Lalowski, M. M., Bobik, M., RUSSELL, M., Strosznajder, J. B., & Frangione, B. (1996) · Biochemical Journal · doi:10.1042/bj3130575 · Cited by 66 · see citing works

The Interaction of Amyloid-β with ApoE

Carter, D. B. (2005) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/0-387-23226-5_13 · Cited by 65 · see citing works

Cochrane review on ‘Statins for the treatment of dementia’

McGuinness, B., O’Hare, J., Craig, D., Bullock, R. A., Malouf, R. S., & Passmore, P. (2012) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3797 · Cited by 64 · see citing works

Cerebrospinal fluid apolipoprotein E level is increased in late-onset Alzheimer's disease

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Interaction of Transthyretin with Amyloid β‐Protein: Binding and Inhibition of Amyloid Formation

Schwarzman, A. L., & Goldgaber, D. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514924.ch10 · Cited by 60 · see citing works

Apolipoproteins and amyloid fibril formation in atherosclerosis

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Diffuse beta-amyloid plaques and hyperphosphorylated tau are unrelated processes in aged dogs with behavioral deficits

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Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants.

Permanne, B., Pérez, C. A., Soto, C., Frangione, B., & Wisniewski, T. (1997) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1006/bbrc.1997.7727 · Cited by 62 · see citing works

Association between Alzheimer's Disease and a Functional Polymorphism in the Myeloperoxidase Gene

Crawford, F., Freeman, M. J., Schinka, J. A., Morris, M. D., Abdullah, L. I., Richards, D., Sevush, S., Duara, R., & MULLAN, M. J. (2001) · Experimental Neurology · doi:10.1006/exnr.2000.7560 · Cited by 59 · see citing works

Apolipoprotein E Carboxyl-terminal Fragments Are Complexed to Amyloids A and L

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Isoform-specific proteolysis of apolipoprotein-E in the brain

Elliott, D. A., Tsoi, K., Holinkova, S., Chan, S. L., Kim, W. S., Halliday, G. M., Rye, K., & Garner, B. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.02.006 · Cited by 57 · see citing works

Suppression of apolipoprotein C‐II amyloid formation by the extracellular chaperone, clusterin

Hatters, D. M., Wilson, M. R., Easterbrook‐Smith, S. B., & Howlett, G. J. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02957.x · Cited by 58 · see citing works

Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice

Pankiewicz, J. E., Guridi, M., Kim, J., Asuni, A. A., Sanchez, S., Sullivan, P. M., Holtzman, D. M., & Sadowski, M. J. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0075-0 · Cited by 57 · see citing works

Apolipoprotein E associated with reconstituted high‐density lipoprotein‐like particles is protected from aggregation

Hubin, E., Verghese, P. B., van Nuland, N., & Broersen, K. (2019) · FEBS Letters · doi:10.1002/1873-3468.13428 · Cited by 73 · see citing works

Targeting Apolipoprotein E/Amyloid β Binding by Peptoid CPO_Aβ17-21 P Ameliorates Alzheimer’s Disease Related Pathology and Cognitive Decline

Liu, S., Park, S.-A., Allington, G., Prelli, F. C., Sun, Y., Martá-Ariza, M., Scholtzova, H., Biswas, G. K., Brown, B., Verghese, P. B., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08604-8 · Cited by 57 · see citing works

A neuropsychological profile of Down syndrome: Cognitive skills and brain morphology

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Immunological and Anti-Chaperone Therapeutic Approaches for Alzheimer Disease

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S182 protein in Alzheimer's disease neuritic plaques

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ROLE OF MACROPHAGES IN ACETAMINOPHEN (PARACETAMOL)-INDUCED HEPATOTOXICITY

Goldin, R. D., Ratnayaka, I., BREACH, C. S., Brown, I. N., & Wickramasinghe, S. N. (1996) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199608)179:4 · Cited by 102 · see citing works

Apolipoprotein E increases the fibrillogenic potential of synthetic peptides derived from Alzheimer's, Gelsolin and AA amyloids

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Apolipoprotein E is highly susceptible to oxidation by myeloperoxidase, an enzyme present in the brain

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Amyloid in Alzheimer's disease and prion-related encephalopathies: studies with synthetic peptides

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Alzheimer Amyloid-β Peptide Forms Denaturant-Resistant Complex with Type ε3 but Not Type ε4 Isoform of Native Apolipoprotein E

Zhou, Z., Smith, J. D., Greengard, P., & Gandy, S. (1996) · Molecular Medicine · doi:10.1007/bf03401614 · Cited by 72 · see citing works

The prionoses and other conformational disorders

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High Levels of Homocysteine Results in Cerebral Amyloid Angiopathy in Mice

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