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Molecular and Cellular Immune Mediators of Neuroprotection
Abstract
Our view of the immune privileged status of the brain has dramatically changed during the past two decades. Even though systemic immune stimuli have the ability to activate different populations of neurons, cells of monocytic lineage also have access to the neuronal tissue and populate it as microglia. Although such a phenomenon is limited in intact brains, it is greatly increased during neurodegenerative processes associated with innate immunity and the release of pro-inflammatory molecules by either resident microglia or those derived from the bone marrow stem cells. The role of these events is currently a matter of great debate and controversy, especially as it relates to brain protection, repair, or further injury. In recent years, accumulating data have supported the notion that when immune molecules are timely released by microglia, they limit neuronal injury in the presence of pathogens and toxic agents, help clear debris from degenerated cells, and restore the cerebral environment for repair. It has been shown that alteration of the natural innate immune response by microglia has direct consequences in exacerbating the damages following acute injury to neurons. This article presents and discusses these data, supporting a powerful neuroprotective role for microglia and their innate immune reactions in response to pathogens and central nervous system insults.
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Glutamate neurotoxicity and diseases of the nervous system
Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,184
Pathobiology of ischaemic stroke: an integrated view
Dirnagl, U., Iadecola, C., & Moskowitz, M. A. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01401-0 · Cited by 3,943
The blood-brain barrier/neurovascular unit in health and disease
Hawkins, B. T., & Davis, T. P. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.4 · Cited by 2,661
Mechanisms, challenges and opportunities in stroke
Lo, E. H., Dalkara, T., & Moskowitz, M. A. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1106 · Cited by 1,808
Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury
Brines, M. L., Ghezzi, P., Keenan, S., Agnello, D., de Lanerolle, N. C., Cerami, C., Itri, L. M., & Cerami, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.19.10526 · Cited by 1,402
Dong, Y., & Benveniste, E. N. (2001) · Glia · doi:10.1002/glia.1107 · Cited by 1,325
Simard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.022 · Cited by 1,265
Self-citationErythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
Sirén, A., Fratelli, M., Brines, M. L., Goemans, C. G., Casagrande, S., Lewczuk, P., Keenan, S., Gleiter, C. H., Pasquali, C., Capobianco, A., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051606598 · Cited by 1,019
Erythropoietin Therapy for Acute Stroke Is Both Safe and Beneficial
Ehrenreich, H., Hasselblatt, M., Dembowski, C., Cepek, L., Lewczuk, P., Stiefel, M., Rustenbeck, H.-H., Breiter, N., Jacob, S., Knerlich‐Lukoschus, F., et al. (2002) · Molecular Medicine · doi:10.1007/bf03402029 · Cited by 1,017
TNFα promotes proliferation of oligodendrocyte progenitors and remyelination
Arnett, H. A., Mason, J., Marino, M., Suzuki, K., Matsushima, G. K., & Ting, J. P.-Y. (2001) · Nature Neuroscience · doi:10.1038/nn738 · Cited by 1,012
In vivo evidence that erythropoietin protects neurons from ischemic damage
Sakanaka, M., Wen, T., Matsuda, S., Masuda, S., Morishita, E., Nagao, M., & Sasaki, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4635 · Cited by 948
Levy, D. E., & Lee, C. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15650 · Cited by 832
The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms
Engelhardt, B., & Ransohoff, R. M. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.07.004 · Cited by 674
Akt/Protein Kinase B Inhibits Cell Death by Preventing the Release of Cytochrome c from Mitochondria
Kennedy, S. G., Kandel, E., Cross, T. K., & Hay, N. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.8.5800 · Cited by 653
Priller, J., Flügel, A., Wehner, T., Boentert, M., Haas, C. A., Prinz, M., Fernández-Klett, F., Prass, K., Bechmann, I., de Boer, B. A., et al. (2001) · Nature Medicine · doi:10.1038/nm1201-1356 · Cited by 637
Toll signaling pathways in the innate immune response
Anderson, K. V. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)00045-x · Cited by 634
Fontaine, V. K., Mohand‐Saïd, S., Hanoteau, N., Fuchs, C., Pfizenmaier, K., & Eisel, U. L. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-j0001.2002 · Cited by 590
Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells
Yin, Y., Henzl, M. T., Lorber, B., Nakazawa, T., Thomas, T. T., Jiang, F., Langer, R., & Benowitz, L. I. (2006) · Nature Neuroscience · doi:10.1038/nn1701 · Cited by 520
Celik, M., Gökmen, N., Erbayraktar, S., Akhisaroğlu, M., Konakç, S., Ulukuş, Ç., Genç, Ş., Genç, K., Sağıroğlu, E., Cerami, A., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042693799 · Cited by 472
Structure of the Blood–Brain Barrier and Its Role in the Transport of Amino Acids
Hawkins, R. A., O’Kane, R. L., Simpson, I. A., & Viña, J. R. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.1.218s · Cited by 453
Marchetti, L., Klein, M., Schlett, K., Pfizenmaier, K., & Eisel, U. L. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311766200 · Cited by 430
Verge, G. M., Milligan, E. D., Maier, S. F., Watkins, L. R., Naeve, G. S., & Foster, A. C. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03593.x · Cited by 386
Neuroprotection and acute spinal cord injury: A reappraisal
Hall, E. D., & Springer, J. E. (2004) · NeuroRx · doi:10.1602/neurorx.1.1.80 · Cited by 380
Toll‐like receptors in central nervous system glial inflammation and homeostasis
Kielian, T. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20767 · Cited by 373
Simard, A. R., & Rivest, S. (2004) · The FASEB Journal · doi:10.1096/fj.04-1517fje · Cited by 362
Self-citationNeuroprotective Function of the PGE 2 EP2 Receptor in Cerebral Ischemia
McCullough, L. D., Wu, L., Haughey, N. J., Liang, X., Hand, T. A., Wang, Q., BREYER, R. M., & Andreasson, K. I. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4485-03.2004 · Cited by 362
Chapman, G. A., Moores, K., Harrison, D. C., Campbell, C. A., Stewart, B. R., & Strijbos, P. J. L. M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-j0004.2000 · Cited by 350
Production and neuroprotective functions of fractalkine in the central nervous system
Mizuno, T., Kawanokuchi, J., Numata, K., & Suzumura, A. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02867-1 · Cited by 342
Erythropoietin as an antiapoptotic, tissue-protective cytokine
Ghezzi, P., & Brines, M. (2004) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401450 · Cited by 327
Autophagy in neurodegenerative disease: friend, foe or turncoat?
Nixon, R. A. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.07.003 · Cited by 321
Heat Shock Proteins as Ligands of Toll-Like Receptors
Vabulas, R. M., Wagner, H., & Schild, H. (2002) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-59430-4_11 · Cited by 279
Microglia: phagocyte and glia cell
Vilhardt, F. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.06.010 · Cited by 258
Corticosteroids for acute traumatic brain injury
Alderson, P., & Roberts, I. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000196.pub2 · Cited by 243
Liang, X., Wang, Q., Hand, T. A., Wu, L., BREYER, R. M., Montine, T. J., & Andreasson, K. I. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3591-05.2005 · Cited by 232
The mechanism of action of methylprednisolone in the treatment of multiple sclerosis
Sloka, J. S., & Stefanelli, M. (2005) · Multiple Sclerosis Journal · doi:10.1191/1352458505ms1190oa · Cited by 210
From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens
Amantea, D., Russo, R., Bagetta, G., & Corasaniti, M. T. (2005) · Pharmacological Research · doi:10.1016/j.phrs.2005.03.002 · Cited by 194
Glucocorticoids Play a Fundamental Role in Protecting the Brain during Innate Immune Response
Nadeau, S., & Rivest, S. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05536.2003 · Cited by 190
Self-citationAndrogens activate mitogen‐activated protein kinase signaling: Role in neuroprotection
Nguyen, T. V., Yao, M., & Pike, C. J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03318.x · Cited by 182
di Bello, I. C., Dawson, M. R. L., Levine, J. M., & Reynolds, R. (1999) · Journal of Neurocytology · doi:10.1023/a:1007069815302 · Cited by 178
Kaur, C., Hao, A., Wu, C., & Ling, E. (2001) · Microscopy Research and Technique · doi:10.1002/jemt.1114 · Cited by 174
Viviani, B., Bartesaghi, S., Corsini, E., Villa, P., Ghezzi, P., Garau, A., Galli, C. L., & Marinovich, M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03033.x · Cited by 165
Werner, P. (2003) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1011 · Cited by 165
Glucocorticoids: Effects on Gene Transcription
Adcock, I. M., Ito, K., & Barnes, P. J. (2004) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200402-001ms · Cited by 160
High-dose methylprednisolone may cause myopathy in acute spinal cord injury patients
Qian, T., Guo, X.-D. E., Levi, A. D., Vanni, S., Shebert, R. T., & Alexander, M. S. (2004) · Spinal Cord · doi:10.1038/sj.sc.3101681 · Cited by 159
Hematopoietic cells maintain hematopoietic fates upon entering the brain
Massengale, M., Wagers, A. J., Vogel, H. S., & Weissman, I. L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050030 · Cited by 159
Chong, Z. Z., Lin, S., Kang, J., & Maiese, K. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10528 · Cited by 157
Soucy, G., Boivin, G., Labrie, F., & Rivest, S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6391 · Cited by 138
Self-citationBrain Response to Injury and Neurodegeneration
Bazan, N. G., Marcheselli, V. L., & Cole-Edwards, K. K. (2005) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2005.tb00018.x · Cited by 135
Glezer, I., Lapointe, A., & Rivest, S. (2006) · The FASEB Journal · doi:10.1096/fj.05-5234fje · Cited by 131
Self-citationBrain Response to Injury and Neurodegeneration: Endogenous Neuroprotective Signaling
Bazan, N. G. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1344.011 · Cited by 130
The protean actions of neurotrophins and their receptors on the life and death of neurons
Kalb, R. G. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.11.003 · Cited by 130
Turrin, N. P., & Rivest, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4032-05.2006 · Cited by 129
Self-citationNeuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia
Liu, D., Wu, L., BREYER, R. M., Mattson, M. P., & Andreasson, K. I. (2005) · Annals of Neurology · doi:10.1002/ana.20461 · Cited by 129
PGE2 receptors rescue motor neurons in a model of amyotrophic lateral sclerosis
Bilak, M. M., Wu, L., Wang, Q., Haughey, N. J., Conant, K. E., Hillaire, C. S., & Andreasson, K. I. (2004) · Annals of Neurology · doi:10.1002/ana.20179 · Cited by 126
Dexamethasone protects against dopaminergic neurons damage in a mouse model of Parkinson's disease
Kurkowska-Jastrzębska, I., Litwin, T., Joniec, I., Ciesielska, A., Przybyłkowski, A., Członkowski, A., & Członkowska, A. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.05.006 · Cited by 117
Markianos, M., Πάνας, Μ., Kalfakis, N., & Vassilopoulos, D. (2005) · Annals of Neurology · doi:10.1002/ana.20428 · Cited by 115
Prostaglandin EP1 Receptor Contributes to Excitotoxicity and Focal Ischemic Brain Damage
Ahmad, A. S., Saleem, S., Ahmad, M., & Doré, S. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfj022 · Cited by 112
Apoptosis: A Key in Neurodegenerative Disorders
Ekshyyan, O. Y., & Aw, T. Y. (2004) · Current Neurovascular Research · doi:10.2174/1567202043362018 · Cited by 110
Turrin, N. P., & Rivest, S. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422901003 · Cited by 107
Self-citationD’Astous, M., Méndez, P., Morissette, M., García‐Segura, L. M., & Paolo, T. D. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.018671 · Cited by 105
Prostaglandins are powerful inducers of NGF and BDNF production in mouse astrocyte cultures
Toyomoto, M., Ohta, M., Okumura, K., Yano, H., Matsumoto, K., Inoue, S., Hayashi, K., & Ikeda, K. (2004) · FEBS Letters · doi:10.1016/s0014-5793(04)00246-7 · Cited by 98
Neuroprotection by stem cell factor in rat cortical neurons involves AKT and NFκB
Dhandapani, K. M., Wade, F. M., Wakade, C. G., Mahesh, V. B., & Brann, D. W. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03319.x · Cited by 93
Pizzi, M., Sarnico, I., Boroni, F., Benarese, M., Dréano, M., Garotta, G., Valerio, A., & Spano, P. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.10.022 · Cited by 92
Simone, R. D., Ajmone‐Cat, M. A., & Minghetti, L. (2004) · Molecular Neurobiology · doi:10.1385/mn:29:2:197 · Cited by 89
Prostaglandin EP4 receptor agonist protects against acute neurotoxicity
Ahmad, A. S., Ahmad, M., de Brum-Fernandes, A. J., & Doré, S. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.068 · Cited by 86
Mitrasinovic, O. M., Grattan, A., Robinson, C. C., Lapustea, N., Poon, C., Ryan, H. S., Phong, C., & Murphy, G. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0514-05.2005 · Cited by 83
Erythropoietin: A Novel Neuroprotective Cytokine
Bartesaghi, S., Marinovich, M., Corsini, E., Galli, C. L., & Viviani, B. (2005) · NeuroToxicology · doi:10.1016/j.neuro.2005.01.016 · Cited by 83
Dantzer, R., Bluthé, R.-M., & Kelley, K. W. (1991) · Brain Research · doi:10.1016/0006-8993(91)90123-d · Cited by 81
Buller, K. M. (2001) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2001.03490.x · Cited by 80
Glucocorticoids: Protectors of the Brain during Innate Immune Responses
Glezer, I., & Rivest, S. (2004) · The Neuroscientist · doi:10.1177/1073858404263494 · Cited by 79
Self-citationRoyo, N., Conte, V., Saatman, K., Shimizu, S., Belfield, C. M., Soltesz, K. M., Davis, J. E., Fujimoto, S. T., & Mcintosh, T. K. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04642.x · Cited by 76
Characterization of cells with proliferative activity after a brain injury
Tatsumi, K., Haga, S., Matsuyoshi, H., Inoue, M., Manabe, T., Makinodan, M., & Wanaka, A. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2004.12.007 · Cited by 70
Vanderlocht, J., Hellings, N., Hendriks, J. J. A., Vandenabeele, F., Moreels, M., Buntinx, M., Hoekstra, D., Antel, J. P., & Stinissen, P. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20781 · Cited by 66
Majdan, M., & Miller, F. D. (1999) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(99)00016-7 · Cited by 66
Promoting repair in multiple sclerosis: problems and prospects
Lubetzki, C., Williams, A., & Stankoff, B. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000169739.83793.e0 · Cited by 63
Activation of membrane estrogen receptors induce pro-survival kinases
Alexaki, V. I., Charalampopoulos, I., Kampa, M., Nifli, A., Hatzoglou, A., Gravanis, A., & Castanas, E. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.08.017 · Cited by 62
Protective Effect of Heat Shock Proteins in the Nervous System
Latchman, D. S. (2004) · Current Neurovascular Research · doi:10.2174/1567202043480206 · Cited by 56
Effects of TNF-α and IFN-γ on Nitric Oxide-Induced Neurotoxicity in the Mouse Brain
Blais, V., & Rivest, S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.7043 · Cited by 55
Self-citationSHARMA, H. S. (2003) · Springer eBooks · doi:10.1007/978-3-7091-0651-8_81 · Cited by 50
Zang, D. W., & Cheema, S. S. (2003) · Journal of Neurotrauma · doi:10.1089/089771503770802880 · Cited by 48
Leeds, P. R., Leng, Y., Chalecka-Franaszek, E., & Chuang, D. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2004.07.001 · Cited by 47
Colony stimulating factor-1 potentiates neuronal survival in cerebral cortex ischemic lesion
Berezovskaya, O. L., Maysinger, D., & FEDOROFF, S. (1996) · Acta Neuropathologica · doi:10.1007/s004010050550 · Cited by 47
Androgens Are Neuroprotective in the Dentate Gyrus of Adrenalectomized Female Rats
Frye, C. A., & McCormick, C. M. (2000) · Stress · doi:10.3109/10253890009001122 · Cited by 44
OLSON, J. (2003) · Molecular Immunology · doi:10.1016/j.molimm.2003.11.010 · Cited by 44
How inflammation promotes regeneration
Filbin, M. T. (2006) · Nature Neuroscience · doi:10.1038/nn0606-715 · Cited by 42
Post-infectious encephalomyelitis
Mihai, C., & Jubelt, B. (2005) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-005-0031-2 · Cited by 41
Veiga, S. J., Azcoitia, Í., & García‐Segura, L. M. (2005) · Neuroreport · doi:10.1097/01.wnr.0000179081.39659.7d · Cited by 41
Estrogens as Neuroprotectants against Ischemic Stroke
de Leciñana, M. A., & Egido, J. A. (2006) · Cerebrovascular Diseases · doi:10.1159/000091703 · Cited by 41
Li, Y., Field, P., & Raisman, G. (1999) · Journal of Neurocytology · doi:10.1023/a:1007026001189 · Cited by 40
Estrogen Modulates Bcl-2 Family Proteins in Ischemic Brain Injury
Won, C., Kim, M. O., & Koh, P. (2006) · Journal of Veterinary Medical Science · doi:10.1292/jvms.68.277 · Cited by 34
Rudehill, S., Muhallab, S., Wennersten, A., von Gertten, C., Nimer, F. A., Sandberg-Nordqvist, A.-C., Holmin, S., & Mathiesen, T. I. (2005) · Acta Neurochirurgica · doi:10.1007/s00701-005-0673-5 · Cited by 32
D’Astous, M., Steinmetz, K. R. M., Dluzen, D. E., & Paolo, T. D. (2005) · Neuroendocrinology · doi:10.1159/000091206 · Cited by 30
Neuroprotection and Neurodegenerative Diseases
Akwa, Y., Allain, H., Bentué‐Ferrer, D., Berr, C., Bordet, R., Geerts, H., Nieoullon, A. L., Onteniente, B., & Vercelletto, M. (2005) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000189053.25817.d6 · Cited by 30
Neurotrophin-based strategies for neuroprotection
Longo, F. M., & Massa, S. M. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6s606 · Cited by 29
Vincent, V. A. M., Robinson, C. C., Simsek, D., & Murphy, G. M. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01087.x · Cited by 29
Coers, S., Tanzer, L., & Jones, K. J. (2002) · Metabolic Brain Disease · doi:10.1023/a:1015415226799 · Cited by 28
Human Monoclonal IgM Antibody Promotes CNS Myelin Repair Independent of Fc Function
Ćirić, B., Howe, C. L., Soldán, M. M. P., Warrington, A. E., Bieber, A. J., Keulen, V. P. V., Rodriguez, M., & Pease, L. R. (2003) · Brain Pathology · doi:10.1111/j.1750-3639.2003.tb00489.x · Cited by 27
Naumann, T., Schnell, O., Zhi, Q., Kirsch, M., Schubert, K. O., Sendtner, M., & Hofmann, H. (2003) · Brain Pathology · doi:10.1111/j.1750-3639.2003.tb00030.x · Cited by 22
McCollum, A. T., & Estus, S. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20184 · Cited by 19
Guo, Z., Iyun, T., Fu, W., Zhang, P., & Mattson, M. P. (2004) · NeuroMolecular Medicine · doi:10.1385/nmm:5:3:219 · Cited by 18
To die or to sleep, perhaps to dream
Gasic, G. P. (2003) · Toxicology Letters · doi:10.1016/s0378-4274(02)00487-3 · Cited by 12
Lesniak, M. S., Kelleher, E., Pardoll, D. M., & Cui, Y. R. (2005) · Neurological Research · doi:10.1179/016164105x49454 · Cited by 7
The Search for Novel Avenues for the Therapy and Prevention of Alzheimer's Disease
Behl, C. (2006) · Drug News & Perspectives · doi:10.1358/dnp.2006.19.1.965869 · Cited by 7
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Self-citationCzéh, M., Gressèns, P., & Kaindl, A. M. (2011) · Developmental Neuroscience · doi:10.1159/000328989 · Cited by 337
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Rolls, A., Shechter, R., London, A., Segev, Y., Jacob–Hirsch, J., Amariglio, N., Rechavi, G., & Schwartz, M. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050171 · Cited by 277
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Polazzi, E., & Monti, B. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.06.009 · Cited by 269
Olah, M., Biber, K. P. H., Vinet, J., & Boddeke, H. W. G. M. (2011) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152711794488575 · Cited by 260
Cerbai, F., Lana, D., Nosi, D., Petkova-Kirova, P., Zecchi, S., Brothers, H. M., Wenk, G. L., & Giovannini, M. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045250 · Cited by 251
Noninvasive Molecular Imaging of Neuroinflammation
Jacobs, A. H., Tavitian, B., & the INMiND consortium (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.53 · Cited by 245
Astaxanthin as a Potential Neuroprotective Agent for Neurological Diseases
Wu, H., Niu, H., Shao, A., Wu, C., Dixon, B. J., Zhang, J., Yang, S., & Wang, Y. (2015) · Marine Drugs · doi:10.3390/md13095750 · Cited by 205
Microglial Phenotype and Adaptation
Eggen, B. J. L., Raj, D. D. A., Hanisch, U., & Boddeke, H. W. G. M. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9490-4 · Cited by 187
Wes, P. D., Holtman, I. R., Boddeke, E. W. G. M., Möller, T., & Eggen, B. J. L. (2016) · Glia · doi:10.1002/glia.22866 · Cited by 167
Microalgae Derived Astaxanthin: Research and Consumer Trends and Industrial Use as Food
Villaró, S., Ciardi, M., Morillas‐España, A., Sánchez‐Zurano, A., Acién, F. G., & Lafarga, T. (2021) · Foods · doi:10.3390/foods10102303 · Cited by 149
Neuropeptide Y Modulation of Interleukin-1β (IL-1β)-induced Nitric Oxide Production in Microglia
Ferreira, R., Xapelli, S., Santos, T., Silva, A. P., Cristóvão, A. J., Cortes, L., & Malva, J. O. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.164020 · Cited by 122
Multifaces of neuropeptide Y in the brain – Neuroprotection, neurogenesis and neuroinflammation
Malva, J. O., Xapelli, S., Baptista, S., Valero, J., Agasse, F., Ferreira, R., & Silva, A. P. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.09.001 · Cited by 127
Microglia and myeloperoxidase: A deadly partnership in neurodegenerative disease
Lefkowitz, D. L., & Lefkowitz, S. S. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.05.021 · Cited by 113
Xanthophyll: Health benefits and therapeutic insights
Aziz, E., Batool, R., Akhtar, W., Rehman, S., Shahzad, T., Malik, A. M., Shariati, M. A., Laishevtcev, A. I., Plygun, S., Heydari, M., et al. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117104 · Cited by 106
Lana, D., Ugolini, F., & Giovannini, M. G. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.585833 · Cited by 87
Neuroprotective Role of Agmatine in Neurological Diseases
Xu, W., Gao, L., Li, T., Shao, A., & Zhang, J. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170808120633 · Cited by 87
The neuropathology of autism: where do we stand?
Schmitz, C., & Rezaie, P. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00872.x · Cited by 87
Neuropeptide Y inhibits interleukin-1β-induced phagocytosis by microglial cells
Ferreira, R., Santos, T., Viegas, M. S., Cortes, L., Bernardino, L. I., Vieira, O. V., & Malva, J. O. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-169 · Cited by 85
Morris, G., Berk, M., Maes, M. H. J., Carvalho, A. F., & Puri, B. K. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1498-1 · Cited by 90
Microglia and Astrocyte Activation by Toll‐Like Receptor Ligands: Modulation by PPAR‐γ Agonists
Gurley, C. M., Nichols, J. R., Liu, S., Phulwani, N. K., Esen, N., & Kielian, T. (2008) · PPAR Research · doi:10.1155/2008/453120 · Cited by 88
The Roles of MicroRNAs in Stroke: Possible Therapeutic Targets
Xu, W., Gao, L., Zheng, J., Li, T., Shao, A., Reis, C., Chen, S., & Zhang, J. (2018) · Cell Transplantation · doi:10.1177/0963689718773361 · Cited by 85
Neuropeptide Y inhibits interleukin‐1 beta‐induced microglia motility
Ferreira, R., Santos, T., Cortes, L., Cochaud, S., Agasse, F., Silva, A. P., Xapelli, S., & Malva, J. O. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07541.x · Cited by 80
Translating concepts of neural repair after stroke: Structural and functional targets for recovery
Regenhardt, R. W., Takase, H., Lo, E. H., & Lin, D. J. (2020) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-190978 · Cited by 75
Gavins, F. N. E., Hughes, E. L., Buss, N. A. P. S., Holloway, P. M., Getting, S. J., & Buckingham, J. C. (2012) · The FASEB Journal · doi:10.1096/fj.12-205971 · Cited by 73
Lana, D., Ugolini, F., Nosi, D., Wenk, G. L., & Giovannini, M. G. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.651973 · Cited by 73
Evolution of Inflammation and White Matter Injury in a Model of Transient Focal Ischemia
Moxon‐Emre, I., & Schlichter, L. C. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181c3ce6c · Cited by 71
Kim, I., Park, Y., Yoon, S., & Lee, H.-B. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.09.019 · Cited by 60
The neuroendocrine control of the innate immune system in health and brain diseases
Bellavance, M., & Rivest, S. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01129.x · Cited by 61
Self-citationAditi, Bhardwaj, R., Yadav, A., Swapnil, P., & Meena, M. (2025) · Biotechnology for Biofuels and Bioproducts · doi:10.1186/s13068-025-02612-x · Cited by 61
RNase L Mediated Protection from Virus Induced Demyelination
Ireland, D. D. C., Stohlman, S. A., Hinton, D. R., Kapil, P., Silverman, R. H., Atkinson, R., & Bergmann, C. C. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000602 · Cited by 54
Larsen, A., Kolind, K., Pedersen, D. S., Doering, P., Pedersen, M. Ø., Danscher, G., Penkowa, M., & Stoltenberg, M. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0448-1 · Cited by 51
Inhibition of Microglia Activation as a Phenotypic Assay in Early Drug Discovery
Figuera-Losada, M., Rojas, C. J., & Slusher, B. S. (2013) · SLAS DISCOVERY · doi:10.1177/1087057113499406 · Cited by 50
New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs
Mahjoubin‐Tehran, M., Rezaei, S., Jesmani, A., Birang, N., Morshedi, K., Khanbabaei, H., Khan, H. Z., Piranviseh, A., Nejati, M., Aschner, M., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111753 · Cited by 48
Shohag, S., Akhter, S., Islam, M. S., Sarker, T., Sifat, M. K., Rahman, M. M., Islam, M. R., & Sharma, R. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7743705 · Cited by 49
Neuroprotective Effects of Stem Cells in Ischemic Stroke
Xu, W., Zheng, J., Gao, L., Li, T., Zhang, J., & Shao, A. (2017) · Stem Cells International · doi:10.1155/2017/4653936 · Cited by 42
Morris, G., Puri, B. K., Maes, M. H. J., OLIVE, L. S., Berk, M., & Carvalho, A. F. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109858 · Cited by 42
Protein changes in CSF of HIV-infected patients: evidence for loss of neuroprotection
Meeker, R. B., Poulton, W., Markovic‐Plese, S., Hall, C. D., & Robertson, K. (2011) · Journal of NeuroVirology · doi:10.1007/s13365-011-0034-5 · Cited by 42
Neuroprotective gain of Apelin/APJ system
Zhou, J.-X., Shuai, N., Wang, B., Jin, X., Kuang, X., & Tian, S. (2021) · Neuropeptides · doi:10.1016/j.npep.2021.102131 · Cited by 40
Aguirre, A., Maturana, C. J., Harcha, P. A., & Sáez, J. C. (2013) · Mediators of Inflammation · doi:10.1155/2013/893521 · Cited by 39
Self-assembling peptide hydrogels promote microglial cells proliferation and NGF production
Chronopoulou, L., Togna, A. R., Guarguaglini, G., Masci, G., Giammaruco, F., Togna, G. I., & Palocci, C. (2012) · Soft Matter · doi:10.1039/c2sm25528f · Cited by 35
Anrather, J., Gallo, E. F., Kawano, T., Orio, M., Abe, T., Gooden, C., Zhou, P., & Iadecola, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025916 · Cited by 36
Extraction methods, encapsulation techniques, and health benefits of astaxanthin
Panagiotakopoulos, I., & Nasopoulou, C. (2024) · Sustainability · doi:10.3390/su162410859 · Cited by 33
TNF-α and Microglial Hormetic Involvement in Neurological Health & Migraine
Kraig, R. P., Mitchell, H. M., Christie-Pope, B. C., Kunkler, P. E., White, D. M., Tang, Y., & Langan, G. P. (2010) · Dose-Response · doi:10.2203/dose-response.09-056.kraig · Cited by 34
Caspases orchestrate microglia instrumental functions
Shen, X., Venero, J. L., Joseph, B., & Burguillos, M. Á. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.09.007 · Cited by 30
Morphine Preconditioning Protects Against LPS-Induced Neuroinflammation and Memory Deficit
Rostami, F., Oryan, S., Ahmadiani, A., & Dargahi, L. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9726-4 · Cited by 29
Sulforaphane: An emerging star in neuroprotection and neurological disease prevention
Wu, N., Luo, Z., Deng, R., Zhang, Z., Zhang, J., Liu, S., Luo, Z., & Qi, Q. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116797 · Cited by 28
Recent Advances and the Mechanism of Astaxanthin in Ophthalmological Diseases
Yang, M., & Wang, Y. (2022) · Journal of Ophthalmology · doi:10.1155/2022/8071406 · Cited by 24
Targeting the hematopoietic system for the treatment of Alzheimer’s disease
Lampron, A., Gosselin, D., & Rivest, S. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.018 · Cited by 22
Self-citationThériault, P., Béhot, A. L., ElAli, A., & Rivest, S. (2016) · Oncotarget · doi:10.18632/oncotarget.9652 · Cited by 23
Self-citationRole of the chemokine receptors CCR2 and CX3CR1 in an experimental model of thrombotic stroke
Cisbani, G., Béhot, A. L., Plante, M.-M., Préfontaine, P., Lecordier, M., & Rivest, S. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.03.008 · Cited by 23
Self-citationChen, J., Koduri, S., Dai, S., Toyota, Y., Hua, Y., Chaudhary, N., Pandey, A. S., Keep, R. F., & Xi, G. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00870-5 · Cited by 22
Zhang, Z., Zhou, L., Liu, Q., Zheng, Y., Tan, X., Huang, Z., Guo, M. S., Wang, X., Chen, X., Liang, S., et al. (2024) · Emerging Microbes & Infections · doi:10.1080/22221751.2024.2353302 · Cited by 20
The Emerging Role of the Receptor for Advanced Glycation End Products on Innate Immunity
Armando Rojas, R., Pérez-Castro, R., González, I., Delgado, F., Romero, J. A., & Rojas, I. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2013.849702 · Cited by 19
Peng, Z., Luchtman, D. W., Wang, X., Zhang, Y., & Song, C. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.01.024 · Cited by 19
Morucci, G., Branca, J. J. V., Gulisano, M., Ruggiero, M., Paternostro, F., Pacini, A., Mannelli, L. D. C., & Pacini, S. (2014) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000000177 · Cited by 19
Phenomic Microglia Diversity as a Druggable Target in the Hippocampus in Neurodegenerative Diseases
Lana, D., Magni, G., Landucci, E., Wenk, G. L., Pellegrini-Giampietro, D. E., & Giovannini, M. G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813668 · Cited by 20
Huang, W., Kuo, W.-C., Hsu, S.-H., Cheng, C.-H., Liu, J.-C., & Cheng, H. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.01.012 · Cited by 18
Rathitharan, G., Truong, J. T., Tong, J., McCluskey, T., Meyer, J. H., Mizrahi, R., Warsh, J. J., Rusjan, P., Kennedy, J. L., Houle, S., et al. (2020) · Addiction Biology · doi:10.1111/adb.12876 · Cited by 15
Zhou, G., Wang, T., & Zha, X. (2021) · The FASEB Journal · doi:10.1096/fj.202002511r · Cited by 15
Toll-Like Receptor 2-Independent and MyD88-Dependent Gene Expression in the Mouse Brain
Naert, G., Laflamme, N., & Rivest, S. (2009) · Journal of Innate Immunity · doi:10.1159/000225990 · Cited by 15
Self-citationYu, T., Cheng, Y.-S., Zhao, P., Kou, D., Sun, K., Chen, B., & Wang, A. (2009) · PubMed · Cited by 13
Microglia: The Bodyguard and the Hunter of the Adult Neurogenic Niche
Valero, J., Eiriz, M. F., Santos, T., Neiva, I., Ferreira, R., & Malva, J. O. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-940-2_14 · Cited by 9
Immunization with Neural-Derived Peptides as a Potential Therapy in Neurodegenerative Diseases
Mestre, H., & Ibarr, A. (2011) · InTech eBooks · doi:10.5772/28029 · Cited by 6
Agmatine: A potential Neurotherapeutic Agent
Binjhade, N., Supare, V., Ghaywat, S. D., Trivedi, S., Wadher, K., & Umekar, M. J. (2021) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v11i4.4855 · Cited by 5
Inflammation and White Matter Injury in Animal Models of Ischemic Stroke
Schlichter, L. C., Hutchings, S., & Lively, S. S. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9123-1_19 · Cited by 4
Neuroprotection Versus Neurotoxicity
Biber, K. P. H., & Block, M. L. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1429-6_6 · Cited by 3
Winter, A. N. (2016) · Digital Commons - DU (University of Denver) · Cited by 2
Xie, Q., Gu, Y., Xi, G., Ya, H., Keep, R. F., & Wan, Y. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115354 · Cited by 1
Immune mediators of central nervous system demyelination and remyelination
Chen, V. S. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/v4b9-9109 · Cited by 1
Ongerth, T. (2014) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.16768
Microglial involvement in brain physiopathology: in vitro studies using rat primary cultures
Mengoni, I. (2014) · AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna) · doi:10.6092/unibo/amsdottorato/6466
Brandão, W. N. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2013.tde-16092013-160405
Studies on microglia in tumor biology and neurobiology
Shen, X. (2017) · Figshare
Lana, D. (2016) · Premio Tesi dottorato/Premio Tesi di dottorato · doi:10.36253/978-88-6655-941-2
Investigating neurobiological mechanisms linking depression and inflammation
Hasebe, K. (2017) · Figshare
White Matter Damage and Inflammation in Rat Models of Ischemic and Hemorrhagic Stroke
Moxon‐Emre, I. (2011) · TSpace (University of Toronto)
Influence of lithium in neuron-glia interaction in hippocampal neurons
Rocha, N. K. R., Forlenza, O. V., Kerr, D. S., Brentani, H., & de Paula, V. D. J. R. (2018) · Revista de Medicina · doi:10.11606/issn.1679-9836.v97i6p533-546
Crustacea (Carotenoids Namely Astaxanthins) Against Cancer
Blundell, R. A., Grech, J. C., & Shah, M. A. (2021) · Food bioactive ingredients · doi:10.1007/978-3-030-74035-1_8
ASTAXANTHIN TỪ VI TẢO: ỨNG DỤNG VÀ THÁCH THỨC TRONG QUÁ TRÌNH SẢN XUẤT VÀ THƯƠNG MẠI
Nguyễn, P. T., & Nguyễn, H. T. (2023) · Tạp chí Dinh dưỡng và Thực phẩm · doi:10.56283/1859-0381/557
Metadata
- Authors
- Turrin, N. P., & Rivest, S.
- Affiliations
- Centre hospitalier de l'Université Laval (CA)
- Corresponding author
- Turrin, Nicolas P.
- ORCID
- Rivest, Serge
- Venue
- Molecular Neurobiology
- Published
- 2006
- Volume
- 34
- Issue
- 3
- Pages
- 221-242
- ISSN
- 0893-7648 (ISSN-L)
- OpenAlex
- W1966525994
- Cited by
- 85
- References
- 103
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 6 · 2012: 8
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- neuroprotection, microglia, innate immunity, neurodegeneration, proinflammatory molecules, neuroinflammation, neuronal injury, central nervous system injury
- MeSH terms
- Animals, Blood-Brain Barrier, Brain, Humans, Immunity, Innate, Inflammation, Neurons, Spinal Cord, Motor Neuron Disease, Cell Death
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