Neuroprotective role of the innate immune system by microglia

Pathogen Recognition and Innate Immunity

Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,974 · see citing works

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631 · see citing works

Toll-Like Receptors

Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143 · see citing works

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,027 · see citing works

Missing Pieces in the NF-κB Puzzle

Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638 · see citing works

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3749 · Cited by 3,374 · see citing works

Innate Immunity: The Virtues of a Nonclonal System of Recognition

Medzhitov, R., & Janeway, C. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80412-2 · Cited by 2,434 · see citing works

Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease

Simard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.022 · Cited by 1,265 · see citing works

Inflammation in Neurodegenerative Disease—A Double-Edged Sword

Wyss-Coray, T., & Mucke, L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00794-8 · Cited by 1,235 · see citing works

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

Hoebe, K. H. N., Du, X., Georgel, P., Janssen, E. M., Tabeta, K., Kim, S. O., Goode, J., Lin, P., Mann, N., Mudd, S., et al. (2003) · Nature · doi:10.1038/nature01889 · Cited by 1,232 · see citing works

Cytokines and acute neurodegeneration

Allan, S. M., & Rothwell, N. J. (2001) · Nature reviews. Neuroscience · doi:10.1038/35094583 · Cited by 1,126 · see citing works

The Toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

Hashimoto, C., Hudson, K., & Anderson, K. V. (1988) · Cell · doi:10.1016/0092-8674(88)90516-8 · Cited by 1,097 · see citing works

TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

Yamamoto, M., Sato, S., Hemmi, H., Uematsu, S., Hoshino, K., Kaisho, T., Takeuchi, O., Takeda, K., & Akira, S. (2003) · Nature Immunology · doi:10.1038/ni986 · Cited by 1,052 · see citing works

Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

Lehnardt, S., Massillon, L., Follett, P., Jensen, F. E., Ratan, R., Rosenberg, P. A., Volpe, J. J., & Vartanian, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432609100 · Cited by 1,052 · see citing works

TNFα promotes proliferation of oligodendrocyte progenitors and remyelination

Arnett, H. A., Mason, J., Marino, M., Suzuki, K., Matsushima, G. K., & Ting, J. P.-Y. (2001) · Nature Neuroscience · doi:10.1038/nn738 · Cited by 1,012 · see citing works

MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES

González-Scarano, F., & Baltuch, G. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.219 · Cited by 984 · see citing works

Tlr4: central component of the sole mammalian LPS sensor.

Beutler, B. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)00046-1 · Cited by 847 · see citing works

Innate immunity: the missing link in neuroprotection and neurodegeneration?

Nguyen, M. D., Julien, J., & Rivest, S. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn752 · Cited by 698 · see citing works

The Toll-Like Receptor TLR4 Is Necessary for Lipopolysaccharide-Induced Oligodendrocyte Injury in the CNS

Lehnardt, S., Lachance, C., Patrizi, S., Lefebvre, S., Follett, P. L., Jensen, F. E., Rosenberg, P. A., Volpe, J. J., & Vartanian, T. K. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02478.2002 · Cited by 684 · see citing works

Microglia in health and disease

Kim, S. U., & de Vellis, J. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20562 · Cited by 663 · see citing works

Molecular determinants of crosstalk between nuclear receptors and toll-like receptors

Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R. K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.029 · Cited by 647 · see citing works

Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment

Priller, J., Flügel, A., Wehner, T., Boentert, M., Haas, C. A., Prinz, M., Fernández-Klett, F., Prass, K., Bechmann, I., de Boer, B. A., et al. (2001) · Nature Medicine · doi:10.1038/nm1201-1356 · Cited by 637 · see citing works

Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells

Galon, J., Franchimont, D., Hiroi, N., Frey, G., Boettner, A., Ehrhart-Bornstein, M., O’shea, J. J., Chrousos, G. P., & Bornstein, S. R. (2002) · The FASEB Journal · doi:10.1096/fj.01-0245com · Cited by 606 · see citing works

SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling

Wald, D. N., Qin, J., Zhao, Z., Qian, Y., Naramura, M., Tian, L., Towne, J. E., Sims, J. E., Stark, G. R., & Li, X. (2003) · Nature Immunology · doi:10.1038/ni968 · Cited by 606 · see citing works

Negative Regulation of Toll-like Receptor-mediated Signaling by Tollip

Zhang, G., & Ghosh, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109537200 · Cited by 598 · see citing works

Neurodegenerative and Neuroprotective Effects of Tumor Necrosis Factor (TNF) in Retinal Ischemia: Opposite Roles of TNF Receptor 1 and TNF Receptor 2

Fontaine, V. K., Mohand‐Saïd, S., Hanoteau, N., Fuchs, C., Pfizenmaier, K., & Eisel, U. L. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-j0001.2002 · Cited by 587 · see citing works

Recognition of microbial infection by Toll-like receptors

Kopp, E. B., & Medzhitov, R. M. (2003) · Current Opinion in Immunology · doi:10.1016/s0952-7915(03)00080-3 · Cited by 547 · see citing works

Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells

Yin, Y., Henzl, M. T., Lorber, B., Nakazawa, T., Thomas, T. T., Jiang, F., Langer, R., & Benowitz, L. I. (2006) · Nature Neuroscience · doi:10.1038/nn1701 · Cited by 516 · see citing works

Interleukin-1β Promotes Repair of the CNS

Mason, J. L., Suzuki, K., Chaplin, D. D., & Matsushima, G. K. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07046.2001 · Cited by 502 · see citing works

Toll‐like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram‐negative bacterial cell wall components

LAFLAMME, N., & RIVEST, S. (2001) · The FASEB Journal · doi:10.1096/fj.00-0339com · Cited by 501 · see citing works

Role of toll-like receptor signalling in A uptake and clearance

Tahara, K., Kim, H.-D., Jin, J.-J., Maxwell, J. A., Li, L., & Fukuchi, K.-I. (2006) · Brain · doi:10.1093/brain/awl249 · Cited by 493 · see citing works

Microglial Phagocytosis Induced by Fibrillar β-Amyloid and IgGs Are Differentially Regulated by Proinflammatory Cytokines

Koenigsknecht-Talboo, J., & Landreth, G. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1808-05.2005 · Cited by 477 · see citing works

The Inflammasome: First Line of the Immune Response to Cell Stress

Ogura, Y., Sutterwala, F. S., & Flavell, R. A. (2006) · Cell · doi:10.1016/j.cell.2006.08.002 · Cited by 474 · see citing works

Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice

Picard-Riéra, N., Decker, L., Delarasse, C., Goude, K., Nait‐Oumesmar, B., Liblau, R., Pham-Dinh, D., & Evercooren, A. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192314199 · Cited by 469 · see citing works

An inflammatory review of glucocorticoid actions in the CNS

Sorrells, S. F., & Sapolsky, R. M. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.11.006 · Cited by 461 · see citing works

Tumor Necrosis Factor (TNF)-mediated Neuroprotection against Glutamate-induced Excitotoxicity Is Enhanced by N-Methyl-D-aspartate Receptor Activation

Marchetti, L., Klein, M., Schlett, K., Pfizenmaier, K., & Eisel, U. L. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311766200 · Cited by 424 · see citing works

Molecular mechanisms of glucocorticoid action and resistance

Schaaf, M. J. M., & Cidlowski, J. A. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00263-7 · Cited by 417 · see citing works

Lipopolysaccharide Intranigral Injection Induces Inflammatory Reaction and Damage in Nigrostriatal Dopaminergic System

Castaño, A., Herrera, A. J., Cano, J., & Machado, A. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70041584.x · Cited by 393 · see citing works

Glatiramer acetate fights against Alzheimer’s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1

Butovsky, O., Koronyo-Hamaoui, M., Kunis, G., Ophir, E., Landa, G., Cohen, H., & Schwartz, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604681103 · Cited by 388 · see citing works

Cooperation of Toll-Like Receptor 2 and 6 for Cellular Activation by Soluble Tuberculosis Factor and Borrelia burgdorferi Outer Surface Protein A Lipoprotein: Role of Toll-Interacting Protein and IL-1 Receptor Signaling Molecules in Toll-Like Receptor 2 Signaling

Bulut, Y., Faure, E., Thomas, L. S., Equils, O., & Arditi, M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.2.987 · Cited by 381 · see citing works

Microglia and inflammatory mechanisms in the clearance of amyloid β peptide

Rogers, J., Strohmeyer, R., Kovelowski, C. J., & Li, R. (2002) · Glia · doi:10.1002/glia.10153 · Cited by 381 · see citing works

Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia

Simard, A. R., & Rivest, S. (2004) · The FASEB Journal · doi:10.1096/fj.04-1517fje · Cited by 354 · see citing works

Different Toll-like receptor agonists induce distinct macrophage responses

Jones, B. W., Means, T. K., Heldwein, K. A., Keen, M. A., Hill, P. J., Belisle, J. T., & Fenton, M. J. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.6.1036 · Cited by 353 · see citing works

LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide

Liu, Y., Walter, S., Stagi, M., Cherny, D., Letièmbre, M., Schulz‐Schaeffer, W., Heine, H., Penke, B., Neumann, H., & Fassbender, K. C. (2005) · Brain · doi:10.1093/brain/awh531 · Cited by 344 · see citing works

Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression

Kotter, M. R., Zhao, C., van Rooijen, N., & Franklin, R. J. M. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.09.019 · Cited by 331 · see citing works

Regulation of the Genes Encoding Interleukin‐6, Its Receptor, and gp130 in the Rat Brain in Response to the Immune Activator Lipopolysaccharide and the Proinflammatory Cytokine Interleukin‐1β

Vallières, L., & Rivest, S. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69041668.x · Cited by 323 · see citing works

Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to β-amyloid deposition in APP/PS1 double transgenic Alzheimer mice

Malm, T. M., Koistinaho, M., Pärepalo, M., Vatanen, T., Ooka, A., Karlsson, S., & Koistinaho, J. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.09.009 · Cited by 301 · see citing works

Neuronal injury in bacterial meningitis: mechanisms and implications for therapy

Nau, R., & Brück, W. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02024-5 · Cited by 295 · see citing works

Diverse compounds mimic Alzheimer disease–causing mutations by augmenting Aβ42 production

Kukar, T. L., Murphy, M. P., Eriksen, J. L., Sagi, S. A., Weggen, S., Smith, T. E., Ladd, T. B., Khan, M. A., Kache, R., Beard, J. D., et al. (2005) · Nature Medicine · doi:10.1038/nm1235 · Cited by 284 · see citing works

Inhibition of NF-κB potentiates amyloid β-mediated neuronal apoptosis

Kaltschmidt, B., Uherek, M., Wellmann, H., Volk, B., & Kaltschmidt, C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9409 · Cited by 280 · see citing works

Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo

Priller, J., Persons, D. A., Fernández‐Klett, F., Kempermann, G., Kreutzberg, G. W., & Dirnagl, U. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200105103 · Cited by 266 · see citing works

Distinct Mutations in IRAK-4 Confer Hyporesponsiveness to Lipopolysaccharide and Interleukin-1 in a Patient with Recurrent Bacterial Infections

Medvedev, A. E., Lentschat, A., Kuhns, D. B., Blanco, J. C. G., Salkowski, C. A., Zhang, S., Arditi, M., Gallin, J. I., & Vogel, S. N. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030701 · Cited by 262 · see citing works

Matrix Metalloproteinase-9 Facilitates Remyelination in Part by Processing the Inhibitory NG2 Proteoglycan

Larsen, P. H., Wells, J. E. A., Stallcup, W. B., Opdenakker, G., & Yong, V. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11127.2003 · Cited by 260 · see citing works

Microglia and neuroprotection: implications for Alzheimer's disease

Streit, W. J. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.013 · Cited by 256 · see citing works

Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity

Vallières, L., & Sawchenko, P. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05197.2003 · Cited by 245 · see citing works

Negative regulation of nuclear factor-kappaB activation and function by glucocorticoids

Almawi, W., & Melemedjian, O. (2002) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0280069 · Cited by 242 · see citing works

Inflammation stimulates remyelination in areas of chronic demyelination

Foote, A. K. (2005) · Brain · doi:10.1093/brain/awh417 · Cited by 230 · see citing works

The Bacterial Endotoxin Lipopolysaccharide has the Ability to Target the Brain in Upregulating Its Membrane CD14 Receptor Within Specific Cellular Populations

Lacroix, S., Feinstein, D., & Rivest, S. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00189.x · Cited by 223 · see citing works

Role of Microglial-Derived Tumor Necrosis Factor in Mediating CD14 Transcription and Nuclear Factor κ B Activity in the Brain during Endotoxemia

Nadeau, S., & Rivest, S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-09-03456.2000 · Cited by 217 · see citing works

Efficient central nervous system remyelination requires T cells

Bieber, A. J., Kerr, S., & Rodriguez, M. (2003) · Annals of Neurology · doi:10.1002/ana.10578 · Cited by 196 · see citing works

Glucocorticoids Play a Fundamental Role in Protecting the Brain during Innate Immune Response

Nadeau, S., & Rivest, S. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05536.2003 · Cited by 190 · see citing works

Central Nervous System-Initiated Inflammation and Neurotrophism in Trauma: IL-1β Is Required for the Production of Ciliary Neurotrophic Factor

Herx, L. M., Rivest, S., & Yong, V. W. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.4.2232 · Cited by 190 · see citing works

Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears β-amyloid in a mouse model of Alzheimer disease

Frenkel, D., Maron, R., Burt, D. S., & Weiner, H. L. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23241 · Cited by 186 · see citing works

Circulating cell wall components derived from gram‐negative, not gram‐positive, bacteria cause a profound induction of the gene‐encoding Toll‐like receptor 2 in the CNS

Laflamme, N., Soucy, G., & Rivest, S. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00603.x · Cited by 185 · see citing works

Effects of Systemic Immunogenic Insults and Circulating Proinflammatory Cytokines on the Transcription of the Inhibitory Factor κBα Within Specific Cellular Populations of the Rat Brain

Laflamme, N., & Rivest, S. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730309.x · Cited by 182 · see citing works

Cooperation between toll‐like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gram‐negative and gram‐positive bacteria

Laflamme, N., Echchannaoui, H., Landmann, R. M., & Rivest, S. (2003) · European Journal of Immunology · doi:10.1002/eji.200323821 · Cited by 160 · see citing works

The role of microglial cells and astrocytes in fibrillar plaque evolution in transgenic APPSW mice

Wegiel, J. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00181-0 · Cited by 159 · see citing works

Hematopoietic cells maintain hematopoietic fates upon entering the brain

Massengale, M., Wagers, A. J., Vogel, H. S., & Weissman, I. L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050030 · Cited by 159 · see citing works

Regulation of Leukocyte‐Endothelial Interactions by Glucocorticoids

Pitzalis, C., Pipitone, N., & Perretti, M. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04208.x · Cited by 150 · see citing works

Indictment of the microglia as the villain in multiple sclerosis

Sriram, S., & Rodriguez, M. (1997) · Neurology · doi:10.1212/wnl.48.2.464 · Cited by 148 · see citing works

Butovsky, O. et al. Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc. Natl Acad. Sci. USA 103, 11784-11789

Butovsky, O., Koronyo‐Hamaoui, M., Kunis, G., Ophir, E., Landa, G., Cohen, H., & Schwartz, M. (2006) · Cited by 144 · see citing works

Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP‐1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines

Thibeault, I., Laflamme, N., & Rivest, S. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1187 · Cited by 129 · see citing works

Tumor Necrosis Factor α But Not Interleukin 1β Mediates Neuroprotection in Response to Acute Nitric Oxide Excitotoxicity

Turrin, N. P., & Rivest, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4032-05.2006 · Cited by 129 · see citing works

Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries

Glezer, I., Lapointe, A., & Rivest, S. (2006) · The FASEB Journal · doi:10.1096/fj.05-5234fje · Cited by 126 · see citing works

Proliferation and phenotype regulation in the subventricular zone during experimental allergic encephalomyelitis: In vivo evidence of a role for nerve growth factor

Calzà, L., Giardino, L., Pozza, M., Bettelli, C., Micera, A., & Aloe, L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3209 · Cited by 123 · see citing works

Microglia Lacking E Prostanoid Receptor Subtype 2 Have Enhanced Aβ Phagocytosis yet Lack Aβ-Activated Neurotoxicity

Shie, F., BREYER, R. M., & Montine, T. J. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62336-x · Cited by 115 · see citing works

Hsp90 Inhibition Accelerates Cell Lysis

Sreedhar, A. S., Mihály, K., Pató, B., Schnaider, T., Steták, A., Kis‐Petik, K., Fidy, J., Simonics, T., Maráz, A., & Csermely, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301371200 · Cited by 97 · see citing works

Decline of immune responsiveness: A pathogenetic factor in Alzheimer’s disease?

Richartz, E., Stransky, E., Batra, A., Simon, P. D., Lewczuk, P., Buchkremer, G., BARTELS, M., & Schott, K. J. (2005) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2004.12.005 · Cited by 95 · see citing works

Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: role of glucocorticoids and CD14

Nadeau, S., & Rivest, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.3370 · Cited by 94 · see citing works

Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system

Soulet, D., & Rivest, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200301097 · Cited by 93 · see citing works

Early and Rapid Engraftment of Bone Marrow-Derived Microglia in Scrapie

Priller, J., Prinz, M., Heikenwälder, M. F., Zeller, N., Schwarz, P., Heppner, F. L., & Aguzzi, A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2275-06.2006 · Cited by 89 · see citing works

Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases

Walker, D. G., & Lue, L.-F. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20484 · Cited by 87 · see citing works

Effect of C-reactive protein on platelet-activating factor-induced platelet aggregation and membrane stabilization.

Vigo, C. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83638-4 · Cited by 81 · see citing works

MK-801 and 7-Ni attenuate the activation of brain NF-κB induced by LPS

Glezer, I., Munhoz, C. D., Kawamoto, E. M., Marcourakis, T., Avellar, M. C. W., & Scavone, C. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00279-x · Cited by 79 · see citing works

Glucocorticoids: Protectors of the Brain during Innate Immune Responses

Glezer, I., & Rivest, S. (2004) · The Neuroscientist · doi:10.1177/1073858404263494 · Cited by 79 · see citing works

Tumor Necrosis Factor Reduces Brain Tumor Growth by Enhancing Macrophage Recruitment and Microcyst Formation

Villeneuve, J., Tremblay, P., & Vallières, L. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3612 · Cited by 78 · see citing works

Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli

Blais, V., Turrin, N. P., & Rivest, S. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03480.x · Cited by 72 · see citing works

Cells of monocyte/microglial lineage are involved in both microvessel amyloidosis and fibrillar plaque formation in APPsw tg mice

Węgiel, J., Imaki, H., Wang, K.-C., Wegiel, J., & Rubenstein, R. (2004) · Brain Research · doi:10.1016/j.brainres.2004.06.058 · Cited by 61 · see citing works

The role of pneumolysin in the pathogenesis of Streptococcus pneumoniae infection

Cockeran, R., Anderson, R., & Feldman, C. H. (2002) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200206000-00004 · Cited by 61 · see citing works

Origin and turnover of microglial cells in fibrillar plaques of APPsw transgenic mice

Węgiel, J., Imaki, H., Wang, K.-C., Wegiel, J., Wronska, A., Osuchowski, M., & Rubenstein, R. (2003) · Acta Neuropathologica · doi:10.1007/s00401-002-0660-3 · Cited by 59 · see citing works

Effects of TNF-α and IFN-γ on Nitric Oxide-Induced Neurotoxicity in the Mouse Brain

Blais, V., & Rivest, S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.7043 · Cited by 55 · see citing works

Effects of dexamethazone on LPS‐induced activationand migration of mouse dendritic cells revealed by a genome‐wide transcriptional analysis

Vizzardelli, C., Pavelka, N., Luchini, A., Zanoni, I., Bendickson, L., Pelizzola, M., Beretta, O., Foti, M., Granucci, F., Nilsen‐Hamilton, M., et al. (2006) · European Journal of Immunology · doi:10.1002/eji.200535488 · Cited by 52 · see citing works

The complement system is an integrated part of the natural innate immune response in the brain

Nadeau, S., & Rivest, S. (2001) · The FASEB Journal · doi:10.1096/fj.00-0709fje · Cited by 49 · see citing works

Modulation of the Innate Immune Response by NMDA Receptors Has Neuropathological Consequences

Glezer, I., Zekki, H., Scavone, C., & Rivest, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11094.2003 · Cited by 41 · see citing works

Relationship between β-AP peptide aggregation and microglial activation

Casal, C., Serratosa, J., & Tusell, J. M. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03362-5 · Cited by 40 · see citing works

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Dinkel, K., Ogle, W. O., & Sapolsky, R. M. (2002) · Journal of NeuroVirology · doi:10.1080/13550280290100914 · Cited by 37 · see citing works

Possible Involvement of Small Oligomers of Amyloid-β Peptides in 15-Deoxy-Δ12,14 Prostaglandin J2-Sensitive Microglial Activation

Takata, K., Kitamura, Y., Umeki, M., Tsuchiya, D., Kakimura, J., Gebicke‐Haerter, P. J., & Shimohama, S. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.91.330 · Cited by 36 · see citing works

Amyloid-β fibril formation is not necessarily required for microglial activation by the peptides

Hashioka, S., Monji, A., Ueda, T., Kanba, S., & Nakanishi, H. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.05.001 · Cited by 31 · see citing works

P-glycoprotein Does Not Protect Cells against Cytolysis Induced by Pore-forming Proteins

Johnstone, R. W., Tainton, K. M., Ruefli, A. A., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010774200 · Cited by 27 · see citing works

Inflammatory processes and Alzheimer’s disease

Walsh, S. P., & Aisen, P. S. S. (2004) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.4.5.793 · Cited by 25 · see citing works

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Blais, V., Zhang, J., & Rivest, S. (2002) · Endocrinology · doi:10.1210/en.2002-220598 · Cited by 22 · see citing works

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Guo, Z., Iyun, T., Fu, W., Zhang, P., & Mattson, M. P. (2004) · NeuroMolecular Medicine · doi:10.1385/nmm:5:3:219 · Cited by 18 · see citing works

Structure and function of the blood–brain barrier

Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185 · see citing works

Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676 · see citing works

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

Tang, Y., & Le, W. (2016) · Molecular Neurobiology · doi:10.1007/s12035-014-9070-5 · Cited by 2,190 · see citing works

A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity

Kadry, H., Noorani, B., & Cucullo, L. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-00230-3 · Cited by 1,853 · see citing works

Systemic inflammation and microglial activation: systematic review of animal experiments

Hoogland, I. C. M., Houbolt, C., van Westerloo, D. J., van Gool, W. A., & van de Beek, D. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0332-6 · Cited by 957 · see citing works

Regulation of innate immune responses in the brain

Rivest, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2565 · Cited by 843 · see citing works

Toll‐like receptor 4 is required for α‐synuclein dependent activation of microglia and astroglia

Fellner, L., Irschick, R., Schanda, K., Reindl, M., Klimaschewski, L., Poewe, W., Wenning, G. K., & Stefanova, N. (2013) · Glia · doi:10.1002/glia.22437 · Cited by 697 · see citing works

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

Erblich, B., Zhu, L., Etgen, A. M., Dobrenis, K., & Pollard, J. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026317 · Cited by 649 · see citing works

The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma.

Ramirez, A. I., de Hoz, R., Salobrar-Garcia, E., Salazar, J. J., Rojas, B., Ajoy, D., López-Cuenca, I., Rojas, P., Triviño, A., & Ramírez, J. M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00214 · Cited by 466 · see citing works

Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain

Cosenza‐Nashat, M., Zhao, M. ‐., Suh, H. ‐., Morgan, J., Natividad, R., Morgello, S., & Lee, S. C. (2009) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.01006.x · Cited by 459 · see citing works

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Bellavance, M.-A., & Rivest, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00136 · Cited by 419 · see citing works

Review: Systemic inflammation and<scp>A</scp>lzheimer's disease

Holmes, C. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01307.x · Cited by 356 · see citing works

Inflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization

Howes, O. D., & McCutcheon, R. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.278 · Cited by 288 · see citing works

Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons

Stefanova, N., Fellner, L., Reindl, M., Masliah, E., Poewe, W., & Wenning, G. K. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.04.013 · Cited by 272 · see citing works

Aging‐dependent changes of microglial cells and their relevance for neurodegenerative disorders

Von Bernhardi, R., Tichauer, J. E., & Eugenín, J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06537.x · Cited by 258 · see citing works

Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy?

Eichler, F. S., Ren, J., Cossoy, M., Rietsch, A. M., Nagpal, S., Moser, A. B., Frosch, M. P., & Ransohoff, R. M. (2008) · Annals of Neurology · doi:10.1002/ana.21391 · Cited by 178 · see citing works

Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment

Singhal, G., Jaehne, E. J., Corrigan, F., & Baune, B. T. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00097 · Cited by 186 · see citing works

Therapeutic effects of glatiramer acetate and grafted CD115⁺monocytes in a mouse model of Alzheimer’s disease

Koronyo, Y., Salumbides, B. C., Sheyn, J., Pelissier, L., Li, S., Ljubimov, V., Moyseyev, M., Daley, D., Fuchs, D.-T., Pham, M., et al. (2015) · Brain · doi:10.1093/brain/awv150 · Cited by 153 · see citing works

Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders

Gil-Martins, E., Barbosa, D. J., Silva, V., Remião, F., & Silva, R. (2020) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2020.107554 · Cited by 152 · see citing works

Hypothalamic inflammation and energy homeostasis: Resolving the paradox

Thaler, J. P., Choi, S. J., Schwartz, M. W., & Wisse, B. E. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.10.002 · Cited by 144 · see citing works

TGF‐β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment

Abutbul, S., Shapiro, J., Szaingurten‐Solodkin, I., Levy, N., Carmy, Y., Baron, R., Jung, S., & Monsonego, A. (2012) · Glia · doi:10.1002/glia.22343 · Cited by 122 · see citing works

Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation

Carrillo-de Sauvage, M. Á., Maatouk, L., Arnoux, I., Pasco, M., Sanz Diez, A., Delahaye, M., Herrero, M. T., Newman, T. A., Calvo, C. F., Audinat, E., et al. (2013) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2013.108 · Cited by 114 · see citing works

Inflammation in transgenic mouse models of neurodegenerative disorders

Schwab, C., Klegeris, A., & McGeer, P. L. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.10.013 · Cited by 97 · see citing works

Lesional Accumulation of CD163+ Macrophages/microglia in Rat Traumatic Brain Injury

Zhang, Z., Zhang, Z.-Y., Wu, Y., & Schluesener, H. J. (2012) · Brain Research · doi:10.1016/j.brainres.2012.04.038 · Cited by 83 · see citing works

Glucocorticoid receptor dimerization is required for proper recovery of LPS-induced inflammation, sickness behavior and metabolism in mice

Silverman, M. N., Mukhopadhyay, P., Belyavskaya, E., Tonelli, L. H., Revenis, B. D., Doran, J. H., Ballard, B. E., Tam, J., Pacher, P., & Sternberg, E. M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.131 · Cited by 64 · see citing works

Exercise-Induced Modulation of Neuroinflammation in Models of Alzheimer’s Disease

Kelly, Á. M. (2018) · Brain Plasticity · doi:10.3233/bpl-180074 · Cited by 55 · see citing works

The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis

Medvedeva, E. V., Dmitrieva, V. G., Povarova, O. V., Limborska, S. A., Skvortsova, V. I., Myasoedov, N. F., & Dergunova, L. V. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-228 · Cited by 33 · see citing works

Alzheimer’s Disease Research Using Human Microglia

Lue, L., Beach, T. G., & Walker, D. G. (2019) · Cells · doi:10.3390/cells8080838 · Cited by 26 · see citing works

Differential Regional Vulnerability of the Brain to Mild Neuroinflammation Induced by Systemic LPS Treatment in Mice

Jung, H., Lee, H., Kim, D., Cheong, E., Hyun, Y., Yu, J., & Um, J. W. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s362006 · Cited by 31 · see citing works

Deciphering the contributions of neuroinflammation to neurodegeneration: lessons from antibody-mediated encephalitis and coronavirus disease 2019

Shir, D., & Day, G. S. (2022) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001033 · Cited by 13 · see citing works

Recent advances in the mechanisms of neuroinflammation and their roles in neurodegeneration

Niranjan, R. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.07.003 · Cited by 112 · see citing works

Review paper Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?

Pluta, R., Bogucka-Kocka, A., Ułamek-Kozioł, M., Furmaga-Jabłońska, W., Januszewski, S., Brzozowska, J., Jabłoński, M., & Kocki, J. (2015) · Folia Neuropathologica · doi:10.5114/fn.2015.52405 · Cited by 34 · see citing works