Cited by 135Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Metabolic Risk Factors of Sporadic Alzheimer's Disease: Implications in the Pathology, Pathogenesis and Treatment

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Chakrabarti, Sasanka, Kumar Khemka, Vineet, Banerjee, Anindita, Chatterjee, Gargi, Ganguly, Anirban, Biswas, Atanu·2015·Aging and disease

DOI 10.14336/ad.2014.002PMC PMC4509477

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Abstract

Alzheimer's disease (AD), the major cause of dementia among the elderly world-wide, manifests in familial and sporadic forms, and the latter variety accounts for the majority of the patients affected by this disease. The etiopathogenesis of sporadic AD is complex and uncertain. The autopsy studies of AD brain have provided limited understanding of the antemortem pathogenesis of the disease. Experimental AD research with transgenic animal or various cell based models has so far failed to explain the complex and varied spectrum of AD dementia. The review, therefore, emphasizes the importance of AD related risk factors, especially those with metabolic implications, identified from various epidemiological studies, in providing clues to the pathogenesis of this complex disorder. Several metabolic risk factors of AD like hypercholesterolemia, hyperhomocysteinemia and type 2 diabetes have been studied extensively both in epidemiology and experimental research, while much less is known about the role of adipokines, pro-inflammatory cytokines and vitamin D in this context. Moreover, the results from many of these studies have shown a degree of variability which has hindered our understanding of the role of AD related risk factors in the disease progression. The review also encompasses the recent recommendations regarding clinical and neuropathological diagnosis of AD and brings out the inherent uncertainty and ambiguity in this area which may have a distinct impact on the outcome of various population-based studies on AD-related risk factors.

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Authors: Chakrabarti, S., Kumar Khemka, V., Banerjee, A., Chatterjee, G., Ganguly, A., & Biswas, A.
Affiliations: Institute of Post Graduate Medical Education and Research (IN)
Bangur Institute of Neurosciences (IN)
ORCID: Chakrabarti, Sasanka
Banerjee, Anindita
Ganguly, Anirban
Biswas, Atanu
Venue: Aging and disease
Publisher: Aging and Disease
Published: 2015
Volume: 6
Issue: 4
Pages: 282
ISSN: 2152-5250 (ISSN-L)
DOI: 10.14336/ad.2014.002
PMC: PMC4509477
OpenAlex: W2103890427
Cited by: 134
References: 189
Citations by year: 2026: 5 · 2025: 12 · 2024: 12 · 2023: 14 · 2022: 10 · 2021: 15 · 2020: 20 · 2019: 9 · 2018: 16 · 2017: 11 · 2016: 7 · 2015: 3
FWCI: 10.00
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Aging and Disease (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: sporadic Alzheimer's disease, metabolic risk factors, hypercholesterolemia, hyperhomocysteinemia, type 2 diabetes, adipokines, inflammatory cytokines, vitamin D, Alzheimer's disease pathogenesis, Alzheimer's disease diagnosis, neuropathology, dementia

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Metabolic Risk Factors of Sporadic Alzheimer's Disease: Implications in the Pathology, Pathogenesis and Treatment

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