Cited by 135Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Metabolic Risk Factors of Sporadic Alzheimer's Disease: Implications in the Pathology, Pathogenesis and Treatment

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Chakrabarti, Sasanka, Kumar Khemka, Vineet, Banerjee, Anindita, Chatterjee, Gargi, Ganguly, Anirban, Biswas, Atanu·2015·Aging and disease

DOI 10.14336/ad.2014.002PMC PMC4509477

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Abstract

Alzheimer's disease (AD), the major cause of dementia among the elderly world-wide, manifests in familial and sporadic forms, and the latter variety accounts for the majority of the patients affected by this disease. The etiopathogenesis of sporadic AD is complex and uncertain. The autopsy studies of AD brain have provided limited understanding of the antemortem pathogenesis of the disease. Experimental AD research with transgenic animal or various cell based models has so far failed to explain the complex and varied spectrum of AD dementia. The review, therefore, emphasizes the importance of AD related risk factors, especially those with metabolic implications, identified from various epidemiological studies, in providing clues to the pathogenesis of this complex disorder. Several metabolic risk factors of AD like hypercholesterolemia, hyperhomocysteinemia and type 2 diabetes have been studied extensively both in epidemiology and experimental research, while much less is known about the role of adipokines, pro-inflammatory cytokines and vitamin D in this context. Moreover, the results from many of these studies have shown a degree of variability which has hindered our understanding of the role of AD related risk factors in the disease progression. The review also encompasses the recent recommendations regarding clinical and neuropathological diagnosis of AD and brings out the inherent uncertainty and ambiguity in this area which may have a distinct impact on the outcome of various population-based studies on AD-related risk factors.

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Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657
The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
Albert, M. S., DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., Gamst, A., Holtzman, D. M., Jagust, W. J., Petersen, R. C., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.008 · Cited by 10,152 · cited 2×
“[18] Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al.”
Background
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238
Hearing loss and cognitive decline in older adults
Lin, F. R., Yaffe, K., Xia, J., Xue, Q.-L., Harris, T. B., Purchase-Helzner, E., Satterfield, S., Ayonayon, H. N., Ferrucci, L., Simonsick, E. M., et al. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.1868 · Cited by 4,017
Neuropathological alterations in Alzheimer disease
Serrano-Pozo, A., Frosch, M. P., Masliah, E., & Hyman, B. T. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006189 · Cited by 3,345
Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease
Seshadri, S., Beiser, A., Selhub, J., Jacques, P. F., Rosenberg, I. H., D'Agostino, R. B., Wilson, P. W. F., & Wolf, P. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011613 · Cited by 3,237
National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease
Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092
Pathways towards and Away from Alzheimer’s Disease
Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898
National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach
Montine, T. J., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., Mirra, S. S., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-011-0910-3 · Cited by 2,894 · cited 6×
“There are other accompaying features of AD pathology like neuronal loss, degeneration of synapses, dendrites and axons, gliosis, white matter rarefaction, ganulovacuolar degeneration and cerebral amyloid angiopathy [20, 22].”
BackgroundInfluential
The Diagnosis of Mild Cognitive Impairment due to Alzheimer’s Disease: Recommendations from the National Institute on Aging-Alzheimer’s Association Workgroups on Diagnostic Guidelines for Alzheimer’s Disease
Albert, M., DeKosky, S. T., Dickson, D. W., Dubois, B., Feldman, H., Fox, N. C., Gamst, A. C., Holtzman, D. M., Jagust, W. J., Petersen, R. C., et al. (2013) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.11.1.96 · Cited by 2,643
Diagnosis of Alzheimer's Disease
Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499
Diabetes mellitus and the risk of dementia: The Rotterdam Study
Ott, A., Stolk, R. P., van Harskamp, F., Pols, H. A. P., Hofman, A., & Breteler, M. M. B. (1999) · Neurology · doi:10.1212/wnl.53.9.1937 · Cited by 2,175
Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · cited 2×
“It is to be emphasized that the impairment of cognitive domains on which the clinical diagnosis of AD is based is in most cases but not always correlate well with the extent of post-mortem AD neuropathology [26, 27].”
Background
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?
Steen, E., Terry, B. M., J. Rivera, E., Cannon, J. L., Neely, T. R., Tavares, R., Xu, X. J., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer's Disease · doi:10.3233/jad-2005-7107 · Cited by 1,703
Epidemiology of Alzheimer disease
Reitz, C., Brayne, C., & Mayeux, R. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.2 · Cited by 1,675
Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study
Kivipelto, M., Helkala, E.-L., Laakso, M. P., Hänninen, T., Hallikainen, M., Alhainen, K., Soininen, H., Tuomilehto, J., & Nissinen, A. (2001) · BMJ · doi:10.1136/bmj.322.7300.1447 · Cited by 1,618
Editorial on Consensus Recommendations for the Postmortem Diagnosis of Alzheimer Disease from the National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer Disease
HYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542
Decreased Prevalence of Alzheimer Disease Associated With 3-Hydroxy-3-Methyglutaryl Coenzyme A Reductase Inhibitors
Wolozin, B. L. (2000) · Archives of Neurology · doi:10.1001/archneur.57.10.1439 · Cited by 1,408
Folate, Vitamin B12, and Serum Total Homocysteine Levels in Confirmed Alzheimer Disease
Clarke, R., Smith, A. D., Jobst, K. A., Refsum, H., Sutton, L., & Ueland, P. M. (1998) · Archives of Neurology · doi:10.1001/archneur.55.11.1449 · Cited by 1,408
Cytokine-Associated Emotional and Cognitive Disturbances in Humans
Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmächer, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.445 · Cited by 1,365
Current Understanding of the Molecular Actions of Vitamin D
Jones, G., Strugnell, S. A., & DeLuca, H. F. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.4.1193 · Cited by 1,276
Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies
Peila, R., Rodriguez, B. L., & Launer, L. J. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1256 · Cited by 1,207
Role of Pro-Inflammatory Cytokines Released from Microglia in Neurodegenerative Diseases
Smith, J. A., Das, A., Ray, S. K., & Banik, N. L. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.10.004 · Cited by 1,165
Tau in Alzheimer Disease and Related Tauopathies
Iqbal, K., Liu, F., Gong, C., & Grundke, I. (2010) · Current Alzheimer Research · doi:10.2174/156720510793611592 · Cited by 1,163
A Meta-Analysis of Cytokines in Alzheimer's Disease
Swardfager, W., Lanctôt, K., Rothenburg, L., Wong, A., Cappell, J., & Herrmann, N. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.012 · Cited by 1,108
Trafficking and Proteolytic Processing of APP
Haass, C., Kaether, C., Thinakaran, G., & Sisodia, S. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006270 · Cited by 1,075
Brain Cholesterol: Long Secret Life Behind a Barrier
Björkhem, I., & Meaney, S. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000120374.59826.1b · Cited by 1,044
Diabetes as a risk factor for dementia and mild cognitive impairment: a meta‐analysis of longitudinal studies
Cheng, G., Huang, C., Deng, H., & Wang, H. (2012) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2012.02758.x · Cited by 1,040
Adiponectin: More Than Just Another Fat Cell Hormone?
Chandran, M., Phillips, S. A., Ciaraldi, T. P., & Henry, R. R. (2003) · Diabetes Care · doi:10.2337/diacare.26.8.2442 · Cited by 1,013
Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature
Wyss-Coray, T., & Rogers, J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006346 · Cited by 975
Diabetes and cognitive dysfunction
McCrimmon, R. J., Ryan, C. M., & Frier, B. M. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60360-2 · Cited by 934
Cholesterol metabolism in the brain
Dietschy, J. M., & Turley, S. D. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200104000-00003 · Cited by 906
New clues about vitamin D functions in the nervous system
Garcion, E., Wion-Barbot, N., Montero-Menei, C. N., Berger, F., & Wion, D. (2002) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(01)00547-1 · Cited by 904
A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines
Rubio-Perez, J. M., & Morillas-Ruiz, J. M. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/756357 · Cited by 864
Oxidative Stress and the Pathogenesis of Alzheimer's Disease
Zhao, Y., & Zhao, B. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/316523 · Cited by 855
Alzheimer Disease as a Vascular Disorder
de la Torre, J. C. (2002) · Stroke · doi:10.1161/01.str.0000014421.15948.67 · Cited by 852
Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system
Godbout, J. P., Chen, J., Abraham, J., Richwine, A. F., Berg, B. M., Kelley, K. W., & Johnson, R. W. (2005) · The FASEB Journal · doi:10.1096/fj.05-3776fje · Cited by 813
Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction
Devi, L., Prabhu, B. M., Galati, D. F., Avadhani, N. G., & Anandatheerthavarada, H. K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1469-06.2006 · Cited by 792
Aggregation of vascular risk factors and risk of incident Alzheimer disease
Luchsinger, J. A., Reitz, C., Honig, L. S., Tang, M. X., Shea, S., & Mayeux, R. (2005) · Neurology · doi:10.1212/01.wnl.0000172914.08967.dc · Cited by 790
Evidence for a cytokine model of cognitive function
McAfoose, J., & Baune, B. T. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.005 · Cited by 760
Brain insulin and insulin receptors in aging and sporadic Alzheimer’s disease
Frölich, L., Blum-Degen, D., Bernstein, H.-G., Engelsberger, S., Humrich, J., Laufer, S., Muschner, D., Thalheimer, A., Türk, A., Hoyer, S., et al. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050068 · Cited by 748
Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease
Eyles, D. W., Burne, T. H. J., & McGrath, J. J. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.07.001 · Cited by 726
Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer’s disease: Link to brain reductions in acetylcholine
Rivera, E. J., Goldin, A., Fulmer, N., Tavares, R., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-8304 · Cited by 723
Cytokine-induced sickness behavior
Kelley, K. W., Bluthé, R.-M., Dantzer, R., Zhou, J.-H., Shen, W.-H., Johnson, R. W., & Broussard, S. R. (2003) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00077-6 · Cited by 716
Risk of Dementia among Persons with Diabetes Mellitus: A Population-based Cohort Study
Leibson, C. L., Rocca, W. A., Hanson, V. A., Cha, R., Kokmen, E., O'Brien, P. C., & Palumbo, P. J. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009106 · Cited by 700
Hyperinsulinemia and risk of Alzheimer disease
Luchsinger, J. A., Tang, M.-X., Shea, S., & Mayeux, R. (2004) · Neurology · doi:10.1212/01.wnl.0000140292.04932.87 · Cited by 683
Alzheimer’s disease: the cholesterol connection
Puglielli, L., Tanzi, R. E., & Kovacs, D. M. (2003) · Nature Neuroscience · doi:10.1038/nn0403-345 · Cited by 677
Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
Ho, L., Qin, W., Pompl, P. N., Xiang, Z., Wang, J., Zhao, Z., Peng, Y., Cambareri, G. M., Rocher, A. B., Mobbs, C. V., et al. (2004) · The FASEB Journal · doi:10.1096/fj.03-0978fje · Cited by 640
Brain fuel metabolism, aging, and Alzheimer’s disease
Cunnane, S. C., Nugent, S., Roy, M., Courchesne‐Loyer, A., Croteau, É., Tremblay, S., Castellano, A., Pifferi, F., Bocti, C., Paquet, N., et al. (2010) · Nutrition · doi:10.1016/j.nut.2010.07.021 · Cited by 633
Tau phosphorylation in neuronal cell function and dysfunction
Johnson, G. V. W., & Stoothoff, W. H. (2004) · Journal of Cell Science · doi:10.1242/jcs.01558 · Cited by 624
Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease
Mosconi, L., Pupi, A., & de Leon, M. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.007 · Cited by 616
Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions
Biessels, G. J., Strachan, M. W. J., Visseren, F. L. J., Kappelle, L. J., & Whitmer, R. A. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70088-3 · Cited by 578
The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective
Shaftel, S. S., Griffin, W. S. T., & O'Banion, M. K. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-7 · Cited by 565
High-Dose B Vitamin Supplementation and Cognitive Decline in Alzheimer Disease
Aisen, P. S. S. (2008) · JAMA · doi:10.1001/jama.300.15.1774 · Cited by 563
Midlife Serum Cholesterol and Increased Risk of Alzheimer’s and Vascular Dementia Three Decades Later
Solomon, A., Kivipelto, M., Wolozin, B., Zhou, J., & Whitmer, R. A. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000231980 · Cited by 557
Epidemiology and risk factors of dementia
van der Flier, W. M. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.082867 · Cited by 550
Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes
Liu, Y. M., Liu, F., Grundke, I., Iqbal, K., & Gong, C. (2011) · The Journal of Pathology · doi:10.1002/path.2912 · Cited by 505
Diabetes, Alzheimer disease, and vascular dementia
Ahtiluoto, S., Polvikoski, T. M., Peltonen, M., Solomon, A., Tuomilehto, J., Winblad, B. G., Sulkava, R. O., & Kivipelto, M. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f4d7f8 · Cited by 499
Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling
Gasparini, L., Gouras, G. K., Wang, R., Gross, R. S., Beal, M. F., Greengard, P., & Xu, H. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02561.2001 · Cited by 492
Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia
Obeid, R., & Herrmann, W. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.04.088 · Cited by 490
Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence
Freiherr, J., Hallschmid, M., Frey, W. H., Brünner, Y. F., Chapman, C. D., Hölscher, C., Craft, S., Felice, F. G. D., & Benedict, C. (2013) · CNS Drugs · doi:10.1007/s40263-013-0076-8 · Cited by 477
Amyloid Precursor Protein, Presenilins, and α-Synuclein: Molecular Pathogenesis and Pharmacological Applications in Alzheimer’s Disease
Suh, Y.-H., & Checler, F. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.3.469 · Cited by 476
Brain metabolic dysfunction at the core of Alzheimer's disease
de la Monte, S. M., & Tong, M. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.012 · Cited by 472
Cytokines and brain excitability
Galic, M. A., Riazi, K., & Pittman, Q. J. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.12.002 · Cited by 462
Clinical features of Alzheimer's disease
Förstl, H., & Kurz, A. (1999) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060050101 · Cited by 444
Association of Plasma Leptin Levels With Incident Alzheimer Disease and MRI Measures of Brain Aging
Lieb, W. (2009) · JAMA · doi:10.1001/jama.2009.1836 · Cited by 428
Association between features of the insulin resistance syndrome and alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study
Kuusisto, J., Koivisto, K. J., Mykkänen, L. M., Helkala, E.-L., Vanhanen, M., Hänninen, T., Kervinen, K., Kesäniemi, Y. A., Riekkinen, P. J., & Laakso, M. (1997) · BMJ · doi:10.1136/bmj.315.7115.1045 · Cited by 426
High total cholesterol levels in late life associated with a reduced risk of dementia
Mielke, M. M., Zandi, P. P., Sjögren, M., Gustafson, D., Östling, S., Steen, B., & Skoog, I. (2005) · Neurology · doi:10.1212/01.wnl.0000161870.78572.a5 · Cited by 411
Increased plasma levels of interleukin-1, interleukin-6 and α-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain?
Licastro, F., Pedrini, S., Caputo, L., Annoni, G., Davis, L. J., Ferri, C., Casadei, V. M., & Grimaldi, L. M. E. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00226-x · Cited by 400
Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein
Grünblatt, E., Šalković‐Petrišić, M., Barilar, J. O., Riederer, P. F., & Hoyer, S. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04368.x · Cited by 376
Common pathological processes in Alzheimer disease and type 2 diabetes: A review
Li, L., & Hölscher, C. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.09.001 · Cited by 367
Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease
Frisardi, V., Solfrizzi, V., Seripa, D., Capurso, C. A., Santamato, A., Sancarlo, D., Vendemiale, G., Pilotto, A., & Panza, F. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.007 · Cited by 365
Oxidative stress in Alzheimer's disease brain: New insights from redox proteomics
Butterfield, D. A., Perluigi, M., & Sultana, R. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.06.026 · Cited by 363
Clinically diagnosed Alzheimer's disease: Autopsy results in 150 cases
Joachim, C. L., Morris, J. H., & Selkoe, D. J. (1988) · Annals of Neurology · doi:10.1002/ana.410240110 · Cited by 362
Abnormalities of mitochondrial enzymes in Alzheimer disease
Gibson, G. E., Sheu, K.-F. R., & Blass, J. P. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050099 · Cited by 345
Alzheimer’s disease and insulin resistance: translating basic science into clinical applications
Felice, F. G. D. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64595 · Cited by 336
Transgenic mouse models of Alzheimer’s disease.
Elder, G. A., Gama Sosa, M. A., & De Gasperi, R. (2010) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20159 · Cited by 336
Type 2 Diabetes as a Risk Factor for Alzheimer's Disease: The Confounders, Interactions, and Neuropathology Associated With This Relationship
Vagelatos, N. T., & Eslick, G. D. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxs012 · Cited by 320
The Treatment of Hyperhomocysteinemia
Maron, B. A., & Loscalzo, J. (2008) · Annual Review of Medicine · doi:10.1146/annurev.med.60.041807.123308 · Cited by 312
Cytokine signals propagate through the brain
Vitković, L., Konsman, J. P., Bockaert, J., Dantzer, R., Homburger, V., & Jacque, C. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000813 · Cited by 306
Adiponectin receptor signalling in the brain
Thundyil, J., Pavlovski, D., Sobey, C. G., & Arumugam, T. V. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01560.x · Cited by 289
Weight loss in Alzheimer disease
Guyonnet, S., Nourhashémi, F., Andrieu, S., de Glisezinski, I., Ousset, P., Rivière, D., Albaréde, J. L., & Vellas, B. J. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.637s · Cited by 283
Possible Implications of Insulin Resistance and Glucose Metabolism in Alzheimer's Disease Pathogenesis
Bosco, D., Fava, A., Plastino, M., Montalcini, T., & Pujia, A. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01318.x · Cited by 283
TNFα plus IFNγ induce the production of Alzheimer β‐amyloid peptides and decrease the secretion of APPs
Blasko, I., Marx, F., Steiner, E., Hartmann, T., & Grubeck-Loebenstein, B. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.1.63 · Cited by 279
Low Serum Vitamin D Concentrations in Alzheimer's Disease: A Systematic Review and Meta-Analysis
Annweiler, C., Llewellyn, D. J., & Beauchet, O. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121432 · Cited by 276
Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy
Zotova, E., Nicoll, J. A. R., Kalaria, R. N., Holmes, C., & Boche, D. (2010) · Alzheimer s Research & Therapy · doi:10.1186/alzrt24 · Cited by 269
Cognitive dysfunction in patients with type 2 diabetes
Reijmer, Y. D., van den Berg, E., Ruis, C., Kappelle, L. J., & Biessels, G. J. (2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1112 · Cited by 258
Cholesterol and Alzheimer’s disease
Simons, M., Keller, P., DICHGANS, J., & Schulz, J. B. (2001) · Neurology · doi:10.1212/wnl.57.6.1089 · Cited by 257
Cerebrospinal Fluid Insulin Levels Increase During Intravenous Insulin Infusions in Man*
Wallum, B. J., Taborsky, G. J., Porte, D., Figlewicz, D. P., Jacobson, L., Beard, J. C., Ward, W. K., & Dorsa, D. M. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-1-190 · Cited by 254
The NLRP3 Inflammasome in Alzheimer’s Disease
Tan, M., Yu, J., Jiang, T., Zhu, X., & Tan, L. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8475-x · Cited by 249
Apolipoprotein E exhibits isoform‐specific promotion of lipid efflux from astrocytes and neurons in culture
Michikawa, M., Fan, Q., Isobe, I., & Yanagisawa, K. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741008.x · Cited by 244 · cited 2×
“APOE polymorphism is considered as a strong risk factor for sporadic AD in subjects carrying ε4 allele, and it has been shown in experiments with cultured neurons that apoE4 isoform is less efficient compared to apoE2 or apoE3 in carrying out efflux of cholesterol from the neurons [76].”
Background
Genome-wide association study of Alzheimer's disease
Kamboh, M. I., Demirci, F. Y., Wang, X., Minster, R. L., Carrasquillo, M. M., Pankratz, V. S., Younkin, S. G., Saykin, A. J., Initiative, A. D. N., Jun, G., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.45 · Cited by 242
Pathogenesis of Alzheimer's disease.
Swerdlow, R. H. (2007) · PubMed Central · Cited by 237
Insulin Resistance and Alzheimers Disease: Molecular Links & Clinical Implications
Neumann, K., Rojo, L., Navarrete, L., Farias, G., Reyes, P., & Maccioni, R. (2008) · Current Alzheimer Research · doi:10.2174/156720508785908919 · Cited by 236
Cholesterol Level and Statin Use in Alzheimer Disease
Shepardson, N. E. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.203 · Cited by 228
Entry of Blood-Borne Cytokines into the Central Nervous System: Effects on Cognitive Processes
Banks, W. A., Farr, S. A., & Morley, J. E. (2002) · NeuroImmunoModulation · doi:10.1159/000071472 · Cited by 228
Serum leptin level and cognition in the elderly: Findings from the Health ABC Study
Holden, K. F., Lindquist, K. J., Tylavsky, F. A., Rosano, C., Harris, T. B., & Yaffe, K. S. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.11.024 · Cited by 224
1α,25-dihydroxyvitamin D3 Interacts with Curcuminoids to Stimulate Amyloid-β Clearance by Macrophages of Alzheimer's Disease Patients
Masoumi, A., Goldenson, B., Ghirmai, S., Avagyan, H., Zaghi, J., Abel, K., Zheng, X., Monteros, A. E. D. L., Mahanian, M., Liu, P. T., et al. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1080 · Cited by 223
The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases
Lahiri, D. K., Maloney, B., & Zawia, N. H. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.82 · Cited by 212
Molecular links between Alzheimer’s disease and diabetes mellitus
Yang, Y., & Song, W. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.07.009 · Cited by 211
Serum cholesterol, APOE genotype, and the risk of Alzheimer’s disease: A population-based study of African Americans
Evans, R. M., Emsley, C. L., Gao, S., Sahota, A. S., Hall, K. S., Farlow, M. R., & Hendrie, H. C. (2000) · Neurology · doi:10.1212/wnl.54.1.240 · Cited by 209
Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation
Correia, S. C., Santos, R. X., Carvalho, C., Cardoso, S., Candeias, E., Santos, M. S., Oliveira, C. R., & Moreira, P. I. (2012) · Brain Research · doi:10.1016/j.brainres.2011.12.063 · Cited by 202
Biomarkers for Insulin Resistance and Inflammation and the Risk for All-Cause Dementia and Alzheimer Disease
van Himbergen, T. M. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.670 · Cited by 202
Reduced 25‐hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia
Afzal, S., Bojesen, S. E., & Nordestgaard, B. G. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.05.1765 · Cited by 196
The role of inflammasome in Alzheimer's disease
Liu, L., & Chan, C. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2013.12.007 · Cited by 196
Reduction of vitamin D hormone receptor mRNA levels in Alzheimer as compared to Huntington hippocampus: correlation with calbindin-28k mRNA levels
Sutherland, M. K., Somerville, M. J., Yoong, L. K. K., Bergeron, C., Haussler, M. R., & McLachlan, D. R. C. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90032-7 · Cited by 196
An update on type 2 diabetes, vascular dementia and Alzheimer’s disease.
Exalto, L. G., Whitmer, R. A., Kappele, L. J., & Biessels, G. J. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.07.014 · Cited by 194
Vitamin D and the central nervous system
Wrzosek, M., Łukaszkiewicz, J., Wrzosek, M., Jakubczyk, A., Matsumoto, H., Piątkiewicz, P., Radziwoń-Zaleska, M., Wojnar, M., & Nowicka, G. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71003-x · Cited by 193
Cholesterol Level and Statin Use in Alzheimer Disease
Shepardson, N. E. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.242 · Cited by 190
Elevated plasma homocysteine levels: Risk factor or risk marker for the development of dementia and Alzheimer's disease?
Seshadri, S. S. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9404 · Cited by 189
A fluid connection: Cholesterol and Aβ
Wolozin, B. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101123198 · Cited by 179
Longitudinal Study of Inflammatory Factors in Serum, Cerebrospinal Fluid, and Brain Tissue in Alzheimer Disease
Lanzrein, A.-S., Johnston, C., Perry, V. H., Jobst, K. A., King, E. M., & Smith, A. D. (1998) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199809000-00016 · Cited by 178
Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects
Heitner, J., & Dickson, D. (1997) · Neurology · doi:10.1212/wnl.49.5.1306 · Cited by 173
Reduction in Levels of 24S-Hydroxycholesterol by Statin Treatment in Patients With Alzheimer Disease
Vega, G. L., Weiner, M., Lipton, A. M., von Bergmann, K., Lütjohann, D., Moore, C. B., & Svetlik, D. A. (2003) · Archives of Neurology · doi:10.1001/archneur.60.4.510 · Cited by 172
A Novel Perspective for Alzheimer's Disease: Vitamin D Receptor Suppression by Amyloid-β and Preventing the Amyloid-β Induced Alterations by Vitamin D in Cortical Neurons
Dursun, E., Gezen‐Ak, D., & Yılmazer, S. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101377 · Cited by 169
Amyloid‐β oligomers set fire to inflammasomes and induce Alzheimer's pathology
Salminen, A., Ojala, J. O., Suuronen, T., Kaarniranta, K., & Kauppinen, A. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00496.x · Cited by 167
The 32-year relationship between cholesterol and dementia from midlife to late life
Mielke, M. M., Zandi, P. P., Shao, H., Wærn, M., Östling, S., Guo, X., Björkelund, C., Lissner, L., Skoog, I. G., & Gustafson, D. (2010) · Neurology · doi:10.1212/wnl.0b013e3181feb2bf · Cited by 166
Homocysteine, vitamin B 6 , and vascular disease in AD patients
Miller, J. W., Green, R., Mungas, D., Reed, B. R., & Jagust, W. (2002) · Neurology · doi:10.1212/wnl.58.10.1471 · Cited by 164
Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?
Zhuo, J., Wang, H., & Praticò, D. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.05.003 · Cited by 163
Apolipoprotein E ε4 Prevalence in Alzheimer’s Disease Patients Varies across Global Populations: A Systematic Literature Review and Meta-Analysis
Crean, S., Ward, A., Mercaldi, C. J., Collins, J. M., Cook, M. N., Baker, N. L., & Arrighi, H. M. (2011) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000321984 · Cited by 163
A Synergistic Dysfunction of Mitochondrial Fission/Fusion Dynamics and Mitophagy in Alzheimer's Disease
Santos, R. X., Correia, S. C., Wang, X., Perry, G. L., Smith, M. A., Moreira, P. I., & Zhu, X. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100666 · Cited by 162
Vascular Risks and Incident Dementia: Results from a Cohort Study of the Very Old
Brayne, C., Gill, C., Huppert, F. A., Barkley, C., Gehlhaar, E., Girling, D. M., O’Connor, D., & Paykel, E. S. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017043 · Cited by 159
Body Mass Index, Weight Change, and Clinical Progression in Mild Cognitive Impairment and Alzheimer Disease
Besser, L. M., Gill, D. P., Monsell, S. E., Brenowitz, W. D., Meranus, D. H., Kukull, W. A., & Gustafson, D. (2013) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000005 · Cited by 150
Adiponectin in plasma and cerebrospinal fluid in MCI and Alzheimer’s disease
Une, K., Takei, Y. A., Tomita, N., Asamura, T., Ohrui, T., Furukawa, K., & Arai, H. (2010) · European Journal of Neurology · doi:10.1111/j.1468-1331.2010.03194.x · Cited by 149
Involvement of N-methyl-d-aspartate receptor and free radical in homocysteine-mediated toxicity on rat cerebellar granule cells in culture
Kim, W.-K., & Pae, Y.-S. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)13011-1 · Cited by 148
Advances in the pathogenesis of Alzheimer’s disease: a re-evaluation of amyloid cascade hypothesis
Dong, S., Duan, Y., Hu, Y., & Zhao, Z. (2012) · Translational Neurodegeneration · doi:10.1186/2047-9158-1-18 · Cited by 147
Association between Vitamin D Receptor Gene Polymorphism and Alzheimer's Disease
Gezen‐Ak, D., Dursun, E., Ertan, T., Hanagasi, H. A., Gurvit, H. I., Emre, M., Eker, E., Öztürk, M., Engin, F., & Yılmazer, S. (2007) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.212.275 · Cited by 144
Vitamin D3-Enriched Diet Correlates with a Decrease of Amyloid Plaques in the Brain of AβPP Transgenic Mice
Yu, J., Gattoni-Celli, M., Zhu, H., Bhat, N. R., Sambamurti, K., Gattoni‐Celli, S., & Kindy, M. S. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101986 · Cited by 141
Peripheral Cytokines and Chemokines in Alzheimer’s Disease
Lee, K. S., Chung, J. H., Choi, T.-K., Suh, S. Y., Oh, B. H., & Hong, C. H. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000245156 · Cited by 140
Homocysteine and Cognitive Performance in the Framingham Offspring Study: Age Is Important
Elias, M. F., Sullivan, L. M., D'Agostino, R. B., Elias, P. K., Jacques, P. F., Selhub, J., Seshadri, S., Au, R., Beiser, A., & Wolf, P. A. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi259 · Cited by 136
Potential Inflammatory biomarkers in Alzheimer's disease
Mrak, R. E., & Griffin, W. S. T. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-8406 · Cited by 135
How and When Environmental Agents and Dietary Factors Affect the Course of Alzheimers Disease: The “LEARn” Model (Latent Early-Life Associated Regulation) May Explain the Triggering of AD
Lahiri, D. K., Maloney, B., Basha, R. M., Ge, Y. W., & Zawia, N. (2007) · Current Alzheimer Research · doi:10.2174/156720507780362164 · Cited by 134
Leptin: A Novel Therapeutic Strategy for Alzheimer's Disease
Tezapsidis, N., Johnston, J. M., Smith, M. A., Ashford, J. W., Casadesús, G., Robakis, N. K. R. K., Wolozin, B. L., Perry, G. L., Zhu, X., Greco, S. J., et al. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1021 · Cited by 127
Obesity, leptin, and Alzheimer's disease
Lee, E. B. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06274.x · Cited by 126
The “LEARn” (Latent Early-life Associated Regulation) model integrates environmental risk factors and the developmental basis of Alzheimer’s disease, and proposes remedial steps
Lahiri, D. K., & Maloney, B. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.001 · Cited by 124
Differential diagnosis of Alzheimer's disease
Geldmacher, D. S., & Whitehouse, P. J. (1997) · Neurology · doi:10.1212/wnl.48.5_suppl_6.2s · Cited by 122
Serum homocysteine and dementia: Meta‐analysis of eight cohort studies including 8669 participants
Wald, D. S., Kasturiratne, A., & Simmonds, M. C. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.08.234 · Cited by 120
Efficacy of Multivitamin Supplementation Containing Vitamins B6 and B12 and Folic Acid as Adjunctive Treatment with a Cholinesterase Inhibitor in Alzheimer's Disease: A 26-Week, Randomized, Double-Blind, Placebo-Controlled Study in Taiwanese Patients
Sun, Y., Lu, C.-J., Chien, K., Chen, S.-T., & Chen, R.-C. (2007) · Clinical Therapeutics · doi:10.1016/j.clinthera.2007.10.012 · Cited by 119
The Pathogenesis of Alzheimer′s Disease: A Reevaluation of the “Amyloid Cascade Hypothesis”
Armstrong, R. A. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/630865 · Cited by 117
Serum paraoxonase activity changes in patients with Alzheimer's disease and vascular dementia
Paragh, G., Balla, P., Katona, E., Seres, I., Égerházi, A., & Degrell, I. (2002) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060200013 · Cited by 114
Hypothalamic leptin regulation of energy homeostasis and glucose metabolism
Morton, G. J. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.135590 · Cited by 114
Reevaluating Metabolism in Alzheimer's Disease from the Perspective of the Astrocyte-Neuron Lactate Shuttle Model
Newington, J. T., Harris, R. A., & Cumming, R. C. (2013) · Journal of Neurodegenerative Diseases · doi:10.1155/2013/234572 · Cited by 109
Role of genes linked to sporadic Alzheimer’s disease risk in the production of β-amyloid peptides
Bali, J., Gheinani, A. H., Zurbriggen, S., & Rajendran, L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201632109 · Cited by 107
Examination of the Clinicopathologic Continuum of Alzheimer Disease in the Autopsy Cohort of the National Alzheimer Coordinating Center
Serrano‐Pozo, A., Qian, J., Monsell, S. E., Frosch, M. P., Betensky, R. A., & Hyman, B. T. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000016 · Cited by 106
Altered Serum Levels of Adipokines and Insulin in Probable Alzheimer's Disease
Khemka, V. K., Bagchi, D., Bandyopadhyay, K., Bir, A., Chattopadhyay, M., Biswas, A., Basu, D., & Chakrabarti, S. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140006 · Cited by 101
Self-citation
1α,25-Dihydroxyvitamin D3 enhances cerebral clearance of human amyloid-β peptide(1-40) from mouse brain across the blood-brain barrier
Ito, S., Ohtsuki, S., Nezu, Y., Koitabashi, Y., Murata, S., & Terasaki, T. (2011) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-8-20 · Cited by 99
Interleukins, Inflammation, and Mechanisms of Alzheimer's Disease
Weisman, D., Hakimian, E., & Ho, G. J. (2006) · Vitamins & Hormones · doi:10.1016/s0083-6729(06)74020-1 · Cited by 95
Cholesterol and APOE genotype interact to influence Alzheimer disease progression
Evans, R. M., Hui, S. L., Perkins, A. J., Lahiri, D. K., Poirier, J., & Farlow, M. R. (2004) · Neurology · doi:10.1212/01.wnl.0000125323.15458.3f · Cited by 95
Novel Disease-Modifying Therapies for Alzheimer's Disease
Jiang, T., Yu, J., & Tan, L. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120640 · Cited by 94
Statins for the prevention of Alzheimer's disease and dementia
Scott, H. D., & Laake, K. (2001) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003160 · Cited by 91
An Integrated and Unifying Hypothesis for the Metabolic Basis of Sporadic Alzheimer's Disease
Erol, A. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13302 · Cited by 89
Diabetes, related conditions, and dementia
Luchsinger, J. A. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2010.08.063 · Cited by 88
Lipids and Adipokines as Risk Factors for Alzheimer's Disease
Warren, M. W., Hynan, L. S., & Weiner, M. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111385 · Cited by 86
Vitamin D Receptor Gene Haplotype Is Associated with Late-Onset Alzheimer's Disease
Gezen‐Ak, D., Dursun, E., Bılgıç, B., Hanagasi, H. A., Ertan, T., Gurvit, H. I., Emre, M., Eker, E., Ulutin, T., Uysal, Ö., et al. (2012) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.228.189 · Cited by 86
Vitamin D in Relation to Cognitive Impairment, Cerebrospinal Fluid Biomarkers, and Brain Volumes
Hooshmand, B., Lökk, J., Solomon, A., Mangialasche, F., Miralbell, J., Spulber, G., Annerbo, S., Andreasen, N., Winblad, B. G., Cedazo-Mı́nguez, Á., et al. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu022 · Cited by 84
Insulin resistance in the brain: an old-age or new-age problem?
Williamson, R., McNeilly, A., & Sutherland, C. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.05.007 · Cited by 82
Altered APP Processing in Insulin-Resistant Conditions Is Mediated by Autophagosome Accumulation via the Inhibition of Mammalian Target of Rapamycin Pathway
Son, S. M., Song, H., Byun, J., Park, K. S., Jang, H. C., Park, Y. J., & Mook‐Jung, I. (2012) · Diabetes · doi:10.2337/db11-1735 · Cited by 81
Vitamin D receptor and Alzheimer's disease: a genetic and functional study
Wang, L., Hara, K., Baaren, J. M. V., Price, J. C., Beecham, G. W., Gallins, P. J., Whitehead, P. L., Wang, G., Lu, C., Slifer, M. A., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.12.038 · Cited by 79
Plasma Folate, Vitamin B12, and Total Homocysteine and Homozygosity for the C677T Mutation of the 5,10-Methylene Tetrahydrofolate Reductase Gene in Patients with Alzheimer’s Dementia
Postiglione, A., Milan, G., Ruocco, A., Gallotta, G., Guiotto, G., & Minno, G. D. (2001) · Gerontology · doi:10.1159/000052822 · Cited by 79
Hypercholesterolemia accelerates intraneuronal accumulation of Aβ oligomers resulting in memory impairment in Alzheimer's disease model mice
Umeda, T., Tomiyama, T., Kitajima, E., Idomoto, T., Nomura, S., Lambert, M. P., Klein, W. L., & Mori, H. (2012) · Life Sciences · doi:10.1016/j.lfs.2011.12.022 · Cited by 78
Raised Serum Proinflammatory Cytokines in Alzheimer’s Disease with Depression
Khemka, V. K. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500170 · Cited by 77
Midlife homocysteine and late-life dementia in women. A prospective population study
Zylberstein, D. E., Lissner, L., Björkelund, C., Mehlig, K., Thelle, D. S., Gustafson, D., Östling, S., Waern, M., Guo, X., & Skoog, I. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.02.024 · Cited by 76
A Common Pathogenic Mechanism Linking Type-2 Diabetes and Alzheimer's Disease: Evidence from Animal Models
Park, S. A. (2011) · Journal of Clinical Neurology · doi:10.3988/jcn.2011.7.1.10 · Cited by 74
Leptin signaling and Alzheimer's disease.
Marwarha, G., & Ghribi, O. (2012) · Europe PMC (PubMed Central) · Cited by 73
Homocysteine induces cytotoxicity and proliferation inhibition in neural stem cells via DNA methylation in vitro
Lin, N., Qin, S., Luo, S., Cui, S., Huang, G., & Zhang, X. (2014) · FEBS Journal · doi:10.1111/febs.12764 · Cited by 73
Systematic analysis of transcription‐level effects of neurodegenerative diseases on human brain metabolism by a newly reconstructed brain‐specific metabolic network
Sertbaş, M., Ülgen, K. Ö., & Çakır, T. (2014) · FEBS Open Bio · doi:10.1016/j.fob.2014.05.006 · Cited by 68
Oxidative Stress and Amyloid Beta Toxicity in Alzheimer’s Disease: Intervention in a Complex Relationship by Antioxidants
Chakrabarti, S., Sinha, M., Thakurta, I. G., Banerjee, P., & Chattopadhyay, M. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990152 · Cited by 63
Self-citation
Vitamin D levels in Alzheimer's and Parkinson's diseases: a meta-analysis
Zhao, Y., Sun, Y., Ji, H.-F., & Shen, L. (2013) · Nutrition · doi:10.1016/j.nut.2012.11.018 · Cited by 61
Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study
Zuliani, G., Donnorso, M. P., Bosi, C., Passaro, A., Nora, E. D., Zurlo, A., Bonetti, F., Mozzi, A. F., & Cortese, C. (2011) · BMC Neurology · doi:10.1186/1471-2377-11-121 · Cited by 61
Sporadic Alzheimer's Disease: The Starving Brain
Mamelak, M. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120370 · Cited by 59
Is There a Causal Link between Inflammation and Dementia?
Enciu, A., & Popescu, B. O. (2013) · BioMed Research International · doi:10.1155/2013/316495 · Cited by 59
Hyperhomocysteinemia and Cardiovascular Risk: Effect of Vitamin Supplementation in Risk Reduction
Ciaccio, M., & Bellia, C. (2010) · Current Clinical Pharmacology · doi:10.2174/157488410790410551 · Cited by 54
Serum Homocysteine, Dehydroepiandrosterone Sulphate and Lipoprotein (a) in Alzheimer's Disease and Vascular Dementia.
Ray, L., Khemka, V. K., Behera, P., Bandyopadhyay, K., Pal, S., Pal, K., Basu, D., & Chakrabarti, S. (2013) · Europe PMC (PubMed Central) · Cited by 51
Self-citation
Adiponectin and Leptin in Relation to Insulin Sensitivity
Soodini, G. R., & Hamdy, O. (2004) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2004.2.114 · Cited by 48
Nongenomic Effects of 1α,25-Dihydroxyvitamin D3
Revelli, A., Massobrio, M., & Tesařík, J. (1998) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(98)00100-3 · Cited by 44
Plasma homocysteine, vitamin B12 and folate in Alzheimer's patients and healthy Arabs in Israel
Mizrahi, E. H., Bowirrat, A., Jacobsen, D. W., Korczyn, A. D., Traoré, F., Petot, G. J., Lerner, A. J., Debanne, S. M., Adunsky, A., DiBello, P. M., et al. (2004) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.08.011 · Cited by 41
Early-Onset Familial Alzheimer Disease
Bird, T. D. (2012) · Cited by 35
When aging-onset diabetes is coming across with Alzheimer disease: Comparable pathogenesis and therapy
Tang, J., Pei, Y., & Zhou, G. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.04.013 · Cited by 28
Plasma cholesterol and risk for late-onset Alzheimer’s disease
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When Will Alzheimer's Disease be Cured? A Pharmaceutical Perspective
Townsend, M. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110020 · Cited by 19
Elevated Plasma Homocysteine Level Is Not Primarily Related to Alzheimers Disease
Nilsson, K. H., Gustafson, L., & Hultberg, B. L. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000342612 · Cited by 19
Role of neuropsychological assessment in the differential diagnosis of Alzheimer's disease and vascular dementia
Pimentel, É. M. L. (2009) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642009dn30300007 · Cited by 15
Mild Hypercholesterolemia, Normal Plasma Triglycerides, and Normal Glucose Levels Across Dementia Staging in Alzheimer’s Disease
Ramdane, S., & Daoudi‐Gueddah, D. (2011) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317511414552 · Cited by 14
Serum Leptin Levels in Patients with Alzheimer’s Disease
Papadimitriou, A., Rizouli, K. A., Karaoulanis, S. E., & Rizouli, K. A. (2012) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 3

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Evans RM, Hui S, Perkins A, Lahiri DK, Poirier J, Farlow MR (2004). Cholesterol and APOE genotype interact to influence Alzheimer disease progression. Neurology, 62:1869-1871. · DOI

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Cline, E. N., Bicca, M. A., Viola, K. L., & Klein, W. L. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179941 · Cited by 870
Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice
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Ganguly, G., Chakrabarti, S., Chatterjee, U., & Saso, L. (2017) · Drug Design Development and Therapy · doi:10.2147/dddt.s130514 · Cited by 305
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Therapies for Prevention and Treatment of Alzheimer’s Disease
Mendiola-Precoma, J., Berumen, L. C., Padilla, K., & García‐Alcocer, G. (2016) · BioMed Research International · doi:10.1155/2016/2589276 · Cited by 262

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Authors: Chakrabarti, S., Kumar Khemka, V., Banerjee, A., Chatterjee, G., Ganguly, A., & Biswas, A.
Affiliations: Institute of Post Graduate Medical Education and Research (IN)
Bangur Institute of Neurosciences (IN)
ORCID: Chakrabarti, Sasanka
Banerjee, Anindita
Ganguly, Anirban
Biswas, Atanu
Venue: Aging and disease
Publisher: Aging and Disease
Published: 2015
Volume: 6
Issue: 4
Pages: 282
ISSN: 2152-5250 (ISSN-L)
DOI: 10.14336/ad.2014.002
PMC: PMC4509477
OpenAlex: W2103890427
Cited by: 134
References: 189
Citations by year: 2026: 5 · 2025: 12 · 2024: 12 · 2023: 14 · 2022: 10 · 2021: 15 · 2020: 20 · 2019: 9 · 2018: 16 · 2017: 11 · 2016: 7 · 2015: 3
FWCI: 10.00
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Aging and Disease (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: sporadic Alzheimer's disease, metabolic risk factors, hypercholesterolemia, hyperhomocysteinemia, type 2 diabetes, adipokines, inflammatory cytokines, vitamin D, Alzheimer's disease pathogenesis, Alzheimer's disease diagnosis, neuropathology, dementia

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Metabolic Risk Factors of Sporadic Alzheimer's Disease: Implications in the Pathology, Pathogenesis and Treatment

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