State of the science on brain insulin resistance and cognitive decline due to Alzheimer's disease

Cites (342)

Items 201–342 of 342

1. Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese
   Stephanie Kullmann, Thomas Goj, Ralf Veit, Louise Fritsche, Lore Wagner, Patrick Schneeweiß, Miriam Hoene, Christoph Hoffmann, Jürgen Machann, Andreas Michael Niess et al. · 2022 · JCI Insight
2. Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer’s model mice
   Kyong Nyon Nam, Anaïs Mounier, Cody M. Wolfe, Nicholas Francis Fitz, Alexis Y. Carter, Emilie L. Castranio, Hafsa Kamboh, Valerie L. Reeves, Jianing Wang, Xianlin Han et al. · 2017 · Scientific Reports
3. Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger
   Stephanie Kullmann, Martin Heni, Ralf Veit, Klaus Scheffler, Jürgen Machann, Hans‐Ulrich Häring, Andreas Fritsche, Hubert T. Preissl · 2017 · Scientific Reports
4. Intranasal Insulin Reduces White Matter Hyperintensity Progression in Association with Improvements in Cognition and CSF Biomarker Profiles in Mild Cognitive Impairment and Alzheimer's Disease
   Derek Kellar, Samuel Neal Lockhart, Paul S. S. Aisen, Rema Raman, Robert A. Rissman, James B. Brewer, Suzanne Craft · 2021 · The Journal of Prevention of Alzheimer s Disease
5. Brain functional magnetic resonance imaging response to glucose and fructose infusions in humans
   Jonathan Q. Purnell, B. A. Klopfenstein, Alexander A. Stevens, Peter Joseph Havel, Sean H. Adams, Tamara N. Dunn, Christine M. Krisky, William D. Rooney · 2010 · Diabetes Obesity and Metabolism
6. Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1–40/42 and Phospho-Tau May Abet Alzheimer Development
   Mini P. Sajan, BARBARA CALEEN HANSEN, Robert A. Ivey, Joshua Sajan, Csilla Ari, Shijie Song, Ursula Braun, Michael Leitges, Margaret G. Higgs, Robert V. Farese · 2016 · Diabetes
7. Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease
   Ramón Velázquez, An Tran, Egide Ishimwe, Larry A. Denner, Nikhil Dave, Salvatore Oddo, Kelly T. Dineley · 2017 · Neurobiology of Aging
8. Long Acting Intranasal Insulin Detemir Improves Cognition for Adults with Mild Cognitive Impairment or Early-Stage Alzhemir's Disease Dementia
   2015 · Journal of Alzheimer s Disease
9. Exercise increases insulin signaling in the hippocampus: Physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice
   Alexandre Pastoris Muller, Jussânia Almeida Gnoatto, Júlia Dübois Moreira, Eduardo Rigon Zimmer, Clarissa Branco Haas, Francisco Lulhier, Marcos L. S. Perry, Diogo Onofre Souza, Ignacio Torres‐Alemán, Luis Valmor Portela · 2010 · Hippocampus
10. Permeability of the Blood-Brain Barrier to Albumin and Insulin in the Young and Aged SAMP8 Mouse
    William A. Banks, Susan A. Farr, John Edward Morley · 2000 · The Journals of Gerontology Series A
11. Immune reactivity towards insulin, its amyloid and protein S100B in blood sera of Parkinson's disease patients
    K. Wilhelm, Kiran Yanamandra, Грудень Марина Алексеевна, Vladimir Zamotin, Mantas Mališauskas, Vida Časaitė, Adas Darinskas, Lars Forsgren, Ludmilla A. Morozova‐Roche · 2007 · European Journal of Neurology
12. Brain Alterations and Clinical Symptoms of Dementia in Diabetes: Aβ/Tau-Dependent and Independent Mechanisms
    Naoyuki Sato, Ryuichi Morishita · 2014 · Frontiers in Endocrinology
13. The role of insulin in the vascular contributions to age-related dementia
    Timothy M. Hughes, Suzanne Craft · 2015 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
14. Insulin Action in the Human Brain: Evidence from Neuroimaging Studies
    Kullmann, S., Heni, M., Fritsche, A., Preissl, H. · 2015 · Journal of Neuroendocrinology
15. The Effect of Acute Hypoglycemia on Brain Function and Activation
    Julian Rosenthal, Stephanie A. Amiel, L Yágüez, Edward Thomas Bullmore, David Hopkins, Mark L. Evans, Andrew Pernet, Helen Reid, Vincent Giampietro, Chris Andrew et al. · 2001 · Diabetes
16. Serum but not cerebrospinal fluid levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) are increased in Alzheimer's disease
    Per Johansson, Daniel Åberg, Jan-Ove Johansson, Niklas Mattsson, Oskar Hansson, Bo Åhrén, Jörgen Isgaard, N. David Åberg, Kaj Blennow, Henrik Zetterberg et al. · 2013 · Psychoneuroendocrinology
17. Insulin Reduces Neuronal Excitability by Turning on GABAA Channels that Generate Tonic Current
    Zhe Jin, Yang Jin, Suresh Kumar Mendu, Eva Degerman, Leif Groop, Bryndis Birnir · 2011 · PLoS ONE
18. The beta secretase BACE1 regulates the expression of insulin receptor in the liver
    Meakin, Paul J., Mezzapesa, Anna, Benabou, Eva, Haas, Mary E., Bonardo, Bernadette, Grino, Michel, Brunel, Jean-Michel, Desbois-Mouthon, Christèle, Biddinger, Sudha B., Govers, Roland et al. · 2018 · Nature Communications
19. Insulin transport into the brain
    Sarah M. Gray, Eugene J. Barrett · 2018 · American Journal of Physiology-Cell Physiology
20. Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer’s disease
    Lisa S. Robison, Olivia J. Gannon, Melissa A. Thomas, Abigail E. Salinero, Charly Abi‐Ghanem, Yannick Poitelon, Sophie Belin, Kristen L. Zuloaga · 2020 · Journal of Neuroinflammation
21. Late-Life Physical and Cognitive Activities Independently Contribute to Brain and Cognitive Resilience
    Casaletto, Kaitlin B., Rentería, Miguel Arce, Pa, Judy, Tom, Sarah E., Harrati, Amal, Armstrong, Nicole M., Rajan, K. Bharat, Mungas, Dan, Walters, Samantha, Kramer, Joel et al. · 2020 · Journal of Alzheimer's Disease
22. CSF and Brain Indices of Insulin Resistance, Oxidative Stress and Neuro-Inflammation in Early versus Late Alzheimer’s Disease
    Ming Tong Chetram Deochand · 2013 · Journal of Alzheimer’s Disease & Parkinsonism
23. Why the cognitive ‘fountain of youth’ may be upstream: pathways to dementia risk and resilience through social connectedness
    Perry, Brea L., McConnell, Will R., Coleman, Max E., Roth, Adam R., Peng, Siyun, Apostolova, Liana G. · 2022 · Alzheimer's & Dementia
24. Intranasal insulin modulates cerebrospinal fluid markers of neuroinflammation in mild cognitive impairment and Alzheimer’s disease: a randomized trial
    Derek Kellar, Thomas C. Register, Samuel Neal Lockhart, Paul S. S. Aisen, Rema Raman, Robert A. Rissman, James B. Brewer, Suzanne Craft · 2022 · Scientific Reports
25. Insulin resistance and hippocampal dysfunction: Disentangling peripheral and brain causes from consequences
    Claudia A. Grillo, Jennifer Lynn Woodruff, Victoria Alice Macht, Lawrence Patrick Reagan · 2019 · Experimental Neurology
26. Insulin Resistance in Peripheral Tissues and the Brain: A Tale of Two Sites
    Rhea, Elizabeth M., Banks, William A., Raber, Jacob · 2022 · Biomedicines
27. Brain Gene Expression of a Sporadic (icv-STZ Mouse) and a Familial Mouse Model (3xTg-AD Mouse) of Alzheimer’s Disease
    Yanxing Chen, Zhu Tian, Zhihou Liang, Shenggang Sun, Chun‐Ling Dai, Moon H. Lee, Frank M. LaFerla, Inge Grundke, Khalid Iqbal, Fei Liu et al. · 2012 · PLoS ONE
28. Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome
    Tramutola, Antonella, Lanzillotta, Chiara, Di Domenico, Fabio, Head, Elizabeth, Butterfield, D. Allan, Perluigi, Marzia, Barone, Eugenio · 2020 · Neurobiology of Disease
29. β-Cell Hyperplasia Induced by Hepatic Insulin Resistance
    Óscar Escribano, Carlos Guillén, Carmen Nevado, Almudena Gómez‐Hernández, C. Ronald Kahn, Manuel Benito · 2009 · Diabetes
30. Brain insulin resistance and altered brain glucose are related to memory impairments in schizophrenia
    S. Andrea Wijtenburg, Dimitrios Kapogiannis, Stephanie A. Korenic, Roger J. Mullins, Joyce Tran, Frank E. Gaston, Shuo Chen, Maja Mustapić, Liyi Elliot Hong, Laura M. Rowland · 2019 · Schizophrenia Research
31. Insulin: An Emerging Treatment for Alzheimer’s Disease Dementia?
    Jill K. Morris, Jeffrey Murray Burns · 2012 · Current Neurology and Neuroscience Reports
32. Lentivirus-mediated downregulation of hypothalamic insulin receptor expression
    Claudia A. Grillo, Kellie L. Tamashiro, Gerardo G. Piroli, Susan J. Melhorn, Justin T. Gass, Ryan J. Newsom, Leah R. Reznikov, Amy C. Smith, Steven P. Wilson, R.R. Sakai et al. · 2007 · Physiology & Behavior
33. Insulin like growth factor‐1 and insulin like growth factor binding proteins in the cerebrospinal fluid and serum from patients with Alzheimer's disease
    Zivar Salehi, Farhad Mashayekhi, Mohammad Naji · 2008 · BioFactors
34. The Role of Insulin Receptor Isoforms in Diabetes and Its Metabolic and Vascular Complications
    Óscar Escribano, Nuria Beneit, Carlota Rubio-Longás, Andrea R. López‐Pastor, Almudena Gómez‐Hernández · 2017 · Journal of Diabetes Research
35. Insulin Resistance Is Associated With Enhanced Brain Glucose Uptake During Euglycemic Hyperinsulinemia: A Large-Scale PET Cohort
    Eleni Rebelos, Marco Bucci, Tomi Karjalainen, Vesa Oikonen, Alessandra Bertoldo, Jarna C. Hannukainen, Kirsi A. Virtanen, Aino Latva‐Rasku, Jussi Hirvonen, ILKKA H. A. HEINONEN et al. · 2021 · Diabetes Care
36. Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose
    Victoria E. Cotero, Vanessa H. Routh · 2009 · American Journal of Physiology-Endocrinology and Metabolism
37. Insulin differentially affects the distribution kinetics of amyloid beta 40 and 42 in plasma and brain
    Suresh Kumar Swaminathan, Kristen M. Ahlschwede, Vidur Sarma, Geoffry L. Curran, Rajesh S. Omtri, Teresa D. Decklever, Val J. Lowe, Joseph F. Poduslo, Karunya K. Kandimalla · 2017 · Journal of Cerebral Blood Flow & Metabolism
38. Cigarette Smoking: An Accessory to the Development of Insulin Resistance
    Ashley Artese, BRYANT A. STAMFORD, Robert J. Moffatt · 2017 · American Journal of Lifestyle Medicine
39. Statin modulates insulin signaling and insulin resistance in liver and muscle of rats fed a high-fat diet
    Cristina Alba Lalli, José Rodrigo Pauli, Patrícia O. Prada, Dennys E. Cintra, Eduardo Rochete Ropelle, Licio Augusto Velloso, Mário J.A. Saad · 2007 · Metabolism
40. The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old APP/PS1 Mice
    Molly Stanley, Shannon L. Macauley, Emily E. Caesar, Lauren J. Koscal, Will Moritz, Grace O. Robinson, Joseph Roh, Jennifer Keyser, Hong Jiang, David M. Holtzman · 2016 · Journal of Neuroscience
41. Insulin-Dependent Activation of MCH Neurons Impairs Locomotor Activity and Insulin Sensitivity in Obesity
    Anne Christine Hausen, Johan Ruud, Hong Jiang, Simon Heß, Hristo Varbanov, Peter Kloppenburg, Jens C. Brüning · 2016 · Cell Reports
42. Characterisation of nasal devices for delivery of insulin to the brain and evaluation in humans using functional magnetic resonance imaging
    Wingrove, Jed, Swedrowska, Magda, Scherließ, Regina, Parry, Mark, Ramjeeawon, Mervin, Taylor, David, Gauthier, Gregoire, Brown, Louise, Amiel, Stephanie, Zelaya, Fernando et al. · 2019 · Journal of Controlled Release
43. Evaluation of Neuropathological Effects of a High-Fat Diet in a Presymptomatic Alzheimer’s Disease Stage in APP/PS1 Mice
    Miren Ettcheto, Dmitry Petrov, Ignacio Pedrós, Norma Alva, Teresa Carbonell, Carlos Beas‐Zárate, Mercè Pallàs, Carme Auladell, Jaume Folch, Antoni Camins · 2016 · Journal of Alzheimer s Disease
44. Early-Stage Alzheimer’s Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways
    Suzanne M. de la Monte, Ming Tong, Lori A. Daiello, Brian R. Ott · 2019 · Journal of Alzheimer s Disease
45. Exploring brain insulin resistance in adults with bipolar depression using extracellular vesicles of neuronal origin
    Rodrigo Barbachan Mansur, Francheska Delgado‐Peraza, Mehala Subramaniapillai, Yena L. Lee, Michelle Iacobucci, Flora Nasri, Nelson B. Rodrigues, Joshua Daniel Rosenblat, Elisa Macedo Brietzke, Victoria E. Cosgrove et al. · 2020 · Journal of Psychiatric Research
46. Brain insulin, insulin‐like growth factor 1 and glucagon‐like peptide 1 signalling in Alzheimer’s disease
    Ferreira, Sergio T. · 2021 · Journal of Neuroendocrinology
47. Changes in cerebrospinal fluid and blood plasma levels of IGF-II and its binding proteins in Alzheimer’s disease: an observational study
    Joakim Hertze, Katarina Nägga, Lennart Minthon, Oskar Hansson · 2014 · BMC Neurology
48. Diabetes: Risk factor and translational therapeutic implications for Alzheimer's disease
    Jeffrey L. Cummings, Andrew Adonay Ortiz, Janelle Castellino, Jefferson W. Kinney · 2022 · European Journal of Neuroscience
49. Agonism and Antagonism at the Insulin Receptor
    Louise Knudsen, Bo F. Hansen, Pia Jensen, Thomas Åskov Pedersen, Kirsten Vestergaard, Lauge Schäffer, Blagoy Blagoev, Martin B. Oleksiewicz, Vladislav V. Kiselyov, Pierre DE MEYTS · 2012 · PLoS ONE
50. Brain insulin resistance and cognitive function: influence of exercise
    Steven K. Malin, Nathan R. Stewart, Andrew A. Ude, Brandon L. Alderman · 2022 · Journal of Applied Physiology
51. High‐fat diet protects the blood–brain barrier in an Alzheimer's disease mouse model
    Shirin Elhaik Goldman, David Goez, David Last, Sharone Naor, Sigal Liraz Zaltsman, Inbal Sharvit‐Ginon, Dana Atrakchi, Chen Shemesh, Rachel Twitto‐Greenberg, Shoval Tsach et al. · 2018 · Aging Cell
52. Disruption of Resting Functional Connectivity in Alzheimer’s Patients and At-Risk Subjects
    L. Krajčovičová, Radek Mareček, Michal Mikl, Irena Rektorová · 2014 · Current Neurology and Neuroscience Reports
53. Effect of insulin on excitatory synaptic transmission onto dopamine neurons of the ventral tegmental area in a mouse model of hyperinsulinemia
    S Liu, Gwenaël Labouèbe, S Karunakaran, Susanne M. Clee, Stephanie L. Borgland · 2013 · Nutrition and Diabetes
54. Insulin modulates emotional behavior through a serotonin-dependent mechanism
    Martin, Hugo, Bullich, Sébastien, Martinat, Maud, Chataigner, Mathilde, Di Miceli, Mathieu, Simon, Vincent, Clark, Samantha, Butler, Jasmine, Schell, Mareike, Chopra, Simran et al. · 2024 · Molecular Psychiatry
55. Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss
    Dorota Kamińska, Maija Hämäläinen, Henna Cederberg, Pirjo Käkelä, Sari Venesmaa, Pekka S. Miettinen, Imre Ilves, Karl‐Heinz Herzig, Marjukka Kolehmainen, Leila J. Karhunen et al. · 2013 · Diabetologia
56. Insulin regulates neurovascular coupling through astrocytes
    Ana Maria Fernandez, Laura Martinez‐Rachadell, Marta Navarrete, Julia Pose‐Utrilla, José Carlos Dávila, Jaime Pignatelli, Sonia Díaz-Pacheco, Santiago Guerra-Cantera, Emilia Viedma-Moreno, Rocío Palenzuela et al. · 2022 · Proceedings of the National Academy of Sciences
57. Circulating IGFBP‐2: a novel biomarker for incident dementia
    McGrath, Emer R., Himali, Jayandra J., Levy, Daniel, Conner, Sarah C., DeCarli, Charles S., Pase, Matthew P., Courchesne, Paul, Satizabal, Claudia L., Vasan, Ramachandran S., Beiser, Alexa S. et al. · 2019 · Annals of Clinical and Translational Neurology
58. Pathways for insulin access to the brain: the role of the microvascular endothelial cell
    Rick I. Meijer, Sarah M. Gray, Kevin W. Aylor, Eugene J. Barrett · 2016 · American Journal of Physiology-Heart and Circulatory Physiology
59. The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells but does not mediate insulin entry from blood to brain
    Maria Hersom, Hans Christian Cederberg Helms, Christoffer Schmalz, Thomas Åskov Pedersen, Stephen Timothy Buckley, Birger Brodin · 2018 · American Journal of Physiology-Endocrinology and Metabolism
60. A human brain vascular atlas reveals diverse cell mediators of Alzheimer’s disease risk
    Yang, Andrew C., Vest, Ryan T., Kern, Fabian, Lee, Davis P., Maat, Christina A., Losada, Patricia M., Chen, Michelle B., Agam, Maayan, Schaum, Nicholas, Khoury, Nathalie et al. · 2021
61. Brain Insulin Administration Triggers Distinct Cognitive and Neurotrophic Responses in Young and Aged Rats
    Clarissa Branco Haas, Eduardo Kalinine, Eduardo Rigon Zimmer, Gisele Hansel, A Brochier, Jean Pierre Oses, Luis Valmor Portela, Alexandre Pastoris Muller · 2015 · Molecular Neurobiology
62. Location of phosphotyrosine-containing proteins by immunocytochemistry in the rat forebrain corresponds to the distribution of the insulin receptor.
    Anne Moss, Jürgen W. Unger, Richard T. Moxley, James N. Livingston · 1990 · Proceedings of the National Academy of Sciences
63. Cerebrospinal fluid levels of insulin in patients with Alzheimer's disease
    José Antonio Pérez-Molina, F J Jiménez-Jiménez, C. Vargas, Pedro Antonio Gómez, Fernando de Bustos, Carlos Gómez-Escalonilla, Martín Zurdo, A. Tallón-Barranco, Antonio Martínez‐Salio, Jesús Porta-Etessam et al. · 2002 · Acta Neurologica Scandinavica
64. Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer’s Disease
    Stefan L.C. Geijselaers, Pauline Aalten, Inez H.G.B. Ramakers, Peter Paul De Deyn, Annemieke C. Heijboer, Huiberdina L. Koek, Marcel G.M. Olde-Rikkert, Janne M. Papma, Fransje E. Reesink, Lieke L. Smits et al. · 2017 · Journal of Alzheimer s Disease
65. PLA2G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment
    Marta Pérez-González, Maite Mendióroz, Sara Badesso, Diego Sucunza, Miren Roldán, María Espelosin, Susana Ursúa, Rafael Luján, Mar Cuadrado‐Tejedor, Ana García‐Osta · 2020 · Progress in Neurobiology
66. Hippocampal-specific insulin resistance elicits behavioral despair and hippocampal dendritic atrophy
    Lawrence Patrick Reagan, Hanson B. Cowan, Jennifer Lynn Woodruff, Gerardo G. Piroli, Jennifer M. Erichsen, A.N. Evans, Hannah E. Burzynski, Nicholas David Maxwell, Frances Zoe Loyo-Rosado, Victoria Alice Macht et al. · 2021 · Neurobiology of Stress
67. Immunohistochemical analysis of transporters related to clearance of amyloid-β peptides through blood–cerebrospinal fluid barrier in human brain
    Matsumoto, Koichi, Chiba, Yoichi, Fujihara, Ryuji, Kubo, Hiroyuki, Sakamoto, Haruhiko, Ueno, Masaki · 2015 · Histochemistry and Cell Biology
68. Receptor-isoform-selective insulin analogues give tissue-preferential effects
    Sara G. Vienberg, Stephan D. Bouman, Heidi Sørensen, Carsten Enggaard Stidsen, Thomas Kjeldsen, Tine Glendorf, Anders R. Sørensen, Grith Skytte Olsen, Birgitte Andersen, Erica Nishimura · 2011 · Biochemical Journal
69. Increased β‐site APP cleaving enzyme 1‐mediated insulin receptor cleavage in type 2 diabetes mellitus with cognitive impairment
    Bao, Hong, Liu, Yiming, Zhang, Mengguo, Chen, Zuolong, Zhang, Weiwei, Ge, Yuhao, Kang, Dongmei, Gao, Feng, Shen, Yong · 2021 · Alzheimer's & Dementia
70. Increased Cerebrospinal Fluid Level of Insulin-like Growth Factor-II in Male Patients with Alzheimer’s Disease
    Daniel Åberg, Per Johansson, Jörgen Isgaard, Anders Wallin, Jan-Ove Johansson, Ulf Andréasson, Kaj Blennow, Henrik Zetterberg, N. David Åberg, Johan Svensson · 2015 · Journal of Alzheimer s Disease
71. Impaired Glucose Tolerance and Reduced Plasma Insulin Precede Decreased AKT Phosphorylation and GLUT3 Translocation in the Hippocampus of Old 3xTg-AD Mice
    Chelsea M. Griffith, Lauren N. Macklin, Yan Cai, Andrew A. Sharp, Xiao‐Xin Yan, Lawrence Patrick Reagan, April D. Strader, Gregory M. Rose, Peter R. Patrylo · 2019 · Journal of Alzheimer s Disease
72. The effect of dietary fat consumption on Alzheimer’s disease pathogenesis in mouse models
    Anna Amelianchik, Lauren Sweetland-Martin, Erin H. Norris · 2022 · Translational Psychiatry
73. Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer’s Disease Pathology and Shows Differential Expression in Transgenic Mice
    Luke W. Bonham, Ethan G. Geier, Natasha Z. R. Steele, Dominic Holland, Bruce L. Miller, Anders Martin Dale, Rahul S. Desikan, Jennifer S. Yokoyama, Alzheimer’s Disease Neuroimaging Initiative · 2018 · Frontiers in Neuroscience
74. A thing of beauty: Structure and function of insulin's “aromatic triplet”
    Michael Aaron Weiss, Michael C. Lawrence · 2018 · Diabetes Obesity and Metabolism
75. Metabolic determinants of Alzheimer’s disease: A focus on thermoregulation
    Marine Tournissac, Manon Leclerc, Josue Valentin‐Escalera, Milène Vandal, Cristina R. Bosoi, Emmanuel Planel, Frédéric Calon · 2021 · Ageing Research Reviews
76. Recent advances in phosphoproteomics and application to neurological diseases
    Justine V. Arrington, Chuan‐Chih Hsu, Sarah G. Elder, W. Andy Tao · 2017 · The Analyst
77. Emerging Pathophysiological Mechanisms Linking Diabetes Mellitus and Alzheimer’s Disease: An Old Wine in a New Bottle
    Vishvas N. Patel, Mehul R. Chorawala, Maitri B. Shah, Kashvi C. Shah, Bhavarth P. Dave, Manal P. Shah, Tanvi M. Patel · 2022 · Journal of Alzheimer s Disease Reports
78. Insulin-like growth factor binding protein-2 interactions with Alzheimer’s disease biomarkers
    Alzheimer’s Disease Neuroimaging Initiative, Elizabeth Lane, Timothy J. Hohman, Angela Lee Jefferson · 2016 · Brain Imaging and Behavior
79. Can insulin signaling pathways be targeted to transport Aβ out of the brain?
    Milène Vandal, Philippe Bourassa, Frédéric Calon · 2015 · Frontiers in Aging Neuroscience
80. Enhancement of Insulin/PI3K/Akt Signaling Pathway and Modulation of Gut Microbiome by Probiotics Fermentation Technology, a Kefir Grain Product, in Sporadic Alzheimer’s Disease Model in Mice
    Nesrine S. El Sayed, Esraa A. Kandil, Mamdooh Helal Ghoneum · 2021 · Frontiers in Pharmacology
81. A historical perspective on the interactions of insulin at the blood‐brain barrier
    Rhea, Elizabeth M., Banks, William A. · 2021 · Journal of Neuroendocrinology
82. Involvement of Insulin-Degrading Enzyme in Insulin- and Atrial Natriuretic Peptide-Sensitive Internalization of Amyloid-β Peptide in Mouse Brain Capillary Endothelial Cells
    Shingo Ito, Sumio Ohtsuki, Sho Murata, Yuki Katsukura, Hiroya Suzuki, Miho Funaki, Masanori Tachikawa, Tetsuya Terasaki · 2013 · Journal of Alzheimer s Disease
83. Liver Sinusoidal Endothelial Cells Link Hyperinsulinemia to Hepatic Insulin Resistance
    Kyoichiro Tsuchiya, Domenico Accili · 2013 · Diabetes
84. Identification of the insulin receptor of cerebral microvessels
    Joyce F. Haskell, Elias Meezan, D. J. Pillion · 1985 · American Journal of Physiology-Endocrinology and Metabolism
85. Increased Cerebrospinal Fluid Amyloid-β During Sleep Deprivation in Healthy Middle-Aged Adults Is Not Due to Stress or Circadian Disruption
    Margaret S. Blattner, Sunil K. Panigrahi, Cristina D. Toedebusch, Terry J. Hicks, Jennifer McLeland, Ian R. Banks, Claire Schaibley, Vitaliy Ovod, Kwasi G. Mawuenyega, Randall John Bateman et al. · 2020 · Journal of Alzheimer s Disease
86. The Mechanisms of Type 2 Diabetes-Related White Matter Intensities: A Review
    Jing Sun, Baofeng Xu, Xuejiao Zhang, Zhidong He, Ziwei Liu, Rui Liu, Guangxian Nan · 2020 · Frontiers in Public Health
87. Aberrant Liver Insulin Receptor Isoform A Expression Normalises with Remission of Type 2 Diabetes after Gastric Bypass Surgery
    Vinko Besic, Hongjun Shi, Richard Strawson Stubbs, Mark Thomas Hayes · 2015 · PLoS ONE
88. Combined Effect of Fatty Diet and Cognitive Decline on Brain Metabolism, Food Intake, Body Weight, and Counteraction by Intranasal Insulin Therapy in 3×Tg Mice
    Elena Sanguinetti, Maria Angela Guzzardi, Daniele Panetta, María Tripodi, Vincenzo De Sena, Mauro Quaglierini, Silvia Burchielli, Piero Antonio Salvadori, Patricia Iozzo · 2019 · Frontiers in Cellular Neuroscience
89. Sex differences in central insulin action: Effect of intranasal insulin on neural food cue reactivity in adults with normal weight and overweight
    Lore Wagner, Ralf Veit, Louise Fritsche, Hans‐Ulrich Häring, Andreas Fritsche, Andreas L. Birkenfeld, Martin Heni, Hubert T. Preissl, Stephanie Kullmann · 2022 · International Journal of Obesity
90. Tissue-specific expression of two alternatively spliced isoforms of the human insulin receptor protein
    Giorgio Sesti, Antonella Nadia Tullio, Rossella D’Alfonso, Maddalena Napolitano, Maria Adelaide Marini, P. Borboni, Renato Longhi, L Albonici Bove, A. Fusco, Anna Maria Aglian� et al. · 1994 · Acta Diabetologica
91. Structural and functional heterogeneity of insulin receptors
    Hans‐Georg Joost · 1995 · Cellular Signalling
92. The Effect of Insulin Infusion on the Metabolites in Cerebral Tissues Assessed With Proton Magnetic Resonance Spectroscopy in Young Healthy Subjects With High and Low Insulin Sensitivity
    Monika Karczewska‐Kupczewska, Eugeniusz Tarasów, Agnieszka Nikołajuk, Magdalena Stefanowicz, Natalia Matulewicz, Elżbieta Otziomek, Maria Górska, Marek Strączkowski, Irina Kowalska · 2013 · Diabetes Care
93. High‐Fat Diet Modulates Hepatic Amyloid β and Cerebrosterol Metabolism in the Triple Transgenic Mouse Model of Alzheimer’s Disease
    Cristina R. Bosoi, Milène Vandal, Marine Tournissac, Manon Leclerc, Hortense Fanet, Patricia L. Mitchell, Mélanie Verreault, Jocelyn Trottier, Jessica Virgili, Cynthia Tremblay et al. · 2020 · Hepatology Communications
94. The Blood-Brain Barrier in Alzheimer’s Disease
    Steffen E. Storck, Anika M. S. Hartz, Claus U. Pietrzik · 2020 · Handbook of experimental pharmacology
95. A High Fat/Cholesterol Diet Recapitulates Some Alzheimer’s Disease-Like Features in Mice: Focus on Hippocampal Mitochondrial Dysfunction
    Gianni Mancini, Cândida Dias, Cátia F. Lourenço, João A.N. Laranjinha, Andreza Fabro De Bem, Ana Ledo · 2021 · Journal of Alzheimer s Disease
96. Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex
    Lenka Žáková, Emília Kletvíková, Martin Lepšı́k, Michaela Collinsová, Christopher J. Watson, J.P. Turkenburg, Jiřı́ Jiráček, Andrzej Marek Brzozowski · 2014 · Acta Crystallographica Section D Biological Crystallography
97. Central nervous system insulin signaling can influence the rate of insulin influx into brain
    Văn Hùng Nguyễn, Peter Thomas, Sarah Pemberton, Alice Babin, Cassidy Noonan, Riley R. Weaver, William A. Banks, Elizabeth M. Rhea · 2023 · Fluids and Barriers of the CNS
98. Intranasal Insulin Transport is Preserved in Aged SAMP8 Mice and is Altered by Albumin and Insulin Receptor Inhibition
    Elizabeth M. Rhea, Samantha R. Humann, Surabhi Nirkhe, Susan A. Farr, John Edward Morley, William A. Banks · 2017 · Journal of Alzheimer s Disease
99. Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age‐dependent manner, normalizes GABA‐activated currents in the tg‐APPSwe mouse model of Alzheimer’s disease
    Hayma Hammoud, Olga Netsyk, Atieh S. Tafreshiha, Sergiy V. Korol, Zhe Jin, Jin-Ping Li, Bryndis Birnir · 2021 · Acta Physiologica
100. Brain metabolism after recurrent insulin induced hypoglycaemic episodes: a PET study.
     Hugues Chabriat, Claude Sachon, M Levasseur, André Grimaldi, Sabina Pappatà, Didier Rougemont, M.C. Masure, Anne de Recondo, Yves Samson · 1994 · Journal of Neurology Neurosurgery & Psychiatry
101. Insulin and IGF-1 elicit robust transcriptional regulation to modulate autophagy in astrocytes
     Shawn J. Geffken, Sohyun Moon, Catherine O. Smith, Sharon S. Tang, Hiu Ham Lee, Kevin Lewis, Chun Wa Wong, Yuan Huang, Qian Huang, Ying-Tao Zhao et al. · 2022 · Molecular Metabolism
102. Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms
     Ariadna Besga, Ángel Cedazo-Mı́nguez, Ingemar Kåreholt, Alina Solomon, Ingemar Björkhem, Bengt G. Winblad, Valerio Leoni, Babak Hooshmand, Gabriela Spulber, Ana María González-Pinto et al. · 2012 · Neuroscience Letters
103. Diabetes Therapies for Dementia
     Chris Moran, Michele L. Callisaya, Velandai K. Srikanth, Zoe Arvanitakis · 2019 · Current Neurology and Neuroscience Reports
104. A New Approach to Model Sporadic Alzheimer’s Disease by Intracerebroventricular Streptozotocin Injection in APP/PS1 Mice
     Sally Kelliny, Liying Lin, Isaac Bul Deng, Jing Xiong, Fiona H. Zhou, Mohammed Al‐Hawwas, Larisa Bobrovskaya, Xin‐Fu Zhou · 2021 · Molecular Neurobiology
105. The APOE E4 Allele Confers Increased Risk of Ischemic Stroke Among Greek Carriers
     Christopher P. Konialis, Konstantinos M. Spengos, Panagiotis Iliopoulos, Sophia Karapanou, ELIAS J. GIALAFOS, Birgitta Hagnefelt, Konstantinos N. Vemmos, Nikolaos Zakopoulos, Constantinos Pángalos · 2016 · Advances in Clinical and Experimental Medicine
106. Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis
     Hirofumi Nagao, Ashok Kumar Jayavelu, Weikang Cai, Hui Pan, Jonathan M. Dreyfuss, Thiago M. Batista, Bruna Brasil Brandão, Matthias Mann, C. Ronald Kahn · 2023 · Nature Communications
107. Prevalent role of the insulin receptor isoform A in the regulation of hepatic glycogen metabolism in hepatocytes and in mice
     Sabela Díaz-Castroverde, Selene Baos, María Luque, Marianna Di Scala, Gloria González‐Aseguinolaza, Almudena Gómez‐Hernández, Nuria Beneit, Óscar Escribano, Manuel Benito · 2016 · Diabetologia
108. Elevating Insulin Signaling Using a Constitutively Active Insulin Receptor Increases Glucose Metabolism and Expression of GLUT3 in Hippocampal Neurons
     Hilaree N. Frazier, Adam O. Ghoweri, Katie L. Anderson, Ruei‐Lung Lin, Gabriel J. Popa, Michael D. Mendenhall, Lawrence Patrick Reagan, Rolf J. Craven, Olivier Thibault · 2020 · Frontiers in Neuroscience
109. Insulin-Like Growth Factor, Inflammation, and MRI Markers of Alzheimer’s Disease in Predominantly Middle-Aged Adults
     Katharina Wittfeld, Mekala R. Raman, Sarah C. Conner, Asra Aslam, Alexander Teumer, Matthias A. Nauck, Norbert Hosten, Mohamad Habes, Charles S DeCarli, Ramachandran Srini Vasan et al. · 2022 · Journal of Alzheimer s Disease
110. Identification of Insulin Receptor Splice Variant B in Neurons by in situ Detection in Human Brain Samples
     Brian J. Spencer, Logan Rank, Jeff Metcalf, Paula Desplats · 2018 · Scientific Reports
111. The SAMP8 mouse for investigating memory and the role of insulin in the brain
     Elizabeth M. Rhea, William A. Banks · 2016 · Experimental Gerontology
112. Associations of Cardiovascular and Non-Cardiovascular Comorbidities with Dementia Risk in Patients with Diabetes: Results from a Large UK Cohort Study
     Bang Zheng, Bowen Su, Chinedu Theresa Udeh‐Momoh, G. Price, Ioanna Tzoulaki, Eszter Panna Vamos, Azeem Majeed, Elio Ríboli, Sara Ahmadi‐Abhari, Lefkos T. Middleton · 2022 · The Journal of Prevention of Alzheimer s Disease
113. Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity
     Andrea R. López‐Pastor, Almudena Gómez‐Hernández, Sabela Díaz-Castroverde, Gloria González‐Aseguinolaza, A. Gonzalez-Rodriguez, G. Garcia, Silvia Fernández, Óscar Escribano, Manuel Benito · 2019 · Disease Models & Mechanisms
114. Long-Term Intranasal Insulin Aspart: A Profile of Gene Expression, Memory, and Insulin Receptors in Aged F344 Rats
     Hilaree N. Frazier, Adam O. Ghoweri, Emily Sudkamp, Eleanor S. Johnson, Katie L. Anderson, Grant A Fox, Keomany Vatthanaphone, Mengfan Xia, Ruei‐Lung Lin, Kendra E Hargis-Staggs et al. · 2019 · The Journals of Gerontology Series A
115. Molecular Mechanisms of Intranasal Insulin in SAMP8 Mice
     Elizabeth M. Rhea, Surabhi Nirkhe, Steven Nguyen, Sarah Pemberton, Theo K. Bammler, Richard Beyer, Michael L. Niehoff, John Edward Morley, Susan A. Farr, William A. Banks · 2019 · Journal of Alzheimer s Disease
116. Insulin deficiency, but not resistance, exaggerates cognitive deficits in transgenic mice expressing human amyloid and tau proteins. Reversal by Exendin‐4 treatment
     Matthew R. King, Nicholas J. Anderson, Mihaela Deciu, Lucie S. Guernsey, Morgan Cundiff, Shohreh Hajizadeh, Corinne G. Jolivalt · 2020 · Journal of Neuroscience Research
117. Neuronal insulin signaling and brain structure in nondemented older adults: the Atherosclerosis Risk in Communities Study
     Keenan A. Walker, Sahil Chawla, Carlos J. Nogueras‐Ortiz, Josef Coresh, Albert Richey Sharrett, Dean Foster Wong, Clifford R. Jack, Anthony J. Spychalla, Rebecca F. Gottesman, Dimitrios Kapogiannis · 2020 · Neurobiology of Aging
118. Combination of human tau and islet amyloid polypeptide exacerbates metabolic dysfunction in transgenic mice
     Nadeeja Wijesekara, Rafaella Araujo Gonçalves, Rosemary Ahrens, Kathy Ha, Fernanda G. De Felice, Paul E. Fraser · 2021 · The Journal of Pathology
119. Insulin resistance, cognition and Alzheimer's disease biomarkers: Evidence that CSF Aβ42 moderates the association between insulin resistance and increased CSF tau levels
     Amy Woodfield, Tenielle Porter, Israa Gilani, Siti Noordin, Qiao‐Xin Li, Steven John Collins, Ralph Nigel Martins, Paul T. Maruff, Colin Louis Masters, Christopher Cleon Rowe et al. · 2022 · Neurobiology of Aging
120. Loss of Microglial Insulin Receptor Leads to Sex-Dependent Metabolic Disorders in Obese Mice
     Irina V. Milanova, Nikita L. Korpel, Felipe Corrêa‐da‐Silva, Eline Berends, Samar Osman, Susanne Eva la Fleur, Eric Fliers, Andries Kalsbeek, Chun‐Xia Yi · 2022 · International Journal of Molecular Sciences
121. Brain effect of bariatric surgery in people with obesity
     Angela Dardano, Gayanè Aghakhanyan, Carlo Moretto, Annamaria Ciccarone, Rosario Bellini, Verónica Sancho, Giovanni Ceccarini, Ferruccio Santini, Duccio Volterrani, Stefano Del Prato et al. · 2022 · International Journal of Obesity
122. Altered cerebral insulin response in transgenic mice expressing the epsilon-4 allele of the human apolipoprotein E gene
     Marie-Thérèse Traversy, Milène Vandal, Cyntia Tremblay, Marine Tournissac, Ariane Giguère-Rancourt, A. David Bennett, Frédéric Calon · 2016 · Psychoneuroendocrinology
123. Design, Synthesis, and Preliminary Evaluation of [68Ga]Ga-NOTA-Insulin as a PET Probe in an Alzheimer’s Disease Mouse Model
     Jillissa Taubel, Nicholas R. Nelson, Aditya Bansal, Geoffrey L. Curran, Lushan Wang, Zengtao Wang, Heather M. Berg, Cynthia J. Vernon, Hoon-Ki Paul Min, Nicholas Bradley Larson et al. · 2022 · Bioconjugate Chemistry
124. Patients with Alzheimer’s Disease Have Increased Levels of Insulin-like Growth Factor-I in Serum but not in Cerebrospinal Fluid
     Alexandra Horváth, Zeinab Salman, Patrick S. Quinlan, Anders Wallin, Johan Svensson · 2020 · Journal of Alzheimer s Disease
125. Proteomic Signature and mRNA Expression in Hippocampus of SAMP8 and SAMR1 Mice during Aging
     Marcella Reale, Erica Costantini, Lisa Aielli, Fabrizio Di Giuseppe, Stefania Angelucci, Mohammad Amjad Kamal, Nigel H. Greig · 2022 · International Journal of Molecular Sciences
126. Effect of Acute Insulin-Induced Hypoglycemia on Fetal versus Adult Brain Fuel Utilization, Assessed by 13C MRS Isotopomer Analysis of [U-13C]Glucose Metabolites
     Aviva Lapidot, S. Haber · 2000 · Developmental Neuroscience
127. Insulin Analogues with Altered Insulin Receptor Isoform Binding Specificities and Enhanced Aggregation Stabilities
     Terezie Páníková, Katarína Mitrová, Tereza Halamová, Karolína Mrzílková, Jan Pícha, Martina Chrudinová, Andrii S. Kurochka, Irena Selicharová, Lenka Žáková, Jiřı́ Jiráček · 2021 · Journal of Medicinal Chemistry
128. Light and electron microscopic analysis of insulin binding sites on neurons in dissociated brain cell cultures
     James A. Weyhenmeyer, A.M. Reiner, I. Reynolds, Anthony K. Killian · 1985 · Brain Research Bulletin
129. Insulin in the brain what is its role?
     Kim A. Heidenreich · 1991 · Trends in Endocrinology and Metabolism
130. Spatial dynamics of the insulin receptor in living neurons
     Matthias Gralle, Simon Labrecque, Charleen Salesse, Paul De Koninck · 2019 · Journal of Neurochemistry
131. The aminosterol Claramine inhibits β-secretase 1–mediated insulin receptor cleavage
     Bénédicte Gaborit, Roland Govers, Alexandre Altié, Jean Michel Brunel, Pierre‐Emmanuel Morange, Franck Peiretti · 2021 · Journal of Biological Chemistry
132. Cerebrovascular insulin receptors are defective in Alzheimerˈs disease
     M. Leclerc, Philippe Bourassa, Cyntia Tremblay, Vicky Caron, Camille Sugère, Vincent Émond, David Alan Bennett, Frédéric Calon · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
133. Radiosynthesis and evaluation of IGF1R PET ligand [11C]GSK1838705A
     Kiran Kumar Solingapuram Sai, Jaya Prabhakaran, Anirudh Sattiraju, J. John Mann, Akiva Mintz, J.S. Dileep Kumar · 2017 · Bioorganic & Medicinal Chemistry Letters
134. In vivo evaluation of IGF1R/IR PET ligand [18F]BMS-754807 in rodents
     Jaya Prabhakaran, Stephen L. Dewey, Richard McClure, Norman R. Simpson, Mohammed Noor Tantawy, J. John Mann, Wellington N. Pham, J.S. Dileep Kumar · 2017 · Bioorganic & Medicinal Chemistry Letters
135. Molecular elevation of insulin receptor signaling improves memory recall in aged Fischer 344 rats
     Hilaree N. Frazier, Katie L. Anderson, Adam O. Ghoweri, Ruei‐Lung Lin, Tara R. Hawkinson, Gabriel J. Popa, Pradoldej M Sompol, Michael D. Mendenhall, Christopher Mark Norris, Olivier Thibault · 2020 · Aging Cell
136. Insulin-Related Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer’s Disease: A Systematic Review1
     Elena Sagües‐Sesé, José Rioja, Francisco Javier Garzón-Maldonado, Manuel Narváez, Juan Antonio García-Arnés, Natalia García‐Casares · 2022 · Journal of Alzheimer s Disease
137. Effect of Peripheral Insulin Administration on Phosphorylation of Tau in the Brain
     Yanli Jiang, Longfei Li, Chun‐Ling Dai, Ranran Zhou, Cheng‐Xin Gong, Khalid Iqbal, Jin‐Hua Gu, Fei Liu · 2020 · Journal of Alzheimer s Disease
138. Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathology
     Jonathan Adrian Zegarra-Valdivia, Ana Maria Fernandez, Laura Martinez‐Rachadell, Raquel Herrero-Labrador, Jansen Fernandes, Ignacio Torres‐Alemán · 2022 · F1000Research
139. Investigating the effects of antipsychotics on brain insulin action: Study protocol for a multi-modality magnetic resonance imaging (MRI) study in healthy controls
     Nicolette Stogios, Laurie Hamel, Emily Smith, Marcos Sanches, Gary J. Remington, Aristotle N. Voineskos, Satya Dash, Ariel Graff‐Guerrero, Margaret Hahn, Sri Mahavir Agarwal · 2022 · PLoS ONE
140. Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathology
     Jonathan Adrian Zegarra-Valdivia, Ana Maria Fernandez, Laura Martinez‐Rachadell, Raquel Herrero-Labrador, Jansen Fernandes, Ignacio Torres‐Alemán · 2022 · F1000Research
141. Central administration of insulin and refeeding lead to Akt and ERK phosphorylation in the chicken medulla
     Takaoki Saneyasu, Mizuki Ueno, Kanami Nagata, Ahmed Kewan, Kazuhisa Honda, Hiroshi Kamisoyama · 2021 · Neuroscience Letters
142. Glial acetate metabolism is increased following a 72-h fast in metabolically healthy men and correlates with susceptibility to hypoglycemia
     David H. McDougal, Moses M. Darpolor, Marina A. DuVall, Elizabeth F. Sutton, Christopher D. Morrison, Kishore M. Gadde, Leanne Maree Redman, Owen Thomas Carmichael · 2018 · Acta Diabetologica