Late-Life Physical and Cognitive Activities Independently Contribute to Brain and Cognitive Resilience

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Deformable Registration of Diffusion Tensor MR Images with Explicit Orientation Optimization

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Exploring the neural basis of cognitive reserve in aging

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Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice

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Association of Lifetime Cognitive Engagement and Low β-Amyloid Deposition

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Diffeomorphic Registration Using B-Splines

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Cognitive activities delay onset of memory decline in persons who develop dementia

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Life-span cognitive activity, neuropathologic burden, and cognitive aging

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Neural Mechanisms of Brain Plasticity with Complex Cognitive Training in Healthy Seniors

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Cognitive Processing Speed in Older Adults: Relationship with White Matter Integrity

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Complexity of Work and Risk of Alzheimer's Disease: A Population-Based Study of Swedish Twins

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Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable β-amyloid deposition

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The role of occupational complexity in trajectories of cognitive aging before and after retirement.

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Experience-dependent plasticity of white-matter microstructure extends into old age

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Dendritic spines provide cognitive resilience against <scp>A</scp> lzheimer's disease

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Youthful Memory Capacity in Old Brains: Anatomic and Genetic Clues from the Northwestern SuperAging Project

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Regional Spatial Normalization: Toward an Optimal Target

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BDNF contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment

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Cognitive and physical activity and dementia: A 44-year longitudinal population study of women

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Midlife cardiovascular fitness and dementia: A 44-year longitudinal population study in women

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Spanish and English Neuropsychological Assessment Scales: Relationship to Demographics, Language, Cognition, and Independent Function.

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Enhanced cognitive activity--over and above social or physical activity--is required to protect Alzheimer's mice against cognitive impairment, reduce Abeta deposition, and increase synaptic immunoreactivity.

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Brain volume change and cognitive trajectories in aging.

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Neuroprotective pathways: lifestyle activity, brain pathology, and cognition in cognitively normal older adults

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Recruitment of a Community-based Cohort for Research on Diversity and Risk of Dementia

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Relation of neuropathology with cognitive decline among older persons without dementia

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A combination of physical activity and computerized brain training improves verbal memory and increases cerebral glucose metabolism in the elderly

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Effect of intellectual enrichment on AD biomarker trajectories

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Relation of cognitive reserve and task performance to expression of regional covariance networks in an event-related fMRI study of nonverbal memory☆

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Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Social Interactions and Stress

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Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease

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The Impact of Physical and Mental Activity on Cognitive Aging

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The Effects of Cognitive Activity Combined with Active Extremity Exercise on Balance, Walking Activity, Memory Level and Quality of Life of an Older Adult Sample with Dementia

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Cognitive activities and cognitive performance in middle-aged adults at risk for Alzheimer’s disease

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Synaptogenesis in adult‐generated hippocampal granule cells is affected by behavioral experiences

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Association between exercise and the risk of dementia: results from a nationwide longitudinal study in China

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Is “Learning” episodic memory? Distinct cognitive and neuroanatomic correlates of immediate recall during learning trials in neurologically normal aging and neurodegenerative cohorts

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Genetic resilience to amyloid related cognitive decline

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Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission

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The Contribution of Physical Exercise to Brain Resilience

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State of the science on brain insulin resistance and cognitive decline due to Alzheimer's disease

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Verbal intelligence is a more robust cross-sectional measure of cognitive reserve than level of education in healthy older adults

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Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling

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Microglial Correlates of Late Life Physical Activity: Relationship with Synaptic and Cognitive Aging in Older Adults

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Lower White Matter Volume and Worse Executive Functioning Reflected in Higher Levels of Plasma GFAP Among Older Adults With and Without Cognitive Impairment

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Linking Brain Age Gap to Mental and Physical Health in the Berlin Aging Study II

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Effects of multi-component non-pharmacological interventions on cognition in participants with mild cognitive impairment: A systematic review and meta-analysis.

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Effects of Sex, APOE4, and Lifestyle Activities on Cognitive Reserve in Older Adults

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Physical Activity, Alzheimer Plasma Biomarkers, and Cognition

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Mobility-Based Smartphone Digital Phenotypes for Unobtrusively Capturing Everyday Cognition, Mood, and Community Life-Space in Older Adults: Feasibility, Acceptability, and Preliminary Validity Study

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Purpose in life promotes resilience to age-related brain burden in middle-aged adults

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Physical activity moderates the association between white matter hyperintensity burden and cognitive change

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Leisure activity engagement across adulthood predicts cognitive change after five years: Do gender and age matter?

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Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort

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Quantifying longitudinal cognitive resilience to Alzheimer's disease and other neuropathologies

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Multimodal lifestyle engagement patterns support cognitive stability beyond neuropathological burden

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Associations between white matter hyperintensities, lacunes, entorhinal cortex thickness, declarative memory and leisure activity in cognitively healthy older adults: A 7-year study

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Recapitulation of anti-aging phenotypes by global overexpression of PTEN in mice

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Physical activity, biomarkers of brain pathologies and dementia risk: Results from the Memento clinical cohort

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The Attributes and Characteristics of Leisure Activity Engagement that Foster Cognition in Aging: A Scoping Review

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Association of combined engagement in cognitive and physical activity with domain‐specific cognitive function: The Shanghai Aging Study

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Cognitive resilience to three dementia-related neuropathologies in an oldest-old man: A case report from The 90+ Study

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Gender specific factors contributing to cognitive resilience in APOE ɛ4 positive older adults in a population-based sample

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Social activities in multidomain dementia prevention interventions: insights from practice and a blueprint for the future

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Mediterranean Diet and Lifestyle in Persons with Mild to Moderate Alzheimer’s Disease

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Randolph, J. J., Lacritz, L. H., Colvin, M. K., Espe‐Pfeifer, P., Carter, K. R., Arnett, P. A., Fox‐Fuller, J. T., Aduen, P. A., Cullum, C. M., & Sperling, S. A. (2023) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acad078 · Cited by 4 · see citing works

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You, M. Y., Lindbergh, C. A., Joie, R. L., Paolillo, E. W., Saloner, R., Diaz, V., Cotter, D. L., Walters, S. M., Altendahl, M., Staffaroni, A. M., et al. (2024) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2024.08.006 · Cited by 3 · see citing works

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Hotterbeex, P., Beeckman, M., Marent, P.-J., Latomme, J., Block, F. D., Baets, L. D., CHASTIN, S. F. M., Cardon, G., & van Uffelen, J. G. Z. (2024) · Journal of Aging Research · doi:10.1155/2024/2438067 · Cited by 3 · see citing works

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Wagner, M., Neuffer, J., Grand, Q. L., Mishra, A., Berr, C., Debette, S., Helmer, C., Proust‐Lima, C., & Samieri, C. (2025) · American Journal of Epidemiology · doi:10.1093/aje/kwaf108 · Cited by 3 · see citing works

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Amián, J. G., Fernández-Portero, C., de la Bella, R., Villalba, M. J. A., López‐Lluch, G., & Alarcón, D. (2024) · Perceptual and Motor Skills · doi:10.1177/00315125241241358 · Cited by 3 · see citing works

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Bruinsma, J., Roodbeen, R. T. J., Menting, G. G. A., Deckers, K., Hendriks, S., & Crutzen, R. (2024) · doi:10.31234/osf.io/q3u9a · Cited by 2 · see citing works

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O’Connor, M. K., Szemko, J. N., McLaren, J. E., Moo, L. R., Metcalf, E. E., Nguyen, A. H., Kraft, M. L., Frank, B. E., Salat, D. H., Randolph, J. J., et al. (2025) · BMC Geriatrics · doi:10.1186/s12877-025-06207-x · Cited by 1 · see citing works

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Menze, I., Bernal, J., Kievit, R., Yakupov, R., Altenstein, S., Bartels, C., Büerger, K., Butryn, M., Dechent, P., Ewers, M., et al. (2025) · medRxiv · doi:10.1101/2025.06.16.25329648

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Peixoto, V. G. D. M. N. P., dos Santos, M. B., Oliveira, A. G., Quiroz, Y. T., & de Almondes, K. M. (2025) · Research Square · doi:10.21203/rs.3.rs-7186952/v1

Additional file 4 of Verbal intelligence is a more robust cross-sectional measure of cognitive reserve than level of education in healthy older adults

Boyle, R., Knight, S. P., Looze, C. D., Carey, D., Scarlett, S., Stern, Y., Robertson, I. H., Kenny, R. A., & Whelan, R. (2021) · Figshare · doi:10.6084/m9.figshare.14966204

Additional file 8 of Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort

Grasset, L., Proust‐Lima, C., Mangin, J., Habert, M., Dubois, B., Paquet, C., Hanon, O., Gabelle, A., Ceccaldi, M. P., Annweiler, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19793151

Additional file 3 of Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort

Grasset, L., Proust‐Lima, C., Mangin, J., Habert, M., Dubois, B., Paquet, C., Hanon, O., Gabelle, A., Ceccaldi, M. P., Annweiler, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19793133

Additional file 2 of Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort

Grasset, L., Proust‐Lima, C., Mangin, J., Habert, M., Dubois, B., Paquet, C., Hanon, O., Gabelle, A., Ceccaldi, M. P., Annweiler, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19793130

Additional file 6 of Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort

Grasset, L., Proust‐Lima, C., Mangin, J., Habert, M., Dubois, B., Paquet, C., Hanon, O., Gabelle, A., Ceccaldi, M. P., Annweiler, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19793145

Additional file 1 of Purpose in life promotes resilience to age-related brain burden in middle-aged adults

Abellaneda‐Pérez, K., Cattaneo, G., Cabello‐Toscano, M. R., Sánchez, J. S., Mulet‐Pons, L., Vaqué‐Alcázar, L., Perellón‐Alfonso, R., Solé‐Padullés, C., Bargalló, N., Tormos, J. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26574853

Additional file 5 of Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort

Grasset, L., Proust‐Lima, C., Mangin, J., Habert, M., Dubois, B., Paquet, C., Hanon, O., Gabelle, A., Ceccaldi, M. P., Annweiler, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19793139

Additional file 4 of Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort

Grasset, L., Proust‐Lima, C., Mangin, J., Habert, M., Dubois, B., Paquet, C., Hanon, O., Gabelle, A., Ceccaldi, M. P., Annweiler, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19793136

Additional file 1 of Multimodal lifestyle engagement patterns support cognitive stability beyond neuropathological burden

Paolillo, E. W., Saloner, R., VandeBunte, A. M., Lee, S., Bennett, D. A., & Casaletto, K. B. (2024) · Figshare · doi:10.6084/m9.figshare.26655634

Additional file 1 of Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort

Grasset, L., Proust‐Lima, C., Mangin, J., Habert, M., Dubois, B., Paquet, C., Hanon, O., Gabelle, A., Ceccaldi, M. P., Annweiler, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19793127

Additional file 9 of Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort

Grasset, L., Proust‐Lima, C., Mangin, J., Habert, M., Dubois, B., Paquet, C., Hanon, O., Gabelle, A., Ceccaldi, M. P., Annweiler, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19793154

Additional file 7 of Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort

Grasset, L., Proust‐Lima, C., Mangin, J., Habert, M., Dubois, B., Paquet, C., Hanon, O., Gabelle, A., Ceccaldi, M. P., Annweiler, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19793148

Serum proteomic correlates of arts and cultural engagement and their associations with health outcomes: cross-sectional and longitudinal analyses in the UK Household Longitudinal Study

Qin, P., Finn, S., & Fancourt, D. E. (2026) · Brain Behavior and Immunity · doi:10.64898/2026.01.09.26343769

Physical fitness supports brain maintenance and cognitive reserve in cognitively normal aging: a cross-sectional examinationPreprint

Schwarck, S., Behrenbruch, N., Schumann‐Werner, B., Molloy, E. N., Garcia‐Garcia, B., Hochkeppler, A., Fischer, L., Büchel, A., Incesoy, E. I., Bernal, J., et al. (2026) · medRxiv · doi:10.64898/2026.01.14.26344098

Integrating Substantia Nigra Hyperechogenicity and Inflammation-Associated Biomarkers: A Classification Model for Staging Cognitive Impairment in Parkinson’s Disease

Zhao, J., Hou, C., Wang, S., Lin, Y., Xu, L., He, W., & Zhang, W. (2026) · Journal of Integrative Neuroscience · doi:10.31083/jin46585

Analysis of engagement motivations for leisure and cognition in older adults participating in lifelong learning

Wenzel, K. C., Puymbroeck, M. V., Lewis, S., McGuire, F. A., & Vidotto, J. (2026) · Journal of Leisure Research · doi:10.1080/00222216.2026.2683435

Putting What Matters First: A Case-Based Approach to Goal Setting to Promote Older Adult Brain Health in the AgeWISE-Action Plan Program

McLaren, J. E., Moo, L. R., Nguyen, A. H., Metcalf, E. E., Kraft, M. L., Frank, B. E., Randolph, J. J., Tripodis, Y., Scoglio, A. A. J., & O’Connor, M. K. (2026) · American Journal of Lifestyle Medicine · doi:10.1177/15598276261460835

A hippocampal-lateral posterior thalamic nucleus neural circuit mediates cognitive impairment and metabolic dysfunction in male mice with type 2 diabetes

Sun, H., Gao, X., Xu, Q., Chen, F., Xu, M., & Ge, J. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168412

Age-Related Prevalence of Abnormal Plasma p-Tau217 Across Racial Ethnic Groups in the Health and Aging Brain Study-Health Disparities

Contreras, J. A., Najmi, Z., Dharmapuri, A., Winston, C. N., Hayes, C. A., & as the HABS-HD Study Team (2026) · Neurology Open Access · doi:10.1212/wn9.0000000000000145

Associations of physical fitness with brain structure, pathology and cognition in cognitively normal older adults

Schwarck, S., Behrenbruch, N., Schumann‐Werner, B., Molloy, E. N., Garcia‐Garcia, B., Hochkeppler, A., Fischer, L., Büchel, A., Incesoy, E. I., Bernal, J., et al. (2026) · npj Aging · doi:10.1038/s41514-026-00512-4

PHYSICAL VERSUS COGNITIVE ACTIVITY FOR SUCCESSFUL AGING: BRAIN MAINTENANCE OR COGNITIVE RESERVE?

Casaletto, K. B., Casaletto, K. B., Pa, J., Tom, S. E., Rentería, M. A., Harrati, A., Armstrong, N. M., & Zahodne, L. B. (2019) · Innovation in Aging · doi:10.1093/geroni/igz038.2307

Distinct effects of late adulthood cognitive and physical activities on gray matter volume

Arenaza‐Urquijo, E. M., de Florès, R., Gonneaud, J., Wirth, M., Ourry, V., Callewaert, W., Landeau, B., Egret, S., Mézenge, F., Desgranges, B., et al. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9617-3 · Cited by 68 · see citing works

Association between physical activity and brain health in older adults

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Data Availability: The aut...

Burzynska, A. Z., Chaddock‐Heyman, L., Voss, M. W., Wong, C. N., Gothe, N. P., Olson, E. A., Knecht, A. M., Lewis, A., Monti, J. M., Cooke, G. E., et al. (2014)

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