Joint Hypermobility Syndrome Affects Response to a Low Fermentable Oligosaccharide, Disaccharide, Monosaccharide and Polyol Diet in Irritable Bowel Syndrome Patients: A Retrospective Study

Fragkos, Konstantinos C.; Keetarut, Katie; Cox, Anna; Eady, Johanna; Emmanuel, Anton V.; Zarate-Lopez, Natalia

doi:10.14740/gr1133

Cited by 11Gastrointestinal motility and disordersGut microbiota and healthConnective tissue disorders research

Joint Hypermobility Syndrome Affects Response to a Low Fermentable Oligosaccharide, Disaccharide, Monosaccharide and Polyol Diet in Irritable Bowel Syndrome Patients: A Retrospective Study

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Fragkos, Konstantinos C., Keetarut, Katie, Cox, Anna, Eady, Johanna, Emmanuel, Anton V., Zarate-Lopez, Natalia·2019·Gastroenterology Research

DOI 10.14740/gr1133PMC PMC6396789

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Abstract

BACKGROUND: The low fermentable oligosaccharide, disaccharide, monosaccharide and polyol (FODMAP) diet causes significant clinical improvement in patients with irritable bowel syndrome (IBS). Joint hypermobility syndrome (JHS), defined as musculoskeletal symptoms in a hypermobile individual in the absence of systemic rheumatological disease, may be associated with functional gastrointestinal symptoms, including IBS. The aim of this study is to examine whether JHS can affect the response to the low FODMAP diet in patients with IBS. METHODS: In this retrospective study, we included patients with IBS according to Rome III criteria who had followed a low FODMAP diet. Symptoms scores were measured before and after the low FODMAP diet. RESULTS: A total of 165 patients (130 females, age 44 ± 14 years) were included. Diarrhea predominant IBS (IBS-D) was present in 40.6% of our patients while JHS was present in 21.2%. The score for abdominal pain was higher for JHS compared to non-JHS prior to intervention (P = 0.011). Symptoms improved in both groups of patients after a low FODMAP diet (P < 0.0001). The largest effects were shown with significant decreases of the average score and bloating. When broken down by JHS and IBS type, a low FODMAP diet significantly improved pain, bloating, diarrhea, constipation, and the average score with the largest effect in JHS/constipation predominant IBS (IBS-C), JHS/mixed IBS and unclassified IBS (IBS-M), JHS/IBS-D, non-JHS/IBS-C and JHS/IBS-M, respectively. CONCLUSIONS: Our study suggests that a low FODMAP diet has a greater effect on IBS symptoms in JHS than non-JHS patients.

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FODMAP diet is efficacious in HSD/hEDS-related DGBI.
“Dietary management: FODMAP diet efficacious in HSD/hEDS‐related DGBI 89”
From Hypermobile Ehlers–Danlos syndrome and disorders of the gastrointestinal tract: What the gastroenterologist needs to know (2022) · cites this paper as [89]

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Authors: Fragkos, K. C., Keetarut, K., Cox, A., Eady, J., Emmanuel, A. V., & Zarate-Lopez, N.
Affiliations: University College London Hospitals NHS Foundation Trust (GB)
ORCID: Fragkos, Konstantinos C.
Keetarut, Katie
Emmanuel, Anton V.
Venue: Gastroenterology Research
Publisher: Elmer Press, Inc.
Published: 2019
Volume: 12
Issue: 1
Pages: 27-36
ISSN: 1918-2805 (ISSN-L)
1918-2813
DOI: 10.14740/gr1133
PMC: PMC6396789
OpenAlex: W2916630329
Cited by: 11
References: 43
Citations by year: 2026: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 1
FWCI: 1.82
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by-nc
Locations: Gastroenterology Research (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
Keywords: joint hypermobility syndrome, irritable bowel syndrome, low FODMAP diet, dietary response, abdominal pain, bloating, diarrhea, constipation, IBS subtypes, functional gastrointestinal symptoms

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Joint Hypermobility Syndrome Affects Response to a Low Fermentable Oligosaccharide, Disaccharide, Monosaccharide and Polyol Diet in Irritable Bowel Syndrome Patients: A Retrospective Study

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