Cited by 101Deep Brain Stimulation and Movement DisordersObsessive-Compulsive Spectrum DisordersTranscranial Magnetic Stimulation Studies

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Double-blind optimization of subcallosal cingulate deep brain stimulation for treatment-resistant depression: a pilot study

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Ramasubbu, Rajamannar, Anderson, Susan, Haffenden, Angela, Chavda, Swati, Kiss, Zelma H.T.·2013·Journal of Psychiatry and Neuroscience

DOI 10.1503/jpn.120160PMC PMC3756116

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Abstract

BACKGROUND: Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) is reported to be a safe and effective new treatment for treatment-resistant depression (TRD). However, the optimal electrical stimulation parameters are unknown and generally selected by trial and error. This pilot study investigated the relationship between stimulus parameters and clinical effects in SCC-DBS treatment for TRD. METHODS: Four patients with TRD underwent SCC-DBS surgery. In a double-blind stimulus optimization phase, frequency and pulse widths were randomly altered weekly, and corresponding changes in mood and depression were evaluated using a visual analogue scale (VAS) and the 17-item Hamilton Rating Scale for Depression (HAM-D-17). In the open-label postoptimization phase, depressive symptoms were evaluated biweekly for 6 months to determine long-term clinical outcomes. RESULTS: Longer pulse widths (270-450 μs) were associated with reductions in HAM-D-17 scores in 3 patients and maximal happy mood VAS responses in all 4 patients. Only 1 patient showed acute clinical or mood effects from changing the stimulation frequency. After 6 months of open-label therapy, 2 patients responded and 1 patient partially responded. LIMITATIONS: Limitations include small sample size, weekly changes in stimulus parameters, and fixed-order and carry-forward effects. CONCLUSION: Longer pulse width stimulation may have a role in stimulus optimization for SCC-DBS in TRD. Longer pulse durations produce larger apparent current spread, suggesting that we do not yet know the optimal target or stimulus parameters for this therapy. Investigations using different stimulus parameters are required before embarking on large-scale randomized sham-controlled trials.

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A rating scale for depression
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059
Which elements are excited in electrical stimulation of mammalian central nervous system: A review
Ranck, J. B. (1975) · Brain Research · doi:10.1016/0006-8993(75)90364-9 · Cited by 2,024
Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy
Fisher, R. S., Salanova, V., Witt, T. C., Worth, R. M., Henry, T. R., Gross, R. E., Oommen, K. J., Osorio, I., Nazzaro, J. M., Labar, D., et al. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02536.x · Cited by 1,930
Diagnosis and definition of treatment-resistant depression
Fava, M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00231-2 · Cited by 1,380
Responsive cortical stimulation for the treatment of medically intractable partial epilepsy
Morrell, M. J. (2011) · Neurology · doi:10.1212/wnl.0b013e3182302056 · Cited by 1,282
Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression
Lozano, A. M., Mayberg, H. S., Giacobbe, P., Hamani, C., Craddock, R. C., & Kennedy, S. H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.034 · Cited by 1,024

Flagged first, then by citations

Show all 30 references

Research works printed but not linked: 5

Puigdemont D, 2011, Int J Neuropsychopharmacol, 1
Moro E, 2006, Arch Neurol, 63, 1266
First MB, 2002, Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition (SCID-I/P)
Thase ME, 1997, J Clin Psychiatry, 58, 23
Dougherty DD, Society of Biological Psychiatry 67th annual scientific convention

Sorted by citations

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Defining critical white matter pathways mediating successful subcallosal cingulate deep brain stimulation for treatment-resistant depression
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Deep brain stimulation for depression.
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Deep brain stimulation (DBS) at the interface of neurology and psychiatry
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Self-citation
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Characterizing the therapeutic response to deep brain stimulation for treatment-resistant depression: a single center long-term perspective
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Zhou, C., Zhang, H., Qin, Y., Tian, T., Xu, B., Chen, J., Zhou, X., Zeng, L., Fang, L., Qi, X., et al. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.11.012 · Cited by 100
Deep brain stimulation for treatment-resistant major depressive disorder: a comparison of two targets and long-term follow-up
Raymaekers, S., Luyten, L., Bervoets, C., Gabriëls, L., & Nuttin, B. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.66 · Cited by 82
Long versus short pulse width subcallosal cingulate stimulation for treatment-resistant depression: a randomised, double-blind, crossover trial
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Self-citation
Charting the road forward in psychiatric neurosurgery: proceedings of the 2016 American Society for Stereotactic and Functional Neurosurgery workshop on neuromodulation for psychiatric disorders
Bari, A., Mikell, C. B., Abosch, A., Ben‐Haim, S., Buchanan, R. J., Burton, A. W., Carcieri, S., Cosgrove, G. R., D’Haese, P.-F., Daskalakis, Z. J., et al. (2018) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-317082 · Cited by 72
Self-citation
Untitled work
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A Review of Brain Stimulation Treatments for Late-Life Depression
Blumberger, D. M., Hsu, J. H., & Daskalakis, Z. J. (2015) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-015-0059-0 · Cited by 66
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Self-citation
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Smart, O., Choi, K. S., Riva-Posse, P., Tiruvadi, V., Rajendra, J., Waters, A. C., Crowell, A. L., Edwards, J., Gross, R. E., & Mayberg, H. S. (2018) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2018.00043 · Cited by 41
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Self-citation
Brain–computer interfaces for neuropsychiatric disorders
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Toward an Understanding of the Neural Circuitry of Major Depressive Disorder Through the Clinical Response to Deep Brain Stimulation of Different Anatomical Targets
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Meta-analysis of the changes in correlations between depression instruments used in longitudinal studies
Bukumirić, Z., Starčević, V., Stanisavljevic, D. M., Marinković, J., Milic, N. M., Djukić, A., Janjic, V. S., Čorac, A., Ilic, A., Kostic, M., et al. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.10.054 · Cited by 17
Biomarkers for Deep Brain Stimulation in Animal Models of Depression
Yuen, J., Rusheen, A. E., Price, J. B., Barath, A. S., Shin, H., Kouzani, A. Z., Berk, M., Blaha, C. D., Lee, K. H., & Oh, Y. (2021) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13483 · Cited by 16
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Yuan, Z., Yang, H., Wang, P., Hou, X., Xu, K., Zhou, Y., Dai, R., Gao, Y., Gao, X., Guo, Q., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.07.018 · Cited by 16
Brain-derived neurotrophic factor and subcallosal deep brain stimulation for refractory depression
Ramasubbu, R., Vecchiarelli, H. A., Hill, M. N., & Kiss, Z. H. T. (2014) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2014.952775 · Cited by 14
Self-citation
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Lapa, J. D. D. S., Duarte, J. F. S., Campos, A. C. P., Davidson, B., Nestor, S. M., Rabin, J. S., Giacobbe, P., Lipsman, N., & Hamani, C. (2024) · Neurosurgery · doi:10.1227/neu.0000000000002910 · Cited by 14
Deep Brain Stimulation for Depression
Filkowski, M. M., & Sheth, S. A. (2019) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2018.12.007 · Cited by 13
Recruitment Challenges for Studies of Deep Brain Stimulation for Treatment-Resistant Depression
Ramasubbu, R., Golding, S., Williams, K., Mackie, A., MacQUEEN, G. M., & Kiss, Z. H. T. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s299913 · Cited by 13
Self-citation
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Persistent Ventral Anterior Cingulate Cortex and Resolved Amygdala Hyper-responses to Negative Outcomes After Depression Remission: A Combined Cross-sectional and Longitudinal Study
Zhang, X., Wang, X., Dong, D., Sun, X., Zhong, X., Xiong, G., Cheng, C., Lei, H., Chai, Y., Yu, M., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.09.003 · Cited by 11
A novel combinational approach of microstimulation and bioluminescence imaging to study the mechanisms of action of cerebral electrical stimulation in mice
Arsenault, D., Drouin‐Ouellet, J., Saint‐Pierre, M., Petrou, P., Dubois, M., Križ, J., Barker, R. A., Cicchetti, A., & Cicchetti, F. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.287243 · Cited by 11
Prefrontal network engagement by deep brain stimulation in limbic hubs
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Deep Brain Stimulation for Depression
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Graph Theory and Modeling of Network Topology in Clinical Neurosurgery
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Invasive Brain Stimulation in the Treatment of Psychiatric Illness: Proposed Indications and Approaches
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Villamil, F., Mandolesi, J., Baudo, M. C., Paolinelli, P. S., Vidal, M. F., & Costanzo, E. Y. (2024) · NeuroTarget · doi:10.47924/neurotarget2024463
Deep brain stimulation for treatment-resistant depression
Riva‐Posse, P. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824067-0.00022-0

Authors: Ramasubbu, R., Anderson, S., Haffenden, A., Chavda, S., & Kiss, Z. H. T.
Affiliations: Alberta Health Services (CA)
ORCID: Ramasubbu, Rajamannar
Kiss, Zelma H.T.
Venue: Journal of Psychiatry and Neuroscience
Publisher: Canadian Science Publishing
Published: 2013-09
Volume: 38
Issue: 5
Pages: 325-332
ISSN: 1180-4882 (ISSN-L)
1488-2434
DOI: 10.1503/jpn.120160
PMC: PMC3756116
OpenAlex: W1964261330
Cited by: 101
References: 30
Citations by year: 2026: 1 · 2025: 4 · 2024: 12 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 11 · 2019: 6 · 2018: 12 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 7 · 2013: 3
FWCI: 5.93
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)
Locations: Journal of Psychiatry and Neuroscience (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords: subcallosal cingulate, deep brain stimulation, treatment-resistant depression, stimulation parameter optimization, pulse duration, stimulation frequency, current spread, long-term clinical outcomes
MeSH terms: Double-Blind Method, Female, Gyrus Cinguli, Humans, Male, Middle Aged, Pilot Projects, Deep Brain Stimulation, Depressive Disorder, Treatment-Resistant

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Double-blind optimization of subcallosal cingulate deep brain stimulation for treatment-resistant depression: a pilot study

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