Muscle strength is a marker of insulin resistance in patients with type 2 diabetes: a pilot study
Open accessAbstract
To examine the effect of muscle strength on insulin resistance, we investigated the association between quantitative lower-extremity muscle strength and insulin resistance index as evaluated by homeostasis model assessment (HOMA-IR) in patients with type 2 diabetes (20 men and 20 women, mean age SD: 53.3 12.7 years). By simple linear regression analyses, the knee extension force normalized for body weight (%KEF) was found to be significantly correlated with HOMA-IR in both male (r = -0.510, P<0.05) and female patients (r = -0.462, P<0.05). Stepwise regression analysis also showed that %KEF was an independent determinant of HOMA-IR (beta = -0.331, F = 5.400, P<0.005), as was BMI (beta = 0.409, F = 8.260, P<0.05). Our data suggest that lower-extremity muscle strength is independently associated with insulin resistance, which seems to be consistent with previous reports that resistance training improves glycemic control in type 2 diabetic patients. Further studies based on a larger study population will be required to confirm this possibility.
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Insulin resistance is essential for protein anabolism, thus directly concerns muscle fiber atrophy.
“Studies have elucidated that insulin resistance is essential for protein anabolism, thus directly concerns muscle fiber atrophy (37).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [37]
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- Authors
- NOMURA, T., IKEDA, Y., NAKAO, S., ITO, K., ISHIDA, K., SUEHIRO, T., & HASHIMOTO, K.
- Affiliations
- Osaka Prefecture University (JP)
- Kōchi University (JP)
- University of Kochi (JP)
- Venue
- Endocrine Journal
- Publisher
- Japan Endocrine Society
- Published
- 2007
- Volume
- 54
- Issue
- 5
- Pages
- 791-796
- ISSN
- 0918-8959 (ISSN-L)
- 1348-4540
- OpenAlex
- W1980882824
- Cited by
- 61
- References
- 27
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 2 · 2012: 5
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrine Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- muscle strength, insulin resistance, type 2 diabetes, lower limb muscle strength, knee extension force, HOMA-IR, body mass index, resistance training, glycemic control
- MeSH terms
- Adult, Aged, Diabetes Mellitus, Type 2, Female, Humans, Insulin Resistance, Knee, Male, Middle Aged, Pilot Projects, Cohort Studies, Biomarkers, Muscle Strength
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