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Cited by 135Nutrition and Health in AgingMuscle metabolism and nutritionDiabetes, Cardiovascular Risks, and Lipoproteins

Insulin resistance and muscle strength in older persons

Abbatecola, A. M., Ferrucci, L., Ceda, G., Russo, C. R., Lauretani, F., Bandinelli, S., Barbieri, M., Valenti, G. +1 more·2005·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
DOI 10.1093/gerona/60.10.1278
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Abstract

BACKGROUND: The functional consequences of an age-related insulin resistance (IR) state on muscle functioning are unknown. Because insulin is needed for adequate muscle function, an age-related insulin-resistant state may also be a determining factor. We evaluated the relationship between IR and handgrip muscle strength in men and women from a large population-based study (n = 968). METHODS: The degree of IR was evaluated by the homeostasis model assessment (HOMA) and muscle strength was assessed using handgrip. RESULTS: Simple sex-stratified correlations demonstrated that, in men, body mass index-adjusted handgrip strength correlated positively with physical activity (r = 0.321; p < .001), muscle area (r = 0.420; p < .001), muscle density (r = 0.263; p = .001), plasma albumin (r = 0.156; p = .001), insulin-like growth factor-1 (r = 0.258; p < .001), calcium (r = 0.140; p = .006), and testosterone (r = 0.325; p < .001) concentrations, whereas a negative association was found for age (r = -0.659; p < .001) and myoglobin plasma levels (r = -0.164; p =.001). In women, body mass index-adjusted handgrip strength correlated positively with physical activity (r = 0.280; p < .001), muscle area (r = 0.306; p < .001), muscle density (r = 0.341; p = .001), plasma albumin (r = 0.140; p =.001), and insulin-like growth factor-1 (r = 0.300; p < .001), whereas a negative association was found for age (r = -0.563; p < .001), myoglobin levels (r = -0.164; p = .001), and IR (r = -0.130; p = .04). CONCLUSIONS: Sex-stratified analyses adjusted for multiple confounders showed that the relationship between IR and handgrip strength was found significant in women, whereas it was negligible and not significant in men.

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Crossref · 10.1093/gerona/60.10.1278

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  • Obese individuals with insulin resistance have a higher rate of muscle catabolism, evidenced by a study that leg muscle strength and quality decrease distinctly in older diabetics.

    “Obese individuals with insulin resistance have a higher rate of muscle catabolism, which has been evidenced in a study that leg muscle strength and quality decrease distinctly in older diabetics (38).”

    From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [38]

  • In older persons, insulin resistance increases substantially with aging and is an independent determinant of weaker muscle strength.

    “Data from the InCHIANTI study showed that insulin resistance substantially increased with aging and was an independent determinant of weaker muscle strength in older persons (1).”

    From Discovering pathways of sarcopenia in older adults: a role for insulin resistance on mitochondria dysfunction (2011) · cites this paper as [1]

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Authors
Abbatecola, A. M., Ferrucci, L., Ceda, G., Russo, C. R., Lauretani, F., Bandinelli, S., Barbieri, M., Valenti, G., & Paolisso, G.
Affiliations
University of Naples Federico II (IT)
ORCID
Venue
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher
Oxford University Press (OUP)
Published
2005-10-01
Volume
60
Issue
10
Pages
1278-1282
ISSN
  • 1079-5006 (ISSN-L)
  • 1758-535X
DOI
10.1093/gerona/60.10.1278
OpenAlex
W2153032251
Cited by
135
References
39
Citations by year
2026: 7 · 2025: 9 · 2024: 8 · 2023: 9 · 2022: 6 · 2021: 10 · 2020: 9 · 2019: 7 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 8 · 2013: 4 · 2012: 9
FWCI
1.79
Type
journal article
Language
en
Open access
closed
Locations
  • The Journals of Gerontology Series A (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
insulin resistance, muscle strength, grip strength, older adults, aging, sex differences, physical activity, muscle area, muscle density, insulin-like growth factor I, testosterone, myoglobin, serum albumin, HOMA, sarcopenia, functional capacity, muscle function, age-related decline, muscular endurance
MeSH terms
Adult, Age Factors, Aged, Aged, 80 and over, Calcium, Female, Humans, Insulin Resistance, Insulin-Like Growth Factor I, Male, Middle Aged, Muscles, Myoglobin, Serum Albumin, Hand Strength

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