Cited by 260Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisProtease and Inhibitor MechanismsPulmonary Hypertension Research and Treatments

Matrix metalloproteases in aberrant fibrotic tissue remodeling

Pardo, Annie, Selman, Moisés·2006·Proceedings of the American Thoracic Society

Abstract

Pulmonary fibrosis, the final result of a large variety of interstitial lung diseases, is characterized by an aberrant remodeling of extracellular matrix (ECM) with a profound disturbance of the normal lung architecture. This remodeling includes the exaggerated accumulation of ECM components in the interstitial and alveolar spaces and the disruption of the basement membranes. It has long been accepted that matrix metalloproteases (MMPs) play an important role in the pathogenesis of pulmonary fibrosis, but the exact mechanisms are not well characterized. Several MMPs are strongly up-regulated in human and experimental lung fibrosis, highlighting the dynamic nature of scarring within the lung. MMPs are collectively capable of cleaving all components of the ECM and basement membranes, but importantly, they also process bioactive mediators such as growth factors, cytokines, chemokines, and cell-surface receptors. Moreover, they participate in the initiation of proteinase cascades that impact much broader substrates. Consequently, MMPs may play a central role in several interrelated processes observed in fibrosis such as ECM remodeling, basement-membrane breakdown, epithelial-cell apoptosis, cell migration, and angiogenesis.

Integrity signals

Registry

Crossref · 10.1513/pats.200601-012tk

Cites

62 of 62 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Pardo, A., & Selman, M.
Affiliations
Instituto Nacional de Enfermedades Respiratorias (MX)
Corresponding author
Pardo, Annie
Venue
Proceedings of the American Thoracic Society
Published
2006-06-01
Volume
3
Issue
4
Pages
383-388
ISSN
  • 1546-3222 (ISSN-L)
  • 1943-5665
OpenAlex
W2110499503
Cited by
260
References
62
Citations by year
2026: 7 · 2025: 8 · 2024: 14 · 2023: 6 · 2022: 14 · 2021: 14 · 2020: 10 · 2019: 13 · 2018: 14 · 2017: 18 · 2016: 13 · 2015: 21 · 2014: 13 · 2013: 15 · 2012: 12
FWCI
2.92
Type
journal article
Language
en
Open access
closed
Locations
  • Proceedings of the American Thoracic Society (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
Keywords
matrix metalloproteinases, pulmonary fibrosis, interstitial lung disease, extracellular matrix remodeling, basement membrane degradation, epithelial apoptosis, cell migration, angiogenesis
MeSH terms
Animals, Extracellular Matrix, Humans, Metalloendopeptidases, Pulmonary Fibrosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review