Oxidative Nerve Cell Death in Alzheimers Disease and Stroke: Antioxidants as Neuroprotective Compounds

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works

Mitochondria and Apoptosis

Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 8,998 · see citing works

Alzheimer's Disease: Genes, Proteins, and Therapy

Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works

Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β

Kuiper, G. G. J. M., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., & Gustafsson, J.-Å. (1998) · Endocrinology · doi:10.1210/endo.139.10.6216 · Cited by 4,203 · see citing works

Polyphenols: Chemistry, dietary sources, metabolism, and nutritional significance

Bravo, L. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1998.tb01670.x · Cited by 4,030 · see citing works

Pathobiology of ischaemic stroke: an integrated view

Dirnagl, U., Iadecola, C., & Moskowitz, M. A. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01401-0 · Cited by 3,943 · see citing works

The Free Radical Theory of Aging Matures

BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879 · see citing works

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

Coyle, J. T., & Puttfarcken, P. (1993) · Science · doi:10.1126/science.7901908 · Cited by 3,762 · see citing works

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506 · see citing works

Molecular diversity of glutamate receptors and implications for brain function

Nakanishi, S. (1992) · Science · doi:10.1126/science.1329206 · Cited by 2,543 · see citing works

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380 · see citing works

Hydrogen peroxide mediates amyloid β protein toxicity

Behl, C. (1994) · Cell · doi:10.1016/0092-8674(94)90131-7 · Cited by 2,074 · see citing works

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012 · see citing works

Strategies of antioxidant defense

SIES, H. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18025.x · Cited by 1,976 · see citing works

Apoptosis in the nervous system

Yuan, J., & Yankner, B. A. (2000) · Nature · doi:10.1038/35037739 · Cited by 1,862 · see citing works

Antioxidants in Human Health and Disease

Halliwell, B. B. (1996) · Annual Review of Nutrition · doi:10.1146/annurev.nu.16.070196.000341 · Cited by 1,707 · see citing works

Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection

Oldendorf, W. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.221.6.1629 · Cited by 1,691 · see citing works

Reactive Oxygen Radicals in Signaling and Damage in the Ischemic Brain

Chan, P. H. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200101000-00002 · Cited by 1,589 · see citing works

Role of Free Radicals in the Neurodegenerative Diseases: Therapeutic Implications for Antioxidant Treatment

Halliwell, B. (2001) · Drugs & Aging · doi:10.2165/00002512-200118090-00004 · Cited by 1,502 · see citing works

Estrogen Actions in the Central Nervous System

McEwen, B. S., & Alves, S. E. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0365 · Cited by 1,483 · see citing works

Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

Cherny, R. A., Atwood, C. S., Xilinas, M. E., Gray, D. N., Jones, W. D., McLean, C. A., Barnham, K. J., Volitakis, I., Fraser, F. W., Kim, Y.-S., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00317-8 · Cited by 1,447 · see citing works

Aging, energy, and oxidative stress in neurodegenerative diseases

Beal, M. F. (1995) · Annals of Neurology · doi:10.1002/ana.410380304 · Cited by 1,434 · see citing works

Oxidative Stress in Neurodegenerative Diseases

Simonian, N. A., & Coyle, J. T. (1996) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.36.040196.000503 · Cited by 1,377 · see citing works

Biochemistry of Oxidative Stress

Sies, H. (1986) · Angewandte Chemie International Edition in English · doi:10.1002/anie.198610581 · Cited by 1,316 · see citing works

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239 · see citing works

Oxidative stress and Alzheimer disease

Christen, Y. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.621s · Cited by 1,158 · see citing works

Amyloid β-Protein Fibrillogenesis

Walsh, D. M., Lomakin, A., Benedek, G. B., Condron, M. M., & Teplow, D. B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.35.22364 · Cited by 1,139 · see citing works

Antioxidant Therapy: A New Pharmacological Approach in Shock, Inflammation, and Ischemia/Reperfusion Injury

Cuzzocrea, S., Riley, D. P., Caputi, A. P., & Salvemini, D. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01484-4 · Cited by 1,087 · see citing works

Amyloid β-Protein Fibrillogenesis

Walsh, D. M., Hartley, D. M., Kusumoto, Y., Fezoui, Y., Condron, M. M., Lomakin, A., Benedek, G. B., Selkoe, D. J., & Teplow, D. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25945 · Cited by 1,046 · see citing works

Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

Klein, W. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01749-5 · Cited by 989 · see citing works

Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons

Hartley, D. M., Walsh, D. M., Ye, C., Diehl, T. S., Vasquez, S., Vassilev, P., Teplow, D. B., & Selkoe, D. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-08876.1999 · Cited by 965 · see citing works

Mechanisms of Neuronal Degeneration in Alzheimer's Disease

Yankner, B. A. (1996) · Neuron · doi:10.1016/s0896-6273(00)80115-4 · Cited by 947 · see citing works

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

Yankner, B. A., Dawes, L. R., Fisher, S., Villa-Komaroff, L., Oster-Granite, M. L., & Neve, R. L. (1989) · Science · doi:10.1126/science.2474201 · Cited by 907 · see citing works

Cannabidiol and (−)Δ ⁹ -tetrahydrocannabinol are neuroprotective antioxidants

Hampson, A. J., Grimaldi, M., Axelrod, J., & Wink, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.8268 · Cited by 850 · see citing works

Flavonoids Protect Neuronal Cells from Oxidative Stress by Three Distinct Mechanisms

Ishige, K., Schubert, D., & Sagara, Y. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00498-6 · Cited by 841 · see citing works

Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier

Gilgun‐Sherki, Y., Melamed, E., & Offen, D. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00019-3 · Cited by 839 · see citing works

Complement activation by beta-amyloid in Alzheimer disease.

Rogers, J., Cooper, N. R., Webster, S., Schultz, J., McGeer, P. L., Styren, S. D., Civin, W. H., Brachova, L., Bradt, B., & Ward, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10016 · Cited by 817 · see citing works

Increased Lipid Peroxidation Precedes Amyloid Plaque Formation in an Animal Model of Alzheimer Amyloidosis

Praticò, D., Uryu, K., Leight, S., Trojanoswki, J. Q., & Lee, V. M.-Y. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04183.2001 · Cited by 777 · see citing works

Intramuscular desferrioxamine in patients with Alzheimer's disease

MCLACHLAN, D. (1991) · The Lancet · doi:10.1016/0140-6736(91)92978-b · Cited by 764 · see citing works

Neuroprotection against Oxidative Stress by Estrogens: Structure-Activity Relationship

Behl, C., Skutella, T., Lezoualc’h, F., Post, A., Widmann, M., Newton, C. J., & Holsboer, F. (1997) · Molecular Pharmacology · doi:10.1124/mol.51.4.535 · Cited by 762 · see citing works

Flavonoid Antioxidants

Rice-Evans, C. A. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013373011 · Cited by 719 · see citing works

Observation of metastable Aβ amyloid protofibrils by atomic force microscopy

Harper, J. D., Wong, S. S., Lieber, C. M., & Lansbury, P. T. (1997) · Chemistry & Biology · doi:10.1016/s1074-5521(97)90255-6 · Cited by 691 · see citing works

Oxidative Stress in Brain Ischemia

Love, S. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00214.x · Cited by 684 · see citing works

The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)

Multhaup, G., Schlicksupp, A., Hesse, L., Beher, D., Ruppert, T., Masters, C. L., & Beyreuther, K. T. (1996) · Science · doi:10.1126/science.271.5254.1406 · Cited by 677 · see citing works

Estrogen Actions in the Central Nervous System

McEwen, B. S. (1999) · Endocrine Reviews · doi:10.1210/er.20.3.279 · Cited by 640 · see citing works

17-β Estradiol Protects Neurons from Oxidative Stress-Induced Cell Death in Vitro

Behl, C., Widmann, M., Trapp, T., & Holsboer, F. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2647 · Cited by 608 · see citing works

Central nervous system trauma and stroke

Hall, E. D., & Braughler, J. M. (1989) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(89)90057-9 · Cited by 590 · see citing works

Vitamin E protects nerve cells from amyloid βprotein toxicity

Behl, C., Davis, J. B., Cole, G. M., & Schubert, D. A. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90837-b · Cited by 582 · see citing works

Estradiol Protects against Ischemic Injury

Dubal, D. B., Kashon, M. L., Pettigrew, L. C., Ren, J. M., Finklestein, S. P., Rau, S. W., & Wise, P. M. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199811000-00012 · Cited by 554 · see citing works

Persistent Activation of ERK Contributes to Glutamate-induced Oxidative Toxicity in a Neuronal Cell Line and Primary Cortical Neuron Cultures

Stanciu, M., Wang, Y., Kentor, R., Burke, N., Watkins, S., Kress, G., Reynolds, I., Klann, E., Angiolieri, M. R., Johnson, J. W., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.12200 · Cited by 539 · see citing works

Neuroprotective effects of estrogens: potential mechanisms of action

Green, P. S., & Simpkins, J. W. (2000) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(00)00017-4 · Cited by 523 · see citing works

A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion.

Li, Y., Maher, P., & Schubert, D. (1997) · Neuron · doi:10.1016/s0896-6273(00)80953-8 · Cited by 509 · see citing works

Copper in disorders with neurological symptoms: Alzheimer’s, Menkes, and Wilson diseases

Strausak, D., Mercer, J. F. B., Dieter, H. H., Stremmel, W., & Multhaup, G. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00454-3 · Cited by 508 · see citing works

Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches

Behl, C. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00055-0 · Cited by 444 · see citing works

The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties

Moosmann, B., & Behl, C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.8867 · Cited by 411 · see citing works

A Quantum Chemical Explanation of the Antioxidant Activity of Flavonoids

van Acker, S. A. B. E., de Groot, M. J., van den Berg, D., Tromp, M. N. J. L., den Kelder, G. M. D.-O., van der Vijgh, W. J. F., & Bast, A. (1996) · Chemical Research in Toxicology · doi:10.1021/tx9600964 · Cited by 408 · see citing works

George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury.

Kontos, H. A. (1985) · Circulation Research · doi:10.1161/01.res.57.4.508 · Cited by 392 · see citing works

Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3

Schroeter, H., Spencer, J. P. E., Rice-Evans, C. A., & WILLIAMS, R. J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3580547 · Cited by 373 · see citing works

Clinical trials with neuroprotective drugs in acute ischaemic stroke: are we doing the right thing?

Keyser, J. D., Sulter, G., & Luiten, P. G. M. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01463-0 · Cited by 367 · see citing works

Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia

Namura, S., Iihara, K., Takami, S., Nagata, I., Kikuchi, H., Matsushita, K., Moskowitz, M. A., Bonventre, J. V., & Alessandrini, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181213498 · Cited by 360 · see citing works

Direct evidence of oxidative injury produced by the Alzheimer's β-Amyloid peptide (1–40) in cultured hippocampal neurons

Harris‐White, M. E., Hensley, K., Butterfield, D. A., Leedle, R. A., & Carney, J. M. (1995) · Experimental Neurology · doi:10.1016/0014-4886(95)90041-1 · Cited by 331 · see citing works

Apoptosis-regulating proteins as targets for drug discovery

Reed, J. C. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02026-3 · Cited by 328 · see citing works

Molecular Basis of Vitamin E Action

Sen, C. K., Khanna, S., Roy, S., & Packer, L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.17.13049 · Cited by 323 · see citing works

Neuronal Oxidative Stress Precedes Amyloid-β Deposition in Down Syndrome

Nunomura, A., Perry, G. L., Pappolla, M. A., Friedland, R. P., Hirai, K., Chiba, S., & Smith, M. A. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.11.1011 · Cited by 322 · see citing works

The Role of Oxidative Stress in Alzheimer Disease

Markesbery, W. R. (1999) · Archives of Neurology · doi:10.1001/archneur.56.12.1449 · Cited by 307 · see citing works

Neurodegenerative disorders and ischemic brain diseases

Mattson, M. P., Duan, W., Pedersen, W. A., & Culmsee, C. (2001) · APOPTOSIS · doi:10.1023/a:1009676112184 · Cited by 306 · see citing works

Ebselen: prospective therapy for cerebral ischaemia

Parnham, M. J., & Sies, H. (2000) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.9.3.607 · Cited by 284 · see citing works

Identification of Proteins Containing Cysteine Residues That Are Sensitive to Oxidation by Hydrogen Peroxide at Neutral pH

Kim, J.-R., Yoon, H. W., Kwon, K., Lee, S.-R., & Rhee, S. G. (2000) · Analytical Biochemistry · doi:10.1006/abio.2000.4623 · Cited by 273 · see citing works

Vitamin E and Alzheimer disease: the basis for additional clinical trials

Grundman, M. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.630s · Cited by 267 · see citing works

Oxygen Radicals in Focal Cerebral Ischemia

Chan, P. H. (1994) · Brain Pathology · doi:10.1111/j.1750-3639.1994.tb00811.x · Cited by 260 · see citing works

Vitamin E: protective role of a Janus molecule

Ricciarelli, R., Zingg, J.-M. A., & Azzi, A. (2001) · The FASEB Journal · doi:10.1096/fj.01-0258rev · Cited by 260 · see citing works

17α-Estradiol Exerts Neuroprotective Effects on SK-N-SH Cells

Green, P. S., Bishop, J., & Simpkins, J. W. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-02-00511.1997 · Cited by 258 · see citing works

Oxidative Glutamate Toxicity Can Be a Component of the Excitotoxicity Cascade

Schubert, D., & Piasecki, D. P. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07455.2001 · Cited by 257 · see citing works

Dopaminergic cell death induced by MPP+, oxidant and specific neurotoxicants shares the common molecular mechanism

Chun, H. S., Gibson, G. E., DeGiorgio, L. A., Zhang, H., Kidd, V. J., & Son, J. H. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00096.x · Cited by 256 · see citing works

Apoptosis and Alzheimer's disease

Behl, C. (2000) · Journal of neural transmission · doi:10.1007/s007020070021 · Cited by 255 · see citing works

Neuroprotective Effects of a Novel Nitrone, NXY-059, after Transient Focal Cerebral Ischemia in the Rat

Kuroda, S., Tsuchidate, R., Smith, M., Maples, K. R., & Siesjö, B. K. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199907000-00008 · Cited by 247 · see citing works

Protective effects of idebenone and α‐tocopherol on β‐amyloid‐(1–42)‐induced learning and memory deficits in rats: implication of oxidative stress in β‐amyloid‐induced neurotoxicity in vivo

Yamada, K., Tanaka, T., Han, D., Senzaki, K., Kameyama, T., & Nabeshima, T. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00408.x · Cited by 238 · see citing works

The Cytosolic Antioxidant Copper/Zinc-Superoxide Dismutase Prevents the Early Release of Mitochondrial Cytochrome c in Ischemic Brain after Transient Focal Cerebral Ischemia in Mice

Fujimura, M., Morita‐Fujimura, Y., Noshita, N., Sugawara, T., 川瀬, 誠., & Chan, P. H. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-08-02817.2000 · Cited by 236 · see citing works

Dehydroascorbic acid, a blood–brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke

Huang, J., Agus, D. B., Winfree, C. J., Kiss, S., Mack, W. J., McTaggart, R. A., Choudhri, T. F., Kim, L. J., Mocco, J., Pinsky, D. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171325998 · Cited by 225 · see citing works

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation

Troy, C. M., Rabacchi, S. A., Xu, Z., Maroney, A. C., Connors, T. J., Shelanski, M. L., & Greene, L. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.t01-1-00218.x · Cited by 223 · see citing works

beta-Amyloid toxicity in organotypic hippocampal cultures: Protection by EUK-8, a synthetic catalytic free radical scavenger

Bruce, A. J., Malfroy, B., & Baudry, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2312 · Cited by 216 · see citing works

Dietary Flavonoids as Potential Neuroprotectants

Youdim, K. A., Spencer, J. P. E., Schroeter, H., & Rice-Evans, C. A. (2002) · Biological Chemistry · doi:10.1515/bc.2002.052 · Cited by 210 · see citing works

Myricetin and quercetin, the flavonoid constituents ofGinkgo biloba extract, greatly reduce oxidative metabolism in both resting and Ca2+-loaded brain neurons

Oyama, Y., Fuchs, P. A., Katayama, N., & Noda, K. (1994) · Brain Research · doi:10.1016/0006-8993(94)91431-1 · Cited by 209 · see citing works

Functional Pleiotropy of the Neurohormone Melatonin: Antioxidant Protection and Neuroendocrine Regulation

Reiter, R. J. (1995) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1995.1014 · Cited by 208 · see citing works

Induction of Reactive Oxygen Species in Neurons by Haloperidol

Sagara, Y. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71031002.x · Cited by 189 · see citing works

Signaling by reactive oxygen species in the nervous system

Maher, P. A., & Schubert, D. A. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000766 · Cited by 184 · see citing works

Phenolic antioxidants:

Noguchi, N., & Niki, E. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00256-2 · Cited by 179 · see citing works

Estrogen Provides Neuroprotection in Transient Forebrain Ischemia Through Perfusion-Independent Mechanisms in Rats

Wang, Q., Santizo, R. A., Baughman, V. L., & Pelligrino, D. A. (1999) · Stroke · doi:10.1161/01.str.30.3.630 · Cited by 170 · see citing works

Sustained efficacy and safety of idebenone in the treatment of Alzheimer’s disease: update on a 2-year double-blind multicentre study

Gutzmann, H., & Hadler, D. (1998) · Journal of Neural Transmission. Supplementa · doi:10.1007/978-3-7091-7508-8_30 · Cited by 162 · see citing works

Protein Aggregation and Pathogenesis of Huntingtons Disease: Mechanisms and Correlations

Wanker, E. E. (2000) · Biological Chemistry · doi:10.1515/bc.2000.114 · Cited by 154 · see citing works

Aging: Phenomena and Theories

Harman, D. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09886.x · Cited by 150 · see citing works

Tirilazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats.

Xue, D., Slivka, A. P., & Buchan, A. M. (1992) · Stroke · doi:10.1161/01.str.23.6.894 · Cited by 147 · see citing works

Prospects for Pharmacological Intervention in Alzheimer Disease

Emilien, G., Beyreuther, K. T., Masters, C. L., & Maloteaux, J. (2000) · Archives of Neurology · doi:10.1001/archneur.57.4.454 · Cited by 140 · see citing works

Efficacy of Antioxidant Therapies in Transient Focal Ischemia in Mice

Clark, W. M., Rinker, L. G., Lessov, N. S., Lowery, S. L., & Cipolla, M. J. (2001) · Stroke · doi:10.1161/01.str.32.4.1000 · Cited by 134 · see citing works

The female sex hormone oestrogen as a neuroprotectant

Behl, C., & Holsboer, F. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01392-9 · Cited by 133 · see citing works

Phase II trial of tirilazad in aneurysmal subarachnoid hemorrhage

Haley, E. C., Kassell, N. F., Alves, W. M., Weir, B., Apperson-Hansen, C., & _, _. (1995) · Journal of neurosurgery · doi:10.3171/jns.1995.82.5.0786 · Cited by 125 · see citing works

S-Allylcysteine Inhibits Free Radical Production, Lipid Peroxidation and Neuronal Damage in Rat Brain Ischemia

Numagami, Y., & Ohnishi, S. T. (2001) · Journal of Nutrition · doi:10.1093/jn/131.3.1100s · Cited by 124 · see citing works

Cytoprotective antioxidant function of tyrosine and tryptophan residues in transmembrane proteins

Moosmann, B., & Behl, C. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01658.x · Cited by 123 · see citing works

A Controlled Study of 2 Doses of Idebenone in the Treatment of Alzheimer’s Disease

Weyer, G., Babej-Dölle, R. M., Hadler, D., Hofmann, S., & Herrmann, W. M. (2008) · Neuropsychobiology · doi:10.1159/000119366 · Cited by 120 · cited 2× · see citing works

Alzheimer disease and neuroinflammation

McGeer, P. L., McGeer, E. G., & Yasojima, K. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6781-6_8 · Cited by 117 · see citing works

Secretory Peptide Hormones Are Biochemical Antioxidants: Structure-Activity Relationship

Moosmann, B., & Behl, C. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.2.260 · Cited by 104 · see citing works

A 1-year controlled trial of acetyl- l -carnitine in early-onset AD

Thal, L. J., Calvani, M., Amato, A., & Carta, A. (2000) · Neurology · doi:10.1212/wnl.55.6.805 · Cited by 102 · see citing works

Apoptosis: Overview and Signal Transduction Pathways

Bredesen, D. E. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.801 · Cited by 101 · see citing works

Science, medicine, and the future: Alzheimer's disease

Masters, C. L., & Beyreuther, K. T. (1998) · BMJ · doi:10.1136/bmj.316.7129.446 · Cited by 95 · see citing works

Tirilazad Mesylate in Acute Ischemic Stroke

(2000) · Stroke · doi:10.1161/01.str.31.9.2257 · Cited by 79 · see citing works

Nonantioxidant Functions of α-Tocopherol in Smooth Muscle Cells

Azzi, A., Breyer, I., Feher, M., Ricciarelli, R., Stocker, A., Zimmer, S., & Zingg, J.-M. A. (2001) · Journal of Nutrition · doi:10.1093/jn/131.2.378s · Cited by 74 · see citing works

Multiple Antioxidants in the Prevention and Treatment of Alzheimer Disease: Analysis of Biologic Rationale

Prasad, K. N., Hovland, A. R., Cole, W. C., Prasad, K. C., Nahreini, P., Edwards‐Prasad, J., & Andreatta, C. P. (2000) · Clinical Neuropharmacology · doi:10.1097/00002826-200001000-00002 · Cited by 74 · see citing works

Protective Activity of Aromatic Amines and Imines against Oxidative Nerve Cell Death

Moosmann, B., Skutella, T., Beyer, K., & Behl, C. (2001) · Biological Chemistry · doi:10.1515/bc.2001.195 · Cited by 70 · see citing works

Alpha tocopherol in CSF of subjects taking high‐dose vitamin E in the DATATOP study

Vatassery, G. T., Fahn, S., & Kuskowski, M. A. (1998) · Neurology · doi:10.1212/wnl.50.6.1900 · Cited by 63 · see citing works

Neuroprotection by 2-h Postischemia Administration of Two Free Radical Scavengers, α-phenyl-n-tert-butyl-nitrone (PBN) and N-tert-butyl-(2-sulfophenyl)-nitrone (S-PBN), in Rats Subjected to Focal Embolic Cerebral Ischemia

Yang, Y., Qiu, L., & Shuaib, A. M. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7364 · Cited by 61 · see citing works

Comparison of the antioxidant effects of equine estrogens, red wine components, vitamin E, and probucol on low-density lipoprotein oxidation in postmenopausal women

Bhavnani, B. R., Cecutti, A., Gerulath, A. H., Woolever, A. C., & Berco, M. (2018) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001222 · Cited by 55 · see citing works

β-Amyloid protein aggregation: its implication in the physiopathology of Alzheimer's disease

Dumery, L., Bourdel, F., Soussan, Y., Fialkowsky, A., Viale, S., Nicolas, P., & Reboud‐Ravaux, M. (2001) · Pathologie Biologie · doi:10.1016/s0369-8114(00)00009-2 · Cited by 55 · see citing works

Comparison of the antioxidant effects of equine estrogens, red wine components, vitamin E, and probucol on low-density lipoprotein oxidation in postmenopausal women

Bhavnani, B. R., Cecutti, A., Gerulath, A. H., Woolever, A. C., & Berco, M. (2001) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-200111000-00005 · Cited by 52 · see citing works

Oestrogens and Dementia

Henderson, V. W. (2000) · Novartis Foundation symposium · doi:10.1002/0470870818.ch18 · Cited by 48 · see citing works

Involvement of the 5‐lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106‐126

Stewart, L. R., White, A. R., Jobling, M. F., Needham, B. E., Maher, F., Thyer, J. M., Beyreuther, K., Masters, C. L., Collins, S. J., & Cappai, R. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1186 · Cited by 47 · see citing works

Phenothiazines as lipid peroxidation inhibitors and cytoprotective agents

Yu, M. J., McCowan, J. R., Thrasher, K. J., Keith, P. T., Luttman, C. A., Ho, P. P. K., Towner, R. D., Bertsch, B., & Horng, J. S. (1992) · Journal of Medicinal Chemistry · doi:10.1021/jm00082a012 · Cited by 46 · see citing works

Effects of the spin trap‐α‐phenyl‐N‐tert‐butyl nitrone (PBN) in transient forebrain ischaemia in the rat

Pahlmark, K., & Siesjö, B. K. (1996) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1996.440167000.x · Cited by 44 · see citing works

Inhibition of Oxidation of Low-Density Lipoprotein by a Novel Antioxidant, BO-653, Prepared by Theoretical Design

Noguchi, N., Okimoto, Y., Tsuchiya, J., Cynshi, O., Kodama, T., & Niki, E. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0331 · Cited by 44 · see citing works

Mechanisms of Neurodegenerative Disorders

Wolozin, B. L., & Behl, C. (2000) · Archives of Neurology · doi:10.1001/archneur.57.6.801 · Cited by 40 · see citing works

Neuroprotective potential of aromatic alcohols against oxidative cell death

Moosmann, B., Uhr, M., & Behl, C. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00961-7 · Cited by 38 · see citing works

A radical approach to stroke therapy

McCulloch, J., & Dewar, D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211430898 · Cited by 37 · see citing works

Scavestrogens Protect IMR 32 Cells from Oxidative Stress-Induced Cell Death

Blum-Degen, D., Haas, M., Pohli, S., Harth, R., Römer, W., Oettel, M., Riederer, P. F., & Götz, M. E. (1998) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1998.8503 · Cited by 35 · see citing works

Beta Amyloid Toxicity Does Not Require RAGE Protein

Liu, Y., Dargusch, R., & Schubert, D. A. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7068 · Cited by 33 · see citing works

Proteolysis by presenilins and the renaissance of tau

Haass, C., & Mandelkow, E. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01576-7 · Cited by 20 · see citing works

Oxidative Stress and Neurodegenerative Disorders

Li, J., Wuliji, O., Li, W., Jiang, Z.-G., & Ghanbari, H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141224438 · Cited by 511 · see citing works

Oestrogen as a neuroprotective hormone

Behl, C. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn846 · Cited by 486 · see citing works

Therapeutic applications of compounds in the Magnolia family

Lee, Y., Lee, Y. M., Lee, C., Jung, J., Han, S., & Hong, J. T. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.010 · Cited by 490 · see citing works

Dietary Antioxidants and Human Cancer

Borek, C. G. (2004) · Integrative Cancer Therapies · doi:10.1177/1534735404270578 · Cited by 303 · see citing works

Phenothiazine: the seven lives of pharmacology's first lead structure

Ohlow, M. J., & Moosmann, B. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.01.001 · Cited by 283 · see citing works

Oxidative stress and β-amyloid protein in Alzheimer’s disease

Cai, Z., Zhao, B., & Ratka, A. (2011) · NeuroMolecular Medicine · doi:10.1007/s12017-011-8155-9 · Cited by 279 · see citing works

Formulation development and systematic optimization of solid lipid nanoparticles of quercetin for improved brain delivery

Dhawan, S., Kapil, R., & Singh, B. (2011) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2010.01225.x · Cited by 257 · see citing works

Highly Divergent Methyltransferases Catalyze a Conserved Reaction in Tocopherol and Plastoquinone Synthesis in Cyanobacteria and Photosynthetic Eukaryotes

Cheng, Z. (2003) · The Plant Cell · doi:10.1105/tpc.013656 · Cited by 223 · see citing works

Selenium homeostasis and antioxidant selenoproteins in brain: Implications for disorders in the central nervous system

Steinbrenner, H., & Sies, H. (2013) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2013.02.021 · Cited by 217 · see citing works

Ca2+-dependent proteases in ischemic neuronal death

Yamashima, T. (2004) · Cell Calcium · doi:10.1016/j.ceca.2004.03.001 · Cited by 213 · see citing works

Antioxidants and Radiation Therapy

Borek, C. G. (2004) · Journal of Nutrition · doi:10.1093/jn/134.11.3207s · Cited by 204 · see citing works

Astrocytic Gap Junctions Composed of Connexin 43 Reduce Apoptotic Neuronal Damage in Cerebral Ischemia

Nakase, T., Fushiki, S., & Naus, C. C. G. (2003) · Stroke · doi:10.1161/01.str.0000079814.72027.34 · Cited by 200 · see citing works

Na+, K+-ATPase: the new face of an old player in pathogenesis and apoptotic/hybrid cell death

Yu, S. P. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00531-8 · Cited by 192 · see citing works

Optical and pharmacological tools to investigate the role of mitochondria during oxidative stress and neurodegeneration

Foster, K. A., Galeffi, F., Gerich, F. J., Turner, D. A., & Müller, M. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.07.001 · Cited by 188 · see citing works

The biochemistry of neuronal necrosis: rogue biology?

Syntichaki, P., & Tavernarakis, N. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1174 · Cited by 182 · see citing works

Antioxidative Properties and Effect of Quercetin and Its Glycosylated Form (Rutin) on Acetylcholinesterase and Butyrylcholinesterase Activities

Ademosun, A. O., Oboh, G., Bello, F. O., & Ayeni, P. O. (2015) · Journal of Evidence-Based Complementary & Alternative Medicine · doi:10.1177/2156587215610032 · Cited by 182 · see citing works

Oxidative stress in Alzheimer disease and mild cognitive impairment: evidence from human data provided by redox proteomics

Swomley, A. M., & Butterfield, D. A. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1556-z · Cited by 171 · see citing works

Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein

Wen, Y., Yang, S., Liu, R., & Simpkins, J. W. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.106 · Cited by 149 · see citing works

Interleukin‐1β: a bridge between inflammation and excitotoxicity?

Fogal, B., & Hewett, S. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05315.x · Cited by 145 · see citing works

Neuroprotection by bioactive components in medicinal and food plant extracts

Aruoma, O. I., Bahorun, T., & Jen, L. (2003) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.06.017 · Cited by 142 · see citing works

Oligodendrocytes and Alzheimer's disease

Cai, Z., & Xiao, M. (2015) · International Journal of Neuroscience · doi:10.3109/00207454.2015.1025778 · Cited by 133 · see citing works

Methionine-35 of A <i>β</i> (1–42): Importance for Oxidative Stress in Alzheimer Disease

Butterfield, D. A., & Sultana, R. (2011) · Journal of Amino Acids · doi:10.4061/2011/198430 · Cited by 124 · see citing works

Long-term d-galactose injection combined with ovariectomy serves as a new rodent model for Alzheimer's disease

Hua, X., Lei, M., Zhang, Y., Ding, J., Qun-ying, H., Hu, G., & Xiao, M. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.02.030 · Cited by 125 · see citing works

Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation

Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works

Study of the oxidative stress in a rat model of chronic brain hypoperfusion

Kašparová, S., Brezová, V., Valko, M., Horecký, J., Mlynárik, V., Liptaj, T., Vančová, O., Uličná, O., & Dobrota, D. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.02.006 · Cited by 119 · see citing works

Protocatechualdehyde Protects Against Cerebral Ischemia-Reperfusion-Induced Oxidative Injury Via Protein Kinase Cε/Nrf2/HO-1 Pathway

Guo, C., Wang, S., Duan, J., Jia, N., Zhu, Y., Ding, Y., Guan, Y., Wei, G., Yin, Y., Xi, M., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9690-z · Cited by 115 · see citing works

Phenylketonuria Pathophysiology: on the Role of Metabolic Alterations

Schuck, P. F., Malgarin, F., Cararo, J. H., Diniz, F., STRECK, E. L., & Ferreira, G. C. (2015) · Aging and Disease · doi:10.14336/ad.2015.0827 · Cited by 113 · see citing works

A Role for NOX NADPH Oxidases in Alzheimer's Disease and Other Types of Dementia?

Zekry, D., Epperson, T. K., & Krause, K. (2003) · IUBMB Life · doi:10.1080/1521654031000153049 · Cited by 112 · see citing works

N-Substituted Phenoxazine and Acridone Derivatives: Structure–Activity Relationships of Potent P2X4 Receptor Antagonists

Hernández‐Olmos, V., Abdelrahman, A., El‐Tayeb, A., Diana, F., Weinhausen, S., & Müller, C. E. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300845v · Cited by 111 · see citing works

Regulation of microglial behavior by ion channel activity

Eder, C. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20476 · Cited by 108 · see citing works

Mitochondrial “swirls” induced by oxygen stress and in the Drosophila mutant hyperswirl

Walker, D. W., & Benzer, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403767101 · Cited by 108 · see citing works

Promises of a biocompatible nanocarrier in improved brain delivery of quercetin: Biochemical, pharmacokinetic and biodistribution evidences

Kumar, P., Sharma, G., Kumar, R., Singh, B., Malik, R., Katare, O. P., & Raza, K. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.10.024 · Cited by 102 · see citing works

Oxidative stress – assassin behind the ischemic stroke

Pradeep, H., Joseph, D. B., Shashikumar, S., & Rajanikant, G. K. (2012) · Folia Neuropathologica · doi:10.5114/fn.2012.30522 · Cited by 102 · see citing works

Effect of Hypoxia/Ischemia and Hypoxic Preconditioning/Reperfusion on Expression of Some Amyloid‐Degrading Enzymes

NALIVAEVAA, N. N., Fisk, L., Kochkina, E. G., Plesneva, S. A., Zhuravin, I. A., Babušíková, E., Dobrota, D., & Turner, A. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.002 · Cited by 100 · see citing works

Estrogen activates rapid signaling in the brain: Role of estrogen receptor α and estrogen receptor β in neurons and glia

Mhyre, A. J., & Dorsa, D. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.019 · Cited by 97 · see citing works

Suppression of neuro-inflammatory signaling cascade by tocotrienol can prevent chronic alcohol-induced cognitive dysfunction in rats

Tiwari, V., Kuhad, A., & Chopra, K. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.05.016 · Cited by 94 · see citing works

Estrogen can protect neurons: modes of action

Behl, C. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00271-6 · Cited by 94 · see citing works

Anti-Oxidative Effects of Rooibos Tea (Aspalathus linearis) on Immobilization-Induced Oxidative Stress in Rat Brain

Hong, I., Lee, H., & Kim, H.-P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087061 · Cited by 92 · see citing works

Contributions of cyclooxygenase-2 to neuroplasticity and neuropathology of the central nervous system

Hewett, S. J., Bell, S. C., & Hewett, J. A. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.04.011 · Cited by 91 · see citing works

On the mechanism of ionic regulation of apoptosis: would the Na+/K+‐ATPase please stand up?

Panayiotidis, M. I., Bortner, C. D., & Cidlowski, J. A. (2006) · Acta Physiologica · doi:10.1111/j.1748-1716.2006.01562.x · Cited by 86 · see citing works

Characterization of the toxic mechanism triggered by Alzheimer's amyloid‐β peptides via p75 neurotrophin receptor in neuronal hybrid cells

Tsukamoto, E., Hashimoto, Y., Kanekura, K., Niikura, T., Aiso, S., & Nishimoto, I. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10703 · Cited by 86 · see citing works

A chronic Alzheimer’s model evoked by mitochondrial poison sodium azide for pharmacological investigations

Szabados, T., Dul, C., Majtényi, K., Hargitai, J., Pénzes, Z., & Urbanics, R. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.01.016 · Cited by 84 · see citing works

Evaluation of sulfur, selenium and tellurium catalysts with antioxidant potential

Giles, G. I., Fry, F. H., Tasker, K. M., Holme, A. L., Peers, C., Green, K. N., Klotz, L., Sies, H., & Jacob, C. (2003) · Organic & Biomolecular Chemistry · doi:10.1039/b308117f · Cited by 81 · see citing works

In vitro Gender Differences in Neuronal Survival on Hypoxia and in 17β-Estradiol-Mediated Neuroprotection

Heyer, A., Hasselblatt, M., von Ahsen, N., Häfner, H., Sirén, A., & Ehrenreich, H. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600056 · Cited by 78 · see citing works

Methyleugenol reduces cerebral ischemic injury by suppression of oxidative injury and inflammation

Choi, Y. K., Cho, G., Hwang, S., Kim, B. W., Lim, J. H., Lee, J., Kim, H., Kim, W.-K., & Kim, Y.-S. (2010) · Free Radical Research · doi:10.3109/10715762.2010.490837 · Cited by 78 · see citing works

Conjugates of Superoxide Dismutase 1 with Amphiphilic Poly(2-oxazoline) Block Copolymers for Enhanced Brain Delivery: Synthesis, Characterization and Evaluation in Vitro and in Vivo

Tong, J., Yi, X., Luxenhofer, R., Banks, W. A., Jordan, R., Zimmerman, M. C., & Kabanov, A. V. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300496x · Cited by 77 · see citing works

Oxidative stress, cancer, and sleep deprivation: is there a logical link in this association?

Noguti, J., Andersen, M. L., Cirelli, C., & Ribeiro, D. A. (2013) · Sleep And Breathing · doi:10.1007/s11325-012-0797-9 · Cited by 75 · see citing works

Protective effect of a synthetic anti‐oxidant on neuronal cell apoptosis resulting from experimental hypoxia re‐oxygenation injury

Rayner, B., Duong, T. T. H., Myers, S. J., & Witting, P. K. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03726.x · Cited by 76 · see citing works

Experimental Evidence that Phenylalanine Provokes Oxidative Stress in Hippocampus and Cerebral Cortex of Developing Rats

Fernandes, C. G., Leipnitz, G., Seminotti, B., Amaral, A. U., Zanatta, Â., Vargas, C. R., Dutra‐Filho, C. S., & Wajner, M. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9455-6 · Cited by 73 · see citing works

Cell Culture Models of Oxidative Stress and Injury in the Central Nervous System

Aksenova, M. V., Aksenov, M. Y., Mactutus, C. F., & Booze, R. M. (2005) · Current Neurovascular Research · doi:10.2174/1567202052773463 · Cited by 73 · see citing works

Neuroprotective effects of dehydroepiandrosterone (DHEA) in rat model of Alzheimer's disease.

Aly, H. F., Metwally, F. M., & Ahmed, H. H. (2011) · Acta Biochimica Polonica · doi:10.18388/abp.2011_2218 · Cited by 72 · see citing works

Silymarin, a natural antioxidant, protects cerebral cortex against manganese-induced neurotoxicity in adult rats

Chtourou, Y., Fetoui, H., Sefi, M., Trabelsi, K., Barkallah, M., Boudawara, T. S., Kallel, H., & Zeghal, N. (2010) · BioMetals · doi:10.1007/s10534-010-9345-x · Cited by 70 · see citing works

Vitamin E Supplementation in Alzheimer's Disease, Parkinson's Disease, Tardive Dyskinesia, and Cataract: Part 2

Pham, D. Q., & Plakogiannis, R. (2005) · Annals of Pharmacotherapy · doi:10.1345/aph.1g271 · Cited by 70 · see citing works

Selective in vitro and in silico enzymes inhibitory activities of phenolic acids and flavonoids of food plants: Relations with oxidative stress

Yener, İ., Kocakaya, Ş. Ö., Ertaş, A., Erhan, B., Kaplaner, E., Oral, E. V., Yilmaz‐Ozden, T., Yılmaz, M. A., Öztürk, M., & Kolak, U. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.127045 · Cited by 70 · see citing works

Melatonin reduces amyloid β‐induced apoptosis in pheochromocytoma (PC12) cells

Feng, Z., & Zhang, J. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00164.x · Cited by 68 · see citing works

Protective effect of curcumin against chronic alcohol-induced cognitive deficits and neuroinflammation in the adult rat brain

Tiwari, V., & Chopra, K. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.03.042 · Cited by 65 · see citing works

Dual Anti-oxidative Effects of Fraxetin Isolated from Fraxinus rhinchophylla

Thương, P. T., Pokharel, Y. R., Lee, M. Y., Kim, S. K., Bae, K., Sự, N. D., Oh, W. K., & Kang, K. W. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.1527 · Cited by 65 · see citing works

Antioxidant Activity of Galantamine and Some of its Derivatives

Tsvetkova, D. D., Obreshkova, D. P., Zheleva‐Dimitrova, D., & Saso, L. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990148 · Cited by 65 · see citing works

Role of antioxidants and a nutrient rich diet in Alzheimer's disease

Veurink, G., Perry, G. L., & Singh, S. K. (2020) · Open Biology · doi:10.1098/rsob.200084 · Cited by 65 · see citing works

Estrogen Action in Mood and Neurodegenerative Disorders: Estrogenic Compounds with Selective Properties–The Next Generation of Therapeutics

Österlund, M. K., Witt, M., & Gustafsson, J.-Α. (2005) · Endocrine · doi:10.1385/endo:28:3:235 · Cited by 63 · see citing works

Memantine in the treatment of mild-to-moderate Alzheimer’s disease

Cosman, K. M., Boyle, L. L., & Porsteinsson, A. P. (2007) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.8.2.203 · Cited by 63 · see citing works

Activation of membrane estrogen receptors induce pro-survival kinases

Alexaki, V. I., Charalampopoulos, I., Kampa, M., Nifli, A., Hatzoglou, A., Gravanis, A., & Castanas, E. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.08.017 · Cited by 62 · see citing works

Carotenoids as Potential Antioxidant Agents in Stroke Prevention: A Systematic Review

Bahonar, A., Saadatnia, M., Khorvash, F., Maracy, M. R., & Khosravi, A. (2017) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_112_17 · Cited by 61 · see citing works

Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain

Sarada, S. K. S., Titto, M., Himadri, P., Saumya, S. M., & Vijayalakshmi, V. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0326-4 · Cited by 60 · see citing works

Sodium Selenite Prevents Paraquat-Induced Neurotoxicity in Zebrafish

Müller, T. E., Nunes, M. E. M., de Menezes, C. C., Marins, A. T., Leitemperger, J., Gressler, A. C. L., Carvalho, F. B., de Freitas, C. M., de Quadros, V. A., Fachinetto, R., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0441-6 · Cited by 57 · see citing works

Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen

Stacpoole, S., Bilican, B., Webber, D. J., Luzhynskaya, A., He, X., Compston, A., Káradóttir, R. T., Franklin, R. J. M., & Chandran, S. (2011) · Nature Protocols · doi:10.1038/nprot.2011.380 · Cited by 56 · see citing works

Antioxidants for the treatment of mild cognitive impairment

Mecocci, P., Mariani, E., Cornacchiola, V., & Polidori, M. C. (2004) · Neurological Research · doi:10.1179/016164104225017659 · Cited by 55 · see citing works

Estrogen Neuroprotection Against the Neurotoxic Effects of Ethanol Withdrawal: Potential Mechanisms

Jung, M. E., Gatch, M. B., & Simpkins, J. W. (2005) · Experimental Biology and Medicine · doi:10.1177/153537020523000102 · Cited by 49 · see citing works

Design and synthesis of 1,2-dithiolane derivatives and evaluation of their neuroprotective activity

Koufaki, M., Kiziridi, C., Nikoloudaki, F., & Alexis, Μ. N. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.05.036 · Cited by 49 · see citing works

Novel imine antioxidants at low nanomolar concentrations protect dopaminergic cells from oxidative neurotoxicity

Hajieva, P., Mocko, J. B., Moosmann, B., & Behl, C. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06114.x · Cited by 48 · see citing works

Mild Cognitive Impairment — No Benefit from Vitamin E, Little from Donepezil

Blacker, D. (2005) · New England Journal of Medicine · doi:10.1056/nejme058086 · Cited by 44 · see citing works

Selection and molecular characterization of a high tocopherol accumulation rice mutant line induced by gamma irradiation

Hwang, J. E., Ahn, J., Kwon, S., Kim, J., Kim, S. H., Kang, S., & Kim, D. S. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3660-1 · Cited by 43 · see citing works

Involvement of ERK1/2 Pathway in Neuroprotection by Salidroside Against Hydrogen Peroxide-Induced Apoptotic Cell Death

Yu, S., Shen, Y., Liu, J., & Ding, F. (2009) · Journal of Molecular Neuroscience · doi:10.1007/s12031-009-9292-6 · Cited by 42 · see citing works

Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats

Leipnitz, G., Seminotti, B., Amaral, A. U., de Bortoli, G., Solano, A. F., Schuck, P. F., Wyse, Â. T. D. S., Wannmacher, C. M. D., Latini, A., & Wajner, M. (2008) · Life Sciences · doi:10.1016/j.lfs.2007.12.024 · Cited by 41 · see citing works

Long-chain 3-hydroxy fatty acids accumulating in LCHAD and MTP deficiencies induce oxidative stress in rat brain

Tonin, A. M., Grings, M., Busanello, E. N. B., Moura, A. P., Ferreira, G. C., Viegas, C. M., Fernandes, C. G., Schuck, P. F., & Wajner, M. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.03.025 · Cited by 39 · see citing works

Derivation of neural precursor cells from human ES cells at 3% O2 is efficient, enhances survival and presents no barrier to regional specification and functional differentiation

Stacpoole, S., Bilican, B., Webber, D. J., Luzhynskaya, A., He, X., Compston, A., Káradóttir, R. T., Franklin, R. J. M., & Chandran, S. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2010.171 · Cited by 39 · see citing works

Interleukin-1β-induced brain injury and neurobehavioral dysfunctions in juvenile rats can be attenuated by α-phenyl-n-tert-butyl-nitrone

Fan, L.-W., Tien, L., Zheng, B., Pang, Y., Rhodes, P. G., & Cai, Z. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.03.024 · Cited by 39 · see citing works

Anatomical Regional Differences in Selenium Levels in the Human Brain

Ramos, P., Santos, A., Pinto, N. R., Mendes, R. P., Magalhães, T., & Almeida, A. A. (2014) · Biological Trace Element Research · doi:10.1007/s12011-014-0160-z · Cited by 39 · see citing works

Medium-chain fatty acids accumulating in MCAD deficiency elicit lipid and protein oxidative damage and decrease non-enzymatic antioxidant defenses in rat brain

Schuck, P. F., Ferreira, G. C., Moura, A. P., Busanello, E. N. B., Tonin, A. M., Dutra‐Filho, C. S., & Wajner, M. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.02.009 · Cited by 39 · see citing works

Evidence that 3‐hydroxy‐3‐methylglutaric acid promotes lipid and protein oxidative damage and reduces the nonenzymatic antioxidant defenses in rat cerebral cortex

Leipnitz, G., Seminotti, B., Haubrich, J., Dalcin, M. B., Dalcin, K. B., Solano, A. F., de Bortoli, G., Rosa, R. B., Amaral, A. U., Dutra‐Filho, C. S., et al. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21527 · Cited by 37 · see citing works

The tocopherol transfer protein mediates vitamin E trafficking between cerebellar astrocytes and neurons

Ulatowski, L. M., Ghelfi, M. D., West, R., Atkinson, J., Finno, C. J., & Manor, D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101712 · Cited by 36 · see citing works

Promotion of oxidative stress by l-tryptophan in cerebral cortex of rats

Feksa, L. R., Latini, A., Rech, V. C., Wajner, M., Dutra‐Filho, C. S., Wyse, Â. T. D. S., & Wannmacher, C. M. D. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.01.001 · Cited by 36 · see citing works

All-Diamond Microfiber Electrodes for Neurochemical Analysis

Rusinek, C. A., Guo, Y., Rechenberg, R., Becker, M., Purcell, E. K., Verber, M., McKinney, C., & Li, W. (2018) · Journal of The Electrochemical Society · doi:10.1149/2.0141812jes · Cited by 31 · see citing works

Memory-Enhancing Effects of Mangosteen Pericarp Water Extract through Antioxidative Neuroprotection and Anti-Apoptotic Action

Oh, Y., Do, H. T. T., Kim, S.-Y., Kim, Y., Chin, Y., & Cho, J. (2020) · Antioxidants · doi:10.3390/antiox10010034 · Cited by 31 · see citing works

Vitamin E affects cell death in adult rat dentate gyrus

Ferri, P., Cecchini, T., Ciaroni, S., Ambrogini, P., Cuppini, R., Santi, S., Benedetti, S., Pagliarani, S., Grande, P. D., & Papa, S. (2003) · Journal of Neurocytology · doi:10.1023/b:neur.0000021909.84327.e8 · Cited by 31 · see citing works

Neurochemical evidence that 3‐methylglutaric acid inhibits synaptic Na+,K+‐ATPase activity probably through oxidative damage in brain cortex of young rats

Ribeiro, C. A. J., Hickmann, F. H., & Wajner, M. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.10.007 · Cited by 30 · see citing works

Glycine Provokes Lipid Oxidative Damage and Reduces the Antioxidant Defenses in Brain Cortex of Young Rats

Leipnitz, G., Solano, A. F., Seminotti, B., Amaral, A. U., Fernandes, C. G., Beskow, A. P., Dutra‐Filho, C. S., & Wajner, M. (2008) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-008-9318-6 · Cited by 30 · see citing works

Lysine induces lipid and protein damage and decreases reduced glutathione concentrations in brain of young rats

Seminotti, B., Leipnitz, G., Amaral, A. U., Fernandes, C., da Silva, L. D. B., Tonin, A. M., Vargas, C. R., & Wajner, M. (2008) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2008.07.011 · Cited by 29 · see citing works

Carvacrol and Thymol Attenuate Cytotoxicity Induced by Amyloid β25-35 Via Activating Protein Kinase C and Inhibiting Oxidative Stress in PC12 Cells

Azizi, Z., Salimi, M., Amanzadeh, A., Majelssi, N., & Naghdi, N. (2020) · Iranian Biomedical Journal · doi:10.29252/ibj.24.4.243 · Cited by 28 · see citing works

Supplementation with a synthetic polyphenol limits oxidative stress and enhances neuronal cell viability in response to hypoxia–re-oxygenation injury

Duong, T. T. H., Antao, S., Ellis, N. A., Myers, S. J., & Witting, P. K. (2008) · Brain Research · doi:10.1016/j.brainres.2008.04.044 · Cited by 28 · see citing works

Effects of vitamin C and aspirin in ischemic stroke‐related lipid peroxidation: Results of the AVASAS (Aspirin Versus Ascorbic acid plus Aspirin in Stroke) Study

Polidori, M. C., Praticò, D., Ingegni, T., Mariani, E., Spazzafumo, L., Sindaco, P., Cecchetti, R., Yao, Y., Ricci, S., Cherubini, A., et al. (2005) · BioFactors · doi:10.1002/biof.5520240131 · Cited by 28 · see citing works

Synthesis and evaluation of berberine derivatives and analogs as potential antiacetylcholinesterase and antioxidant agents

Roselli, M., Cavalluzzi, M. M., Bruno, C., Lovece, A., Carocci, A., Franchini, C., Habtemariam, S., & Lentini, G. (2016) · Phytochemistry Letters · doi:10.1016/j.phytol.2016.10.005 · Cited by 27 · see citing works

Involvement of anxiety-like behaviors and brain oxidative stress in the chronic effects of alarm reaction in zebrafish populations

de Quadros, V. A., Rosa, L. V., Costa, F. V., Müller, T. E., Stefanello, F. V., Loro, V. L., & Rosemberg, D. B. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104488 · Cited by 26 · see citing works

Identification of oxidized serum albumin in the cerebrospinal fluid of ischaemic stroke patients

Moon, G. J., Shin, D. H., Im, D. S., Bang, O. Y., Nam, H. S., Lee, J., Joo, I. S., Huh, K. H., & Gwag, B. J. (2011) · European Journal of Neurology · doi:10.1111/j.1468-1331.2011.03357.x · Cited by 26 · see citing works

SILKWORM PUPAE PROTECT AGAINST ALZHEIMER’S DISEASE

Wattanathorn, J., Muchimapura, S., Boosel, A., Kongpa, S., Kaewrueng, W., Tong-un, T., Wannanon, P., & Thukham-mee, W. (2012) · American Journal of Agricultural and Biological Sciences · doi:10.3844/ajabssp.2012.330.336 · Cited by 26 · see citing works

Tryptophan administration induces oxidative stress in brain cortex of rats

Feksa, L. R., Latini, A., Rech, V. C., Feksa, P. B., Koch, G. D. W., do Amaral, M. F. A., Leipnitz, G., Dutra‐Filho, C. S., Wajner, M., & Wannmacher, C. M. D. (2008) · Metabolic Brain Disease · doi:10.1007/s11011-008-9087-4 · Cited by 26 · see citing works

Induction of oxidative stress by the metabolites accumulating in isovaleric acidemia in brain cortex of young rats

Solano, A. F., Leipnitz, G., de Bortoli, G., Seminotti, B., Amaral, A. U., Fernandes, C. G., Latini, A., Dutra‐Filho, C. S., & Wajner, M. (2008) · Free Radical Research · doi:10.1080/10715760802311179 · Cited by 26 · see citing works

Effect of Chronic Treatment with Conventional and Organic Purple Grape Juices (Vitis labrusca) on Rats Fed with High-Fat Diet

Cardozo, M. G., Medeiros, N. D. S., Lacerda, D. D. S., de Almeida, D. C., Henriques, J. A. P., Dani, C., & Funchal, C. (2013) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-013-9978-8 · Cited by 25 · see citing works

Biol. Chem.

Behl, C., & Moosmann, B. (2002) · MPG.PuRe (Max Planck Society)

Free Radic. Biol. Med.

Behl, C., & Moosmann, B. (2002) · MPG.PuRe (Max Planck Society)

Antioxidant neuroprotection in Alzheimer’s disease as preventive and therapeutic approach2 2This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.

Behl, C., & Moosmann, B. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00883-3 · Cited by 301 · see citing works

Neuroprotective Therapies for Alzheimers Disease

Huber, A., Stuchbury, G., Bürkle, A., Burnell, J. N., & Münch, G. W. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206775474251 · Cited by 39 · see citing works

Novel Neuroprotective Therapies for Alzheimer's and Parkinsons's Disease

(2012) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9781608052080110050015