Development of a neurotechnological system for relieving phantom limb pain using transverse intrafascicular electrodes (TIME)
Abstract
Phantom limb pain (PLP) is a chronic condition that develops in the majority of amputees. The underlying mechanisms are not completely understood, and thus, no treatment is fully effective. Based on recent studies, we hypothesize that electrical stimulation of afferent nerves might alleviate PLP by giving sensory input to the patient if nerve fibers can be activated selectively. The critical component in this scheme is the implantable electrode structure. We present a review of a novel electrode concept to distribute highly selective electrode contacts over the complete cross section of a peripheral nerve to create a distributed activation of small nerve fiber ensembles at the fascicular level, the transverse intrafascicular multichannel nerve electrode (TIME). The acute and chronic implantations in a small animal model exhibited a good surface and structural biocompatibility as well as excellent selectivity. Implantation studies on large animal models that are closer to human nerve size and anatomical complexity have also been conducted. They proved implant stability and the ability to selectively activate nerve fascicles in a limited proximity to the implant. These encouraging results have opened the way forward for human clinical trials in amputees to investigate the effect of selective electrical stimulation on PLP.
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Most clinical neural interfaces function in a monopolar configuration with a common and distant return ground placed several millimetres away.
“Most clinical neural interfaces function in a monopolar configuration with a common and distant return ground placed several millimetres away [9-12].”
From Three-dimensional multilayer concentric bipolar electrodes restrict spatial activation in optic nerve stimulation (2022) · cites this paper as [11]
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Borda, E., Gaillet, V., Airaghi Leccardi, M. J. I., Zollinger, E. G., Moreira, R. C., & Ghezzi, D. (2022) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac6d7e · Cited by 11 · see citing works
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- Authors
- Stieglitz, T., Boretius, T., Navarro, X., Badia, J., Guiraud, D., Divoux, J.-L., Micera, S., Rossini, P. M., Yoshida, K., Harreby, K. R., Kundu, A., & Jensen, W.
- Affiliations
- University of Freiburg (DE)
- Universitat Autònoma de Barcelona (ES)
- Laboratoire d'Informatique, de Robotique et de Microélectronique de Montpellier (FR)
- Scuola Superiore Sant'Anna (IT)
- Università Campus Bio-Medico (IT)
- Indiana University – Purdue University Indianapolis (US)
- Aalborg University (DK)
- Corresponding author
- Stieglitz, Thomas
- ORCID
- Venue
- Biomedizinische Technik/Biomedical Engineering
- Publisher
- Walter de Gruyter GmbH
- Published
- 2012-01-01
- Volume
- 57
- Issue
- 6
- Pages
- 457-65
- ISSN
- 0013-5585 (ISSN-L)
- 1862-278X
- OpenAlex
- W2052860794
- Cited by
- 11
- References
- 19
- Citations by year
- 2022: 1 · 2021: 1 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 3
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomedizinische Technik/Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
- CINECA IRIS Institutional Research Information System (Sant'Anna School of Advanced Studies) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- phantom limb pain, peripheral nerve stimulation, amputees, chronic pain relief, biocompatibility, implant stability, large animal model
- MeSH terms
- Animals, Electrodes, Implanted, Electric Stimulation Therapy, Equipment Design, Peripheral Nerves, Phantom Limb, Treatment Outcome, Equipment Failure Analysis, Mice
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