Topographical distribution of motor fascicles in the sciatic‐tibial nerve of the rat
Open accessAbstract
Knowledge of the intraneural topography of peripheral nerves may help to improve nerve repair after injuries and the selectivity of neural interfaces. We studied the fascicular pattern of motor fibers of the rat sciatic–tibial nerve. We carried out an anatomical dissection of the muscular tributaries of the tibial nerve in the leg. Immunohistochemistry against choline acetyltransferase was used to identify motor axons. Retrograde tracing allowed localization of the muscular fascicles at proximal levels of the sciatic trunk. The distribution of motor fibers in transverse section of the tibial nerve is not homogeneous; two clusters were identified, each one containing fibers of functionally related muscles. Retrograde tracing allowed for the identification of motor fascicles, each one well localized along the sciatic nerve. In the rat there is a somatotopic organization of the sciatic nerve, with muscular fascicles maintaining the same relative position along the entire nerve. Muscle Nerve, 2010
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The muscular fascicles of the rat sciatic nerve have a known topographical distribution, with TA fibers in the peroneal branch and GM and PL fibers in distinct locations of the tibial branch.
“The fibers innervating the TA muscle are located in the peroneal branch, whereas those innervating the GM and the PL muscles are in distinct locations in the tibial branch.”
From Comparative analysis of transverse intrafascicular multichannel, longitudinal intrafascicular and multipolar cuff electrodes for the selective stimulation of nerve fascicles (2011) · cites this paper as Badia et al 2010
The PL, GM and TA muscles are innervated by different fascicles or subfascicles of the rat sciatic nerve.
“Electromyographic (EMG) signals were simultaneously recorded from the PL, GM and TA muscles, which are innervated by different fascicles or subfascicles of the sciatic nerve (Badia et al 2010).”
From Comparative analysis of transverse intrafascicular multichannel, longitudinal intrafascicular and multipolar cuff electrodes for the selective stimulation of nerve fascicles (2011) · cites this paper as Badia et al 2010
The motor fibers innervating the intrinsic muscles of the foot are distributed in a large central area in comparison with the motor fibers innervating the GM muscle, which are grouped at the periphery of the tibial nerve.
“The motor fibers innervating the intrinsic muscles of the foot are distributed in a large central area in comparison with the motor fibers innervating the GM muscle, which are grouped at the periphery of the tibial nerve (Badia et al 2010).”
From Comparative analysis of transverse intrafascicular multichannel, longitudinal intrafascicular and multipolar cuff electrodes for the selective stimulation of nerve fascicles (2011) · cites this paper as Badia et al 2010
Identification of fascicular contact points for electrode positioning is absolutely essential to selective interfacing with individual fascicles in a particular nerve.
“According to Gustafson et al. (2009) and Badia et al. (2010), the identification of fascicular contact points for electrode positioning is absolutely essential to selective interfacing with individual fascicles in a particular nerve.”
From Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review. (2017) · cites this paper as Badia et al., 2010
The authors developed a novel, high electrode-density (25 electrodes/mm2), high electrode-count (48-96 electrodes) penetrating neural interface designed for stimulation and recording in sub-millimeter neuroanatomical structures, such as small diameter nerves (<2 mm).
“We have developed a novel, high electrode-density (25 electrodes/mm 2 ), high electrode-count (48-96 electrodes) penetrating neural interface, designed for use in stimulation and recording in sub-millimeter neuroanatomical structures, such as small diameter nerves (<2 mm) like the rat sciatic [37], feline pudendal [38], or feline/human cochlear nerves [46].”
From A new high-density (25 electrodes/mm<sup>2</sup>) penetrating microelectrode array for recording and stimulating sub-millimeter neuroanatomical structures (2013) · cites this paper as [37]
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Self-citationElectrical Stimulation of the Nervous System
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A Soft and Stretchable Multielectrode Cuff for Selective Peripheral Nerve Stimulation
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Gli1 Regulates the Postnatal Acquisition of Peripheral Nerve Architecture
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Engineered Graphene Material Improves the Performance of Intraneural Peripheral Nerve Electrodes
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Peripheral nerve alterations after spinal cord injury in the adult rat
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Self-citationAxonal Fusion via Conduit-Based Delivery of Hydrophilic Polymers
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Self-citationTargeting SARM1 improves autophagic stress-induced axonal neuropathy
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A rodent model of partial muscle re-innervation
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Long-term implantable flexible neural interfaces for electrophysiological monitoring
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Pudendal, but not tibial, nerve stimulation modulates vulvar blood perfusion in anesthetized rodents
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A review of source separation and source localization approaches in peripheral nerves
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Self-citationOrganization of Axons in Their Tracts
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Disruption of Lactate Metabolism in the Peripheral Nervous System Leads to Motor‐Selective Deficits
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- Authors
- Badia, J., Pascual‐Font, A., Vivó, M., Udina, E., & Navarro, X.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Corresponding author
- Navarro, Xavier
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 2010-04-14
- Volume
- 42
- Issue
- 2
- Pages
- 192-201
- ISSN
- 0148-639X (ISSN-L)
- 1097-4598
- OpenAlex
- W2042450181
- Semantic Scholar
- cec8f5f14a89258831963365ad12ba1cee6342b4
- Cited by
- 98
- References
- 48
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 12 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 4 · 2013: 7 · 2012: 11
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Muscle & Nerve (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Surgery › Nerve Injury and Rehabilitation
- Keywords
- somatotopic organization, motor axons, choline acetyltransferase, retrograde tracing, nerve repair, neural interfaces, rats
- MeSH terms
- Animals, Axons, Choline O-Acetyltransferase, Immunohistochemistry, Models, Anatomic, Motor Neurons, Sciatic Nerve, Muscle, Skeletal, Rats, Neuronal Tract-Tracers
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