Per3 length polymorphism in patients with type 2 diabetes mellitus
Open accessAbstract
BACKGROUND: A number of observations support the involvement of circadian clock genes in the regulation of metabolic processes. One of these circadian genes, Per3, exhibits a variable number tandem repeat length polymorphism, consisting of two alleles, namely four and five repeat alleles, in its exon 18. The objective of this study was to examine the existence of Per3 variants in patients with type 2 diabetes mellitus (T2DM) as compared to a non T2DM control group. METHODS: Intravenous blood samples were collected to obtain white blood cells from 302 T2DM patients and 330 non-diabetic, age- and sex-matched, individuals. Per3 genotyping was performed on DNA by polymerase chain reaction. RESULTS: Frequency of five repeat allele was higher, and that of four repeat allele lower, in T2DM patients as compared to non-diabetic controls (χ2=6.977, p=0.0082) CONCLUSIONS: The results indicate an association of Per3 five repeat allele with T2DM occurrence and suggest that individuals with five repeat allele may be at a greater risk for T2DM as compared to those carrying the four repeat allele.
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The PER3 variable number tandem repeat 5-repeats allele was associated with a greater risk of type 2 diabetes mellitus compared with the 4-repeats allele.
“These authors found that those with the 5-repeats allele had a greater risk of type 2 diabetes mellitus compared with those carrying the 4-repeats allele.”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [62]
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Circadian rhythms, metabolism, and chrononutrition in rodents and humans
Johnston, J. D., Ordovás, J. M., Scheer, F. A., & Turek, F. W. (2016) · Advances in Nutrition · doi:10.3945/an.115.010777 · Cited by 258 · see citing works
- Authors
- Karthikeyan, R., Marimuthu, G., Sooriyakumar, M., BaHammam, A. S., Spence, D. W., Pandi-Perumal, S. R., Brown, G. M., & Cardinali, D. P.
- Affiliations
- Department of Animal Behaviour and Physiology, School of Biological Sciences, Madurai Kamaraj University, Madurai, India
- Madurai Kamaraj University (IN)
- Madurai Medical College (IN)
- King Saud University (SA)
- Independent Researcher, 652 Dufferin Street, Toronto, Canada
- Somnogen Canada Inc., Toronto, Canada
- Centre for Addiction and Mental Health (CA)
- Pontificia Universidad Católica Argentina (AR)
- Corresponding author
- Marimuthu, Ganapathy
- ORCID
- Venue
- Hormone Molecular Biology and Clinical Investigation
- Publisher
- Walter de Gruyter GmbH
- Published
- 2013-12-14
- Volume
- 18
- Issue
- 3
- Pages
- 145-149
- ISSN
- 1868-1883 (ISSN-L)
- 1868-1891
- OpenAlex
- W2105064534
- Cited by
- 23
- References
- 38
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 2 · 2016: 4 · 2015: 4 · 2014: 1
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-sa
- Locations
- Hormone Molecular Biology and Clinical Investigation (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Agencia Nacional de Promoción Científica y Tecnológica
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- Per3, type 2 diabetes, variable number tandem repeats, length polymorphism, clock genes, genetic susceptibility, exon 18
- MeSH terms
- Adult, Alleles, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Polymorphism, Genetic, Case-Control Studies, Genetic Predisposition to Disease, Genetic Association Studies, Period Circadian Proteins
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