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Berberine: a potential phytochemical with multispectrum therapeutic activities

Vuddanda, Parameswara Rao, Chakraborty, Subhashis, Singh, Sanjay·2010·Expert Opinion on Investigational Drugs
DOI 10.1517/13543784.2010.517745
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Abstract

IMPORTANCE OF THE FIELD: The use of traditional medicines of natural origin is being encouraged for the treatment of chronic disorders, as synthetic drugs in such cases may cause unpredictable adverse effects. Berberine, a traditional plant alkaloid, is used in Ayurvedic and Chinese medicine for its antimicrobial and antiprotozoal properties. Interestingly, current clinical research on berberine has revealed its various pharmacological properties and multi-spectrum therapeutic applications. AREAS COVERED IN THIS REVIEW: An extensive search in three electronic databases (Unbound Medline, PubMed and ScienceDirect) and internet search engines (Scirus and Google Scholar) were used to identify the clinical studies on berberine, without any time constraints. This review elaborates the recent studies which reveal that with time, the drug has evolved with superior therapeutic activities. In addition, this review will also attract the attention of formulation scientists towards the issues and challenges associated in its drug delivery and the probable approaches that may be explored to help patients reap the maximum benefit of this potentially useful drug. WHAT THE READER WILL GAIN: A relatively large number of studies discussed here have revealed the possible areas where this phytochemical constituent can exhibit its therapeutic activities in the treatment of chronic ailments or diseases including diabetes, cancer, depression, hypertension and hypercholesterolemia. TAKE HOME MESSAGE: The potential of the drug remains to be harvested by designing a suitable formulation that could overcome its inherent low bioavailability.

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Metadata

Authors
Vuddanda, P. R., Chakraborty, S., & Singh, S.
Venue
Expert Opinion on Investigational Drugs
Publisher
Informa UK Limited
Published
2010-09-13
Volume
19
Issue
10
Pages
1297-1307
ISSN
  • 1354-3784 (ISSN-L)
  • 1744-7658
DOI
10.1517/13543784.2010.517745
OpenAlex
W2076903615
Cited by
316
References
2
FWCI
11.07
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Berberine: a potential phytochemical with multispectrum therapeutic activities. https://app.cochat.ai/papers/10.1517/13543784.2010.517745
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Vuddanda, P. R., Chakraborty, S., & Singh, S. (2010). Berberine: a potential phytochemical with multispectrum therapeutic activities. Expert Opinion on Investigational Drugs. https://doi.org/10.1517/13543784.2010.517745

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.