The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Toxicological considerations when creating nanoparticle-based drugs and drug delivery systems
Open accessAbstract
INTRODUCTION: The biggest challenge faced by the scientific community involved in drug development is to deliver safe and effective dosage of drugs without causing systemic toxicity. Therefore, novel nano-based delivery vehicles specifically targeting tumors but not normal tissues are urgently needed. AREAS COVERED: Nanoparticles have beneficial aspects but can be toxic themselves, which is always a concern for any drug or delivery agent. This review examines and details the toxicological aspects that should be considered when planning to use nanoparticles in animals or in man for drug delivery or imaging. Subjects discussed in this review include i) overviews of applications of various nanoparticles for drug delivery and imaging; ii) toxicological aspects to consider when selecting particular nanoparticles for use in various applications in animals or man; iii) hurdles faced when examining nanoparticle toxicity; and iv) current approaches for assessing nanoparticle toxicity. EXPERT OPINION: Nanotechnology has significant potential for advancing therapeutic efficacy and imaging in cancer; however, these agents can be toxic. Therefore, toxicity needs to be considered when selecting nanoparticles for a particular application. Methods for assessing nanoparticle toxicity need to be improved and standardized across all nanotechnology platforms in order to speed up the application of nanoparticle use in humans.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diffusion of univalent ions across the lamellae of swollen phospholipids
Bangham, A. D., Standish, M. M., & Watkins, J. C. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80093-6 · Cited by 4,664
Biodegradation and biocompatibility of PLA and PLGA microspheres
Anderson, J. M., & Shive, M. S. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00048-3 · Cited by 2,617
Toxicity of cationic lipids and cationic polymers in gene delivery
Lv, H., Zhang, S., Wang, B., Cui, S., & Yan, J. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.04.014 · Cited by 2,286
Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage
Li, N., Sioutas, C., Cho, A., Schmitz, D., Misra, C., Sempf, J., Wang, M., Oberley, T., Froines, J., & Nel, A. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6000 · Cited by 2,097
New-Concept Chemotherapy by Nanoparticles of Biodegradable Polymers: Where Are We Now?
Feng, S.-S. (2006) · Nanomedicine · doi:10.2217/17435889.1.3.297 · Cited by 1,951
Athanasiou, K. A., Niederauer, G. G., & Agrawal, C. M. (1996) · Biomaterials · doi:10.1016/0142-9612(96)85754-1 · Cited by 1,497
The convergence of synthetic organic and polymer chemistries
Hawker, C. J., & Wooley, K. L. (2005) · Science · doi:10.1126/science.1109778 · Cited by 1,298
Respiratory toxicity of multi-wall carbon nanotubes
Muller, J., Huaux, F., Moreau, N., Misson, P., Heilier, J.-F., Delos, M., Arras, M., Fonseca, A., Nagy, J. B., & Lison, D. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2005.01.008 · Cited by 1,123
Minireview: Nanoparticles and the Immune System
Zolnik, B. S., González-Fernández, A., Sadrieh, N., & Dobrovolskaia, M. A. (2010) · Endocrinology · doi:10.1210/en.2009-1082 · Cited by 914
Liposome application: problems and prospects.
Barenholz, Y. (2001) · Current Opinion in Colloid & Interface Science · doi:10.1016/s1359-0294(00)00090-x · Cited by 659
Cited by
Baati, T., Njim, L., Neffati, F., Kerkeni, A., Bouttemi, M., Gref, R., Najjar, M. F., Zakhama, A., Couvreur, P., Serre, C., et al. (2013) · Chemical Science · doi:10.1039/c3sc22116d · Cited by 405
Rai, R., Alwani, S., & Badea, I. (2019) · Polymers · doi:10.3390/polym11040745 · Cited by 350
Nanotechnology-based antiviral therapeutics
Chakravarty, M., & Vora, A. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00818-0 · Cited by 334
Wei, X., Shao, B., He, Z., Ye, T., Luo, M., Sang, Y., Liang, X., Wang, W., Luo, S., Yang, S., et al. (2015) · Cell Research · doi:10.1038/cr.2015.9 · Cited by 306
Microglia-targeting nanotherapeutics for neurodegenerative diseases
Zhao, N., Francis, N. L., Calvelli, H. R., & Moghe, P. V. (2020) · APL Bioengineering · doi:10.1063/5.0013178 · Cited by 104
Metadata
- Authors
- Sharma, A., Madhunapantula, S. V., & Robertson, G. P.
- Venue
- Expert Opinion on Drug Metabolism & Toxicology
- Publisher
- Informa UK Limited
- Published
- 2011-11-19
- Volume
- 8
- Issue
- 1
- Pages
- 47-69
- ISSN
- 1742-5255 (ISSN-L)
- 1744-7607
- OpenAlex
- W2126153146
- Cited by
- 242
- References
- 13
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Toxicological considerations when creating nanoparticle-based drugs and drug delivery systems. https://app.cochat.ai/papers/10.1517/17425255.2012.637916
- The paper
- Sharma, A., Madhunapantula, S. V., & Robertson, G. P. (2012). Toxicological considerations when creating nanoparticle-based drugs and drug delivery systems. Expert Opinion on Drug Metabolism & Toxicology. https://doi.org/10.1517/17425255.2012.637916
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
